• 구강생물연구
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• 제42권4호
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• pp.228-234
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• 2018

The aim of this study was to determine the condition of supportive periodontal therapy (SPT) in implant patients and the effect of SPT on implant long-term survival. Implants placed at the Dept. of Periodontology, Chonnam National University Dental Hospital over a 5-year period, were traced for up to 8 years. Patients who had visited the hospital at least once a year were defined as regular SPT, and patients who were treated by active periodontal therapy were defined as patients with periodontitis. Kaplan-Meier survival analysis was performed based on the observation periods, and the effect of SPT and history of periodontitis on implant survival assessed by chisquare test. A total of 183 patients (age: 21-91, 98 males and 85 females), and 508 implants were used for this study. Three hundred eight implants were under SPT and 87 implants was under regular SPT. For the patients with periodontitis 136 implants were placed. The 5-year survival rate was 94.8%. The overall survival rate in patients who received SPT was 97.1% and 91.0% for those who did not (p=0.004). The survival rate in patients who received regular SPT was 97.7%, and 96.8% for patients received irregular SPT. The survival rate was 93.4% in patients with periodontitis and 95.2% in patients without periodontitis. Among patients with periodontitis, the survival rate was 100.0% in patients who received regular SPT and 89.2% for irregular SPT (p=0.012). These results suggest that regular SPT improves implant survival rate and is more effective in patients with periodontitis.

• 기술혁신연구
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• 제25권4호
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• pp.189-209
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• 2017

전 세계적으로 금융선진국을 비롯한 각 국가의 금융당국은 금융기관과 금융소비자 간의 정보비대칭 완화 및 이를 통한 리스크관리를 위하여 금융기관이 참여하는 신용정보 공유제도를 운영하고 있다. 본 연구는 한국에서 공유되고 있는 신용정보 중 사고정보를 대상으로 하여 실제로 공유중인 신용정보 데이터를 분석하였다. 사고정보를 사고횟수, 사고기간, 사고금액의 세 종류로 구분하여, 생존분석에서는 사고정보가 기업의 생존기간에 미치는 영향을 분석하였고, 이후 집단 간 비교분석을 통해 업력 7년 이하의 창업기업과 그 외 기존기업 간에 존재하는 사고정보양상 차이를 검증하였다. 총 449,579개 기업의 사고정보에 대한 정량적인 분석을 시행한 결과 생존분석에서 사고횟수가 사고후생존기간과 정(+)의 상관관계를 보였는데 이는 사고횟수를 부정적인 요소로 판단하고 있는 금융기관의 현행 리스크정책에 반증적 성격을 갖는다. 또한, 집단 간 비교분석에서는 창업기업의 사고양상이 기존기업보다 생존기간에 더 긍정적인 모습을 보이고 있음에 따라 창업기업의 특성을 고려한 신용정보 공유제도의 개선이 필요하다는 시사점을 도출할 수 있었다.

• 생물환경조절학회지
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• 제29권3호
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• pp.219-230
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• 2020

본 연구는 시설 딸기(Fragaria × ananassa Duch. cv. Maehyang)의 삽목묘 생산을 위해 적절한 배지 및 가습 기간을 구명하기 위해 수행되었다. 2019년 2월에 코이어(CO), 암면(RW), 페놀폼(PF), 유기성형배지(OFM)에 삽수를 삽목하여 0, 3, 6, 9, 12일간 포깅 처리를 하였으며, 2019년 6월에 현장실증 실험으로 코이어(CO), 암면(RW), 페놀폼(PF), 유기성형배지(OFM)에 삽수를 삽목하여 0, 6, 9, 12, 15일간 미스팅 처리를 하였다. 포깅 처리에서 삽목묘의 발근율과 생존율은 포깅 기간이 길어질수록 증가하는 경향을 보였으며, CO 배지에서 9일 이상 포깅 처리하였을 때 발근율과 생존율이 유의적으로 높았다. 미스팅 처리에서 발근율은 CO와 RW 배지에서 9일 이상 미스팅 처리하였을 때, 생존율은 12일 이상 미스팅 처리하였을 때 유의적으로 높았다. 육묘기에 배지 및 가습 처리에 따른 지상부와 지하부의 생육은 유의적인 차이가 없었다. 따라서 발근율과 생존율을 고려하였을 때, CO 배지에서 9일간 가습 처리하는 것이 안정적인 삽목묘의 생산에 유리할 것으로 판단된다.

• Communications for Statistical Applications and Methods
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• 제21권6호
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• pp.487-500
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• 2014

A new method to calculate the transmittable prevalence of an epidemic disease is proposed based on a back-calculation formula. We calculated the probabilities of reactivation and of parasitemia as well as transmittable prevalence (the number of persons with parasitemia in the incubation period) of malaria in South Korea using incidence of 12 years(2001-2012). For this computation, a new probability function of transmittable condition is obtained. The probability of reactivation is estimated by the least squares method for the back-calculated longterm incubation period. The probability of parasitemia is calculated by a convolution of the survival function of the short-term incubation function and the probability of reactivation. Transmittable prevalence is computed by a convolution of the infected numbers and the probabilities of transmission. Confidence intervals are calculated using the parametric bootstrap method. The method proposed is applicable to other epidemic diseases in other countries where incidence and a long incubation period are available. We found the estimated transmittable prevalence in South Korea was concentrated in the summer with 276 cases on a peak at the $31^{st}$ week and with about a 60% reduction in the peak from the naive prevalence. The statistics of transmittable prevalence can be used for malaria prevention programs and to select blood transfusion donors.

• 대한한의학회지
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• 제25권4호
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• pp.152-160
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• 2004

Objective : Recently, an increasing portion of cancer patients use various therapies of complementary and alternative medicine (CAM) including traditional oriental medicine, which is believed to improve the consequence of cancer according to clinical experience and laboratory data. But the clinical-based systemic statistic validity of these therapies is lacking, so this study was aimed to validate the traditional oriental therapies (TOT) for terminally ill cancer patients. Patients and methods : This retrospective study was performed on 273 patients who were diagnosed with terminally ill cancer in Korea and treated with TOT in the oriental hospital of Daejeon University, from March 1997 to June 2003. We examined the median duration of the terminal period and the correlations between 9 factors and survival of terminally ill cancer patients. Results : During the study period, we could confirm 142 patients' death (52.01%) in 273 subjects. The median length of survival in terminally ill cancer patients was 16 weeks (95%CI 14.0∼20.0) and 40.15% (95%CI 40.07∼40.22) of patients had survived more than 24 weeks. According to Cox's proportional hazard model including gender, age, conventional therapies (chemotherapy, radiotherapy and surgery), performance status and clinical symptoms as independent variables, history of conventional therapies (RR 0.581, 95%CI 0.381∼0.885), higher performance status (RR 1,855, 95%CI 1.454∼2.366) and absence of ascites and pleural effusion (RR 1.631, 95%CI 1.047∼2.538) showed independent prognostic value of survival. Conclusion : Our findings suggest that TOT offer potential benefits for cancer patients at the terminal stage.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권5호
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• pp.367-371
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• 2009

Purpose: The purpose of this study was to evaluate the feasibility of the outfracture osteotomy sinus graft technique with the evaluation of 5-year survival rate of the implants placed in the atrophic edentulous posterior maxillary area. Materials and methods: One hundred and thirteen cases of 96 patients who visited our center from Aug 2004 to July 2009 and were diagnosed as atrophic edentulous maxillary alveolar ridge, were selected and underwent augmentation sinus surgery with outfracture osteotomy technique. Feasibility of the outfracture osteotomy technique was investigated with clinical and radiographic evaluation to assess the survival rate of the total dental implants in augmentation sinus surgery of this new kind. Total fixture number available in follow-up period was 179, in which the lost 10 patients were excluded out of 96 patients. Results: Five-year cumulative survival rate was 97.2% with 5 failures of total 179 fixtures. The average follow-up period was 29 and a half months, with the minimum and maximum follow-up periods of 4 months 21 days and 59 months 14 days, respectively. Conclusion: Traditional infracture technique is a popular method for an augmentation sinus surgery. The authors modified this classical method by outfracturing and readapting the bony window after sinus graft, with excellent treatment results evidenced by high survival rate of 97.2% (174 out of 179 fixtures), which proves the feasibility of the newly-designed outfracture osteotomy sinus graft technique.

• Journal of Gastric Cancer
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• 제11권1호
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• pp.38-45
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• 2011

Purpose: Bone metastasis from stomach cancer occurs only rarely and it is known to have a very poor prognosis. This study examined the clinical characteristics and prognosis of patients who were diagnosed with stomach cancer and bone metastasis. Materials and Methods: The subjects were 19 patients who were diagnosed with stomach cancer at Hanyang University Medical Center from June 1992 to August 2010 and they also had bone metastasis. The survival rate according to many clinicopathologic factors was retrospectively analyzed. Results: 11 patients out of 18 patients (61%) who received an operation were in stage IV and the most common bone metastasis location was the spine. Bone scintigraphy was mostly used for diagnosing bone metastasis and PET-CT and magnetic resonance imaging were used singly or together. The serum alkaline phosphatase at the time of diagnosis had increased in 12 cases and there were clinical symptoms (bone pain) in 16 cases. Treatment was given to 14 cases and it was mostly radiotherapy. There were 2 cases of discovering bone metastasis at the time of diagnosing stomach cancer. The interval after operation to the time of diagnosing bone metastasis for the 18 cases that received a stomach cancer operation was on average $14.9{\pm}17.3$ months and the period until death after the diagnosis of bone metastasis was on average $3.8{\pm}2.6$ months. As a result of univariate survival rate analysis, the group that was treated for bone metastasis had a significantly better survival period when the bone metastasis was singular rather than multiple, as compared to the non-treatment group, yet both factors were not independent prognosis factors on multivariate survival analysis. Conclusions: An examination to confirm the status of bone metastasis when conducting a radio-tracer test after the initial diagnosis and also after an operation is needed for stomach cancer patients, and bone scintigraphy is the most helpfully modality. Making the diagnosis at the early stage and suitable treatments are expected to enhance the survival rate and improve the quality of life even for the patients with bone metastasis.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3455-3458
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• 2016

Osteosarcoma is a common primary malignant bone tumor in children and adolescents. Recent worldwide average incidences of osteosarcoma in people aged 0 to 24 years were 4.3 and 3.4 per million, respectively, with a ratio of 1.4:1. However, data on the incidence of osteosarcoma in Thailand are limited. This study analyzed the incidence of osteosarcoma in the upper northern region of Thailand, with a population of 5.85 million people (8.9% of the total Thai population), using data for the years 1998 to 2012, obtained from the Chiang Mai Cancer Registry (CMCR) at Chiang Mai University Hospital and the Lampang Cancer Registry (LCR) at the Lampang Cancer Hospital, a total of 144 cases. The overall annual incidence of osteosarcoma was 1.67 per million with a male:female ratio of 1.36:1. Incidences by age group (male and female) at 0 to 24, 25 to 59 and over 60 years were 3.5 (3.9 and 3.0), 0.8 (0.9 and 0.6), and 0.7 (0.8 and 0.5), respectively. The peak incidence occurred at 15 to 19 years for males and at 10 to 14 years for females. The median survival time was 18 months with a 5-year survival rate of 43%. Neither the age group nor the 5-year interval period of treatment was significantly correlated with survival during the 15-year period studied.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제35권2호
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• pp.94-99
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• 2013

Purpose: The purpose of this study was to evaluate the feasibility of the outfracture osteotomy sinus graft technique with the evaluation of 8.5 year survival rate of the implants placed in the atrophic edentulous posterior maxillary area. Methods: One hundred and seventy-six cases of 145 patients who visited our center from August 2004 to February 2013 and were diagnosed as atrophic edentulous maxillary alveolar ridge, were selected and underwent sinus graft with outfracture osteotomy sinus graft technique. Feasibility of the outfracture osteotomy sinus graft technique was investigated with clinical and radiographic evaluation to assess the survival rate of the total dental implants in augmentation sinus surgery. Total fixture number available in follow-up period was 320, in which the lost 15 patients were excluded out of 160 patients. Results: Eight point five year cumulative survival rate was 95.6% with 14 failures of total 320 fixtures. The average follow-up period was 28 months 16 days with the minimum and maximum follow-up periods of 4 months 5 days and 94 months 10 days, respectively. Conclusion: Traditional infracture technique is a popular method for an augmentation sinus surgery. The authors modified this classical method by outfracturing and readapting the bony window after sinus graft, with excellent treatment results evidenced by high survival rate, which proves the feasibility of the newly-designed outfracture osteotomy sinus graft technique.

• Radiation Oncology Journal
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• 제11권2호
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• pp.347-354
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• 1993

This is a retrospective analysis of 67 patients with histologically proven invasive carcinoma of uterine cervix treated with surgery followed by adjuvant radiotherapy at Inje University Seoul Paik Hospital between october 1983 and september 1991, Postoperative radiotherapy was carried out in patients with high risks of locoregional recurrence such as positive pelvic lymph node (38 pts), large tumor size more than 3 cm (22 pts), cervical stromal invasion more than 2/3 (46 pts), parametrial involvement (9 pts), positive resection margin (14 pts), endo/myometrial extension (10 pts), and angiolymphatic invasion (13 pts). Stage I A, I B, and IIA were 2 $(3\%),$ 39 $(58.2\%),\;and\;26\;(38.8\%),$ respectively. Median follow-up period was 48 months with ranges from 13 to 115 months. All 67 patients were treated externally with standard pelvic field with radiation dose ranging from 4080 to 6120 cGy in 4~6 weeks period of time. Of these, 45 patients received intracavitary radiotherapy. The overall survival rate and disease free survival rate at 5-year were $88.0\%\;and\;82.1\%,$ respectively. The survival rates by stage were $87.1\%$ in IB and $88.4\%$ in IIA. Local control rate was $80.6\%(58\;pts).$ The treatment failure was noted in 12 of 67 patients $(17.9\%):$ locoregional failure in $7(10.4\%),$ distant metastasis in 3 $(4.5\%),$ and locoregional and distant metastasis in $2(3\%),$ The univariate analysis of prognostic factors disclosed endo/myometrial extension as a significant factor of survival and recurrence $(70.0\%\;vs\;91.1\%\;P<0.05\;&\;30.0\%\;vs\;15.8\%,\;respectively).$ The complication of postoperative radiothrapy was not significant and all patient were well tolerated. In conclusion, postoperative radiotherapy in patients with high risks of locoreginal recurrence is relatively well tolerated and it gives significantly improved survival rate especially in patients with positive lymph nodes, bulky tumor size $(\geqq3\;cm),$ parametrial involvement, cervical stromal invasion more than 2/3, positive resection margin and angiolymphatic invasion.