• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8469-8474
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• 2014

Introduction: Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer. Objectives: In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance. Materials and Methods: SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects. Results: SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively). Conclusions: Our results show that SOCS-1 has no prognostic significance in colorectal cancer.

• BMB Reports
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• v.48 no.3
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• pp.159-165
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• 2015

Although the short isoform of ErbB3-binding protein 1 (Ebp1), p42 has been considered to be a potent tumor suppressor in a number of human cancers, whether p42 suppresses tumorigenesis of lung cancer cells has never been clarified. In the current study we investigated the tumor suppressor role of p42 in non-small cell lung cancer cells. Our data suggest that the expression level of p42 is inversely correlated with the cancerous properties of NSCLC cells and that ectopic expression of p42 is sufficient to inhibit cell proliferation, anchorage-independent growth, and invasion as well as tumor growth in vivo. Interestingly, p42 suppresses Akt activation and overexpression of a constitutively active form of Akt restores the tumorigenic activity of A549 cells that is ablated by exogenous p42 expression. Thus, we propose that p42 Ebp1 functions as a potent tumor suppressor of NSCLC through interruption of Akt signaling.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2006.11a
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• pp.89-92
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• 2006

In the present study, the flow field of a mesh type suppressor with varying holes at the central portion is studied to investigate drain flow characteristics in a cylindrical tank. Further, an attempt is made to understand the changes in the flow field brought about by the suppressors of different kinds in a circular tank which ultimately prevents vortex formation. For this purpose, flow visualization studies using PIV (Particle Image Velocimetry) to determine the flow patterns in a cylindrical tank with circular cross section without suppressor and with suppressor are carried out after imparting rotation to the liquid in the tank. Results are obtained when there is no draining and with draining. The flow field is visualized both in horizontal and vertical planes.

• Proceedings of the KIPE Conference
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• 2001.10a
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• pp.822-828
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• 2001

Three-phase four-wire electrical distribution systems are widely employed in manufacturing plants, commercial and residential buildings. Due to the nonlinear loads connected to the distribution system, the neutral conductor carries excessive harmonic currents even under balanced loading since the triplen harmonics in phase currents do not cancel each other. This may result in wiring failure of the neutral conductor and overloading of the distribution transformer. In response to these concerns, a cost-effective neutral current harmonic suppressor system has been proposed [6]. This paper proposes an improved control method for the harmonic suppressor system under unbalanced load conditions. The proposed control method compensates for only the harmonic components in the neutral conductor, and the zero-sequence fundamental component due to unbalanced loading is prevented from flowing through the harmonic suppressor system. This remedies overloading and power loss of the system. The experimental results on a prototype validate the proposed control approach.

• Journal of Life Science
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• v.17 no.9 s.89
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• pp.1303-1307
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• 2007

A tumor suppressor, merlin is a member of ERM family proteins. It consists of N-terminal FERM domain, ${\alpha}-helical$ region, and C-terminal domain. Alternative splicing of merlin's mRNA generates two isotypes of merlin. Isotype I, which has exon17 at the C-terminus instead of exon16 in isotype II, is known to have tumor suppressor activity. Like other ERM proteins, the C-terminal domain of merlin isotype I interacts to its FERM domain. That of isotype II, however, was reported not to bind FERM domain despite the large common part of C-terminal domain, which possibly binds FERM domain. Here, we show the binding of FERM domain to both C-terminal domains of merlin's two isotypes by isothermal titration calorimetry. These results support that merlin isotype II also can form a closed conformation or a multimer by intramolecular or intermolecular interactions using their FERM domain and C-terminal domain.

• Korean Journal of Microbiology
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• v.20 no.1
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• pp.1-10
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• 1982

From Aspergillus nidulans, six suppressor mutants, MSI-MS6, were isolated, and their characteristics were analysed. These were the suppressor mutants for acriflavin resistant and nicotinamide auxotrophic mutant phenotypes. MS1, MS2, MS5 and MS6, were linked to the chromosome IV, I, II respectively, and MS2 was linked to one of the rest chromosomes, MS3 and MS6 mutants had both suppressors for acriflavin resistant marker and for nicotinamide auxotrophic marker. In order to know the stability and efficiency of the suppressors, their reversion frequencies, that is, frequencies of losing the suppressibility, were analysed. Only MS3 and MS5 were reversed with high frequency. The four mutants didn't lose their suppressibilities, and this meant that the suppressors of these four were very stable and highly effcient. The suppressor specificities of these mutants were tested for other mutant's phenotype marker. One of the six suppressors, MS1, had the suppressor specificity for acriflavin resistant marker of 163 strain.

• Proceedings of the Korean Society of Marine Engineers Conference
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• 2005.06a
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• pp.1166-1169
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• 2005

This paper describes a new transient voltage suppressor(TVS) with a low insertion loss and a high cut-off frequency to protect antenna circuit from transient voltages. Conventional protection devices have some problems such as a low frequency bandwidth and a high insertion loss. In order to improve these limitations, a coaxal type TVS, which consists of a gas tube is developed. The performance of the proposed transient voltage suppressor is tested by using a combination surge generator specified in IEC 61000-4-5 standard and by using a network analyzer of 40 MHz ${\sim}$ 5 GHz bandwidth. From the experimental results, it is confirmed that the proposed TVS has an enough protection performance in a low insertion loss and a high cut-off frequency.

• Journal of the Korean Geosynthetics Society
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• v.8 no.1
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• pp.41-51
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• 2009

This paper reviews many of the design considerations surrounding the topic of tiedback landslide suppressor walls primarily for soils app1ications. The design requires combining knowledge of many aspects of soil mechanics and geology to obtain a design a wall that fits site specific conditions. Many of the aspects necessary to complete the design are stil1 not comprehensively studied or understood. This paper provides an overview of the more traditional aspects of tieback wall design and a discussion of newer issues such as suppressor wall earth pressures and rotation of stresses due to tiebacks. An overview is also provided regarding the effect of seismic forces.

• Journal of Power Electronics
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• v.3 no.3
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• pp.151-158
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• 2003

Three-phase four-wire electrical distribution systems are widely employed in manufacturing plants, commercial and residential buildings Due to the nonlinear loads connected to the distribution system, the neutral conductor carries excessive harmonic currents even under balanced loading since the triplen harmonics in phase currents do not cancel each other This may result in wiring failure of the neutral conductor and overloading of the distribution transformer In response to these concerns, a cost-effective neutral current harmonic suppressor system has been proposed. This paper proposes an improved control method for the harmonic suppressor system under unbalanced load conditions The proposed control method compensates for only the harmonic components in the neutral conductor, and the zero-sequence fundamental component due to unbalanced loading is prevented from flowing through the harmonic suppressor system This remedies overloading and power loss of the system The experimental results on a prototype validate the proposed control approach.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2016.11a
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• pp.128-128
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• 2016

Cu 배선폭 미세화 기술은 반도체 디바이스의 성능 향상을 위한 핵심 기술이다. 현재 배선 기술은 lithography, deposition, planarization등 종합적인 공정 기술의 발전에 따라 10x nm scale까지 감소하였다. 하지만 지속적인 feature size 감소를 위하여 요구되는 높은 공정 기술 및 비용과 배선폭 미세화로 인한 재료의 물리적 한계로 인하여 배선폭 미세화를 통한 성능의 향상에는 한계가 있다. 배선폭 미세화를 통한 2차원적인 집적도 향상과는 별개로 chip들의 3차원 적층을 통하여 반도체 디바이스의 성능 향상이 가능하다. 칩들의 3차원 적층을 위해서는 별도의 3차원 배선 기술이 요구되는데, TSV(through-Si-via)방식은 Si기판을 관통하는 via를 통하여 chip간의 전기신호 교환이 최단거리에서 이루어지는 가장 진보된 형태의 3차원 배선 기술이다. Si 기판에 $50{\mu}m$이상 깊이의 via 및 seed layer를 형성 한 후 습식전해증착법을 이용하여 Cu 배선이 이루어지는데, via 내부 Cu ion 공급 한계로 인하여 일반적인 공정으로는 void와 같은 defect가 형성되어 배선 신뢰성에 문제를 발생시킨다. 이를 해결하기 위해 각종 유기 첨가제가 사용되는데, suppressor를 사용하여 Si 기판 상층부와 via 측면벽의 Cu 증착을 억제하고, accelerator를 사용하여 via 바닥면의 Cu 성장속도를 증가시켜 bottom-up TSV filling을 유도하는 방식이 일반적이다. 이론적으로, Bottom-up TSV filling은 sample 전체에서 Cu 성장을 억제하는 suppressor가 via bottom의 강한 potential로 인하여 국부적 탈착되고 via bottom에서만 Cu가 증착되어 되어 이루어지므로, accelerator가 없이도 void-free TSV filling이 가능하다. Accelerator가 Suppressor를 치환하여 오히려 bottom-up TSV filling을 방해한다는 보고도 있었다. 본 연구에서는 유기 첨가제의 치환으로 인한 TSV filling performance 저하를 방지하고, 유기 첨가제 조성을 단순화하여 용액 관리가 용이하도록 하기 위하여 suppressor만을 이용한 TSV filling 연구를 진행하였다. 먼저, suppressor의 흡착, 탈착 특성을 이해하기 위한 연구가 진행되었고, 이를 바탕으로 suppressor만을 이용한 bottom-up Cu TSV filling이 진행되었다. 최종적으로 $60{\mu}m$ 깊이의 TSV를 1000초 내에 void-free filling하였다.