Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Subacute Toxicity of HRccine (HFRS-virus vaccine) in Rabbits

HRccine(HFRS-virus vaccine)의 토끼에서의 아급성독성

  • 임동문 (제일제당(주) 종합연구소) ;
  • 백영옥 (제일제당(주) 종합연구소) ;
  • 조효진 (제일제당(주) 종합연구소) ;
  • 최재묵 (제일제당(주) 종합연구소) ;
  • 김달현 (제일제당(주) 종합연구소) ;
  • 박관하 (제일제당(주) 종합연구소) ;
  • 조정식 (제일제당(주) 종합연구소) ;
  • 이영순 (서울대학교 수의과대학)
  • Published : 1995.06.01
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Abstract

HRccine was administered subcutaneously for 4 weeks to rabbits at dose levels of 300, 60 and 12 times the expected clinical dose to evaluate the subacute toxicity. There were no effects in clinical signs, body weight changes, food consumption, water consumption, urinalysis and blood biochemistry in any animals tested. In hematological examinations, decrease of lymphocyte counts and increase of platelet counts were observed in the medium- and high-dose treated groups. Absolute weights of thymus were tending to decrease, but no pathological changes were observed in microscopic examinations. The no-effect dose in subacute toxicity study of rabbits was considered to be 300 times the expected clinical dose.

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References

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  2. 新毒性試驗法 成績の推計學的 評價 小坂 忠司と眞板 敬三;白須 泰顔と吐山 豊秋(編)
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