• Nuclear Engineering and Technology
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• v.55 no.12
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• pp.4447-4464
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• 2023

This paper focuses on the development of a new computational model of the CNESTEN's TRIGA Mark II research reactor using the 3D continuous energy Monte-Carlo code TRIPOLI-4 (T4). This new model was developed to assess neutronic simulations and determine quantities of interest such as kinetic parameters of the reactor, control rods worth, power peaking factors and neutron flux distributions. This model is also a key tool used to accurately design new experiments in the TRIGA reactor, to analyze these experiments and to carry out sensitivity and uncertainty studies. The geometry and materials data, as part of the MCNP reference model, were used to build the T4 model. In this regard, the differences between the two models are mainly due to mathematical approaches of both codes. Indeed, the study presented in this article is divided into two parts: the first part deals with the development and the validation of the T4 model. The results obtained with the T4 model were compared to the existing MCNP reference model and to the experimental results from the Final Safety Analysis Report (FSAR). Different core configurations were investigated via simulations to test the computational model reliability in predicting the physical parameters of the reactor. As a fairly good agreement among the results was deduced, it seems reasonable to assume that the T4 model can accurately reproduce the MCNP calculated values. The second part of this study is devoted to the sensitivity and uncertainty (S/U) studies that were carried out to quantify the nuclear data uncertainty in the multiplication factor k_eff. For that purpose, the T4 model was used to calculate the sensitivity profiles of the k_eff to the nuclear data. The integrated-sensitivities were compared to the results obtained from the previous works that were carried out with MCNP and SCALE-6.2 simulation tools and differences of less than 5% were obtained for most of these quantities except for the C-graphite sensitivities. Moreover, the nuclear data uncertainties in the k_eff were derived using the COMAC-V2.1 covariance matrices library and the calculated sensitivities. The results have shown that the total nuclear data uncertainty in the k_eff is around 585 pcm using the COMAC-V2.1. This study also demonstrates that the contribution of zirconium isotopes to the nuclear data uncertainty in the k_eff is not negligible and should be taken into account when performing S/U analysis.

• The korean journal of orthodontics
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• v.31 no.1 s.84
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• pp.149-157
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• 2001

The purpose of this study was to investigate the property of a new Korean stainless steel wire(Jinsung Ind.) comparing with other foreign Products. Five types of stainless steel wires (Standard, Resilient, HI-T of Unitek, Stainless steel of Ormco and Jinsung Ind.) in 0.016x0.022 and 0.019x0.02 were tested to observe for Composition analysis, size difference, tensile properties, flexure bending property, tortion property, surface hardness and surface topography by means of SEM. The findings suggest that: 1. In maximum tensile strength of tensile properties, Unitek Hi-T showed the greatest value, followed by Unitek Resilient, Jinsung Stainless Steel, Ormco Stainless Steel, Unitek Standard in 0.016x0.022, and Unitek Hi-T showed highest value, followed by Jinsung Stainless Steel, Ormco Stainless Steel, Unitek Resilient, Unitek Standard in 0.019x 0.025. 2. In elongation rate, Unitek Standard showed the greatest value, fellowed by Ormco Stainless Steel, Unitek Hi-T, Unitek Resilient, Jinsung Stainless Steel in 0.016x0.022, and Unitek Hi-T showed the highest value, followed by Unitek Standard, Ormco Stainless Steel, Jinsung Stainless Steel, Unitek Resilient in 0.019x0.025. 3. In modulus of elasticity, Jinsung Stainless Steel showed the greatest value, followed by Unitek Hi-T, Unitek Resilient, Ormco Stainless Steel, Unitek Standard in 0.016x0.022, and Unitek Resilient showed the highest value followed by Jinsung Stainless Steel, Ormco Stainless Steel, Unitek Hi-T, Unitek Standard in 0.019x0.025. 4. In bending fatigue test, Jinsung Stainless Steel showed the greatest fracture resistance, followed by Unitek Hi-T, Unitek Standard, Unitek Resilient, Ormco Stainless Steel in 0.016x0.022, and Unitek Hi-T showed the greatest fracture resistance followed by Jinsung Stainless Steel, Unitek Resilient, Unitek Standard, Ormco Stainless Steel in 0.019x0.025. 5. In twist test, Unitek Resilient showed the greatest fracture resistance, followed by Jinsung Stainless Steel, Unitek Hi-7, Ormco Stainless Steel, Unitek Standard in 0.016x0.022, and Jinsung showed the greatest fracture resistance, followed by Unitek Resilient, Unitek Standard, Ormco Stainless Steel, Unitek Hi-T. 6. In surface topography, every products showed indentation and pitting. Jinsung stainless steel wire showed long thin indentation and relatively smooth surface. Unitek wires showed indentation and pitting and Ormco wire showed a lot of irregular pittings.

• Journal of Pharmaceutical Investigation
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• v.38 no.4
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• pp.269-275
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• 2008

The purpose of the present study was to evaluate the bioequivalence of two levofloxacin tablets, Jeil $Cravit^{TM}$ tablet (Jeil Pharm. Co., Ltd., Korea, reference drug) and $Lesacin^{TM}$ tablet (Ilhwa. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received two tablets containing levofloxacin 200 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of levofloxacin were monitored for over a period of 24 hr after administration by using a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The area under the plasma concentration-time curve from time zero to 24 hr ($AUC_t$), maximum plasma drug concentration ($C_{max}$) and time to reach $C_{max}\;(T_{max})$ were complied from the plasma concentration-time data. Analysis of variance (ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Lesacin^{TM}$/Jeil $Cravit^{TM}$ were $\log\;0.9527{\sim}\log\;0.9981$ and $\log\;0.8712{\sim}\log\;1.0556$, respectively. These values were within the acceptable bioequivalence intervals of $\log\;0.80{\sim}\log\;1.25$, recommended by KFDA. In all of these results, we concluded that $Lesacin^{TM}$ tablet was bioequivalent to Jeil $Cravit^{TM}$ tablet, in terms of rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.39 no.6
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• pp.457-463
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• 2009

The purpose of the present study was to evaluate the bioequivalence of meloxicam capsule, $Mobic^{TM}$ capsule( Boehringer Ingelheim Ltd., Korea) as a reference drug and $Meloxifen^{TM}$ capsule (Kukje Pharma Ind. Co., Ltd., Korea) as a test drug, according to the guidelines of Korea Food and Drug Administration(KFDA). Thirty two healthy male Korean volunteers received capsule containing meloxicam 7.5 mg in a $2{\times}2$ crossover study. There was a one-week above washout period between the doses. Plasma concentrations of meloxicam were monitored for over a period of 72 hr after administration by using a high performance liquid chromatography-tandem mass spectrometer(LC-MS/MS). $AUC_t$(the area under the plasma concentration-time curve from time zero to 72 hr), $C_{max}$(maximum plasma drug concentration) and $T_{max}$(time to reach $C_{max}$) were complied from the plasma concentration-time data. Analysis of variance(ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t$ and $C_{max}$. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for $Meloxifen^{TM}/Mobic^{TM}$ were log 0.8605-log 0.9847 and log 0.9765-log 1.1503, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25, recommended by KFDA. In all of these results, we concluded that $Meloxifen^{TM}$ capsule was bioequivalent to $Mobic^{TM}$ capsule, based on the rate and extent of absorption.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.12 no.1
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• pp.103-130
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• 2008

Background: For standardizing of Han-Yeol [寒熱], which is a kind of diagnosis method in oriental medicine, it is necessary to investigate into relationship of symptoms and signs representative of Han-Yeol [寒熱] to the biofunctional medical signals; thermal temperature by Thermography, Pulse-Respiration Ratio and so on. By correlation analysis of these data items acquired from patients, it could be provides the fundamental data for standardizing of Han-Yeol [寒熱]. Objectives: We performed this study to check the characteristics of thermal temperature with Han-Yeol [寒熱] statue by pulse-respiration ratio. Methods: We selected nine regions around acupoints including Yin dang[印堂], Sugu[水溝, GV26], Ch'ondol[天突, CV22], Chonjung[CV17], Chung-wan[中脘, CV12], Chonchu[天樞 S25], No-gung[勞官, P8], and calculated based on the utility of R.O.I.(Region of Integer) by IR-2000 these points temperature from 68 subjects. In practicing pulse-respiration ratio over 4.0 means the statues of Yeol [熱], pulse-respiration ratio below 4.0 means the statues of Han [寒]. To optimum conditions thermal temperature, which are not effected by internal and external variables, we studied preceding research. The results shows that optimal time period is 20minutes after undressed and the optimal region is the region around acupoints including Sugu [水溝, GV26]. Based on a preceding research results, we analyzed these data by Paired T-test between GV26 Region and 8-Thermography Regions and two-way repeated ANOVA with thermography$({\Delta}T)$ and Han-Yeol [寒熱] statue by pulse-respiration ratio. Results: 1. In applying of two-way repeated ANOVA with thermography$({\Delta}T)$ and Han-Yeol [寒熱] statue by pulse-respiration ratio, Sugu [水溝穴, GV26] - [印堂穴, HN1], Sugu 水溝, GV26] - Chonjung[CV17], Sugu [水溝, GV26] -Chung-wan[中脘, CV12]had significant differences. 2. In applying of Paired T-test between Sugu [水溝穴, GV26] Region and 8- Thermography Regions, there were significant differences except of Sugu [水溝穴, GV26] -Chondolp[天突, CV22]. 3. In the difference of Sugu [水溝, GV26] -Chung-wan[中脘, CV12], thermal temperature increases a lot in the statues of Yeol [熱], thermal temperature decreases a lot in the statues of Han [寒]. Conclusions: On the analysis of Thermography, we obtain the measurement conditions were considered the individual variations. And it is different that the thermal temperature change on Thermography according to Han-Yeol [寒熱] statue by pulse-respiration ratio.

• The Korean Journal of Nuclear Medicine Technology
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• v.18 no.1
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• pp.158-162
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• 2014

Purpose: Reference material (RM) is defined as material that is safe and homogeneous enough about specified characteristic that is made with a purpose of using test of measurement or nominal characteristic. Certified reference material (CRM), which is issued by authorized organization, is defined as reference material that provides characteristic value, link uncertainty and retroactivity. The purpose of this paper was to evaluate recovery of radioimmunoassay by Certified Reference Material enclosed with a certificate and therefore to enhance reliability of test. Materials and Methods: WHO certified reference material is purchased from NIBSC (National Institute for Biological Standard and Control, United Kingdom) and made of 3 levels that are C-1 (low concentration), C-2 (medium concentration) and C-3 (high concentration) and measured for kit at the Seoul National University Hospital. Recovery rate is evaluated after measurement at four different days. Results: Recovery rate results using WHO certified reference material are T4 90%, Ferritin 88%, PSA 94%, Prolactin 99%, AFP 94% and TSH 93%. Conclusion: A procedure that appropriate accuracy, precision, specificity, sensitivity, reproducibility, and validate on the subject of kit for radioimmunoassay is essential. Recovery rate assay as extraction efficiency of analysis process is percent about already measuring results of analysis result after all measuring process. This is very important assessment standards of performance evaluation of immunoassay kit. Recovery rate results of 6 type used WHO CRM are satisfactory to 88~99%. This demonstrates that the radioimmunoassay is a very accurate measurement, which is very effectively utilized in clinical practice.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.398-404
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• 2017

The aim of this study was to determine the effect of a non-elastic fixation belt on the balance ability and fall prevention in elderly women. Elderly women experience reduced balance ability and an increased risk of falls due to a weakening of the surrounding sacroiliac joint and pelvic muscles during childbirth and menopause. On the other hand, specific studies are still needed. The subjects were allocated randomly to two groups: control (n=20) and experimental (n=20). The experimental group used a non-elastic fixation belt, whereas the control group had no fixation belt. The balance ability and the fall index were measured in all subjects using a balance measurement device, and the low abdominal muscle thickness was determined in the experimental group using ultrasound imaging for the exact application of the non-elastic fixation belt. The following statistical analysis was performed: an independent t-test for the general characteristics of the subjects, $2{\times}2$ analysis of variance with repeated measures for the balance and fall index score, and a paired t-test for the abdominal muscle thickness. The group ${\times}$ time interaction effect showed significant improvement in the General Stability Index (F1,38=47.24, p=0.001), Fourier Harmony Index (F1,38=88.83, p=0.001), Weight Distribution Index (F1,38=50.21, p=0.001), and Fall Index (F1,38=21.59, p=0.001). The thicknesses of the transverse abdominal (p=0.001) and internal oblique (p=0.001) muscles were increased significantly in the experimental group after using the non-elastic fixation belt. Overall, the application of a non-elastic fixation belt could be effective in improving the balance ability and fall prevention in elderly women.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.10
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• pp.209-217
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• 2019

This is a descriptive research study undertaken to confirm the relationship between depression, fear-avoidance beliefs, catastrophizing, and the quality of life in the elderly with chronic pain, and how psychological factors affect their quality of life. The subjects were 147 seniors aged 65 years or older, who visited a neuropathy clinic in A city from March 4, 2019 to March 18, 2019. Statistical analysis was achieved by applying t-test, ANOVA, Pearson's correlation coefficients, and multiple regression analyses using the SPSS/WIN 22.0 software. Considering the demographic characteristics of the elderly, quality of life revealed significant differences with respect to age (F=3.464, p<0.001), the presence of the spouse (F=3.464, p<0.001), health condition (t=4.545, p<0.001), and pain degree (F=14.76, p<0.001). Further analysis revealed that factors affecting quality of life in the elderly with chronic pain are depression (${\beta}=-0.25$, p<0.001), pain degree (${\beta}=0.25$, p<0.001), catastrophizing (${\beta}=-0.28,$p<0.001) and health condition $({\beta}=-0.19$, p<0.001), with a total explanation power of 49%. Hence, researches on the negative psychological factors, such as depression and catastrophizing, are required to improve the quality of life for the elderly. In addition, the development of a systematic nursing arbitration program is necessary to positively recognize active pain control and health conditions.

• Journal of Industrial Convergence
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• v.16 no.4
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• pp.1-8
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• 2018

This study aimed to provide basic data on health promotion programs to prevent cardiocerebrovascular Disease by identifying knowledge, attitude and self-efficacy. Data were collected from 198 middle-aged adults in S-city. The data analysis was analyzed with technical statistics and t-test, ANOVA, Pearson's correlation coefficient. There were significant differences in knowledge depending on the age, education level, monthly income and there were significant differences in attitude depending on the education level and monthly income. There were also significant differences in self-efficacy between gender. The correlation analysis also showed a significant correlation between knowledge of cardiovascular disease and attitudes toward prevention(t=.45, p<.001). In other words, the higher your knowledge of cardiovascular disease, the more positive you are about preventing it. Therefore, it is necessary to develop education and mediation programs that can form a positive attitude toward preventing cardiocerebrovascular disease and to develop programs that enhance the self-efficacy of middle-aged men.

• Journal of Broadcast Engineering
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• v.25 no.6
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• pp.973-979
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• 2020

This study aims to objectively and quantitatively determine the social emotion of empathy by collecting pupillary response. 52 subjects (26 men and 26 women) voluntarily participated in the experiment. After the measurement of the reference of 30 seconds, the experiment was divided into the task of imitation and spontaneously self-expression. The two subjects were interacted through facial expressions, and the pupil images were recorded. The pupil data was processed through binarization and circular edge detection algorithm, and outlier detection and removal technique was used to reject eye-blinking. The pupil size according to the empathy was confirmed for statistical significance with test of normality and independent sample t-test. Statistical analysis results, the pupil size was significantly different between empathy (M ± SD = 0.050 ± 1.817)) and non-empathy (M ± SD = 1.659 ± 1.514) condition (t(92) = -4.629, p = 0.000). The rule of empathy according to the pupil size was defined through discriminant analysis, and the rule was verified (Estimation accuracy: 75%) new 12 subjects (6 men and 6 women, mean age ± SD = 22.84 ± 1.57 years). The method proposed in this study is non-contact camera technology and is expected to be utilized in various virtual reality with smart glasses.