• 제목/요약/키워드: Survival Program

검색결과 338건 처리시간 0.027초

국가유공자 암환자의 생존율 (Survival Rate of Cancer Patients of National Merit)

  • 박운제
    • 보건행정학회지
    • /
    • 제31권1호
    • /
    • pp.35-45
    • /
    • 2021
  • Background: As a descriptive study targeting 2,068 cancer patients as men of national merit in 2013, this study aims to provide the basic data for systematizing the early diagnosis and treatment of cancer by comparatively analyzing the 5-year survival rate. Methods: This study researched the survival of cancer patients through Electronic Medical Record and Patriots-Veterans Qualification Program, targeting 2,068 newly-diagnosed cancer patients verified in five veterans hospitals and consigned management system. This study verified differences between general characteristics of cancer patients as men of national merit and analyzed their survival rate. Results: The cancer patients as men of national merit were super-aged as their average age was 72.5. In the analysis of general characteristics of five major prevalent cancers, there were statistically significant differences according to age, region, cancer diagnostic path, differentiation, diagnostic method, treatment method, SEER stage, and survival period, except for the types of the man of national merit (p<0.001). The whole survival rate of cancer patients as men of national merit was 50%. The 5-year survival rates of predisposing cancers were shown as prostate cancer (79%), colorectal cancer (64%), gastric cancer (57%), liver cancer (32%), and lung cancer (12%). In the cancer diagnostic path, all the predisposing cancers showed the highest survival rate in medical examination. In the treatment method, the surgery showed the highest survival rate. The cancer patients as men of national merit showed a lower survival rate than the general cancer patients of Korea. Conclusion: It would be needed to guarantee the honorable and happy life through health recovery as special treatment of contribution and sacrifice of super-aged men of national merit by increasing the cancer survival rates through regular checkup, early diagnosis, and high-quality treatment system that could have important effects on the survival rate according to the occurrence of cancers.

The Autophagy Protein CsATG8 is Involved in Asexual Development and Virulence in the Pepper Anthracnose Fungus Colletotrichum scovillei

  • Kwang Ho Lee;Adiyantara Gumilang;Teng Fu;Sung Wook Kang;Kyoung Su Kim
    • Mycobiology
    • /
    • 제50권6호
    • /
    • pp.467-474
    • /
    • 2022
  • Autophagy serves as a survival mechanism and plays important role in nutrient recycling under conditions of starvation, nutrient storage, ad differentiation of plant pathogenic fungi. However, autophagy-related genes have not been investigated in Colletotrichum scovillei, a causal agent of pepper fruit anthracnose disease. ATG8 is involved in autophagosome formation and is considered a marker of autophagy. Therefore, we generated an ATG8 deletion mutant, ΔCsatg8, via homologous recombination to determine the functional roles of CsATG8 in the development and virulence of C. scovillei. Compared with the wild-type, the deletion mutant ΔCsatg8 exhibited a severe reduction in conidiation. Conidia produced by ΔCsatg8 were defective in survival, conidial germination, and appressorium formation. Moreover, conidia of ΔCsatg8 showed reduced lipid amount and PTS1 selectivity. A virulence assay showed that anthracnose development on pepper fruits was reduced in ΔCsatg8. Taken together, our results suggest that CsATG8 plays various roles in conidium production and associated development, and virulence in C. scovillei.

The Impact of Government Innovation Subsidies on the Survival of SMEs in Korea

  • Kim, Sangsin
    • STI Policy Review
    • /
    • 제9권1호
    • /
    • pp.55-76
    • /
    • 2018
  • This study analyzed the effect of the government R&D subsidy program on long-term firm survival. In order to estimate the average treatment effect for the treated group, we used the survival analysis and matching method by constituting a comprehensive dataset of more than 90,000 observations. The analysis results show that the government R&D subsidy has a negative impact on long-term firm survival. In particular, not only the subsidy does not have a statistically significant effect on firm survival in the relatively short-term, the survival probability of the subsidized firms is statistically significantly lower than the non-subsidized firms after six years. These results can be seen as weakening the justification of government R&D support. There may be problems in the subsidy policy itself and the process of selection of subsidy awardees; however, the more fundamental problem is that the subsidy policy is concluded as the one-time event. Admittedly, it would be difficult for the government to precisely manage the subsidized projects over a long term period. However, in the case of a project in which short-term performance is detected, it would be necessary to provide a step-by-step support to strengthen the firm's competitiveness through further support and continuous development of performance. Of course, mid- and long-term evaluations of subsidy support policy should be performed in parallel with such phased support.

제한된 평균 생존시간을 이용한 위암 3기 자료 분석에 관한 연구 (Analysis of stage III stomach cancer using the restricted mean survival time)

  • 김빛나;이민정
    • 응용통계연구
    • /
    • 제34권2호
    • /
    • pp.255-266
    • /
    • 2021
  • 본 연구는 미국 국립암연구소의 SEER 프로그램에서 제공하는 위암 3기 자료에 대해 항암치료의 효과를 비교하고 위암 생존율에 유의한 영향을 미치는 요인을 알아보고자 한다. 본 연구에서 분석한 위암 3기 자료는 비례위험 가정이 성립하지 않아 대안으로 제한된 평균 생존시간을 이용한 분석 방법을 자료 분석에 적용하였다. 의사-관측들을 이용하여 제한된 평균 생존시간을 추정하였고, 제한된 평균 생존시간 추정량에 기반한 검정통계량을 이용하여 항암치료의 효과를 파악하였다. 일반화 선형모형을 이용한 회귀모형을 통해 위암 3기 환자의 평균 생존시간에 유의한 영향을 미치는 공변량들의 효과를 추정하였다. 항암치료법에 따라 위암 3기 환자의 평균 생존시간에 유의한 차이가 있음을 확인하였고, 진단연령, 인종, 세분화병기, 분화도, 종양의 크기, 수술여부, 항암치료가 위암 3기 환자의 평균 생존시간에 유의한 영향을 미치는 요인들이였으며, 그 중 수술여부가 위암 3기 환자의 평균 생존시간을 늘리는데 가장 큰 영향을 미치는 요인임을 확인하였다.

살조개, Protothaca jedoensis 치패의 저질입도에 따른 잠입율 (Immersion rate of Protothaca jedoensis spat on Different Grain Sizes)

  • 라성주;안윤근;박일웅;김정;최상덕
    • 한국양식학회지
    • /
    • 제20권2호
    • /
    • pp.127-131
    • /
    • 2007
  • 인공종묘 생산된 살조개, Protothaca jedoensis 치패를 대상으로 치패크기에 따른 잠입율, 저질선택성 및 생존율을 조사하였다. 살조개 치패의 저질별 잠입율을 조사한 결과 약 10분 후 살조개 치패는 점차 수관을 내고 호흡하였으며, 몇몇 개체는 패각을 뒤틀며 잠입하는 형태를 나타내었다. 실험 개시후 72시간째 중립실트에서 90.0%, 세립사 76.7%, 중립사 61.7%, 극조립사 85.0%의 잠입율을 나타내었다. 또한 살조개 치패의 생존율은 중립실트에서 90.0%, 세립사 98.3%, 중립사 86.7%, 극조립사 93.3%의 생존율을 나타내었다. 대조구인 저질이 없는 실험구에서 75.0%의 생존율을 보였다. 각장 크기에 따른 잠입능력은 각장이 증가할수록 잠입시간은 길어지며, 잠입율도 증가하였다.

Effect of diluent variation on cryopreservation of large yellow croaker Larimichthys crocea

  • Lim, Han Kyu;Irfan, Zidni;Lee, Hyo Bin;Song, Ji Hoon;Lee, Yun Ho
    • Fisheries and Aquatic Sciences
    • /
    • 제24권2호
    • /
    • pp.63-77
    • /
    • 2021
  • The aim of this research was to investigate different factors, including cryoprotective agents (CPAs), diluents, dilution ratios, equilibrium times, freezing rates, and thawing methods to optimize cryopreservation protocols for large yellow croaker (Larimichthys crocea). The parameters evaluated were sperm motility, sperm activity index (SAI), survival rate, and DNA damage. Different types of CPAs, such as dimethyl sulfoxide (DMSO), propylene glycol (PG), ethylene glycol (EG), methanol, and glycerol, were tested for sperm preservation. The highest motility, SAI, and survival rate were observed when EG was used. Different diluents such as Stein's solution, Hank's balanced salt solution, marine fish Ringer's solution, artificial seminal plasma (ASP) of small yellow croaker, and Cortland solution were investigated. The highest post-thaw motility was observed upon using ASP as the diluent. Different concentrations of EG were then mixed with ASP to identify the optimal EG concentration. Experimental results showed that the motility (70.33 ± 1.20%), SAI (5), and survival rate (78.30 ± 0.42%) of post-thaw sperm were optimum when 10% EG and ASP were used as the CPA and diluent of cryopreservation, respectively. Post-thaw sperm motility was high at equilibration times below 150 s and at an optimum dilution ratio of 1:1 (sperm: CPA + diluent) and was not significantly different compared with fresh sperm motility. The freezing rate was found to be slow below -10℃/min. The thawing temperature of 45℃ was identified as ideal. The percentage of tail DNA in post-thaw sperm at 10% EG and ASP was also investigated and was found to have more significant DNA damage than that in fresh sperm but significantly lower damage than that in post-thaw sperm at EG concentrations of 5%, 15%, and 20% (p < 0.05). The cryopreservation protocols obtained in this study will be useful in large yellow croaker hatcheries.

학제 간 융합연구를 위한 생존수영프로그램 참여 초등학생의 안전의식과 자아효능감 및 생명존중의 관계 분석 (The Relationship analysis between Safety Consciousness, Self-Efficacy, and Life-Respect according to Participation in Survival Swimming Program of Elementary School Students for interdisciplinary convergence research)

  • 강효민;이용국
    • 디지털융복합연구
    • /
    • 제17권6호
    • /
    • pp.401-408
    • /
    • 2019
  • 이 연구는 학제 간 융합연구를 위한 생존수영프로그램 참여 초등학생의 안전의식과 자아효능감 및 생명존중의 관계를 실증적으로 구명하는데 목적이 있었다. 이러한 연구목적을 수행하기 위하여 강원도 지역에 있는 초등학교 재학생 248명을 대상으로 자료를 수집하여 분석하였다. 수집된 자료는 IBM SPSS 23 프로그램을 이용하여 기술통계, 신뢰도, 탐색적 요인분석, 상관분석을 실시하였으며, AMOS 23 프로그램을 이용하여 확인적요인분석 및 구조방정식모형 검증을 실시하였다. 이상의 연구 과정을 통해 다음과 같은 결론을 얻었다. 첫째, 초등학생의 안전의식은 자아효능감에 유의한 영향을 미친다. 둘째, 초등학생의 안전의식은 생명존중에 유의한 영향을 미치지 않는다. 셋째, 초등학생의 자아효능감은 생명존중에 유의한 영향을 미친다. 결론적으로 초등학생의 생존수영프로그램 참가에 따른 안전의식은 자아효능감에 영향을 미친다. 또한 자아효능감을 매개로 생명존중에 긍정적 영향을 미친다. 따라서 학제 간 융합연구 관점에서 생존수영 교육 프로그램에 대한 다양한 접근이 필요하다.

Detection of Recurrence in a Surveillance Program for Epithelial Ovarian Cancer

  • Suprasert, Prapaporn;Chalapati, Wadwilai
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제14권12호
    • /
    • pp.7193-7196
    • /
    • 2013
  • Ovarian cancer patients need a surveillance program for the detection of tumor progression after completion of treatment. The methods generally consist of history taking, physical examination, tumor marker monitoring and imaging. However, the details of recurrence detection with each method are not well defined. To clarify this issue, ovarian cancer patients who achieved complete or partial responses and developed tumor progression at the follow up time between January 2004 and December 2010 in University Hospital Chiang Mai, Thailand, were reviewed. Clinical data, CA 125 level and imaging results at the tumor progression time were recorded and analyzed. There were 144 ovarian cancer patients meeting the inclusion criteria with the mean age of 51 years and 62.5% of them were in an advanced stage. Complete response was achieved in 89 patients (61.8%) after primary treatment. The median progression free survival and overall survival were 15.5 months and 37.5 months, respectively. Abnormal symptoms presented in 49.3% of the studied patients and 59.7% developed physical examination abnormalities. In addition, CA 125 was elevated in 89.6% while in 74.3% of tumor progression was identified by CT-scan. Short treatment time period and a high level of CA 125 were significant independent prognostic factors in these patients. In conclusion, careful history taking, physical examination and monitoring of CA 125 levels are important methods for tumor progression detection in a surveillance program for epithelial ovarian cancer patients.

Breast Cancer Characteristics and Survival Differences between Maori, Pacific and other New Zealand Women Included in the Quality Audit Program of Breast Surgeons of Australia and New Zealand

  • Campbell, Ian;Scott, Nina;Seneviratne, Sanjeewa;Kollias, James;Walters, David;Taylor, Corey;Roder, David
    • Asian Pacific Journal of Cancer Prevention
    • /
    • 제16권6호
    • /
    • pp.2465-2472
    • /
    • 2015
  • Background: The Quality Audit (BQA) program of the Breast Surgeons of Australia and New Zealand (NZ) collects data on early female breast cancer and its treatment. BQA data covered approximately half all early breast cancers diagnosed in NZ during roll-out of the BQA program in 1998-2010. Coverage increased progressively to about 80% by 2008. This is the biggest NZ breast cancer database outside the NZ Cancer Registry and it includes cancer and clinical management data not collected by the Registry. We used these BQA data to compare socio-demographic and cancer characteristics and survivals by ethnicity. Materials and Methods: BQA data for 1998-2010 diagnoses were linked to NZ death records using the National Health Index (NHI) for linking. Live cases were followed up to December $31^{st}$ 2010. Socio-demographic and invasive cancer characteristics and disease-specific survivals were compared by ethnicity. Results: Five-year survivals were 87% for Maori, 84% for Pacific, 91% for other NZ cases and 90% overall. This compared with the 86% survival reported for all female breast cases covered by the NZ Cancer Registry which also included more advanced stages. Patterns of survival by clinical risk factors accorded with patterns expected from the scientific literature. Compared with Other cases, Maori and Pacific women were younger, came from more deprived areas, and had larger cancers with more ductal and fewer lobular histology types. Their cancers were also less likely to have a triple negative phenotype. More of the Pacific women had vascular invasion. Maori women were more likely to reside in areas more remote from regional cancer centres, whereas Pacific women generally lived closer to these centres than Other NZ cases. Conclusions: NZ BQA data indicate previously unreported differences in breast cancer biology by ethnicity. Maori and Pacific women had reduced breast cancer survival compared with Other NZ women, after adjusting for socio-demographic and cancer characteristics. The potential contributions to survival differences of variations in service access, timeliness and quality of care, need to be examined, along with effects of comorbidity and biological factors.

이종 환경에서 운용되는 부품의 신뢰도 평가 방법 연구 (Study on the Reliability Evaluation Method of Components when Operating in Different Environments)

  • 황정택;김종학;전주연;한재현
    • 한국안전학회지
    • /
    • 제32권5호
    • /
    • pp.115-121
    • /
    • 2017
  • This paper is to introduce the main modeling assumptions and data structures associated with right-censored data to describe the successful methodological ideas for analyzing such a field-failure-data when components operating in different environments. The Kaplan - Meier method is the most popular method used for survival analysis. Together with the log-rank test, it may provide us with an opportunity to estimate survival probabilities and to compare survival between groups. An important advantage of the Kaplan - Meier curve is that the method can take into account some types of censored data, particularly right-censoring. The above non-parametric method was used to verify the equality of parts life used in different environments. After that, we performed the life distribution analysis using the parametric method. We simulated data from three distributions: exponential, normal, and Weibull. This allowed us to compare the results of the estimates to the known true values and to quantify the reliability indices. Here we used the Akaike information criterion to find a suitable life time distribution. If the Akaike information criterion is the smallest, the best model of failure data is presented. In this paper, no-nparametrics and parametrics methods are analyzed using R program which is a popular statistical program.