• Korean Journal of Pharmacognosy
• /
• v.43 no.2
• /
• pp.163-166
• /
• 2012

In the present study, we investigated the effect of the water extract of Perilla frutescens var. acuta (Labiatae; WEPF) on the mast cell-mediated allergic reactions. WEPF was anally administered to mice for high and fast absorption. WEPF inhibited compound 48/80-induced systemic allergic reaction. WEPF attenuated immunoglobulin E (IgE)-mediated local allergic reaction. In addition, WEPF decreased the gene expression of pro-inflammatory cytokines in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated HMC-1 cells. These results indicate that WEPF inhibits mast cell-mediated allergic reactions in vivo and in vitro.

• Korean Journal of Acupuncture
• /
• v.25 no.1
• /
• pp.213-227
• /
• 2008

Objectives : We studied on anti-allergic effects of Semen Perillae Herbal Acupuncture(SPHA) and Semen Perillae Herbal Acupuncture Solution(SP). Methods : In vivo, Animals were herbal-acupunctured SPHA at both ST36 three times for 5 days. Then, we investigated compound 48/80-induced active systemic anaphylaxis (ASA) using ICR mice and anti-DNP IgE-induced passive cutaneous anaphylaxis (PCA) using Sprague Dawley rat. In vitro, we measured cell viability, b-hexosaminidase release, IL-4 and TNF-a from RBL-2H3 cells after treatment of SP of various concentrations. Results : In vivo, SPHA pretreatments at both ST36 inhibited compound 48/80-induced ASA. PCA was inhibited by SPHA pretreatments at both ST36 and optional points. In vitro, SP treatments were not affect on cell viability and inhibited b-hexosaminidase release, IL-4 and TNF-a. Conclusions : These results suggest that SPHA and SP may be beneficial in the inhibition of allergic inflammatory response.

• The Journal of Internal Korean Medicine
• /
• v.36 no.4
• /
• pp.570-581
• /
• 2015

Objectives The purpose of this study was to investigate the experimental studies which was performed by single or complex herbal medicines on hypothyroidism.Methods I searched the domestic experimental studies about single or complex herbal medicines’ effects on hypothyroidism that published since 2000 on 4 Korean databases by keywords, ‘thyroid gland’, ‘hypofunction’, ‘hypothyroidism’.Results 11 single herbal medicines and 9 complex herbal medicines in 20 experimental studies have reported their effectiveness and safetiness in PTU-induced hypothyroidism rats by evaluating the changes of several biochemical and hematological indexes.Conclusions In order to make new and more effective medicines on hypothyroidism, there should be further studies by using combinations of herbal medicines and the differences of their mechanisms.

• The Korean Journal of Pain
• /
• v.2 no.2
• /
• pp.167-173
• /
• 1989

Inadequate pain relief after upper abdominal surgery increases the incidence of pulmonary complications due to the difficulty in coughing and deep breathing. Kvalheim and Reiestad (1984) introduced intrapleural administration of local anesthetic solutions to produce analgesia following cholecystectomy performed through a subcostal incision, unilateral breast surgery and renal surgery. We studied continuous intrapleural administration of bupivacaine and epinephrine, and its effect in controlling pain after cholecystectomy. In 9 patients, an intermittent dosage technique was used. An intrapleural catheter was inserted and 20 ml of 0.5% bupivacaine and 1:100,000 epinephrine was administered. Results were as following: 1) Mean analgesic duration from the initial intrapleural injection to secondary administration of supplementary bupivacaine was 13.5 hours. 2) No specific changes were noted on vital signs and arterial blood gases. 3) Effective analgesia, produced by intrapleural bupivacaine resulted in significant improvement in tidal volume as measured by spirometry. 4) No signs of systemic toxicity and complications were encountered. 5) Intrapleural administration of a local anesthetics after cholecystectomy provides a satisfactory duration of analgesia.

• Journal of Pharmaceutical Investigation
• /
• v.18 no.1
• /
• pp.5-8
• /
• 1988

Physical properties of oral adhesive tablets prepared with four kinds of gums for topical or systemic drug delivery were investigated. Oral adhesive tablets containing 5mg of brilliant blue(BB) were prepared from direct compression. Viscosity of 2% gum solutions, water absorption, fracture resistance, stickiness of tablets, and dissolution of BB in pH 6.8 dissolution medium were tested. Acacia showed good stickiness and fracture resistance, and tragacanth showed good retarding effect on the release of BB from tablets. Therefore, tablets with varing ratios of acacia and tragacanth were prepared and their physical properties were examined. In conclusion, it was possible to obtain some adequate properties by compounding acacia and tragacanth.

• Archives of Pharmacal Research
• /
• v.13 no.2
• /
• pp.161-165
• /
• 1990

For evaluating the cytolytic effects on the mouse thymocytes, four typical antiinflammatory steroids (dexamethasone, triamcinolone acetonide, prednisolone, hydrocortisone) were selected in this study. When steroids were treated to the mouse thymocytes in vitro cytolysis occurred with dose-dependent fashion and the activities were found to be paralle with the known local anti-inflammatory activities. In vivo thymus atrophogenic activities appeared by the treatment of topical and subcutaneous applications of the derivatives were also found to dose-dependent, but not coincided with the thymocyte cytolytic activities in vitro and local anti-inflammaatory activity in the case of triamcinolone acetonide. Triamicinolone acetonide induced potent thymocyte cytolysis in vitro, but showed less thymus atrophy.

• Archives of Pharmacal Research
• /
• v.10 no.3
• /
• pp.184-187
• /
• 1987

ln order to develope anti-inflammatory glucocorticoids for local use without systemic side-effects, ester and amide derivatives of 20$\xi$-dihydroprednisolonic acid have been prepared. When binding affinities of these compounds to glucocorticoid receptor of rat liver cytosol were compared, all a-isomer at C-20 showed higher binding affinities than the corres¬ponding $\beta$-isomer. The size of the substituents at C-21 had significant influences on binding affinities, which were related with their lipophilicity.

• YAKHAK HOEJI
• /
• v.41 no.5
• /
• pp.647-651
• /
• 1997

We studied the effects of the powders of Spirulina platensis (SPP) on anaphylactic reactions. SPP inhibited systemic anaphylaxis induced by compound 48/80 in rats. SPP also inhibited local anaphylaxis activated by anti-dinitrophenyl(DNP) IgE. Moreover, SPP dose-dependently inhibited histamine release in rat peritoneal mast cells activated by compound 48/80 or anti DNP-IgE. These results suggest that SPP may contain compounds with actions that inhibit mast cell degranulation in the rat.

• Journal of Chest Surgery
• /
• v.26 no.1
• /
• pp.12-17
• /
• 1993

Among the many deleterious effects of cardiopulmonary bypass[CPB], deterioration of plasma lipoprotein is a significant problem. Break-down of lipoprotein releases free fatty acids into the systemic circulation which, in turn, can cause microembolism. This study conducted on 30 patients undergoing CPB, was designed to elucidate the changes of plasma lipoproteins during and after CPB. Blood samples were taken at pre-CPB, on-CPB 30 minutes and 60 minutes, postoperative 1st, 3rd, 7th days. The levels of total cholesterol and triglyceride were measured and lipoprotein was subdivided into three kinds on electrophoresis. During CPB, the amounts of plasma total cholesterol and triglyceride decreased significantly and were recovered to pre-CPB levels after postoperative third day. There was no significant correlation between the duration and the severity of decrease in plasma total cholesterol and triglyceride levels. During CPB, the fraction of VLDL decreased and that of LDL increased. After cessation of CPB, the fraction of LDL decreased and that of HDL increased. After postoperative 1st day, the fraction of HDL decreased and that of LDL increased.

• English Language & Literature Teaching
• /
• v.13 no.2
• /
• pp.1-23
• /
• 2007

The purpose of this research is to explore the effects of systematic teaching English pronunciation and listening in English. Focusing on phonemes and words in pairs and sentences, the sound systems of the English and Korean languages are dealt with in conjunction with the test data. This paper first discusses the systemic, or primary interference and the habitual, or secondary interference that hinder comprehension of certain English sounds. Second, the analysis of input and output test data on the contrasting vowels and consonants shows statistic significance in terms of the probability (p value) of t-test. Third, the comparative data by means of percentile of right answers on contrasting vowel and consonant sounds expound the different sound systems of the English and Korean languages. With this data, problems in pronunciation of and listening to English, and the factors that may cause these problems are analyzed so that they can be used as a guideline for a systematic approach in teaching English learners, thus leading to more satisfactory performance.