• Applied Microscopy
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• v.18 no.2
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• pp.187-204
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• 1988

The present experiment was performed to investigate the acute and subacute effect of lead acetate on ultrastructural and biochemical changes in mouse diencephalon. In acute case, mouse were peritoneally injected with lead acetate at a dose of 0.26 mmole/kg body weight, and after treatment, mouse were sacrificed at time intervals of 12, 24, 48, and 96 hours. In subacute case, mouse were injected at doses of 0.07 mmoie/kg B. W. and 0.13 mmole/kg B.W. once at two days, and after treatment, mouse wee sacrificed at 1 week, 2 weeks, and 3 weeks. It was observed that after acute treatment, changes composed of increased monoamine oxidase activity, $Na^{+}-K^{+}$ ATPase activity, decreased $Mg^{2+}$-APTase activity, wrinkled myelin, swollen Golgi apparatus and more dense synaptic vesicle in nerve terminal. After subacute treatment, decreased monoamine oxidase activity, increased $Mg^{2+}$-ATPase, $Na^{+}-K^{+}$ ATPase, lose of myelin, uneven mitochondrial distribution, synaptic vesicular density and edema, but at a higher dose the effect was more severe. Therefore, lead acetate caused abnormal change of diencephalon, and at a subacute, it appears metal accumulative toxicity.

• Journal of Korean Academy of Nursing
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• v.36 no.2
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• pp.227-235
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• 2006

Purpose: This study aimed to: 1) determine the core nursing interventions, and 2) compare acute interventions with subacute interventions recorded in the nursing notes of patients with cerebrovascular accidents (CVA). Methods: The nursing records covering the first 10 days of 30 patients with a CVA who were admitted from January to December 2004 at C University Hospital in Korea were examined. Data was collected using the nursing interventions classification (NIC) from January to April 2005. Finally, data analysis was carried out using mean, SD, and paired t-test according to domains, classes, and interventions. Results: The most frequent nursing intervention at both stage was 'Neurologic monitoring'. There were differences in interventions belonging to the 'Physiological: complex,' 'Behavioral,' 'Safety,' and 'Health system' domains between the acute and subacute stages. The frequency of interventions belonging to the 'Immobility management,' 'Neurological management,' 'Tissue perfusion management,' 'Patient education,' 'Risk management,' 'Health system mediation,' and 'Information management' classes at the acute stage was higher compared to the subacute stage. Conclusions: This study found out that nurses relatively recorded more nursing interventions during the acute stage hence the unsuccessful documentation of the subacute stage particularly in describing the specific nursing interventions at this stage.

• Molecular & Cellular Toxicology
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• v.5 no.2
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• pp.153-159
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• 2009

In this study, we assessed the acute and subacute toxicity of Angelica gigas Nakai (A. gigas Nakai) extracts, which are comprised of decursin and decursinol angelate (D/DA) in rats. For the oral acute toxicity test, Sprague-Dawley (SD) male and female rats were gavaged with two doses of D/DA (200 and 2,000 mg/kg body weight) and then observed for any toxic symptoms for 2 weeks. The LD$_{50}$ value for the rats was greater than 2,000 mg/kg body weight for both male and female rats, which indicates that there were no toxic symptoms induced by doses of up to 2,000 mg/kg body weight. For the subacute toxicity study, rats were treated with D/DA at doses of 2 and 20 mg/kg body weight once a day for 30 days. There were no significant changes in body weight and food intake observed during the subacute toxicity study. In addition, no differences were observed between the control and treated groups when urinalysis was conducted or when hematology and biochemical parameters were evaluated. Finally, histopathological examination of the organs did not reveal any lesions in the control or treated groups. Taken together, these findings indicate that D/DA is safe and non-toxic.

• Preventive Nutrition and Food Science
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• v.20 no.3
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• pp.190-197
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• 2015

The aim of this study was to investigate the acute and subacute oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum HD1 in Sprague-Dawley rats. In the acute toxicity study, the crude antifungal compounds (0.625, 1.25, 2.5, and 5.0 g/kg) did not produce mortality, significant changes in general behavior, or changes in the gross appearance of the organs. In the subacute toxicity study, the crude antifungal compounds were administered orally to rats at doses of 0, 0.5, 1.0, and 2.0 g/kg daily for 28 days. There were no test article-related deaths, abnormal clinical signs, or body weight changes. The study also showed no significant differences between the control and treated groups in hematological and serum biochemical parameters, histopathological examination, or any other findings. These results suggest that acute or subacute oral administration of crude antifungal compounds from L. plantarum HD1 is not toxic in rats.

• Journal of Pharmacopuncture
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• v.4 no.2
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• pp.27-33
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• 2001

Objectives : The treatment of Bell's palsy must be divided into three states(acute, subacute and healing state). 41 cases of the patient suffering from Bell's palsy were treated and observed from january 2000 to July 2001. The usage of herbal acupunctures on that disease have been effective. So I propose a method of herbal acupunctures on Bell's palsy. Methods : By the states(acute, subacute and healing state) of Bell's palsy, SY(消炎) herbal acupuncture is used at the acute state, Hominis Placenta(紫河車) at the subacute, JGH(中氣下陷) at the healing state. Results : 1. At the acute state, SY(消炎) herbal acupuncture is effective to postauricular pain. 2. At the subacute state, Hominis Placenta(紫河車) herbal acupuncture is effective to decreasing pain and improving symptoms. 3. By the states(acute, subacute and healing state) of Bell's palsy, SY(消炎), Hominis Placenta(紫河車) and JGH(中氣下陷) herbal acupuncture is effective to improving symptoms of Bell's palsy.

• The Journal of Korean Physical Therapy
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• v.33 no.2
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• pp.62-68
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• 2021

Purpose: This study examined whether mirror therapy could improve the balance, gait, and motor function of patients with subacute stroke. Methods: Thirty-three patients with subacute stroke were divided randomly into three groups: experimental group1, experimental group2, and the control group. The patients in experimental group1 performed a mirror therapy program on the unaffected side of the lower extremities, and the patients in experimental group2 performed mirror therapy on the affected side of the lower extremities. Both groups performed the exercise for 30 minutes per session, five times a week for four weeks. The control group did not receive mirror therapy. BBS, POMA, 10MWT, and the BRS were used to evaluate the balance, the quality of gait, gait speed, and the motor function before and after the intervention. Results: The gait speed increased significantly in the experimental groups1 and 2 after the intervention. The control group showed no significant difference in the gait speed after the intervention. The change in gait speed before and after the intervention showed a significant difference among the groups. Experimental group1 showed a significant increase in the gait speed compared to that of the control group. Conclusion: This study suggests that mirror therapy could be an effective intervention to improve the gait speed of patients with subacute stroke. On the other hand, there was no difference in the effectiveness of mirror therapy and therapeutic exercise on the balance, gait, and motor function.

• Toxicological Research
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• v.11 no.1
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• pp.147-155
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• 1995

HRccine was administered subcutaneously for 4 weeks to rabbits at dose levels of 300, 60 and 12 times the expected clinical dose to evaluate the subacute toxicity. There were no effects in clinical signs, body weight changes, food consumption, water consumption, urinalysis and blood biochemistry in any animals tested. In hematological examinations, decrease of lymphocyte counts and increase of platelet counts were observed in the medium- and high-dose treated groups. Absolute weights of thymus were tending to decrease, but no pathological changes were observed in microscopic examinations. The no-effect dose in subacute toxicity study of rabbits was considered to be 300 times the expected clinical dose.

• Toxicological Research
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• v.11 no.1
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• pp.137-145
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• 1995

HRccine was administered subcutaneously to rats for 4 weeks at dose levels of 300, 60 and 12 times the expected clinical dose to evaluate the subacute toxicity. There were no treatment-related effects in clinical signs, body weight changes, food consumption, water consumption, urinalysis and blood biochemistry in any dose groups. In hematological examinations, increase of leucocyte counts and decrease of hemoglobin concentration were observed in the high dose-treated group. However, no treatment-attributable pathological changes were observed in microscopic examinations. The no-effect dose in subacute toxicity study of rats was considered to be 300 times the expected clinical dose.

• Pediatric Infection and Vaccine
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• v.4 no.1
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• pp.150-154
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• 1997

Since 1972, a unique lymphadenitis called as subacute necrotizing lymphadenitis has been described in many Japanese literature. Originally described in Japan, it now appears worldwide. It mainly affects young women and usually manifests as fever and lymphdenopathy. The pathology is characterized by necrosis with loss of nodal architecture, infiltration with many histiocytes, and an absence of granulocytes. We report a case of subacute necrotizing lymphadenitis in axillary area. 4 10-year-old male child was admitted with a one-month history of fever, swelling in the axillary area. He treated with intravenous antibiotics. Despite treatment he remained febrile for the next ten days. 4 dissection of the axillary swelling was then performed, as was a diagnostic lymph node biopsy. The patient's condition resolved over several days and he was discharged.

• Korean Journal of Pharmacognosy
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• v.21 no.2
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• pp.179-185
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• 1990

The acute and subacute toxicities and pharmacological actions of two preparations of Ssanghwa Tang prescriptions have been evaluated in mice, rats and rabbits. The two prescriptions were found to be safe drugs because those preparations exhibited almost no acute and subacute toxicities even at a high dosage level. The two prescriptions elicited CNS depressant activities characterized by potentiation of hexobarbital-induced narcosis, antipyretic activity in typhoid-vaccinated rabbits and a significant antifatigue effect against cold immobilized stress, the activities of prescription B being more potent.