• Nuclear Engineering and Technology
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• 제55권11호
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• pp.3973-3982
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• 2023

As for two-phase flow in rectangular channels, the flow regimes especially like churn-turbulent and annular flow are significant for the physical problem like Countercurrent Flow Limitation (CCFL). In this study, the rectangular channels with cross-sections of 4 × 66 mm, 6 × 66 mm, 8 × 66 mm are adopted to investigate the flow regimes of air-water vertical upward two phase flow under adiabatic condition. The gas and liquid superficial velocities are 0 ≤ j_g ≤ 20m/s and 0.25 ≤ j_f ≤ 3m/s respectively which covering bubbly to annular flow. The flow regimes are identified by random forest algorithm and the flow regime maps are obtained. As the results, the transitional void fraction from slug to churn turbulent flow fluctuate from 0.47 to 0.58 which is significantly affected by the dimensional size of channel and flow rate. Besides, the void fraction at transitional points from churn-turbulent (slug) to annular flow are 0.66-0.67, which are independent with the gap size. Furthermore, a new criteria of slug to churn-turbulent flow is established in this study. In addition, by introducing the interfacial force model, the criteria of churn-turbulent (slug) flow to annular flow is verified.

• Biomolecules & Therapeutics
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• 제29권6호
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• pp.630-636
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• 2021

Eupafolin, a constituent of the aerial parts of Phyla nodiflora, has neuroprotective property. Because reducing the synaptic release of glutamate is crucial to achieving pharmacotherapeutic effects of neuroprotectants, we investigated the effect of eupafolin on glutamate release in rat cerebrocortical synaptosomes and explored the possible mechanism. We discovered that eupafolin depressed 4-aminopyridine (4-AP)-induced glutamate release, and this phenomenon was prevented in the absence of extracellular calcium. Eupafolin inhibition of glutamate release from synaptic vesicles was confirmed through measurement of the release of the fluorescent dye FM 1-43. Eupafolin decreased 4-AP-induced [Ca²⁺]_i elevation and had no effect on synaptosomal membrane potential. The inhibition of P/Q-type Ca²⁺ channels reduced the decrease in glutamate release that was caused by eupafolin, and docking data revealed that eupafolin interacted with P/Q-type Ca²⁺ channels. Additionally, the inhibition of calcium/calmodulin-dependent protein kinase II (CaMKII) prevented the effect of eupafolin on evoked glutamate release. Eupafolin also reduced the 4-AP-induced activation of CaMK II and the subsequent phosphorylation of synapsin I, which is the main presynaptic target of CaMKII. Therefore, eupafolin suppresses P/Q-type Ca²⁺ channels and thereby inhibits CaMKII/synapsin I pathways and the release of glutamate from rat cerebrocortical synaptosomes.

• Nuclear Engineering and Technology
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• 제53권6호
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• pp.1769-1785
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• 2021

The Integral Pressurized Water Reactors (IPWRs) as the innovative advanced and generation-III + reactors are under study and developments in a lot of countries. This paper is aimed at the thermal hydraulic study of the hot and average fuel sub-channel in a Generation III + IPWR by loose external coupling to the neutronic simulation. The power produced in fuel pins is calculated by the neutronic simulation via MCNPX2.6 then fuel and coolant temperature changes along fuel sub-channels evaluated by computational fluid dynamic thermal hydraulic calculation through an iterative coupling. The relative power densities along the fuel pin in hot and average fuel sub-channel are calculated in sixteen equal divisions. The highest centerline temperature of the hottest and the average fuel pin are calculated as 633 K (359.85 ℃) and 596 K (322.85 ℃), respectively. The coolant enters the sub-channel with a temperature of 557.15 K (284 ℃) and leaves the hot sub-channel and the average sub-channel with a temperature of 596 K (322.85 ℃) and 579 K (305.85 ℃), respectively. It is shown that the spacer grids result in the enhancement of turbulence kinetic energy, convection heat transfer coefficient along the fuel sub-channels so that there is an increase in heat transfer coefficient about 40%. The local fuel pin temperature reduction in the place and downstream the space grids due to heat transfer coefficient enhancement is depicted via a graph through six iterations of neutronic and thermal hydraulic coupling calculations. Working in a low fuel temperature and keeping a significant gap below the melting point of fuel, make the IPWR as a safe type of generation -III + nuclear reactor.

• Bulletin of the Korean Chemical Society
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• 제32권4호
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• pp.1187-1194
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• 2011

The hydrogen abstraction reaction of $CF_3CH_2CHO$ + OH has been studied theoretically by dual-level direct dynamics method. Two stable conformers, trans- and cis-$CF_3CH_2CHO$, have been located, and there are four distinct OH hydrogen-abstraction channels from t-$CF_3CH_2CHO$ and two channels from c-$CF_3CH_2CHO$. The required potential energy surface information for the kinetic calculation was obtained at the MCG3-MPWB//M06-2X/aug-cc-pVDZ level. The rate constants, which were calculated using improved canonical transitionstate theory with small-curvature tunneling correction (ICVT/SCT) were fitted by a four-parameter Arrhenius equation. It is shown that the reaction proceeds predominantly via the H-abstraction from the -CHO group over the temperature range 200-2000 K. The calculated rate constants were in good agreement with the experimental data between 263 and 358 K.

• Bulletin of the Korean Chemical Society
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• 제30권12호
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• pp.2973-2978
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• 2009

The decomposition reaction mechanism of $CH_3CF_2O$ radical formed from hydroflurocarbon, $CH_3CHF_2$ (HFC-152a) in the atmosphere has been investigated using ab-initio quantum mechanical methods. The geometries of the reactant, products and transition states involved in the decomposition pathways have been optimized and characterized at DFT-B3LYP and MP2 levels of theories using 6-311++G(d,p) basis set. Calculations have been carried out to observe the effect of basis sets on the optimized geometries of species involved. Single point energy calculations have been performed at QCISD(T) and CCSD(T) level of theories. Out of the two prominent decomposition channels considered viz., C-C bond scission and F-elimination, C-C bond scission is found to be the dominant path involving a barrier height of 12.3 kcal/mol whereas the F-elimination path involves that of a 28.0 kcal/mol. Using transition-state theory, rate constant for the most dominant decomposition pathway viz., C-C bond scission is calculated at 298 K and found to be 1.3 ${\times}$ 10$^4s{-1}$. Transition states are searched on the potential energy surfaces involving both decomposition channels and each of the transition states are characterized. The existence of transition states on the corresponding potential energy surface are ascertained by performing Intrinsic Reaction Coordinate (IRC) calculation.

• Nuclear Engineering and Technology
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• 제53권6호
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• pp.1786-1795
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• 2021

Printed Circuit Heat Exchanger (PCHE) is a widely used heat exchanger in the supercritical carbon dioxide (sCO₂) Brayton cycle because it can work under high temperature and pressure, and has been a hot topic in Next Generation Nuclear Plant (NGNP) projects for use as recuperators and condensers. Most previous studies focused on channel structures or shapes. However, no clear advancement has so far been seen in the allover size of the PCHE. In this paper, we proposed an optimal size of the PCHE with a fixed volume. Two boundary conditions of PCHE were simulated, respectively. When the volume of PCHE was fixed, the heat transfer rate and pressure loss were picked as the optimization objectives. The Pareto front was obtained by the Multi-objective optimization procedure. We got the optimized number of PCHE channels under two different boundary conditions from the Pareto front. The comprehensive performance can be increased by 5.3% while holding in the same volume. The numerical results from this study can be used to improve the design of PCHE with straight channels.

• Nuclear Engineering and Technology
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• 제54권9호
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• pp.3540-3550
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• 2022

The supercritical carbon dioxide (S-CO₂) Brayton cycle is an important energy conversion technology for the fourth generation of nuclear energy. Since the printed circuit heat exchanger (PCHE) used in the S-CO₂ Brayton cycle has narrow channels, Rayleigh-Bénard (RB) convection is likely to exist in the tiny channels. However, there are very few studies on RB convection in supercritical fluids. Current research on RB convection mainly focuses on conventional fluids such as water and air that meet the Boussinesq assumption. It is necessary to study non-Boussinesq fluids. PRB convection refers to RB convection that is affected by horizontal incoming flow. In this paper, the computational fluid dynamics simulation method is used to study the PRB convection phenomenon of non-Boussinesq fluid-supercritical carbon dioxide. The result shows that the inlet Reynolds number (Re) of the horizontal incoming flow significantly affects the PRB convection. When the inlet Re remains unchanged, with the increase of Rayleigh number (Ra), the steady-state convective pattern of the fluid layer is shown in order: horizontal flow, local traveling wave, traveling wave convection. If Ra remains unchanged, as the inlet Re increases, three convection patterns of traveling wave convection, local traveling wave, and horizontal flow will appear in sequence. To characterize the relationship between traveling wave convection and horizontal incoming flow, this paper proposes the relationship between critical Reynolds number and relative Rayleigh number (r).

• Molecules and Cells
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• 제44권10호
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• pp.758-769
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• 2021

Calcium homeostasis modulator 1 (CALHM1) is a membrane protein with four transmembrane helices that form an octameric ion channel with voltage-dependent activation. There are four conserved cysteine (Cys) residues in the extracellular domain that form two intramolecular disulfide bonds. We investigated the roles of C42-C127 and C44-C161 in human CALHM1 channel biogenesis and the ionic current (I_CALHM1). Replacing Cys with Ser or Ala abolished the membrane trafficking as well as I_CALHM1. Immunoblotting analysis revealed dithiothreitol-sensitive multimeric CALHM1, which was markedly reduced in C44S and C161S, but preserved in C42S and C127S. The mixed expression of C42S and wild-type did not show a dominant-negative effect. While the heteromeric assembly of CALHM1 and CALHM3 formed active ion channels, the co-expression of C42S and CALHM3 did not produce functional channels. Despite the critical structural role of the extracellular cysteine residues, a treatment with the membrane-impermeable reducing agent tris(2-carboxyethyl) phosphine (TCEP, 2 mM) did not affect I_CALHM1 for up to 30 min. Interestingly, incubation with TCEP (2 mM) for 2-6 h reduced both I_CALHM1 and the surface expression of CALHM1 in a time-dependent manner. We propose that the intramolecular disulfide bonds are essential for folding, oligomerization, trafficking and maintenance of CALHM1 in the plasma membrane, but dispensable for the voltage-dependent activation once expressed on the plasma membrane.

• 한국음향학회지
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• 제42권6호
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• pp.491-499
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• 2023

해수면 거칠기에 의해 해수면 산란이 발생하면 통신신호의 주파수 확산과 통신채널 시변동성을 야기하여 통신성능을 악화시킨다. 수면 거칠기에 따른 통신채널의 시변동성 차이를 비교하기 위하여 한양대학교 해양음향공학연구실 수조에서 실험을 수행하였다. 수조에서 인위적인 수면 거칠기를 생성하고 대역폭에 따른 차이를 비교하기 위하여 3가지 대역폭을 갖는 통신신호를 사용하였다. 측정된 수면 거칠기는 레일리 파라미터로 변환하여 거칠기에 대한 파라미터로써 사용하였으며, 수면 경로의 시변 채널 특성은 도플러 확산과 상관시간을 이용하여 통계적 분석을 수행하였다. 수면 경로의 도플러 확산은 통신신호의 반송 주파수와 대역폭의 영향을 보정한 가중 유효 도플러 확산(Weighted Root Mean Square Doppler spread, w_fσ_ν)을 사용하였다. 수면 경로의 상관시간과 직접 경로와 수면 경로의 에너지 비율을 이용하여 전체 채널의 상관관계를 모의하고 측정된 전체 채널의 상관시간과 비교하였다. 본 연구에서는 해수면 거칠기에 따른 해수면 경로의 시변 채널특성을 이용하여 임의의 해양환경에서 효율적인 통신신호 설계를 위한 방법을 제안한다.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.473-478
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• 2004

This work presents the Thermal Hydraulic analysis has been performed for a 19-pin wire-spacer fuel assembly using three-dimensional Reynolds-averaged Navier-Stokes equations. SST model is used as a turbulence closure. The whole fuel assembly has been analyzed for one period of the wire-spacer using periodic boundary condition at inlet and outlet of the calculation domain. The overall results far a preliminary calculation show a good agreement with the experimental observations. It has been found that the major unidirectional flows are the axial velocity in sub-channels and the peripheral sweeping flows and the velocities are found to be following a cyclic path of period equal to the wire-wrap pitch. The temperature is found to be maximum in the central region and also, there exist a radial temperature gradient between the fuel rods. The major advantage of performing this kind of analysis is the prediction of thermal-hydraulic behavior of a fuel assembly with much ease.