• 한국콘텐츠학회논문지
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• 제12권2호
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• pp.505-516
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• 2012

본 연구에서는 65세 이상의 한국노인을 대상으로 노후 개념의 원형적 요인들은 무엇인지 알아보고, 그 원형의 개념 추출을 위해 511명을 대상으로 무선 표집하여 90문항의 2차 예비척도 문항 개발하였고, 2차552명을 대상으로 구성요인 확인, 3차 399명을 대상으로 구성타당도, 그리고 공인타당도, 성공적 노후척도와 성별, 연령, 학력에 따른 차이 검증을 실시하였다. 그 결과 '한국노인의 성공적 노후 척도'는 총 47문항으로 '일상적 삶의 순조로움', '자녀성공', '경제적 안정', '심리적 지지', '적극적 활동', '부부관계만족', '가족지지'와 같은 7개의 요인으로 구성됨을 확인하였다. 그리고 한국노인의 성공적 노후의 신뢰도는 .932로 높은 내적 일치도를 보였고, 탐색적 요인분석을 통해 요인과 문항 간의 관계가 통계적으로 유의미함을 확인하여 요인구조에 대한 타당도를 확인하였다.

• 건축역사연구
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• 제20권1호
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• pp.77-93
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• 2011

Across the culture of Western Europe, dichotomy based on the visual sense has evolved. They believed eyes and ears requiring a distance related in recognition, are more developed than any other human senses in human body. Dominant position, as a condition to using a perspective, the eye has been just concentrated in the development of optical sight. But developed a variety of modern media, highlighting the importance of the other perception, it makes dichotomy to the expansion of perception over the single function of visuality. Recently, Guille Deleuze and Merleau-Ponty try to recover the sense of tactility segregated in skin from body keeping eyes for distance. By the result, the activity can be happened by being connected to the body rather than to eye in the space between the subject and object. From the phase of recognition where the human body tries to identify the object in the space considering a time, it will be changed for the subject to the phase of structure vice versa. Visual tactility is to eliminate the distance between subject and object. If the visual tactility is to erase the distance different from the visual in dichotomy, it will be occurred to having a tension and makes new relationship to work trying to move the subjective point of view in object. Like this evidence in analysis of architecture, it can be easy to find the Korean architecture rather than western architecture in terms of emphasizing the time and space. The fact, architecture of Lee Dynasty had been preserved and consisted basic form and style over the centuries makes us assume that visual tactility was considered as well as the visual sense. This study will be intensive in terms of visual and tactile inherent in the subject and how it is being connected to the movement in the space and time.

• 한국콘텐츠학회논문지
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• 제18권12호
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• pp.263-271
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• 2018

여성가족패널(KLoWF)조사 4차년도(2011-2012) 자료를 활용하여 최종 2,120명의 기혼 여성을 선정하였으며, 남편지지와 결혼행복감 및 우울의 변수를 고려하였다. 남편지지는 남편과의 충분한 대화, 남편과의 견해 일치, 부부생활 만족도와 남편신뢰, 남편과의 문화생활, 운동과 봉사 및 공동체 참여, 시댁식구 만남, 친청식구 만남, 가사노동 만족도 그리고 돌봄 만족도로 11개의 문항을 고려하였다. 결혼행복감은 매우 불행하다 10점 리커드 척도로 측정되었고, 우울은 CES-D 10으로 측정되었다. 분석 결과, 인구사회학적 특성별 남편지지와 결혼행복감 및 우울은 유의한 차이가 있었다. 게다가 남편지지가 높을수록 결혼행복감 또한 높았으며 우울은 낮아지는 경향이었다. 구조방정식모형 결과, 남편인식은 우울에 직접적인 영향을 미쳤고, 결혼행복감을 매개로 우울에 간접적인 영향도 미쳤다. 부부활동과 가사분담 또한 우울에 직접적인 영향을 미쳤고, 결혼행복감을 매개로 우울에 간접적인 영향도 미쳤다. 그러나 부모방문은 우울에 간접적인 영향만 미쳤다. 남편지지 중 기혼여성의 남편에 대한 인식은 우리나라 기혼 여성의 우울에 가장 큰 영향 요인이었고, 부부활동, 부모방문 그리고 가사분담 순으로 나타났다. 이상의 연구 결과는 우리나라 기혼 여성의 우울을 줄이는 정책적 계획 설계에 도움이 될 것이다.

• Archives of Pharmacal Research
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• 제19권4호
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• pp.312-316
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• 1996

A series of N-Cbz${alpha}$-aminosucinimides (1), combining common moieties of various anticonvulsants such as N-CO-C-N and cyclic imide in a single molecule, were synthesized from the corresponding (R)- and (S)-N-Cbz-aspartic acid (2). And their in vivo anticonvulsant evaluations in MES and PTZ test were investigated. And also the rotorod test for neurotoxicity was investigated. All the tested compounds (1), except 1c and 1f, showed significant anticonvulsant activities in both MES and PTZ test. And the most active compound among them in MES test was (R)-N-Cbz-${alpha}$-amino-N-methylsuccinimide (1b) $(ED_50/=52.5 mg/kg)$ and (S)-N-Cbz-aminosuccinimide((1d) was most active in PTZ test $(ED_50/=78.1 mg/kg)$. And the $TD_50$ values of the tested compounds were above 117.5 mg/kg. These pharmacological data were comparable to those of currently available anticonvulsants. And also we found that the pharmacological effects were dependent on their N-substituted alkyl chains and their stereochemistry.

• 간호행정학회지
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• 제16권2호
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• pp.162-171
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• 2010

Purpose: Nursing home quality indicators have been focused widely on result outcomes, not for the environment in that quality of service are delivered, This study aimed to examine structural factors influencing quality management activities in nursing homes. Method: Sample was 170 nursing homes responded to the survey questionnaire which was distributed to the 543 nursing homes nation-wide, Data were collected on structural characteristics, types of services, and quality management activities, Data were analyzed with the descriptive statistics, Pearson correlations, and multiple regression. Result: Most of the nursing homes were operated as free of charge by the social welfare ownership. Average number of residents was 52.1 with severe and mild dementia and bedridden status, In terms of quality management activities, 34% of the sample had CQI committee that focused their activities on services delivery process, performance appraisal, record keeping regularly. 30.6% of quality management activities were accounted for by the number of residents with dementia, the ratio of RN to residents, rehabilitation services, and social wefare services in nursing homes. Conclusion: We recommend that more comprehensive quality management activities should be developed as process quality indicators in conjunction with the outcome indicators.

• 통합자연과학논문집
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• 제10권2호
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• pp.78-84
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• 2017

CXC chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. CXCR2 antagonist may reduce the neutrophil chemotaxis and alter the inflammatory response because the neutrophilic inflammation in the lung diseases is found to be largely regulated through CXCR2 receptor. Hence, in the present study, Hologram based Quantitative Structure Activity Relationship Study was performed on a series of CXCR2 antagonist named pyrimidine-5-carbonitrile-6-alkyl derivatives. The best HQSAR model was obtained using atoms, bonds, and chirality as fragment distinction parameter using hologram length 151 and 6 components with fragment size of minimum 4 and maximum 7. Significant cross-validated correlation coefficient ($q^2=0.774$) and non cross-validated correlation coefficients ($r^2=0.977$) were obtained. The model was then used to evaluate the six external test compounds and its $r^2_{pred}$ was found to be 0.614. Contribution map show that presence of cyclopropyl ring and its bulkier substituent's makes big contributions for improving the biological activities of the compounds. We hope that our HQSAR model and analysis will be helpful for future design of novel and structurally related CXCR2 antagonists.

• 품질경영학회지
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• 제46권3호
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• pp.523-538
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• 2018

Purpose: The purpose of this study was to propose useful suggestions by analyzing causal effect relationship between sharing bicycle service quality, customer satisfaction, CSV, and continuos use intention in China. Methods: The collected data through the survey were analyzed using structure equation model analysis. The measurement tools used for this study were divided into four dimensions such as service quality, customer satisfaction, creating shared value, and continuous use intention. Results: The results of this study are as follows; regarding the influence of sharing bicycle service quality dimension on customer satisfaction(reliability and response), it was found that customer satisfaction was not significant on economic value. but it was significant on social value. It was found that social value made statistically significant influence on use intention. Conclusion: Sharing bicycle industry needs to activity of response to customer, and paying attention to view of social value for the sharing economy in the future.

• 한국환경과학회지
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• 제25권7호
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• pp.937-950
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• 2016

Algal blooming in 4 major rivers introduces substantial impacts to water front activity. Concentrations of algae are increasing at major points along the Geum River. Ecosystem food webs can be affected by algal blooming because blue-green algae release toxic materials. Even though there have been many studies on blue-green algae, its causality to environmental factors has not been completely determined yet. This study analyzed the exclusive correlation between various hydrometeorological, water quality, and hydrologic variables and the cell number of cyanobacteria to understand causality of blue-green algae in the Geum River. A prewhitening process was introduced to remove the autocorrelation structure and periodicity, which is useful to evaluate the effective relationship between two time series.

• BMB Reports
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• 제31권4호
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• pp.399-404
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• 1998

In order to gain further insight on the relationship between structure and function of glutathione S-transferase (GST), the six active-site mutants, R13T, K44T, Q51A, Q64A, S65A, and D98A, of human GST P1-1 were expressed in Escherichia coli and purified to electrophoretic homogeneity by affinity chromatography on immobilized GSH. The active-site mutants showed marked differences in substrate specificity. The substitution of Gln51 with threonine resulted in a drastic decrease in the specific activities to <10% of the wild-type value. The substitution of Arg13 with threonine resulted in more decreased specific activity toward cumene hydroperoxide and in the $I_{50}$ values of S-(2,4-dinitrophenyl) glutathione and benanstatin A. These results suggest that the substitution of Arg13 with threonine changes the conformation of the active site to increase the affinity for the product or electrophilic substrate. Lys44 seems to be in the vicinity of the H-site of hGST P1-1 or may contribute to some extents to the electrophile binding.

• Reproductive and Developmental Biology
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• 제34권1호
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• pp.7-13
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• 2010

The binding affinity constants ($p(Od)_{50}$) and molecular docking scores (OS) between porcine odorant binding proteins pOBP (1HQP) and pPBP (1GM6) as receptor and a series of tetrahydrofuran-2-yl (A & B) analogues as substrate, and their interactions were discussed quantitatively using three-dimensional quantitative structure-activity relationship (30-QSAR) models. The statistical qualities of the optimized CoMF A models for pOBP were better than those of the CoMSIA models. The binding affinity constants and OS between substrate and receptor molecules were dependent upon steric and hydrophobic interaction. The DS constants of the substrates into the binding site of OBP (1HQP) were bigger than those of PBP (1GM6). The resulting contour maps produced by the optimized CoMFA model were used to identify the structural features relevant to the binding affinity in binding site of pOBP.