Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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The Acute and Subacute Toxicities and Pharmacological Actions of Gami Ssanghwa Tang Preparations

가미쌍화탕류(加味雙和湯類)의 독성(毒性) 및 약효연구(藥效硏究)

  • Shin, Kuk-Hyun (Natural Products Research institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Products Research institute, Seoul National University) ;
  • Jung, Myung-Sook (Natural Products Research institute, Seoul National University) ;
  • Kim, Oon-Ja (Natural Products Research institute, Seoul National University) ;
  • Yoon, Ki-Young (Natural Products Research institute, Seoul National University)
  • Published : 1990.06.30
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Abstract

The acute and subacute toxicities and pharmacological actions of two preparations of Ssanghwa Tang prescriptions have been evaluated in mice, rats and rabbits. The two prescriptions were found to be safe drugs because those preparations exhibited almost no acute and subacute toxicities even at a high dosage level. The two prescriptions elicited CNS depressant activities characterized by potentiation of hexobarbital-induced narcosis, antipyretic activity in typhoid-vaccinated rabbits and a significant antifatigue effect against cold immobilized stress, the activities of prescription B being more potent.

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