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Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid

  • Ekhoye, Ehitare Ikekhuamen;Olerimi, Samson Eshikhokhale;Ehebha, Santos Ehizokhale
    • Clinical and Experimental Reproductive Medicine
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    • v.47 no.3
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    • pp.168-179
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    • 2020
  • Objective: This study investigated testicular oxidative stress status and physiomorphological function in Wistar rats fed with yaji and cadmium chloride (CdCl2). Methods: Sixty male albino Wistar rats (12 per group) were randomly assigned to five groups: group I (control), group II (300 mg/kg.bw of yaji), group III (500 mg/kg.bw of yaji), group IV (2.5 mg/kg.bw of CdCl2), and group V (2.5 mg/kg.bw of yaji+4 mg/kg.bw omega-3). Each group was evenly subdivided into two subgroups and treatment was administered for 14 days and 42 days, respectively. Semen quality (sperm count, progressive motility, normal morphology, and gonadosomatic index), hormones (testosterone, follicle-stimulating hormone, and luteinizing hormone), testicular oxidative stress markers (superoxide dismutase, catalase, glutathione peroxidase, and malonaldehyde) and testicular histomorphological features were examined. Results: Yaji caused significant (p< 0.05) dose- and duration-dependent reductions in semen quality, the gonadosomatic index, testosterone, follicle-stimulating hormone, and luteinizing hormone. Yaji also caused significant (p< 0.05) dose- and duration-dependent decreases in superoxide dismutase, catalase, and glutathione peroxidase activity, as well as increased testicular malonaldehyde levels. Yaji induced distortions in the testicular histological architecture. CdCl2 damaged testicular function by significantly (p< 0.05) reducing semen quality, reproductive hormone levels, and oxidative stress markers in albino Wistar rats. CdCl2 also altered the histology of the testis. Conclusion: This study shows that yaji sauce has similar anti-fertility effects to those of CdCl2, as it adversely interferes with male reproduction by impairing oxidative stress markers and the function and morphological features of the testis.

Sub-pixel Point Spread function Estimation for Fully Digital Auto-Focusing System (완전디지털 자동초점 시스템 구현을 위한 부화소단위 점확산함수 추정)

  • 황성현;신정호;백준기
    • Proceedings of the IEEK Conference
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    • 2003.07e
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    • pp.1727-1730
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    • 2003
  • In this paper we propose a sub-pixel point spread function (PSF) estimation method for a fully digital auto-focusing system. We assume that the amount of out-of-focus is the same along the concentric circle. In order to estimate the accurate PSF, sub-pixel information is considered in the proposed PSF estimation procedure. The feasibility of the proposed algorithm is experimentally demonstrated.

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Comparison of Measured and Calculated Carboxylation Rate, Electron Transfer Rate and Photosynthesis Rate Response to Different Light Intensity and Leaf Temperature in Semi-closed Greenhouse with Carbon Dioxide Fertilization for Tomato Cultivation (반밀폐형 온실 내에서 탄산가스 시비에 따른 광강도와 엽온에 반응한 토마토 잎의 최대 카복실화율, 전자전달율 및 광합성율 실측값과 모델링 방정식에 의한 예측값의 비교)

  • Choi, Eun-Young;Jeong, Young-Ae;An, Seung-Hyun;Jang, Dong-Cheol;Kim, Dae-Hyun;Lee, Dong-Soo;Kwon, Jin-Kyung;Woo, Young-Hoe
    • Journal of Bio-Environment Control
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    • v.30 no.4
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    • pp.401-409
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    • 2021
  • This study aimed to estimate the photosynthetic capacity of tomato plants grown in a semi-closed greenhouse using temperature response models of plant photosynthesis by calculating the ribulose 1,5-bisphosphate carboxylase/oxygenase maximum carboxylation rate (Vcmax), maximum electron transport rate (Jmax), thermal breakdown (high-temperature inhibition), and leaf respiration to predict the optimal conditions of the CO2-controlled greenhouse, for maximizing the photosynthetic rate. Gas exchange measurements for the A-Ci curve response to CO2 level with different light intensities {PAR (Photosynthetically Active Radiation) 200µmol·m-2·s-1 to 1500µmol·m-2·s-1} and leaf temperatures (20℃ to 35℃) were conducted with a portable infrared gas analyzer system. Arrhenius function, net CO2 assimilation (An), thermal breakdown, and daylight leaf respiration (Rd) were also calculated using the modeling equation. Estimated Jmax, An, Arrhenius function value, and thermal breakdown decreased in response to increased leaf temperature (> 30℃), and the optimum leaf temperature for the estimated Jmax was 30℃. The CO2 saturation point of the fifth leaf from the apical region was reached at 600ppm for 200 and 400µmol·m-2·s-1 of PAR, at 800ppm for 600 and 800µmol·m-2·s-1 of PAR, at 1000ppm for 1000µmol of PAR, and at 1500ppm for 1200 and 1500µmol·m-2·s-1 of PAR levels. The results suggest that the optimal conditions of CO2 concentration can be determined, using the photosynthetic model equation, to improve the photosynthetic rates of fruit vegetables grown in greenhouses.

Reducing Common-Mode Voltage of Three-Phase VSIs using the Predictive Current Control Method based on Reference Voltage

  • Mun, Sung-ki;Kwak, Sangshin
    • Journal of Power Electronics
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    • v.15 no.3
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    • pp.712-720
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    • 2015
  • A model predictive current control (MPCC) method that does not employ a cost function is proposed. The MPCC method can decrease common-mode voltages in loads fed by three-phase voltage-source inverters. Only non-zero-voltage vectors are considered as finite control elements to regulate load currents and decrease common-mode voltages. Furthermore, the three-phase future reference voltage vector is calculated on the basis of an inverse dynamics model, and the location of the one-step future voltage vector is determined at every sampling period. Given this location, a non-zero optimal future voltage vector is directly determined without repeatedly calculating the cost values obtained by each voltage vector through a cost function. Without utilizing the zero-voltage vectors, the proposed MPCC method can restrict the common-mode voltage within ± Vdc/6, whereas the common-mode voltages of the conventional MPCC method vary within ± Vdc/2. The performance of the proposed method with the reduced common-mode voltage and no cost function is evaluated in terms of the total harmonic distortions and current errors of the load currents. Simulation and experimental results are presented to verify the effectiveness of the proposed method operated without a cost function, which can reduce the common-mode voltage.

Phase Doppler Measurements and Probability Density Functions in Liquid Fuel Spray (연료분무의 위상도플러 측정과 확률밀도함수의 도출)

  • 구자예
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.18 no.4
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    • pp.1039-1049
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    • 1994
  • The intermitternt and transient fuel spray have been investigated from the simultaneous measurement of droplet sizes and velocities by using Phase/Doppler Particle Analyzer(PDPA). Measurement have been done on the spray axis and at the edge of the spray near nozzle at various gas-to-liquid density ratios(.rho./sub g//.rho./sub l/) that ranges from those found in free atmospheric jets to conditions typical of diesel engines. Probability density distributions of the droplet size and velocity were obtained from raw data and mathematical probability density functions which can fit the experimental distribations were extracted using the principle of maximum likelihood. In the near nozzle region on the spray axis, droplet sizes ranged from the lower limit of the measurement system to the order of nozzle diameter for all (.rho./sub g/ /.rho./sub l/) and droplet sizes tended to be small on the spray edge. At the edge of spray, average droplet velocity peaked during needle opening and needle closing. The rms intensity is greatly incresed as the radial distance from the nozzle is increased. The probability density function which can best fit the physical breakage process such as breakup of fuel drops is exponecially decreasing log-hypebolic function with 4 parameters.

THE KRONECKER FUNCTION RING OF THE RING D[X]N*

  • Chang, Gyu-Whan
    • Bulletin of the Korean Mathematical Society
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    • v.47 no.5
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    • pp.907-913
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    • 2010
  • Let D be an integrally closed domain with quotient field K, * be a star operation on D, X, Y be indeterminates over D, $N_*\;=\;\{f\;{\in}\;D[X]|\;(c_D(f))^*\;=\;D\}$ and $R\;=\;D[X]_{N_*}$. Let b be the b-operation on R, and let $*_c$ be the star operation on D defined by $I^{*_c}\;=\;(ID[X]_{N_*})^b\;{\cap}\;K$. Finally, let Kr(R, b) (resp., Kr(D, $*_c$)) be the Kronecker function ring of R (resp., D) with respect to Y (resp., X, Y). In this paper, we show that Kr(R, b) $\subseteq$ Kr(D, $*_c$) and Kr(R, b) is a kfr with respect to K(Y) and X in the notion of [2]. We also prove that Kr(R, b) = Kr(D, $*_c$) if and only if D is a $P{\ast}MD$. As a corollary, we have that if D is not a $P{\ast}MD$, then Kr(R, b) is an example of a kfr with respect to K(Y) and X but not a Kronecker function ring with respect to K(Y) and X.

3-D Simulation of Nanoscale SOI n-FinFET at a Gate Length of 8 nm Using ATLAS SILVACO

  • Boukortt, Nour El Islam;Hadri, Baghdad;Caddemi, Alina;Crupi, Giovanni;Patane, Salvatore
    • Transactions on Electrical and Electronic Materials
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    • v.16 no.3
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    • pp.156-161
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    • 2015
  • In this paper, we present simulation results obtained using SILVACO TCAD tools for a 3-D silicon on insulator (SOI) n-FinFET structure with a gate length of 8 nm at 300K. The effects of variations of the device’s key electrical parameters, such as threshold voltage, subthreshold slope, transconductance, drain induced barrier lowering, oncurrent, leakage current and on/off current ratio are presented and analyzed. We will also describe some simulation results related to the influence of the gate work function variations on the considered structure. These variations have a direct impact on the electrical device characteristics. The results show that the threshold voltage decreases when we reduce the gate metal work function Φm. As a consequence, the behavior of the leakage current improves with increased Φm. Therefore, the short channel effects in real 3-D FinFET structures can reasonably be controlled and improved by proper adjustment of the gate metal work function.

Screening of Natural Product Libraries for the Extension of Cell Life-span through Immune System (면역시스템을 통한 세포수명연장 천연물질 스크린)

  • Yoo, Bo-Kyung;Kwon, Kisang;Ko, Young Hwa;Kim, Hong Geun;Lee, Seokhyun;Park, Kwan-Ho;Choi, Ji-Young;Kwon, O-Yu
    • Journal of Life Science
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    • v.26 no.3
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    • pp.359-363
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    • 2016
  • We have screened four natural products against 640 single compounds, which shows more two folds gene expression for both endoplasmic reticulum aminopeptidase 1 (ERAP1) and FOXO-family transcription factor (FOXO1). The results were as follows. (±)-Car-3-ene-2,5-dione from Asarum sieboldii Miq. is C10H12O2 molecular formula and the 164 kDa molecular weight. Cinobufagin from Bufonis Venennum is C26H34O6 molecular formula and 442 kDa molecular weight. So far reported main biological function is Na+/K+-ATPase inhibition. Corilagin from Euphorbia pekinensis is C27H22O18 molecular formula and 634 kDa molecular weight. Carbonic anhydrase inhibition is well known its biological function. Corydaline from Corydalis turtschaninovii is C22H27NO4 molecular formula and 369 kDa molecular weight. The main biological function is acetylcholinesterase inhibition. In the short future, four types of natural products will be used in longevity experiments with insects. The results may give one of the clues for studying new drug development candidates of the longevity.

Oxidative stress impairs the meat quality of broiler by damaging mitochondrial function, affecting calcium metabolism and leading to ferroptosis

  • Chen, Zuodong;Xing, Tong;Li, Jiaolong;Zhang, Lin;Jiang, Yun;Gao, Feng
    • Animal Bioscience
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    • v.35 no.10
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    • pp.1616-1627
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    • 2022
  • Objective: This work was conducted to investigate the effects of oxidative stress on meat quality, mitochondrial function, calcium metabolism and ferroptosis of broilers. Methods: In this study, a total of 144 one-day-old male Ross 308 chicks were divided into 3 groups (control group, saline group, and hydrogen peroxide [H2O2] group) with 6 replicates of 8 broilers each. The study lasted for 42 d. The broilers in the saline and H2O2 groups were intraperitoneally injected with 0.75% saline and 10.0% H2O2 on the 16th and 37th day of the experimental period respectively, the injection volumes were 1.0 mL/kg of broiler body weight. On the 42nd day of the experimental period, two chicks were randomly selected from each cage, a total of thirty-six chicks were stunned by electric shock and slaughtered to collect breast muscle samples. Results: The H2O2 exposure reduced pH value, increased drip loss and shear force of breast meat (p<0.05), impaired the ultrastructure and function of mitochondria. The H2O2 exposure damaged the antioxidant system in mitochondria, excessive reactive oxygen species carbonylation modified calcium channels on mitochondria, which impaired the activities of key enzymes on calcium channel, resulted in the increased calcium concentration in cytoplasm and mitochondria (p<0.05). In addition, the H2O2 exposure increased the iron content and lipid peroxidation (p<0.05), which induced ferroptosis. Conclusion: Oxidative stress could impair meat quality by causing mitochondrial dysfunction, resulting in calcium metabolism disorder and ferroptosis.