• Nutrition Research and Practice
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• v.17 no.4
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• pp.789-802
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• 2023

BACKGROUND/OBJECTIVES: Habitual coffee consumption was inversely associated with type 2 diabetes (T2D) and hyperglycemia in observational studies, but the causality of the association remains uncertain. This study tested a causal association of genetically predicted coffee consumption with T2D using the Mendelian randomization (MR) method. SUBJECTS/METHODS: We used five single-nucleotide polymorphisms (SNPs) as instrumental variables (IVs) associated with habitual coffee consumption in a previous genome-wide association study among Koreans. We analyzed the associations between IVs and T2D, fasting blood glucose (FBG), 2h-postprandial glucose (2h-PG), and glycated haemoglobin (HbA1C) levels. The MR results were further evaluated by standard sensitivity tests for possible pleiotropism. RESULTS: MR analysis revealed that increased genetically predicted coffee consumption was associated with a reduced prevalence of T2D; ORs per one-unit increment of log-transformed cup per day of coffee consumption ranged from 0.75 (0.62-0.90) for the weighted mode-based method to 0.79 (0.62-0.99) for Wald ratio estimator. We also used the inverse-variance-weighted method, weighted median-based method, MR-Egger method, and MR-PRESSO method. Similarly, genetically predicted coffee consumption was inversely associated with FBG and 2h-PG levels but not with HbA1c. Sensitivity measures gave similar results without evidence of pleiotropy. CONCLUSIONS: A genetic predisposition to habitual coffee consumption was inversely associated with T2D prevalence and lower levels of FBG and 2h-PG profiles. Our study warrants further exploration.

• Clinical Nutrition Research
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• v.11 no.2
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• pp.120-132
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• 2022

Numerous clinical trials have examined the beneficial effects of Juglans regia leaf extract (JRLE) in patients with type 2 diabetes mellitus (T2DM); however, the results of these studies are inconsistent. Therefore, we conducted the current systematic review and meta-analysis to evaluate the effect of JRLE on glycemic control and lipid profile in T2DM patients. We searched online databases including PubMed, Scopus, EMBASE, and Web of Science for randomized controlled clinical trials that examined the effect of JRLE on glycemic and lipid indices in T2DM patients. Data were pooled using both fixed and random-effect models and weighted mean difference (WMD) was considered as the overall effect size. Of the total records, 4 eligible studies, with a total sample size of 195 subjects, were included. The meta-analysis revealed that JRLE supplementation significantly reduces fasting blood glucose (WMD, -18.04; 95% confidence interval [CI], -32.88 mg/dL, -3.21 mg/dL; p = 0.017) and significantly increases fasting insulin level (WMD, 1.93; 95% CI, 0.40 U/L, 3.45 U/L; p = 0.014). Although the overall effect of JRLE supplementation on hemoglobin A1c was not significant, a significant reduction was seen in studies with an intervention duration of > 8 weeks (WMD, -0.64; 95% CI, -1.16%, -0.11%; p = 0.018). Moreover, we also found no significant change in lipid parameters. Our findings revealed a beneficial effect of JRLE supplementation on glycemic indices in T2DM patients, but no significant improvement was found for lipid profile parameters.

• Journal of Gastric Cancer
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• v.13 no.3
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• pp.164-171
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• 2013

Purpose: Laparoscopy-assisted distal gastrectomy for early gastric cancer has gained acceptance and popularity worldwide. However, laparoscopy-assisted distal gastrectomy for advanced gastric cancer is still controversial. Therefore, we propose this prospective randomized controlled multi-center trial in order to evaluate the safety and feasibility of laparoscopy assisted D2-gastrectomy for advanced stage gastric cancer. Materials and Methods: Patients undergoing distal gastrectomy for advanced gastric cancer staged cT2/3/4 cN0/1/2/3a cM0 by endoscopy and computed tomography are eligible for enrollment after giving their informed consent. Patients will be randomized either to laparoscopyassisted distal gastrectomy or open distal gastrectomy. Sample size calculation revealed that 102 patients are to be included per treatment arm. The primary endpoint is the non-compliance rate of D2 dissection; relevant secondary endpoints are three-year disease free survival, surgical and postoperative complications, hospital stay and unanimity rate of D2 dissection evaluated by reviewing the intraoperative video documentation. Discussion: Oncologic safety is the major concern regarding laparoscopy-assisted distal gastrectomy for advanced gastric cancer. Therefore, the non-compliance rate of clearing the N2 area was chosen as the most important parameter for the technical feasibility of the laparoscopic procedure. Furthermore, surgical quality will be carefully reviewed, that is, three independent experts will review the video records and score with a check list. For a long-term result, disease free survival is considered a secondary endpoint for this trial. This study will offer promising evidence of the feasibility and safety of Laparoscopy-assisted distal gastrectomy for advanced gastric cancer. Trial Registration: NCT01088204 (international), NCCCTS-09-448 (Korea).

• Asian-Australasian Journal of Animal Sciences
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• v.12 no.5
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• pp.677-681
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• 1999

Estimates were made of genetic parameters for average daily gain (ADG) and average backfat thickness (ABF), and of the effect of sex on estimates of variance-covariance components for average daily gain of boars (DGM) and gilts (DGF) and average bacfat thickness of boars (BFM) and gilts (BFF) by residual maximum likelihood (REML) under a bivariate animal model. Data included a total of 2233 records (757 for boars and 1476 for gilts) of the Large White breed born between 1981 and 1986 in Miyazaki and Iwate prefectures in Japan. Heritability estimates for ADG and ABF were 0.43 and 0.69, respectively, with a genetic correlation of -0.08. Heritability estimates for DGM and DGF were 0.54 and 0.46, respectively, with a genetic correlation of 0.79, including that the two traits are influenced by similar but not identical genes. Respective estimates for BFM and BFF were 0.71 and 0.72 with a genetic correlation of 0.95, indicating that identical genes influence backfat thickness in boars and gilts.

• Proceedings of the Korea Water Resources Association Conference
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• 2009.05a
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• pp.2088-2092
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• 2009

비점오염원은 면으로 분포하는 오염원으로 강우시 지표유출에 의해 유출되기 때문에 발생지점 및 발생량 추정이 어려우며, 이에 대한 처리가 어려운 실정이다. 현재 점오염원의 처리는 어는 정도 도달한 선진국에서는 비점오염원이 가장 중요한 오염원으로 대두되고 있는 실정이다. 따라서, 본 연구에서는 소양호 상류유역의 지류하천인 내린천, 인북천, 북천을 대상으로 부영영화를 일으키는 수질인자 BOD, COD, SS, T-N, T-P를 대상으로 강우량에 따른 수질농도가 변화하는 양상을 고찰하였다. 연구결과, 강우시 기간이 6월 ${\sim}$ 8월에 오염물질의 유출이 크게 발생하는 것을 알 수 있었으며, 연구지점 모두 비강우시에는 1급수의 수질상태를 보였으나, 강우시에는 3급수 이하의 수질로 악화되는 것을 알 수 있었다. 또한, 각 지류하천으로부터 유입되는 부하량을 추정하여 유역면적대비 유출량 - 오염부하량의 회귀식을 작성하였다. 끝으로, 유출량비를 이용하여 각 지류 하천의 유역면적대비 연간 총 오염유출량을 산정하였다.

• Journal of Environmental Impact Assessment
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• v.12 no.4
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• pp.259-270
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• 2003

To investigate the water quality and the pollution state of lower Yeongsan river system, 38 water samples were taken from the main stream of the Yeongsan river, Gomakwon and Hampyeong streams of the system in dry and flood seasons, May and August, 2001. The Yeongsan river is typically natural in accordance with pH-& diagram. But the chemistry based on Piper's diagram indicates that the river is influenced by seawater. BOD increases as the sampling sites are approaching the downstream in Gomakwon and Hampyeong streams overwhelming WQS V grade of 12.40mg/l. T-N and T-P of the river are mainly loaded not in above branch streams but in the main stream of the river, which are caused by manure for farming, domestic animal discharges and life-sewage, in possible. Meanwhile, heavy metal contents are below WQS or not detect in whole water samples. So, it shows that the above river waters be polluted by not industrial but life/agricultural foul waters.

• Structural Engineering and Mechanics
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• v.47 no.2
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• pp.149-166
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• 2013

Flexible behaviors in new aerospace structures can lead to a degradation of their control and guidance system and undesired performance. The objectives of the current work are to analyze the vibration resulting from the propulsion force on a Single Stage to Orbit (SSTO) launch vehicle (LV). This is modeled as a follower force on a free-free Euler-Bernoulli beam consisting of two concentrated masses at the two free ends. Once the effects on the oscillation of the actuators are studied, a solution to reduce these oscillations will also be developed. To pursue this goal, the stability of the beam model is studied using Ritz method. It is determined that the transverse and rotary inertia of the concentrated masses cause a change in the critical follower force. A new dynamic model and an adaptive control system for an SSTO LV have been developed that allow the aerospace structure to run on its maximum bearable propulsion force with the optimum effects on the oscillation of its actuators. Simulation results show that such a control model provides an effective way to reduce the undesirable oscillations of the actuators.

• Journal of Korean Neurosurgical Society
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• v.45 no.2
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• pp.99-102
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• 2009

Inflammatory pseudotumor is an uncommon lesion with unknown etiology characterized by sclerosing inflammation which clinically and radiographically mimics a neoplastic lesion. A 47-year-old man presented with sudden headache and dysarthria. Brain CT scan revealed a $2.6{\times}2.2\;cm$ sized, round, and hyperdense mass in the anterolateral wall of the left lateral ventricular trigone. On MR imaging studies, the mass showed low signal intensity in the wall of the trigone on T2-weighted image, central mixed (iso- and high-) signal intensity with peripheral low-signal intensity on T1-weighted image. Subtle staining of left choroid plexus with irregular shaped distal branch of anterior choroidal artery was found on the cerebral angiography. These findings suggested a small tumorous lesion originated from the left choroid plexus. During the hospital days, the mass manifested as repeated hemorrhages. The mass was successfully removed via left occipital transcortical approach. The histopathological report of the specimen was hemorrhage and fibrosis, with dense lymphoplasma cell infiltration, suggestive of an inflammatory pseudotumor.

• BMB Reports
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• v.49 no.8
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• pp.443-448
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• 2016

The arginylation branch of the N-end rule pathway is a ubiquitin-mediated proteolytic system in which post-translational conjugation of Arg by ATE1-encoded Arg-tRNA-protein transferase to N-terminal Asp, Glu, or oxidized Cys residues generates essential degradation signals. Here, we characterized the ATE1^−/− mice and identified the essential role of N-terminal arginylation in neural tube development. ATE1-null mice showed severe intracerebral hemorrhages and cystic space near the neural tubes. Expression of ATE1 was prominent in the developing brain and spinal cord, and this pattern overlapped with the migration path of neural stem cells. The ATE1^−/− brain showed defective G-protein signaling. Finally, we observed reduced mitosis in ATE1^−/− neuroepithelium and a significantly higher nitric oxide concentration in the ATE1^−/− brain. Our results strongly suggest that the crucial role of ATE1 in neural tube development is directly related to proper turn-over of the RGS4 protein, which participate in the oxygen-sensing mechanism in the cells.

• Journal of Biosystems Engineering
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• v.19 no.4
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• pp.311-317
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• 1994

Warts and barks of apple trees were vector of White rot. Two devices removing warts and barks for the use of pest control on apple trees were developed and evaluated in this study, and their results are as follows ; 1. A total of 148 warts were examined to determine the average size. About 35 percent of the examined warts were 6~8mm long, 4~8mm wide and 4~6mm thick in size. About 30 percent of the examined warts were 4~6mm long, 2~4mm wide and 6~8mm thick in size. 2. Seventy-one percent of the examined barks removed were 4~8mm in thickness. 3. A blade with 30 degree of cutting angle required 3 to 22 percent less cutting energy than those with 15 and 45 degrees of cutting angles. 4. The cutting torque decreased from 31 N-cm to 12 N-cm with an increase of cutting speed from 26cm/s to 104cm/s for a feeding speed of 0.31 mm/s with the blade angle of 30 degrees. 5. The cutting torque increased from 6N-cm to 32N-cm with an increase of branch diameter from 6mm to 14mm for a feeding speed of 0.31 mm/s with the blade angle of 30 degrees. 6. Two devices mounted on a mower for removing warts and barks were evaluated and proved effective.