• Journal of Magnetics
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• 제17권3호
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• pp.219-224
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• 2012

In the present study, changes in signal-to-noise ratio (SNR) and apparent diffusion coefficient (ADC) of the diffusion-weighted images in the normal livers were investigated using changes in b values in 1.5 T MR (magnetic resonance) instruments. Respective diffusion-weighted images and ADC map images were obtained from 20 healthy individuals by increasing b values from 50 to 400 and 800 $s/mm^2$ using 1.5T MR scanner between January 2011 and November 2011. At each ADC map image obtained at each b value, ADCs in the right hepatic lobe, spleen and kidney were measured. As a result, ADCs of the right hepatic lobe, spleen and kidney have gradually decreased in the diffusion-weighted images in accordance with the reduced b value. This outcome may be used as preliminary data for applications to various abdominal diseases.

• Animal cells and systems
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• 제10권2호
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• pp.79-83
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• 2006

Tissue plasminogen activator (tPA) is used to lyse clots and reperfuse brain in ischemic stroke. However, sideeffects of intracerebral hemorrhage (ICH) and edema limit their clinical application. In part, these phenomena has been linked with elevations in matrix metalloproteinase-9 (MMP-9) in neurovascular unit. However little is known about their regulatory signaling pathways in brain cells. Here, I examine the role of MAP kinase pathways in tPA-induced MMP-9 regulation in rat cortical astrocytes. tPA $(1-10\;{\mu}g/ml)$ induced dose-dependent elevations in MMP-9 and MMP-2 in conditioned media. Although tPA increased phosphorylation in two MAP kinases (ERK, JNK), only inhibition of the JNK pathway by the JNK inhibitor SP600126 significantly reduced MMP-9 upregulation. Neither ERK inhibition with U0126 nor p38 inhibition with SB203580 had any significant effects. Taken together, these results suggest that c-jun N-terminal kinase (JNK) plays an essential role for tPA-induced MMP-9 upregulation.

• BMB Reports
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• 제47권12호
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• pp.685-690
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• 2014

The Ras/Raf/MEK/Erk signaling pathway is important for regulation of cell growth, proliferation, differentiation, survival, and apoptosis in response to a variety of extracellular stimuli. Lack of Erk MAPK activation is observed in several cancer cells despite active activation of Ras. However, little is known about the modulation of Erk1/2 activity by active Ras. Here, we show that overexpression of active H-Ras (H-RasG12R) in NIH3T3 fibroblasts impaired FGF2-induced Erk1/2 phosphorylation, as compared to wild-type cells. Northern blot analysis revealed that prolonged expression of active Ras increased MAP kinase phosphatase 3 (MKP3) mRNA expression, a negative regulator of Erk MAPK. Inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway abrogated active Ras-induced up-regulation of MKP3 expression, leading to the rescue of Erk1/2 phosphorylation. Our results demonstrated that the Ras/Raf/MEK/Erk signaling cascade is negatively regulated by the PI3K/Aktdependent transcriptional activation of the MKP3 gene.

• 호남수학학술지
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• 제27권1호
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• pp.101-113
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• 2005

We define and study a concept of $T_A$-space which is closely related to the generalized Gottlieb group. We know that X is a $T_A$-space if and only if there is a map $r:L(A,\;X){\rightarrow}L_0(A,\;X)$ called a $T_A$-structure such that $ri{\sim}1_{L_0(A,\;X)}$. The concepts of $T_{{\Sigma}B}$-spaces are preserved by retraction and product. We also introduce and study a dual concept of $T_A$-space.

• BMB Reports
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• 제47권2호
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• pp.115-120
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• 2014

In this study, we show that Mycobacterium avium subsp. paratuberculosis MAP1305 induces the maturation of bone marrow-derived dendritic cells (BMDCs), a representative antigen presenting cell (APC). MAP1305 protein induces DC maturation and the production of pro-inflammatory cytokines (Interleukin (IL)-6), tumor necrosis factor (TNF)-${\alpha}$, and IL-$1{\beta}$) through Toll like receptor-4 (TLR-4) signaling by directly binding with TLR4. MAP1305 activates the phosphorylation of MAPKs, such as ERK, p38MAPK, and JNK, which is essential for DC maturation. Furthermore, MAP1305-treated DCs transform naive T cells to polarized $CD4^+$ and $CD8^+$ T cells, thus indicating a key role for this protein in the Th1 polarization of the resulting immune response. Taken together, M. avium subsp. paratuberculosis MAP1305 is important for the regulation of innate immune response through DC-mediated proliferation of $CD4^+$ and $CD8^+$ T cells.

• 한국측량학회지
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• 제37권2호
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• pp.91-97
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• 2019

In automatic map generalization, the formalization of cartographic principles is important. This study proposes and evaluates the selection method for road network generalization that analyzes existing maps using reverse engineering and formalizes the selection rules for the road network. Existing maps with a 1:5,000 scale and a 1:25,000 scale are compared, and the criteria for selection of the road network data and the relative importance of each network object are determined and analyzed using $T{\ddot{o}}pfer^{\prime}s$ Radical Law as well as the logistic regression model. The selection model derived from the analysis result is applied to the test data, and road network data for the 1:25,000 scale map are generated from the digital topographic map on a 1:5,000 scale. The selected road network is compared with the existing road network data on the 1:25,000 scale for a qualitative and quantitative evaluation. The result indicates that more than 80% of road objects are matched to existing data.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2004년도 제9차 학술대회 초록집
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• pp.17-17
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• 2004

• 대한수학회논문집
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• 제18권1호
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• pp.105-115
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• 2003

It is well known that there exists a regular branched covering map from T$^2$ onto $\={C}$ iff the ramification indices are (2,2,2,2), (2,4,4), (2,3,6) and (3,3,3). In this paper we construct (count-ably many) chaotic homeomorphisms induced by hyperbolic toral automorphism and regular branched covering map corresponding to the ramification indices (2,2,2,2). And we also gave an example which shows that the above construction of a chaotic map is not true in general if the ramification indices is (2,4,4) and also show that there are no chaotic homeomorphisms induced by hyperbolic toral automorphism and regular branched covering map corresponding to the ramification indices (2,3,6) and (3,3,3).

• Korean Journal of Mathematics
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• 제27권3호
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• pp.735-741
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• 2019

Let ${\mathcal{H}}$ be a complex Hilbert space and ${\mathcal{B}}({\mathcal{H}})$ the algebra of all bounded linear operators on ${\mathcal{H}}$. In this paper, we prove that if ${\varphi}:{\mathcal{B}}({\mathcal{H}}){\rightarrow}{\mathcal{B}}({\mathcal{H}})$ is a unital surjective bounded linear map, which preserves m- isometries m = 1, 2 in both directions, then there are unitary operators $U,V{\in}{\mathcal{B}}({\mathcal{H}})$ such that ${\varphi}(T)=UTV$ or ${\varphi}(T)=UT^{tr}V$ for all $T{\in}{\mathcal{B}}({\mathcal{H}})$, where $T^{tr}$ is the transpose of T with respect to an arbitrary but fixed orthonormal basis of ${\mathcal{H}}$.

• 대한수학회보
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• 제44권1호
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• pp.83-86
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• 2007

We determine the largest integer i such that $0 and the coefficient of $t^{i}$ is odd in the polynomial $(1+t+t^{2}+{\cdots}+t^{n})^{n+1}$. We apply this to prove that the co-index of the tangent bundle over $FP^{n}$ is stable if $2^{r}{\leq}n<2^{r}+\frac{1}{3}(2^{r}-2)$ for some integer r.