• 한국염색가공학회지
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• 제6권3호
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• pp.37-43
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• 1994

Commercial Poly(ethylene terephthalate) (PET) filaments were treated in solvents mixtures such as benzyl alcohol/perchloroethylene(BA/PER), benzyl alcohol/trichloroethylene(BA/TRI), benzyl alcohol/ethylene chloride(BA/EC), metha nol/perchloroethylene(ME/PER), and methanol/trichloroethyle(ME/TRI). Swelling of PET in solvent mixtures showed rapidly in the middle range of mixture ratio. Contribution of swelling of each component to total swelling of binary mixtures with increasing treated time was generally showed in proportion to the mixture ratio of the each component in dependence of the extend of swelling.

• 센서학회지
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• 제21권4호
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• pp.256-262
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• 2012

Hyaluronic acid(HA) hydrogels were synthesized by immersing HA microbeads in phosphate buffered saline solutions having different pH levels to assess the effect of pH on the swelling ratio of HA hydrogels for smart drug delivery systems. No beads were formed when the HA solution(below pH 9) was crosslinked with divinyl sulfone(DVS) because DVS is a basic solution. The variation regarding the size of the microbead was not significant, suggesting that the bead size is not a function of pH(10 ~ 14). However, the pore size of the microbeads decreased with increasing pH from 10 to 14, leading to the surface smoothness and dense network as a result of higher crosslinking. The swelling ratio of hydrogels increased when the pH rose from 2(acidic) to 6(neutral). Afterwards, it decreased with further increasing pH(basic). The lower swelling ratio may be due to the lack of ionization of the carboxyl groups. On the other hand, a higher swelling ratio is likely due to the increased electrostatic repulsions between negatively charged carboxyl groups on different chains. Experimental results suggested that pH-responsive HA hydrogels can be applicable to the controlled drug delivery systems.

• Elastomers and Composites
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• 제48권1호
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• pp.55-60
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• 2013

디클로로아세트산의 처리 여부에 따른 무수말레산-그래프트 EPDM (MAH-g-EPDM) 원재료(시험편-R)와 압축 시험편(시험편-C)의 팽윤 거동을 조사하였다. 시험편의 구조적 특징은 핵자기공명분광법(NMR)과 감쇠전반사-후리에변환 적외선분광법(ATR-FTIR)으로 분석하였다. 디클로로아세트산으로 처리하지 않았을 때, 시험편-R의 팽윤비가 시험편-C의 팽윤비보다 2배 정도 컸으며 팽윤과 건조 과정을 반복하여도 팽윤비의 변화는 거의 없었다. 디클로로아세트산으로 처리하였을 때는 1차 팽윤비는 증가하였으나 건조 후 2차 팽윤비는 감소하였다. 시험편-C의 경우, 디클로로아세트산으로 처리하지 않았을 때의 팽윤비와 디클로로아세트산으로 처리한 시험편의 2차 팽윤비는 거의 유사하였다. 하지만, 시험편-R의 경우, 디클로로아세트산으로 처리한 시험편의 2차 팽윤비는 디클로로아세트산으로 처리하지 않았을 때의 팽윤비보다 크게 작았다. 디클로로아세트산으로 처리하였을 때 나타난 팽윤비 변화는 기존 가교점의 분해와 새로운 가교점의 형성으로 설명하였다.

• Biomaterials and Biomechanics in Bioengineering
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• 제1권2호
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• pp.105-116
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• 2014

Synthesis of interpenetrating polymer network (IPN) of chitosan-gelatin (Cs-Ge) (as a primary network) and N-isopropylacrylamide (NIPAAm) monomer (as the secondary network) was carried out with different ratio. Its structure was characterized by FT-IR, which indicated that the IPN was formed. The memberanes were studied by swelling, weight loss with time. The interior morphology of the IPN hydrogels was revealed by scanning electron microscopy (SEM); the IPN hydrogels showed a interpenetrated network of NIPAAm/chitosan has layers with more minute stoma and canals compared to interpenetrated network of NIPAAm/gelatin. Lower critical solution temperature (LCST), equilibrium swelling ratio (ESR) and deswelling kinetics were measured. The DSC results noticed that LCST of IPN hydrogels with different ratio of Cs/Ge/PNIPAAm are around $33{\pm}2^{\circ}C$. The ESR obtained results showed that with a ratio of Cs/Ge/NIPAAm: 1/1/6, the swelling ratio increased drastically from room temperature to $36^{\circ}C$ but with a ratio of Cs/Ge/PNIPAAm: 1/3/6, decrease significantly at the same condition. Therefore the hydrogels have been changed from a hydrophilic structure to a hydrophobic structure. Furthermore with an increase in temperature from room to the LCST, the ESR of IPN with higher concentration of (PNIPAAm) and (Ge) decreases but de-swelling kinetics of them are faster. Due to the suitable and different kinetics of de-swelling and the equilibrium swelling ratio (ESR) in various proportions, and because of the morphology inside the mass which confirms other tests, these hydrogels are very appropriate as a smart thermosensitive hydrogels with rapid response.

• Korean Membrane Journal
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• 제6권1호
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• pp.37-43
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• 2004

Comb-type graft hydrogels composed of alginate and poly(N-isopropylacrylamide) (PNIPAAm) were prepared to manifest rapid temperature and pH sensitivity. To appear the electro-sensitivity, the polyaniline, conducting polymer, was added into the matrix. The swelling kinetics and ratios were compared under the various compositions of polyaniline. The swelling behaviors revealed that conducting polymer/hydrogel composites could control the swelling ratio and kinetics. The addition of polyaniline in the matrix improved the thermal stability in comparison with that of the hydrogel without polyaniline. In temperature sensitivity, the adding the polyaniline into the matrix decreased the degree of change in the swelling ratio. The swelling ratios continuously increased with increasing pH values. The drug release rate from the hydrogel increased with the adding the polyaniline and the applying the direct voltage to the hydrogels.

• Macromolecular Research
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• 제12권3호
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• pp.269-275
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• 2004

To graft N-isopropylacrylamide (NIPAAm) onto alginate, varying dosages of ${\gamma}$-rays were irradiated onto alginate films in deionized water and methanol media, which are non-solvents of alginate. We investigated the hydrogels graft ratio, mechanical strength, swelling kinetics and ratio, and behavior with respect to drug release. The graft yield of NIPAAm increased upon increasing the irradiation dose. The use of the aqueous solution increased the graft yield relative to that obtained in methanol. The mechanical strength of the grafted hydrogels increased after grafting with NIPAAm. In a study of the swelling kinetics, we found that all hydrogels reached an equilibrium swollen state within 3 h. The equilibrium swelling ratio of the hydrogels decreased upon increasing the irradiation dose. The swelling ratio of the hydrogels decreased dramatically between 30 and 35$^{\circ}C$ because phase separation of NIPAAm occurred at 32$^{\circ}C$. The swelling process, with respect to the temperature change, was repeatable. An NIPAAm-grafted alginate containing a drug sustained its release rate until 3 h after an initial high drug release caused by a burst effect.

• Geomechanics and Engineering
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• 제6권5호
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• pp.437-453
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• 2014

This paper studies the swelling and strength characteristics of unimproved and improved expansive soils in terms of the swell potential, swelling pressure, rate of secondary swelling, unconfined compressive strength and California bearing ratio (CBR). The admixtures used in this study are locally available cement and fly ash. The soils used in this study were taken from the Mae Moh power plant, Lampang Province, in northern Thailand. A conventional consolidation test apparatus was used to determine the swelling of the soil specimen. The optimum admixture contents are determined to efficiently reduce the swelling of unimproved soil. The rate of secondary swelling for unimproved soil is within the range of highly plastic montmorillonite clay, whereas the specimens improved with optimum admixture contents can be classified as non-swelling kaolinite. A soil type affects the swelling pressure. Expansive soil improvement with fly ash alone can reduce swelling percentage but cannot enhance the unconfined compressive strength and CBR. The strength and swelling characteristics can be predicted well by the swelling percentage in this study.

• Korean Membrane Journal
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• 제5권1호
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• pp.36-42
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• 2003

A Prediction of pervaporation performance was studied by solubility parameter calculation approach for the benzene/cyclohexane mixture system using rubbery blend membrane with various solubility parameters. The solubility parameter of the rubbery blend membranes were controlled with different blend ratio of the poly(acrylonitrile-co-butadiene), poly(styrene-co-butadiene) and poly(vinyl chloride). Screening of blend formulations was accomplished by simple swelling tests. When the content of NBR is increased, the swelling of both benzene and cyclohexane are decreased. However, the ratio of benzene swelling to swelling by cyclohexane (the swelling selectivity) increases. The same is true for blends in which the PVC content is increased. Adoption of a solubility parameter calculation provides an a priori methodology for seeking the best blend formulation.

• Journal of Pharmaceutical Investigation
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• 제24권3호
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• pp.155-165
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• 1994

Some mucoadhesive polymers such as hydroxypropylcelluose (HPC) and carbopol-934 (CP) have been employed for the preparation of mucoadhesive polymeric systems, and their physical properties including mucoadhesion, swelling, and drug release were evaluated. A new simple experimental technique that can quantitatively measure the bioadhesive properties of various polymeric systems has been developed by the methods of detachment force test. As the polymeric systems, the discs of freeze-dried HPC/CP solid dispersions were prepared. The mucosa used in these tests were upper, middle, and lower parts of small intestine of male rats weighing $300{\sim}350\;g$. Detachment forces were increased as the mole fraction of CP increased in discs of HPC/CP solid dispersions. In the points of intestinal site dependence of mucoadhesion, the solid dispersions revealed non-specific mucoadhesion to the intestine. Swelling and drug release characteristics of mucoadhesive polymeric systems were studied extensively to find out the feasibility for the oral controlled delivery systems. Swelling ratio, expressed as the final height/initial height, has been determined in various pH buffer solutions. Hydrochlorothiazide (HCT) was employed as a model drug for release study. Apparent swelling and drug release rate constants, $K_s$ and $K_r$ respectively, were obtained from the square-root time plot of either swelling ratio or released amount of drug, particularly for the time periods before reaching the equilibrium. As a result, the swelling ratio of HPC/CP solid dispersions was increased as the weight percentage of CP increased. Similarly, the release of HCT from the solid dispersions was dependent on pH changes and CP contents, resulted in the slower release of HCT with the increases of pH and CP contents.

• Archives of Pharmacal Research
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• 제26권10호
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• pp.880-885
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• 2003

Research in this paper focuses on the kinetic evaluation of swelling of the liquid crystalline phases of glyceryl monooleate (GMO). Swelling of the lamellar and cubic liquid crystalline phases of GMO was studied using two in vitro methods, a total immersion method and a Franz cell method. The swelling of the lamellar phase and GMO having 0 %w/w initial water content was temperature dependent. The swelling ratio was greater at $20^{\circ}^C than 37^{\circ}^C$ . The water uptake increased dramatically with decreasing initial water content of the liquid crystalline phases. The swelling rates obtained using the Franz cell method with a moist nylon membrane to mimic buccal drug delivery situation were slower than the total immersion method. The swelling was studied by employing first-order and second-order swelling kinetics. The swelling of the liquid crystalline phases of GMO could be described by second-order swelling kinetics. The initial stage of the swelling (t < 4 h) followed the square root of time relationship, indicating that this model is also suitable for describing the water uptake by the liquid crystalline matrices. These results obtained from the current study demonstrate that the swelling strongly depends on temperature, the initial water content of the liquid crystalline phases and the methodology employed for measuring the swelling of GMO.