• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.50 no.4
• /
• pp.359-365
• /
• 2017

To develop new functional materials, Saccharina japonica (S. japonica) was cultivated with Phellinus linteus (P. linteus) mycelia by solid culture. S. japonica was fermented with P. linteus mycelia. The various radical scavenging activities of extracts of fermented S. japonica with P. linteus mycelia (FSPM) were investigated and compared to the antioxidant capabilities of unfermented S. japonica and P. linteus mycelia. The antioxidant activities of FSPM extracts were evaluated using ferric reducing antioxidant power (FRAP) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity. FSPM showed stronger free radical scavenging abilities than P. linteus mycelia or S. japonica alone. These results indicate that fermentation of S. japonica changes its chemical nature and could provide beneficial antioxidant effects.

• 한국약용작물학회:학술대회논문집
• /
• 2010.10a
• /
• pp.355-356
• /
• 2010

• 한국약용작물학회:학술대회논문집
• /
• 2010.10a
• /
• pp.339-340
• /
• 2010

• 한국약용작물학회:학술대회논문집
• /
• 2009.05a
• /
• pp.217-218
• /
• 2009

• 한국약용작물학회:학술대회논문집
• /
• 2009.05a
• /
• pp.213-214
• /
• 2009

• 한국약용작물학회:학술대회논문집
• /
• 2009.05a
• /
• pp.101-102
• /
• 2009

• 한국약용작물학회:학술대회논문집
• /
• 2009.05a
• /
• pp.215-216
• /
• 2009

• Journal of Microbiology and Biotechnology
• /
• v.26 no.1
• /
• pp.28-37
• /
• 2016

Numerous plants have been documented to contain phenolic compounds. Thymol is one among these phenolic compounds that possess a repertoire of pharmacological activities, including anti-inflammatory, anticancer, antioxidant, antibacterial, and antimicrobial effects. Despite of the plethora of affects elicited by thymol, its activity profile on gastric cancer cells is not explored. In this study, we discovered that thymol exerts anticancer effects by suppressing cell growth, inducing apoptosis, producing intracellular reactive oxygen species, depolarizing mitochondrial membrane potential, and activating the proapoptotic mitochondrial proteins Bax, cysteine aspartases (caspases), and poly ADP ribose polymerase in human gastric AGS cells. The outcomes of this study displayed that thymol, via an intrinsic mitochondrial pathway, was responsible for inducing apoptosis in gastric AGS cells. Hence, thymol might serve as a tentative agent in the future to treat cancer.

• Journal of Microbiology and Biotechnology
• /
• v.22 no.10
• /
• pp.1381-1387
• /
• 2012

We applied enzymatic hydrolysis and tangential flow filtration (TFF) to purify a novel anticancer peptide from Mytilus coruscus (M. coruscus) and investigated its anticancer properties. To prepare the peptide, eight proteases were employed for enzymatic hydrolysis. Pepsin hydrolysates, which showed clearly superior cytotoxic activity on prostate cancer cells, were further purified using a flow filtration system using a TFF and consecutive chromatographic methods. Finally, a novel anticancer peptide was obtained, and the sequence was identified as Ala-Phe-Asn-Ile-His-Asn-Arg-Asn-Leu-Leu. The peptide from M. coruscus effectively induced cell death on prostate, breast and lung cancer cells but not on normal liver cells. This is the first report of an anticancer peptide derived from the hydrolysates of M. coruscus.

• Korean Journal of Applied Biomechanics
• /
• v.21 no.5
• /
• pp.521-528
• /
• 2011

The purpose of this study was to analyze the kinematic characteristics of the finalists in the women's 100 m event to provide important information to coaches and athletes. Three different biomechanics techniques were applied for analyzing sprinter motion: LAVEG, a panning technique, and 12 video cameras for 3 dimensional analysis of the 40 m - 70 m portion of the race. Carmelita Jeter(USA) performed the maximum speed of 10.54 m/s at the distance of 58.2 m. There was a tendency to show a better performance time with a high number of steps (p=.13) and shorter stride length (p=.14) among the 8 sprints. Furthermore, the stride frequency and the performance time were negatively correlated as a higher stride frequency had a positive impact on the performance time (p=.02). Based on 3 dimensional analysis, the 4 top ranked sprinters used the different strategies to maintain a high COM (Center of Mass) velocity during the mid portion of the race (40 m - 70 m). Carmelita Jeter(USA) showed more flexed knee and hip motion at heel contact (HC) to maintain a high COM velocity while S.A. Fraser-Pryce (JAM) showed more extended knee and hip motion at HC. On the other hands, Veronica Campbell-Brown (JAM) and Kelly-Ann Baptiste (TRI) showed a tendency to have high knee lifts during the swing phase to maintain the high COM velocity during the race. These biomechanical analyses of the women's 100 m final event in the 2011 WC, Daegu, will provide important scientific information to coaches and athletes for understanding the sprinting mechanism of today's top-class sprinters.