• Title/Summary/Keyword: Substance over Form

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Early Healing Responses of the Skin Wounds in the Korean Fire-Bellied Toad, Bombina orientalis (무당개구리 (Bombina orientalis) 피부의 초기 상처치유반응)

  • Jeong, Moon-Jin;Moon, Myung-Jin
    • Applied Microscopy
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    • v.28 no.3
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    • pp.329-343
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    • 1998
  • Early wound healing responses in the skin of the Korean fire bellied toad, Bombina orientalis, were examined using histochemical , scanning and transmission electron microscopical techniques. Cutaneous wounds were induced by sharp razor blade , and maintained in special cages for up to 3 days. By this treatment whole parts of epithelium and dermis were profoundly affected. After injury, retraction of damaged surface of the skin was observed. At 3 hours after injury, poly-band was form by mucous substance. The wound skin consisted of mucous gland secreted mucous substance which flows into wound cavity and the wound area was sealed by mucous substance which form thick layer at 6 hours. It appeared that natural disposition showed acid and neutral mucous substance by reaction of PAS and Alcian blue (pH 2.5) staining. After formation of the poly-band, epithelial cells were formed by migration of regenerating epithelial cells. These cells moved over the wound surface by migration at 12 hours after wounding. Poly-band was much increased in thickness and migrating cells were completely formed wound closure at 24 hours post-wounding. After 72 hours regenerated epithelial layer consists of four or five cell layers which are similar to clear, granular, and spinous layer.

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Drug Polymorphism and its Importance on Drug Development Process

  • Jeong, Seong-Hoon;Youn, Yu-Seok;Shin, Beom-Soo;Park, Eun-Seok
    • Journal of Pharmaceutical Investigation
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    • v.40 no.spc
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    • pp.9-17
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    • 2010
  • Polymorphism has been recognized to be a critical issue throughout the drug product development process. Most of solid phase drugs have polymorphism, which has generated a great deal of interest and the field has been evolving rapidly. Preferably, thermodynamically most stable form of a drug substance is selected to obtain consistent bioavailability over its shelf life and various storage conditions. Moreover, it has the lowest potential for conversion from one polymorphic form to another. However, metastable or amorphous forms may be used intentionally to induce faster dissolution rate for rapid drug absorption and higher efficacy. For pharmaceutical industry, polymorphism is one of the key activities in form selection process together with salt selection. This article introduces the main features in the investigation of solid form selection especially polymorphic behavior with thermodynamic backgrounds, physicochemical properties with solubility, dissolution, and mechanical properties, and characterization techniques for proper analysis. The final form can be recommended based on the physicochemical and biopharmaceutical properties and by the processability, scalability and safety considerations. Pharmaceutical scientists especially in charge of formulation need to be well aware of the above issues to assure product quality.

Formation of Efflorescence and Dissolving Experiments for Removing Control on the Stone Pagoda of the Mireuksaji Temple Site, Iksan, Korea (익산 미륵사지 석탑의 백화현상과 제어를 위한 용출실험)

  • Lee, Dong-Sik;Lee, Chan-Hee;Kim, Sa-Dug
    • Journal of Conservation Science
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    • v.19
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    • pp.5-18
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    • 2006
  • The Mireuksaji stone pagoda of the Iksan was built in Muwang King of Baekjae Kingdom and has maintained its present status through several rebuilding process. Recently, the structural unbalance of the pagoda has worsened, so for scientific maintenance recovery of its original pagoda form, the pagoda is under dismantling process. The original form of this pagoda is being presumed to be a plane square pagoda of nine stories, though only a portion of six stories remains until today. The destroyed part from collapse was liked in insecure pagoda form by Japanese in year of 1915. On the surface of the stone which has gone through the present time, efflorescence appeared as precipitation substance over crusted and due to this phenomenon, the structure and color of thee original stone haven't been preserved. Therefore, quantitative analysis on its kind, emitted status and contamination type of secondary inorganic contamination substance of the over crusted surface were analyzed. Also through reaction experiments, contamination type was defined and tests have been applied to find the requirements that will wash out the contaminants. The result of this study will provide the base of quantitative analysis on the kind of inorganic contamination of the surface of stone assets, and it shall also contribute to the application of scientific maintenance recovery of surface cleaner for efflorescence.

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A Study on the Unique point about the Tracking at Electrical fire spot (화재현장에서 분석 절차에 따른 전기화재 조사기법 개발)

  • Kim, Dong-Ook;Lee, Ki-Yeon;Gil, Hyung-Jun;Kim, Hyang-Kon;Chung, Young-Sik
    • Proceedings of the KIEE Conference
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    • 2011.07a
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    • pp.2130-2131
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    • 2011
  • Electric fire breaks out by various causes such as electric short, overload(over current), leakage current, poor contact, static electricity, insulation deterioration, partial disconnection and etc. In this paper, we studied analysis technique for scientific and systematic judgment for distinction of electricity fire existence and nonexistence, and described about electricity fire cause analysis process for collecting physical evidences. We handled external form analysis, Substance extension analysis, X-ray transmission analysis, cross-section analysis, thermal analysis, chemical structure analysis, surface structure analysis, component analysis, electrical properties analysis, and circuit analysis by analysis technique for electricity fire cause judgment. We expect that analysis technic elevation and correct cause of fire analysis of scene of a fire investigators and analysts through this paper which see help.

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Electrodeposited Nano-flakes of Manganese Oxide on Macroporous Ni Electrode Exhibiting High Pseudocapacitance

  • Gobal, F.;Jafarzadeh, S.
    • Journal of Electrochemical Science and Technology
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    • v.3 no.4
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    • pp.178-184
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    • 2012
  • A porous nickel (P-Ni) substrate was prepared by selective leaching of zinc from pressed pellets containing powders of Ni & Zn in 4 M NaOH solution. Anodic deposition of manganese oxide onto the porous Ni substrate ($MnO_x$/P-Ni) formed nano-flakes of manganese oxide layers as revealed in SEM studies. Pseudocapacitance of this oxide electrode was evaluated by cyclic voltammetry (CV) and chronopotentiometry (CHP) in 2 M NaOH solution. The specific capacitance of the Mn oxide electrode was as high as 1515 F $g^{-1}$, which was ten times higher than Mn oxide deposited on a flat Ni-ribbon. 80% of capacity was retained after 200 charge/discharge cycles. The system showed no loss of activity in dry form over period of days. The impedance studies indicated highly conducting $MnO_x$/P-Ni substance and the obtained specific capacitance from impedance data showed good agreement with the charge/discharge measurements.

The Sophisticated Causes in the Phaedo (『파이돈』에서의 세련된 원인들)

  • Chun, Hunsang
    • Journal of Korean Philosophical Society
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    • no.122
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    • pp.1-23
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    • 2018
  • In the final argument for the immortality of the soul in the Phaedo, Socrates establishes a new type of cause which he describes as 'more sophisticated' and on the basis of it attempts to show that the soul is immortal. In the process, he introduces three examples for the cause, i.e. three, fire, and snow. But there has been considerable controversy over the ontological status of the three and the soul. Some scholars think that they are all forms; others believe that neither of them is. In this paper I argue that in fact one of them is a form, while the others are not. I also argue that the fact that they do not have the same ontological status and the uncertainty in the nature of the soul itself weaken the cogency of the final argument as a whole.

The Distribution of DOM and POM and the Composition of Stable Carbon Isotopes in Streams of Agricultural and Forest Watershed Located in the Han River System (한강수계 농경지역 하천과 삼림지역 하천에서 DOM과 POM의 분포 및 안정탄소동위원소 조성비)

  • Kim, Jai-Ku;Kim, Bom-Chul;Jung, Sung-Min;Jang, Chang-Won;Shin, Myoung-Sun;Lee, Yun-Kyoung
    • Korean Journal of Ecology and Environment
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    • v.40 no.1
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    • pp.93-102
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    • 2007
  • The runoff characteristics of organic matter in turbid water were investigated in eleven tributary streams of the Han River system, Korea. The flow-weighted event mean concentrations of organic matter ranged from 1.5 to 3.2 mg $L^{-1}$ of DOM and 2.2 of 29.1 mg $L^{-1}$ of POM, respectively. The SUVA value which reflects the proportion of humic substance in organic matters was higher during the rainfall season, meaning that the runoff of refractory form increase in this period. Stable carbon isotope ratios of both POM and DOM were different among streams, which reflect the sources of organic matter. DOM isotope ratios were less depleted of $^{13}C$ than that of POM by approximately 1 to $2%_{\circ}$ ${\delta}^{13}C$ of the several turbid streams (the Mandae Stream, the Jawoon Stream, and the Daegi stream) were heavier than those of clear streams. ${\delta}^{13}C$ values in the turbid upstream tributaries were similar to those of downstream reaches (such as the Soyang River, the Sum River, and the Seo River). From the ${\delta}^{13}C$ analysis of POM it could be calculated that $C_4$ pathway contributed approximately 15.9 to 23.6% of organic matter in several turbid upstream sites, and over 20% in the three sites of large downstream reaches. On the contrary it contributed only 9.1 to 12.8% in clear streams of forest watersheds. In the Soyang River, $C_4$ pathway organic matter contributed 8.8% of the DOM pool.

Assessment of Acid Solubility Test on Korean Asbestos by Transmission Electron Microscope Equipped with Energy Dispersive X-ray Spectrometer (한국산 석면의 산 용해도 평가 연구)

  • Chung, Yong Hyun;Han, Jeong Hee
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.24 no.2
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    • pp.146-151
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    • 2014
  • Objectives: Chrysotile is mineralogically distinct from amphiboles, displaying a notably different chemical structure. The thin sheets that form chrysotile fiber lead to the ability of the lung/macrophage system to decompose the chrysotile fibers. This study was performed in order to compare the physicochemical characteristics of Korean asbestos with those of Canadian amphiboles. Materials: An acid solubility test for each test substance was done to compare pH 4.5 and pH 1.2 distilled water. Asbestos fibers which had been placed in acid solutions for five days, five weeks and weeks were analyzed with a transmission electron microscope equipped with an energy dispersive X-ray spectrometer (TEM-EDS). Results: The composition element (Mg) of Korean chrysotile, Korean anthophyllite and Canadian amosite significantly decreased from 5 days and also decreased significantly after 5 weeks and 10 weeks. Only the composition (Mg) of Canadian crocidolite did not change under any conditions. From 5 days, the Mg of Korean chrysotile, Korean anthophyllite and Canadian amosite were significantly lower than before the acid treatment, but there were no changes over time or by the pH of the acid solutions. Particularly after 10 weeks, the composition (Mg) of Korean chrysotile in the pH 1.2 acid solution showed a rapid reduction of 15.86%. Conclusions: Korean chrysotile was very weak in an acid environment, beginning to show significant changes after 5 days. The Mg component rapidly decreased after 10 weeks in the pH 1.2 acid solution.

A Study on the SCC Arbitration Case - Quasar de Valores SICAV SA and others v. The Russian Federation - (국제투자중재에서 과세와 관련된 사례의 검토 - 러시아 유코스사(社) 사건을 중심으로 -)

  • Kim, Hee-Jun
    • Journal of Arbitration Studies
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    • v.24 no.1
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    • pp.45-58
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    • 2014
  • It is a well recognised rule in international law that the property of aliens cannot be taken. The question of whether indirect expropriation and government regulatory measures require compensation is an important issue in international investment law. Bilateral investment treaties and other investment agreements contain brief and general indirect expropriation provisions. These focus on the effect of government action and do not address the distinction between compensable and non-compensable regulatory actions. It is generally accepted that a state is not responsible for loss of property or for other economic disadvantages resulting from bona fide general taxation accepted as within the police power of states, provided it is not discriminatory. Yukos Oil Company is a Russian oil and gas company engaged in exploration, refining, and marketing activities. It is one of the largest oil and gas companies in the world. Yukos Oil Company has its production operations in Russia and markets its products in Europe. An international tribunal ordered the Russian government to compensate a group of Spanish investors for the losses they suffered when Russia seized the Yukos Oil Company on July 26, 2012. This has been the subject of several judicial proceedings and academic publications. This paper explores which circumstances do not lead to taxation amounting to expropriation. The author suggests that under the following circumstances, taxation would not amount to expropriation. First, taxation should be non-discriminatory. Also a lawful exercise of the taxation powers of governments would not amount to expropriation.

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Design of $2{\times}1$ Array Antenna Using Stack Structure for IEEE 802.11a (적층구조를 이용한 IEEE 802.11a용 $2{\times}1$ 배열 안테나 설계)

  • Park, Jung-Ah;Bu, Chong-Bae;Kim, Kab-Ki
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2007.10a
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    • pp.849-852
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    • 2007
  • In this paper, the high gain and the broadband microstrip patch antenna, which is applicable to 5 GHz band wireless LAN, is designed in order to integrate IEEE 802.11a's detailed standards($a:5.15{\sim}5.25$, $b:5.25{\sim}5.35$, $c:5.725{\sim}5.875$ [GHz]). Designed patch antenna has settled resonance frequency by insert substance(polyurethane: ${\varepsilon}_r=6.5$) between the separated parasitic patch and radiation patch for the purpose of miniaturize. And the form (${\varepsilon}_r=1.03$) were to fix the separated radiation patch and ground plans by air. Designed frequency bandwidth(VSWR 2:1) of the antenna showed broadband characteristic of $4.9[GHz]{\sim}6.1[GHz]$ to about 1.2[GHz]. Also the E-plan and H-plan profit 12[dBi] above, the 3[dB] beamwidth showed the characteristic over the E-plan $30^{\circ}$ and H-plan $60^{\circ}$ to be improved.

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