Journal of Sensor Science and Technology (센서학회지)

The Korean Sensors Society (한국센서학회)
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Effect of pH on Swelling Property of Hyaluronic Acid Hydrogels for Smart Drug Delivery Systems

  • Kim, Jin-Tae (Department of Materials Engineering, Daelim University) ;
  • Lee, Deuk-Yong (Department of Materials Engineering, Daelim University) ;
  • Kim, Young-Hun (Department of Materials Engineering, Korea Aerospace University) ;
  • Lee, In-Kyu (Department of Materials Engineering, Korea Aerospace University) ;
  • Song, Yo-Seung (Department of Materials Engineering, Korea Aerospace University)
  • Received : 2012.06.22
  • Accepted : 2012.07.09
  • Published : 2012.07.31
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Abstract

Hyaluronic acid(HA) hydrogels were synthesized by immersing HA microbeads in phosphate buffered saline solutions having different pH levels to assess the effect of pH on the swelling ratio of HA hydrogels for smart drug delivery systems. No beads were formed when the HA solution(below pH 9) was crosslinked with divinyl sulfone(DVS) because DVS is a basic solution. The variation regarding the size of the microbead was not significant, suggesting that the bead size is not a function of pH(10 ~ 14). However, the pore size of the microbeads decreased with increasing pH from 10 to 14, leading to the surface smoothness and dense network as a result of higher crosslinking. The swelling ratio of hydrogels increased when the pH rose from 2(acidic) to 6(neutral). Afterwards, it decreased with further increasing pH(basic). The lower swelling ratio may be due to the lack of ionization of the carboxyl groups. On the other hand, a higher swelling ratio is likely due to the increased electrostatic repulsions between negatively charged carboxyl groups on different chains. Experimental results suggested that pH-responsive HA hydrogels can be applicable to the controlled drug delivery systems.

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References

  1. I. Tomatsu, Ke Peng, and A. Kros, "Photoresponsive hydrogels for biomedical applications", Adv. Drug Delivery Rev., vol. 63, pp. 1257-1266, 2011. https://doi.org/10.1016/j.addr.2011.06.009
  2. A.K. Bajpai, S.K. Shukla, S. Bhanu, and S. Kankane, "Responsive polymers in controlled drug delivery", Prog. Polymer Sci., vol. 33, pp. 1088-1118, 2008. https://doi.org/10.1016/j.progpolymsci.2008.07.005
  3. H. Omidian, J. G. Rocca, and K. Park, "Advances in superporous hydrogels", J. Control. Release, vol. 102, pp. 3-12, 2005. https://doi.org/10.1016/j.jconrel.2004.09.028
  4. J.T. Kim, D.Y. Lee, and J.H. Choi, "Preparation and characterization of hyaluronic acid microbeads", Biomater. Res., vol. 14, pp. 157-160, 2010.
  5. J. Kopecek and J. Yang, "Hydrogels as smart biomaterials", Polymer Intl., vol. 56, pp. 1078-1098, 2007. https://doi.org/10.1002/pi.2253
  6. A.C. Jen, M.C. Wake, and A.G. Mikos, "Review : Hydrogels for cell immobilization", Biotech, Bioeng., vol. 50, pp. 357-364, 1996. https://doi.org/10.1002/(SICI)1097-0290(19960520)50:4<357::AID-BIT2>3.3.CO;2-F
  7. W.E. Hennink and C.F. Van Nostrum, "Novel crosslinking methods to design hydrogels", Adv. Drug Deliv. Rev., vol. 54, pp. 13-36, 2002. https://doi.org/10.1016/S0169-409X(01)00240-X
  8. A.S. Hoffman, "Hydrogels for biomedical applications", Adv. Drug Deliv. Rev., vol. 54, pp. 3-12, 2002. https://doi.org/10.1016/S0169-409X(01)00239-3
  9. Y. Qiu and K. Park, "Environment-sensitive Hydrogels for Drug Delivery", Adv. Drug Deliv. Rev., vol. 53, pp. 321-339, 2001. https://doi.org/10.1016/S0169-409X(01)00203-4
  10. Y. Shin, K.S. Kim and B. Kim, "Loading behavior of pH-responsive P(MAA-co-EGMA) hydrogel microparticles for intelligent drug delivery applications", Polymer, vol. pp. 421-426, 2008.
  11. S. Choi and J. Lee, "Thermoresponsive graft copolymers of hyaluronic acid", Polymer, vol. 35, pp. 223-227, 2011.
  12. J.T. Kim and J.H. Choi, "Production and evaluation of hyaluronic acid gel for soft tissue augmentation", Biomater. Res., vol. 13, pp. 105-108, 2009.
  13. J. Kim, J. Choi, and D.Y. Lee, "Pyrogenicity of hyaluronic acid hydrogel cross-linked by divinyl sulfone for soft tissue augmentation", Natural Sci., vol. 2, pp. 764-768, 2010. https://doi.org/10.4236/ns.2010.27096
  14. G.D. Prestwitch, D.M. Marecak, and J.F. Marecek, "Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives", J. Control. Rel., vol. 53, pp. 93-103, 1998. https://doi.org/10.1016/S0168-3659(97)00242-3
  15. S.N. Park, H.J. Lee, K.H. Lee, and H. Suh, "Characterization of porous collagen/hyaluronic acid scaffold modified by 1-ethyl-3-(3-dimethylaminopropyl) carbodimide cross-linking", Biomat., vol. 22, pp. 1403-1415, 2002.
  16. J.T. Kim, D.Y. Lee, and J.H. Choi, "Implanting test of re-hydrated hydrogels by hyaluronic acid microbeads", Biomat. Res., vol. 15, pp. 125-128, 2011.
  17. P. Gupta, K. Vermani, and S. Garg, "Hydrogels : from controlled release to pH-responsive drug delivery", Drug Delivery Today, vol. 7, pp. 569-579, 2002. https://doi.org/10.1016/S1359-6446(02)02255-9
  18. K.V.R. Rao and K.P. Devi, "Swelling controlledrelease systems : recent developments and applications", Int. J. Pharm., vol. 48, pp. 1-13, 1988. https://doi.org/10.1016/0378-5173(88)90245-1
  19. E.J. Oh, S. Kang, B. Kim, G. Jiang, I.H. Cho, and S.K. Hahn, "Control of the molecular degradation of hyaluronic acid hydrogels for tissue augmentation", J. Biomed. Mater. Res., vol. 86A, pp. 685-693, 2008. https://doi.org/10.1002/jbm.a.31681
  20. C.E. Schante, G. Zuber, C. Herlin, and T.F. Vandamme, "Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications", Carbohydrate Polymer., vol. 85, pp. 469-489, 2011. https://doi.org/10.1016/j.carbpol.2011.03.019
  21. G.D. Prestwich and K.P. Vercruysse, "Therapeutic applications of hyaluronic acid and hyaluronan derivatives", Pharm. Sci. Technol. Today, vol. 1, pp. 42-43, 1998. https://doi.org/10.1016/S1461-5347(98)00011-X

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