• Journal of the Korean Institute of Intelligent Systems
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• v.14 no.5
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• pp.583-586
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• 2004

Transition jitter noise is one of major sources of detection errors in high density recording channels. Implementation complexity of the optimal detector for such channels is high due to the data dependency and correlated nature of the jitter noise. In this paper, two types of hardware efficient sub-optimal detectors are derived by modifying branch metric of Viterbi algorithm and applied to partial response (PR) channels combined with run length limited modulation coding. The additional complexity over the conventional Viterbi algorithm to incorporate the modified branch metric is either a multiplication or an addition for each branch metric in the Viterbi trellis.

• Journal of Communications and Networks
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• v.10 no.1
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• pp.71-78
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• 2008

We propose a sub-band spreading technique for adaptive modulation (AM) in orthogonal frequency division multiplexing (OFDM) systems in order to reduce signaling overheads and to average frequency selective fading channels causing different signal-to-noise ratio (SNR) values for subcarriers in each subband. The conventional sub-band based AM schemes can also reduce signaling overheads and complexity for allocating a resource per sub-band at a time. However, they may suffer from the channel variation in a sub-band when the sub-band size is larger than the channel coherence bandwidth (BW). The sub-band spreading at the transmitter enables the received symbols in each sub-band to have an identical reliability even in a frequency selective fading channel. We rigorously analyze the averaged SNR value at the receiver of the sub-band spreading system and the analyzed average SNR in a sub-band is used for an adaptation criterion. The proposed AM scheme outperforms the conventional sub-band based OFDM scheme without spreading, and it can yield better throughput performance than the conventional subcarrier based AM schemes when we consider the signaling overheads.

• Steel and Composite Structures
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• v.45 no.4
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• pp.513-533
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• 2022

This study presents similarities and differences between Turkish Building Code for Steel Structures, which are TS 648 and SDCCSS (Specification for Design, Calculation and Construction of Steel Structures) in terms of the design of the members. Hot-rolled I-shaped steel sections for symmetrical and U-shaped steel sections (i.e., channels) for monosymmetric sections were elaborated in detail. The design strength of tension members under tensile load, compression members under axial load and flexural members under flexure and shear were examined separately. Connection details for tension members, slenderness for compression members and distance between lateral supports for flexural members were considered as prime variables. Analysis results revealed the design strength of the tension members where at least one of the cross-sectional parts is not connected to the connection plates, I-shaped compression members where a slenderness ratio is below 39 (𝛌<39), U-shaped compression members and flexural members where L_b is between L_p and L_r (L_pb≤L_r) designed based on TS 648 are greater than those designed based on SDCCSS 2018. Strength differences between the specification can reach 79% for tensile members, 13% for compression members and 9% for flexural members.

• Membrane Journal
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• v.33 no.4
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• pp.181-190
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• 2023

Wastewater purification is one of the most important techniques for controlling environmental pollution and fulfilling the demand for freshwater supply. Various technologies, such as different types of distillations and reverse osmosis processes, need higher energy input. Capacitive deionization (CDI) is an alternative method in which power consumption is deficient and works on the supercapacitor principle. Research is going on to improve the electrode materials to improve the efficiency of the process. A reverse electrodialysis (RED) is the most commonly used desalination technology and osmotic power generator. Among many studies conducted to enhance the efficiency of RED, MXene, as an ion exchange membrane (IEM) and 2D nanofluidic channels in IEM, is rising as a promising way to improve the physical and electrochemical properties of RED. It is used alone and other polymeric materials are mixed with MXene to enhance the performance of the membrane further. The maximum desalination performances of MXene with preconditioning, Ti₃C₂T_x, Nafion, and hetero-structures were respectively measured, proving the potential of MXene for a promising material in the desalination industry. In terms of osmotic power generating via RED, adopting MXene as asymmetric nanofluidic ion channels in IEM significantly improved the maximum osmotic output power density, most of them surpassing the commercialization benchmark, 5 Wm^-2. By connecting the number of unit cells, the output voltage reaches the point where it can directly power the electronic devices without any intermediate aid. The studies around MXene have significantly increased in recent years, yet there is more to be revealed about the application of MXene in the membrane and osmotic power-generating industry. This review discusses the electrodialysis process based on MXene composite membrane.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.267-275
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• 2023

Cardiotoxicity, particularly drug-induced Torsades de Pointes (TdP), is a concern in drug safety assessment. The recent establishment of human induced pluripotent stem cell-derived cardiomyocytes (human iPSC-CMs) has become an attractive human-based platform for predicting cardiotoxicity. Moreover, electrophysiological assessment of multiple cardiac ion channel blocks is emerging as an important parameter to recapitulate proarrhythmic cardiotoxicity. Therefore, we aimed to establish a novel in vitro multiple cardiac ion channel screening-based method using human iPSC-CMs to predict the drug-induced arrhythmogenic risk. To explain the cellular mechanisms underlying the cardiotoxicity of three representative TdP high- (sotalol), intermediate- (chlorpromazine), and low-risk (mexiletine) drugs, and their effects on the cardiac action potential (AP) waveform and voltage-gated ion channels were explored using human iPSC-CMs. In a proof-of-principle experiment, we investigated the effects of cardioactive channel inhibitors on the electrophysiological profile of human iPSC-CMs before evaluating the cardiotoxicity of these drugs. In human iPSC-CMs, sotalol prolonged the AP duration and reduced the total amplitude (TA) via selective inhibition of I_Kr and I_Na currents, which are associated with an increased risk of ventricular tachycardia TdP. In contrast, chlorpromazine did not affect the TA; however, it slightly increased AP duration via balanced inhibition of I_Kr and I_Ca currents. Moreover, mexiletine did not affect the TA, yet slightly reduced the AP duration via dominant inhibition of I_Ca currents, which are associated with a decreased risk of ventricular tachycardia TdP. Based on these results, we suggest that human iPSC-CMs can be extended to other preclinical protocols and can supplement drug safety assessments.

• Journal of Magnetics
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• v.14 no.1
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• pp.23-26
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• 2009

Spin injection from a ferromagnet into an n-doped $In_{0.53}Ga_{0.47}As$ channel was electrically detected by a ferromagnetic detector. At T = 20 K, using non-local and local spin-valve measurements, a non-local signal of $2\;{\mu}V$ and a local spin valve signal of 0.041% were observed when the bias current was 1 mA. The band calculation and Shubnikov-de Haas oscillation measurement in a bulk channel showed that the gate controlled spin-orbit interaction was not large enough to control the spin precession but it could be a worthy candidate for a logic device using spin accumulation and diffusion.

• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.511-514
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• 2012

A continuous flow hyperpolarized (HP) $^{129}Xe$ NMR spectroscopy was employed for the first time to investigate $TiO_2$ nanotubes (Ti-NTs) synthesized from commercial nanoparticles with different reaction times. A single peak attributing to channels for Ti-NTs was observed for variable temperature HP $^{129}Xe$ NMR spectra. It was also noted that there is alteration in value for heat of adsorption, ${\Delta}H$ from $12.6{\pm}1.3$ to $16.4{\pm}0.4kJ/mol$ and variation in chemical shift of the xenon adsorbed in channels, ${\delta}_s$ from $120{\pm}2\sim135{\pm}9ppm$ which were closely correlated to channel length and it was shown that P25-24 Ti-NTs with longest channel is most favorite Ti-NTs for Xe adsorption.

• Molecules and Cells
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• v.22 no.1
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• pp.65-69
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• 2006

In murine gastrointestinal myocytes muscarinic stimulation activates nonselective cation channels via a G-protein and $Ca^{2+}$-dependent pathway. We recorded inward cationic currents following application of carbachol ($I_{CCh}$) to murine gastric myocytes held at -60 mV, using the whole-cell patch-clamp method. The properties of the inward cationic currents were similar to those of the nonselective cation channels activated by muscarinic stimulation in other gastrointestinal smooth muscle cells. CCh-induced $I_{CCh}$ and spontaneous decay of $I_{CCh}$ (desensitization of $I_{CCh}$) occurred. Unlike the situation in guinea pig gastric myocytes, desensitization was not affected by varying $[EGTA]_i$. Pretreatment with the PLC inhibitor (U73122) blocked the activation of $I_{CCh}$, and desensitization of $I_{CCh}$ was attenuated in PLC ${\beta}_1$ knock-out mice. These results suggest that the desensitization of $I_{CCh}$ in murine gastric myocytes is not due to a pathway dependent on intracellular $Ca^{2+}$ but to the PLC ${\beta}_1$ pathway.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.8
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• pp.2157-2169
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• 2023

In order to handle the problem that puncture patterns will change the position distribution of original information bits and frozen bits in polar codes, which affects performance of puncture polar codes further, a minimum row weight and polar spectrum based puncture polar codes construction algorithm (called PA-MRWP) is proposed in this paper. The algorithm calculates row weight of generator matrix and sorts the row weight in ascending order first. Next, the positions with the minimum row weight are selected as initial puncture positions. If the rows with the same row weight cannot all be punctured, polar spectrum based auxiliary puncture scheme is used. In sub-channels with the same row weight, rows corresponding to the polarized sub-channels with higher reliability are selected as puncture positions to construct puncture vector, and the reliability is calculated based on polar spectrum. It is actually a two-step selection strategy, the proposed minimum row weight puncture (MRWP) algorithm is used for primary selection and polar spectrum based auxiliary puncture is used for adjustment. Simulation results show that, compared with worst quality puncture (WQP) algorithm, the proposed PA-MRWP algorithm and Gaussian approximation-aided minimum row weight puncture (GA-MRWP) algorithm provide gains of about 0.46 dB and 0.29 dB at bit error rate (BER) of 10^-4, respectively when code length N=400, code rate R=1/2. In addition, the proposed puncture algorithms improve the BER performance significantly with respect to quasi-uniform puncture (QUP) algorithm.

• Journal of Pharmacopuncture
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• v.16 no.2
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• pp.55-61
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• 2013

Objective: Ulmi Pumilae Cortex (UPC) is a deciduous tree with uneven pinnate leaves and is classified as a subfamily of Ulmuceae and contains many pharmacologically active constituents. The aim of this study was to investigate the effects of UPC on the growth and survival of AGS cells, the most common human gastric adenocarcinoma cell lines. Methods: The AGS cells were treated with varying concentrations of UPC. Analyses of the sub G1, caspase-3 activity, and mitochondrial depolarization were conducted to determine whether AGS cell death occured by apoptosis. Furthermore, to identify the role of the transient receptor potential melastatin (TRPM) 7 channels in AGS cell growth and survival, we used human embryonic kidney (HEK) 293 cells overexpressed with TRPM7 channels. Results: The addition of UPC to a culture medium inhibited AGS cell growth and survival. Experimental results showed that the sub G1, caspase-3 activity, and mitochondrial depolarization were increased. Furthermore, TRPM7 channel overexpression in HEK 293 cells exacerbated UPC-induced cell death. Conclusion: These findings indicate that UPC inhibits the growth and survival of gastric cancer cells due to a blockade of the TRPM7 channel activity. Therefore, UPC is a potential drug for treatment of gastric cancer, and TRPM7 channels may play an important role in survival in cases of gastric cancer.