• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2011.04a
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• pp.735-741
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• 2011

In the early phase of vehicle development, CAE is conducted as tool for vehicle performance assessment. To maintain acceptable road noise performance, solution for reduced vehicle sensitivity is required. Chassis interface dynamic stiffness characteristics are key component to isolating vibration and noise of road from the vehicle interior. This research provide how to set up the optimized dynamic characteristics under noise effect through DFSS study. CAE-based DOE is performed to build prediction math model, CMS process involves DOE to achieve very fast run times while giving results very comparable. Minimized $95^{th}$ percentile of performance distribution is applied to minimize vehicle sensitivity and road noise levels variation during the optimization process. Finally, the results of optimization were reviewed for performance and robustness.

• Korean journal of food and cookery science
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• v.28 no.6
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• pp.655-663
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• 2012

This study was carried out response surface analysis for brown sauce optimization. Three factors of heating time (10, 20, 30, 40, and 50 min), the added gelatin content (0, 4, 8, 12, and 16%) and the added tomato paste amount (0, 6, 12, 18, and 24%) were encoded into 5 levels (-2, -1, 0, 1, 2). After the central synthesis plan was set up to produce samples in 16 pre-arranged conditions and the sensory tests were conducted, the investigation on optimum level of these factors was conducted. The scope of optimum conditions for extraction was established through reading the range of reaction surfaces superimposed between those representing sensory properties such as color, flavor, taste, viscosity and overall acceptability was established. In this study, it was found out that the scope of optimum conditions for brown sauce extraction was 30 min for heating time, 9.00% for gelatin content and 11.25% for tomato paste amount. The reliability test proved the mentioned scope to have a similar value to that of the estimated scope when compared to the experimental values which was observed through experiments conducted under the same conditions as applied to values predicted through RSM program, enabling the verification of the reliability of derived regression formula.

• Bulletin of the Society of Naval Architects of Korea
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• v.25 no.1
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• pp.11-20
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• 1988

From the engineering point of view, a synthesis as well as an analysis technique is explored to search for the improved design of grillage which is common in ship structure. As an approximate analysis method for the grillage, an interaction reaction method is developed and compared with the finite element method. It is found that the discrepancy between these two methods is so negligible that the percent method could be used effectively for the grillage analysis. As an optimization technique, a feasible direction method could be used is combined with the intersection reaction method in order to design a minimum weight optimal grillage. The feasible direction method shows a good numerical performance although it requires more calculation times compared with the direct search method. Finally, the application of multiple objective optimization method to grillage is investigated in order to resolve conflicts existed between the multiple objectives which is a common characteristic of structure design problem. Goal programming method is extended to handle a nonlinear property of constraints and objective functions. It seems that the nonlinear goal programming could help not only to establish a relative importance of each objective, but also enable the designer to choose the best combination of design variables.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.21 no.7
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• pp.674-681
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• 2011

In the early phase of vehicle development, CAE is conducted as tool for vehicle performance assessment. To maintain acceptable road noise performance, solution for reduced vehicle sensitivity is required. Chassis interface dynamic stiffness characteristics are key component to isolating vibration and noise of road from the vehicle interior. This research provide how to set up the optimized dynamic characteristics under noise effect through DFSS study. CAE-based DOE is performed to build prediction math model, CMS process involves DOE to achieve very fast run times while giving results very comparable. Minimized 95th percentile of performance distribution is applied to minimize vehicle sensitivity and road noise levels variation during the optimization process. Finally, the results of optimization were reviewed for performance and robustness.

• Applied Chemistry for Engineering
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• v.31 no.4
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• pp.377-382
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• 2020

A sequential design of experiments was employed to optimize MOF-235 synthesis for acetylene adsorption process. Two experimental designs were applied: a two-level factorial design for screening and a central composite design, one of response surface methodologies (RSM). In this study, 2³ factorial design of experiment was used to evaluate the effect of parameters of synthesis temperature and time, and also mixing speed on crystallinity of MOF-235. Experiments were conducted 16 times follwing MINITAB 19 design software for MOF-235 synthesis. Half-normal, pareto, residual, main and interaction effects were drawn based on the XRD results. The analysis of variance (ANOVA) of test results depicts that the synthesis temperature and time have significant effects on the crystallinity of MOF-235 (response variable). After screening, a central composite design was performed to optimize the acetylene adsorption capacity of MOF-235 based on synthesis conditions. From nine runs designed by MINITAB 19, the result was calculated using the second order model equation. It was estimated that the maximum adsorption capacity (18.7 mmol/g) was observed for MOF-235 synthesized at optimum conditions of 86.3 ℃ and 28.7 h.

• Journal of the Korean Society of Hazard Mitigation
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• v.10 no.3
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• pp.31-38
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• 2010

In this study, it is suggested that it has to reliability-based design methodology with respect to bridge structure-rail longitudinal interaction and bridge structure-vehicle interaction. For the structural analysis, commercial package, ABAQUS, are used for a three-dimensional finite element analysis. The optimization process utilizes a well-known optimizer, ADS(Automated Design Synthesis). Optimization technique is utilized the ALM-BFGS method for global area search and Golden Section Method for 1-D search. In general, ALM-BFGS method don't need the 1-D search, and that algorithm converge a 0.1~0.2 of Push-Off factor. But in this study, value of Push-Off factor is used 90, therefore 1-D search should be needed for effective convergency. That algorithm contains the "heuristic decision method". As a result of optimum design of 2-main steel girder birdge with 5${\times}$(1@50m), design methodology suggested in this study was demonstrated more economic and efficient than existing design and LCC optimization not considering bridge-rail longitudinal interaction and bridge-vehicle interaction.

• Journal of the Institute of Electronics and Information Engineers
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• v.49 no.12
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• pp.209-218
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• 2012

Recently, the Field Programmable Stateful Logic Array (FPSLA) was proposed as one of the most promising system integration technologies which will extend the life of the Moore's law. This work is the first proposal of the FPSLA design automation flow, and the approaches to logic synthesis, synchronization, physical mapping, and automatic placement of the FPSLA designs. The synchronization at each gate for pipelining determines the x-coordinates of cells, and reduces the placement to 1-dimensional problems. The objective function and its gradients for the non-linear optimization of the net length and placement density have been remodeled for the reduced global placement problem. Also, a recursive algorithm has been proposed to legalize the placement by relaxing the density overflow of bipartite bin groups in a top-down hierarchical fashion. The proposed model and algorithm are implemented, and validated by applying them to the ACM/SIGDA benchmark designs. The output state of a gate in an FPSLA needs to be duplicated so that each fanout gate can be connected to a dedicated copy. This property has been taken into account by merging the duplicated nets into a hyperedge, and then, splitting the hyperedge into edges as the optimization progresses. This yields additional 18.4% of the cell count reduction in the most dense logic stage. The practicality of the FPSLA can be further enhanced primarily by incorporating into the logic synthesis the constraint to avoid the concentrated fains of gates on some logic stages. In addition, an efficient algorithm needs to be devised for the routing problem which is based on a complicated graph. The graph models the nanowire crossbar which is trimmed to be embedded into the FPSLA fabric, and therefore, asymmetric. These CAD tools can be used to evaluate the fabric efficiency during the architecture enhancement as well as automate the design.

• Bulletin of the Korean Chemical Society
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• v.27 no.6
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• pp.909-917
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• 2006

2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.5
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• pp.533-540
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• 2008

In the sum and difference pattern synthesis problem of the equi-spaced monopulse tracking linear array antennas, an efficient numerical approach to deriving the relative excitation current weights of antenna elements is presented for the desired patterns. This method is based on the optimum perturbation of null points which are inherent to the Schelkunoffs polynomial representing the pattern array factor. Accordingly, opposite to the conventional method in which the excitation weights are directly optimized, this method is advantageous in that the patterns with the desired individual sidelobe levels(SLLs) and the corresponding excitation weights are easily synthesized by the control of null points. Furthermore, it is showed that two types of difference patterns can be synthesized as imposing the different initial values of null points in the optimization process. The proposed method is numerically validated by synthesizing the patterns with the arbitrary SLLs and substituting the extracted results into the array factor equation.

• Journal of Microbiology and Biotechnology
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• v.23 no.3
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• pp.343-350
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• 2013

(R)-[3,5-Bis(trifluoromethyl)phenyl] ethanol is a key chiral intermediate for the synthesis of aprepitant. In this paper, an efficient synthetic process for (R)-[3,5- bis(trifluoromethyl)phenyl] ethanol was developed via the asymmetric reduction of 3,5-bis(trifluoromethyl) acetophenone, catalyzed by Leifsonia xyli CCTCC M 2010241 cells using isopropanol as the co-substrate for cofactor recycling. Firstly, the substrate and product solubility and cell membrane permeability of biocatalysts were evaluated with different co-substrate additions into the reaction system, in which isopropanol manifested as the best hydrogen donor of coupled NADH regeneration during the bioreduction of 3,5-bis(trifluoromethyl) acetophenone. Subsequently, the optimization of parameters for the bioreduction were undertaken to improve the effectiveness of the process. The determined efficient reaction system contained 200mM of 3,5-bis(trifluoromethyl) acetophenone, 20% (v/v) of isopropanol, and 300 g/l of wet cells. The bioreduction was executed at $30^{\circ}C$ and 200 rpm for 30 h, and 91.8% of product yield with 99.9% of enantiometric excess (e.e.) was obtained. The established bioreduction reaction system could tolerate higher substrate concentrations of 3,5- bis(trifluoromethyl) acetophenone, and afforded a satisfactory yield and excellent product e.e. for the desired (R)-chiral alcohol, thus providing an alternative to the chemical synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol.