• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권2호
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• pp.147-153
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• 2018

Epstein-Barr virus (EBV) infection can be presented with various clinical manifestations and different levels of severity when infected. Infectious mononucleosis, which is most commonly caused by EBV infection in children and adolescents, is a clinical syndrome characterized by fatigue, malaise, fever, sore throat, and generalized lymphadenopathy. But rarely, patients with infectious mononucleosis may present with gastrointestinal symptoms and complicated by gastritis, splenic infarction, and splenic rupture. We encountered a 16-year-old girl who presented with fever, fatigue, and epigastric pain. Splenic infarction and EBV-associated gastritis were diagnosed by using esophagogastroduodenoscopy and abdominal computed tomography. Endoscopy revealed a generalized hyperemic nodular lesion in the stomach, and the biopsy findings were chronic gastritis with erosion and positive in situ hybridization for EBV. As splenic infarction and acute gastritis are rare in infectious mononucleosis and are prone to be overlooked, we must consider these complications when an infectious mononucleosis patient presents with gastrointestinal symptom.

• 한국치위생학회지
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• 제12권2호
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• pp.293-305
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• 2012

Objectives : The purpose of this study was to confirm effects of oral exercise program intended to improve the condition of salivary hypofunction and to provide basic data for development of oral health program for the elderly Methods : The subjects were 125 elderly women who resided in Gyeong-In area and were aged 65 years and older. During a 2-month period, an oral exercise was conducted twice a week. A survey was conducted by interviewing the selected elders to determine the state of their subjective dry mouth. Unstimulated whole saliva was measured before and after the oral exercise program. Results : There was a significant improvement in subjective dry mouth symptoms, severity scores of dry mouth after the oral exercise, and there were affected by age and income level. There was a significant increase in unstimulated whole-saliva after the oral exercise program. There was positive interrelationship between dry mouth Symptom improvement level and inconvenience improvement level, and between inconvenience improvement level and the increase of unstimulated whole-saliva. Conclusions : This study showed the effects of the oral exercise program. It is suggested that this oral exercise program has positive effects on the condition of dry mouth. For the explicit improvement effect on the condition of dry mouth, the oral exercise program needs to be carried out in consideration of the elderly's general characteristics.

• 대한약침학회지
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• 제10권1호통권22호
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• pp.137-155
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• 2007

Purpose : This study was undertaken to make a diagnosis weakness and firmness (虛實) of Dysmenorrhea patients by diagnosis questionnaires system(Diagnosis System of Oriental Medicine-DSOM) Methods : The subjects were 58 volunteers who was suffering for dysmenorrhea, employed using Measure of Menstrual Pain (MMP) questionnaire. The had agreed to take part in this experiment, with didn't take any anodyne drugs. The MMP score by using 7 questions and the Menstrual Symptom Severity List(MSSL-D) was measured before and after menstruation cycle. Results and Conclusions : The findings of this study were as follows; 1. We examined Pathogenic Factor's frequency of DSOM, Coldness(寒) was 45 persons 80.36%, Damp(濕) was 40 persons 71.43%, Heart(心) was 37 persons 66.07%, Heat syndrom(熱) was 9 persons 16.07%, insufficiency of Yang(陽虛) was 6 persons 10.71%. 2. We divided Dysmenorrhea patients into two groups(weakness and firmness) by Results of DSOM, Firmness was 25 Persons 43.1%, Weakness was 23 persons 39.7%, Unknown was 10 persons 17.2%. 3. In estimation based on Measure of Menstrual Pain (MMP) questionnaire Severe menstrual pain is weakness, Mild menstrual pain is Firmness. 4. In estimation of coldness and heat syndrom, Coldness was 40 persons 69.0%, Heat syndrom, was 2 persons 3.5%, Possess both coldness and heat syndrom was 9 persons 15.5%.

• 정신신체의학
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• 제25권1호
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• pp.56-62
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• 2017

Objectives : The objective of this study was to investigate the relationship between psychological distress and pain in cancer patients. Methods : 249 patients with cancer who visited National Health Insurance Service Ilsan Hospital between April 2013 and March 2014 were evaluated with National Cancer Center Psychological Symptom Inventory(NCC-PSI) which consisted of Modified Distress Thermometer(MDT) and Modified Impact Thermometer(MIT). Each scale was divided into 3 subscales targeting separate symptoms: insomnia, anxiety, and depression. Psychological distress was defined as positive for those who scored above the cutoff values in at least one of all six subscales. The Numeric Rating Scale for Pain(NRS-Pain) was used to assess the subjective severity of pain. Logistic regression was performed to investigate the association between psychological distress and pain. Results : Univariate logistic regression analysis showed that pain, gender, compliance, and two subscale scores of Hospital Anxiety and Depression Scale(HADS) were significantly associated with psychological distress. Multivariate logistic regression analysis showed that pain and HADS anxiety subscale score maintained a statistically significant association with psychological distress adjusted for variables including age, gender, years of education, Eastern Cooperative Oncology Group performance status, cancer stage, Charlson Comorbidity Index, compliance, and HADS depression subscale score. One point increase in pain was 1.31 times more likely to cause psychological distress. In secondary analysis, pain was significantly associated with all subscales of NCC-PSI, except MIT-anxiety subscale. Conclusions : This study suggests that NCC-PSI, a screening tool for psychological distress, reflects pain. We recommend that physicians who treat cancer patients consider the examination of psychological distress which provides comprehensive evaluation of various factors regarding quality of life.

• 대한불안의학회지
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• 제13권2호
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• pp.123-131
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• 2017

Objective : The PTSD Checklist (PCL) is a self-report screen for posttraumatic stress disorder (PTSD) that can be scored for both diagnostic assessment and symptom severity measurement. The most recent revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) contains a number of changes to the definition of PTSD, and the aim of this study was to assess the psychometric properties of the Korean version of the PCL for the DSM-5 (PCL-5-K). Methods : The participants were 204 Korean veterans of the Vietnam War who completed the PCL-5-K, the Mini Mental Status Examination (MMSE), PTSD module of Structured Clinical Interview for DSM-5, Research Version (SCID5-RV PTSD module), Korean version of Impact of Event Scale-Revised (IES-R-K) and Combat Exposure Scale (CES-K). Results : The PCL-5-K demonstrated good internal consistency (${\alpha}=0.972$) and test-retest reliability (r=0.96); the suggested cut-off score for PTSD diagnosis was ${\geq}37$ with 0.88 sensitivity and 0.96 specificity. The PCL-5-K scale correlated highly with the IES-R-K and CES-K. Factor analysis identified only one factor. Conclusion : Among elderly Korean veterans of the Vietnam War, the PCL-5-K demonstrated similar psychometric qualities to those of both the original PCL and subsequent versions. It is expected that the PCL-5-K will be a useful PTSD screening tool.

• The Korean Journal of Pain
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• 제31권3호
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• pp.155-173
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• 2018

Chronic postsurgical pain (CPSP) is an unwanted adverse event in any operation. It leads to functional limitations and psychological trauma for patients, and leaves the operative team with feelings of failure and humiliation. Therefore, it is crucial that preventive strategies for CPSP are considered in high-risk operations. Various techniques have been implemented to reduce the risk with variable success. Identifying the risk factors for each patient and applying a timely preventive strategy may help patients avoid the distress of chronic pain. The preventive strategies include modification of the surgical technique, good pain control throughout the perioperative period, and preoperative psychological intervention focusing on the psychosocial and cognitive risk factors. Appropriate management of CPSP patients is also necessary to reduce their suffering. CPSP usually has a neuropathic pain component; therefore, the current recommendations are based on data on chronic neuropathic pain. Hence, voltage-dependent calcium channel antagonists, antidepressants, topical lidocaine and topical capsaicin are the main pharmacological treatments. Paracetamol, NSAIDs and weak opioids can be used according to symptom severity, but strong opioids should be used with great caution and are not recommended. Other drugs that may be helpful are ketamine, clonidine, and intravenous lidocaine infusion. For patients with failed pharmacological treatment, consideration should be given to pain interventions; examples include transcutaneous electrical nerve stimulation, botulinum toxin injections, pulsed radiofrequency, nerve blocks, nerve ablation, neuromodulation and surgical management. Physical therapy, cognitive behavioral therapy and lifestyle modifications are also useful for relieving the pain and distress experienced by CPSP patients.

• Journal of Nutrition and Health
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• 제33권3호
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• pp.324-331
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• 2000

A deteriorating North Korean economy, coupled with a devastating natural disaster such as flooding and drought in recent years, brought about a severe food shortage and malnutrition problem which caused a migration of its population including young children to neighboring countries. We conducted a nutritional survey on a total of 436 children, aged 4-19 years old, who migrated to the China side of the border from July to September, 1999. The study subjects were interviewed by Korean-Chinese interviewers who were trained for anthropometric measurements and dietary surveys. Heights, weights, and chest circumference of the subjects were 70-90% of the South Korean reference values for the corresponding age and sex. Dietary intakes of the subjects were found to be extremely poor-the average number of food, mostly of plant origin, consumed in a day was 2.8, and the proportion of the subject who reported to take all three meals in a day while residing in North Korea was as low as 36.2%. Ninety five percent of the subjects had at least one clinical symptom related to malnutrition, 68.6% had 2-4 symptoms, and 15.1% had 5 or more symptoms. The results of this study provided an objective data for the first time on the severity of the food crisis and malnutrition problem that afflicted North Korean older children and adolescents as well as children aged 7 or under as previously reported elsewhere. the wasted and stunted children and youths prevailing in North Korea could exert a negative influence on the country's health and economy. More researches are needed in the future to investigate on the impact of malnutrition in North Korean children on the country's social, economic, and cultural state as well as on the health and nutrition situation.

• International Journal of Contents
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• 제11권4호
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• pp.31-37
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• 2015

The objectives of this study were: 1) to determine smartphone addiction, visual display terminal syndrome (VDTS) related symptoms, and state anxiety among adolescents, and 2) to identify the relationship among these variables. Data were collected via selfadministrated questionnaire survey from May to June, 2013. The survey was carried out with 540 voluntary participants at 13 to 24 years old from middle schools, high schools, and universities in Korea. The presence and severity of smartphone addiction, VDTS symptoms, and state anxiety were measured using Korean Smartphone Addiction Proneness Scale, VDTS Questionnaire, and State Anxiety Inventory, respectively. Data were analyzed by Cohen’s Kappa coefficient, Kruskal-Wallis test, and Mann-Whitney U test. The mean score of smartphone addiction for all students was 2.17 ± 0.51. The mean scores of smartphone addiction depending on school grade were 2.12 ± 0.53, 2.03 ± 0.48, and 2.42 ± 0.43 for middle school, high school, and college students, respectively. Subjects who experienced minor level of VDTS symptoms had a score of 0.49 ± 0.49 for VDTS symptoms. The score was increased when the level of addiction was higher. There were significant differences in VDTS subjective symptoms among smartphone addiction groups (p<.001). High-risk group of smartphone addiction had the highest scores in every subdomain of VDTS symptoms. Differences were also found in state anxiety among the three groups with smartphone addiction. The findings of this study showed that approximately one out of three adolescents might be classified into problematic smartphone users. Therefore, it is important to educate problematic smartphone users about smartphone addiction and VDTS symptoms to prevent further addiction and aggravation of anxiety.

• Journal of Korean Neurosurgical Society
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• 제38권2호
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• pp.102-106
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• 2005

Objective : The purposes of this study are to evaluate the efficacy of en bloc open-door laminoplasty and to investigate the validity of various factors as prognotic indicators in patients with multisegmental spondylotic myelopathy and ossification of posterior longitudinal ligament[OPLL]. Methods : The authors reviewed 43 cases in whom laminoplasty were performed for cervical myelopathy between January 2000 and December 2002. Clinical symptoms and results were evaluated using the Japanese Orthopaedic Association[JOA] scale. The recovery rate was calculated and then assessed for prognostic factors such as preoperative JOA scores, ages, history of previous trauma, duration of symptoms and signal change in cord on T2-weighted magnetic resonance Image. Results : In cervical stenosis, canal widening of antero-posterior diameter and dimension after laminoplasty is 4.16mm, $87.43mm^2$ and in OPLL is 6.20mm, $117.61mm^2$. In all cases there wasn't neurologic deterioration, mild postoperative complications developed in seven cases. Four patient had a limitation of range of neck motion and the other one showed kyphotic change and another two showed C5 radiculopathy. The recovery rate of JOA score in cervical stenosis and OPLL was 62% and 68% respectively. Duration of symptoms, the severity[preoperative JOA score], and signal change in cord on T2-weighted magnetic resonance image had close relationship to the clinical outcomes. Conclusion : Unilateral en bloc laminoplasty is simultaneous expansile and decompressive method. And preoperative JOA score, symptom duration and high signal intensity on T2-weighted magnetic resonance image can be used to predict prognosis.

• 약학회지
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• 제56권2호
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• pp.92-98
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• 2012

This study was conducted to determine if YJ-1, a novel herbal complex from a mixture of six oriental herbs (Hydnocarpi Semen, Sesami Semen, Dictamni Radicis Cortex, Momordicae Semen, Xanthii Fructus, and Sophorae Radix), has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD like symptom-induced NC/Nga mice by 1-chloro 2,4-dinitrobenzene (DNCB), the effectiveness of YJ-1 on AD was evaluated. Elidel cream$^{(R)}$ (1% pimecrolimus) was used as a control. Dermal application of YJ-1 reduced major clinical signs of AD such as erythema, pruritus, lichenification, edema/escoriations, and dryness. Interestingly, YJ-1 more improved AD-related symptoms including decrease of spleen weight, IL-4, and IgE level in the serum as well as reduction of scratching counts and clinical skin severity in the NC/Nga AD mouse model. Especially, treatment of YJ-1 at 20% in NC/Nga mice more effected than Elidel cream. These results suggest that the ointment of YJ-1 may enhance the process of AD healing by alleviating allergic reaction and has potential for therapeutic reagent for the treatment of AD.