• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5005-5006
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• 2015

Gastric cancer as one of the most common cancers worldwide has various genetic and environmental risk factors including Helicobacter pylori (H.pylori) infection. Recently, loss of a tumor suppressor gene named promyelocytic leukemia (PML) has been identified in gastric cancer. However, no mutation has been found in this gene in gastric cancer samples. Cag A H.pylori protein has been shown to exert post transcriptional regulation of some tumor suppressor genes. In order to assess such a mechanism for PML degradation, we performed in silico analyses to establish any interaction between PML and Cag A proteins. In silico interaction and docking studies showed that these two proteins may have stable interactions. In addition, we showed that imatinib kinase inhibitor can restore PML function by inhibition of casein kinase 2.

• Proceedings of the IEEK Conference
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• 2006.06a
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• pp.345-346
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• 2006

In this paper, we propose the noise suppressor with the psychoacoustic model and wavelet packet transform. The objective of the scheme is to enhance speech corrupted by colored or non-stationary noise. If corrupted noise is colored, subband approach would be more efficient than whole band one. To avoid serious residual noise and speech distortion, we must adjust the Wavelet Coefficient threshold. In this paper, the subband is designed matching with the critical band. And WCT is adapted by noise masking threshold(NMT) and segmental signal to noise ratio(seg_SNR). Consequently this work improve the PESQ-MOS about 0.23 in the case of coded speech.

• Molecules and Cells
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• v.21 no.2
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• pp.167-173
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• 2006

The literature provides strong precedent for both pro-tumorigenic and tumor suppressor roles for the c-Jun N-terminal kinases (JNKs) in the setting of oncogenesis. Clearly, JNKs are activated by numerous oncogenes and growth factors and the literature documents a role for these MAP kinases in cell proliferation and transformation. By contrast, JNKs mediate signals from diverse stimuli that result in cell death or differentiation and a role for JNKs as tumor suppressors has emerged. This enigmatic nature of the JNKs in the setting of oncogenesis is considered herein. Further illumination of the complex and context-dependent functions of the JNKs in cancer cells is of obvious importance for the rational use of small molecule JNK inhibitors as therapeutics.

• Genomics & Informatics
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• v.13 no.2
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• pp.26-30
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• 2015

nc886 (=vtRNA2-1, pre-miR-886, or CBL3) is a newly identified non-coding RNA (ncRNA) that represses the activity of protein kinase R (PKR). nc886 is transcribed by RNA polymerase III (Pol III) and is intriguingly the first case of a Pol III gene whose expression is silenced by CpG DNA hypermethylation in several types of cancer. PKR is a sensor protein that recognizes evading viruses and induces apoptosis to eliminate infected cells. Like viral infection, nc886 silencing activates PKR and induces apoptosis. Thus, the significance of the nc886:PKR pathway in cancer is to sense and eliminate pre-malignant cells, which is analogous to PKR's role in cellular innate immunity. Beyond this tumor sensing role, nc886 plays a putative tumor suppressor role as supported by experimental evidence. Collectively, nc886 provides a novel example how epigenetic silencing of a ncRNA contributes to tumorigenesis by controlling the activity of its protein ligand.

• Proceedings of the KIPE Conference
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• 2015.07a
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• pp.11-12
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• 2015

This study has looked into ways to cut the power supply by predicting electrical fire that may occur in low-voltage cable, which is most frequently used in industrial settings and households. In addition, we have designed a system that cuts off electricity to prevent the fire upon occurrence of events that may cause electrical fire, including short circuit, tracking and contact failure. A lot of previous researches have designed arc suppressors built in analog circuit, which left much to be desired such as difficulty in remote control and inability to identify the location of arc suppressor when it is activated. To address these issues, the study seeks to develop an arc suppressor using micom and to verify its performance through simulations designed to detect arc faults.

• Smart Structures and Systems
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• v.33 no.3
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• pp.217-225
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• 2024

In this study, an electromagnetic dynamic vibration suppressor and energy harvester is designed and studied. In this system, a gear mechanism is used to convert the linear motion to continuous rotary motion. Governing equations of motion for the system are derived and validated using the experimental results. Effects of changing the main parameters of the presented system, such as mass ratio, stiffness ratio and gear ratio on the electro-mechanical behavior of system are investigated. Moreover, using so-called Weighted Cost Function, the optimum parameters of the system are obtained. Finally, it is shown that the presented electromagnetic dynamic vibration absorber not only can reduce the undesired vibration of the main system but also it can harvest acceptable electrical energy.

• Tuberculosis and Respiratory Diseases
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• v.87 no.1
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• pp.22-30
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• 2024

Tumor immune evasion is a complex process that involves various mechanisms, such as antigen recognition restriction, immune system suppression, and T cell exhaustion. The tumor microenvironment contains various immune cells involved in immune evasion. Recent studies have demonstrated that granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immune evasion in lung cancer by modulating neutrophils and myeloid-derived suppressor cells. Here we describe the origin and function of G-CSF and GM-CSF, particularly their role in immune evasion in lung cancer. In addition, their effects on programmed death-ligand 1 expression and clinical implications are discussed.

• Proceedings of the Korean Magnestics Society Conference
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• 2003.12a
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• pp.201-201
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• 2003

• Proceedings of the Korean Society of Applied Pharmacology
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• 2002.07a
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• pp.241-241
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• 2002

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 1998.06a
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• pp.346.1-347
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• 1998