• Journal of Pharmacopuncture
• /
• v.20 no.2
• /
• pp.93-99
• /
• 2017

Objectives: Selaginella bryopteris L. (family: Selaginaceae), is often used in traditional Indian systems of medicine for the prevention and cure of several disorders and for the treatment of patient with spermatorrhoea, venereal disease, constipation, colitis, urinary tract infections, fever, epilepsy, leucorrhoea, beri-beri and cancer. It is also used as a strength tonic. This study aimed to evaluate the mechanisms underlying the anti-inflammatory effects of topically administered aqueous, polar and non-polar methanolic fractions ($10mg/20{\mu}L$) of Selaginella bryopteris. Methods: An acute oral toxicity study of Selaginella bryopteris at doses from 250 to 2,000 mg/kg body weight (bw) was performed. Aqueous, polar and non-polar methanolic extracts ($10mg/20{\mu}L$) applied topically for 5 days were evaluated for their anti-inflammatory effects against 12-tetra-O-decanoyl phorbol acetate (TPA)- induced inflammation by using the redness in the ear, the ear's weight (edema), oxidative stress parameters, such as lipid-peroxide (LPO) and nitric oxide (NO), and the pro-inflammatory cytokines involved in inflammation, such as tumour necrosis factor $(TNF)-{\alpha}$, interleukin $(IL)-1{\beta}$ and IL-6. Indomethacine ($0.5mg/20{\mu}L$) was used for the positive control. Results: Selaginella bryopteris produced no mortalities when administered orally at doses from 250 to 2,000 mg/kg bw. Topical treatment with the non-polar methanolic fraction ($10mg/20{\mu}L$) significantly suppressed redness ($2.4{\pm}0.5$) and edema ($30.4{\pm}1$) and effectively reduced the LPO level ($32.3{\pm}3.3$). The NO level was ($8.07{\pm}0.55$), and the $TNF-{\alpha}$, $IL-1{\beta}$, and IL-6 levels were decreased to $69.6{\pm}15.5$, $7.7{\pm}4.8$ and $82.6{\pm}5.9$, respectively. Conclusion: This study demonstrated for the first time the mechanisms underlying the anti-inflammatory effect of medicinal plants like Selaginella bryopteris and quantified the pharmacological interactions between them. The present study showed this herbal product to be a promising anti-inflammatory phytomedicine for the treatment of patients with inflammatory skin diseases.

• Tunnel and Underground Space
• /
• v.18 no.6
• /
• pp.491-502
• /
• 2008

A certain range of the original ground around the tunnel should be preserved to ensure structural safety of the tunnel when other structures are made around the tunnel, and thus this range is defined as safety zone of the tunnel. The main points to ensure the stability of an existing tunnel when constructing a new tunnel in an inter-crossing area are distance between two tunnels, size of the new tunnel, excavation method for the new tunnel, ground condition around the tunnel, and lining type of the existing tunnel etc. When the new tunnel is excavated above the existing tunnel, the existing tunnel is likely to suffer deformation at a crown zone, damage of arching effect, and live load of the new tunnel etc. On the other hand, when the new tunnel is excavated below the existing tunnel, the existing tunnel is likely to be damaged due to settlement. This study has been made on the behavior of the existing tunnel by means of model test and numerical analysis when the new tunnel is excavated below the existing tunnel. Safety zone of the tunnel was estimated by the results of strength/stress ratio obtained from numerical analysis, and the movement of ground was estimated by the model test. The results of earth pressure, ground displacements, and convergence of the tunnel obtained from model test were compared with those of numerical analysis, and show a similar trend.

• Tunnel and Underground Space
• /
• v.19 no.3
• /
• pp.236-247
• /
• 2009

Overpopulation has significantly increased the use of underground spaces in urban areas, and led to the developments of shallow-depth underground space. Due to unexpected rock fall, however, it is very necessary to understand and categorize the rock mass behaviors prior to the tunnel excavation, by which unnecessary casualties and economic loss could be prevented. In case of cave-in, special attention should be drawn since it occurs faster and greater in magnitude compared to rock fall and plastic deformation. Types of cave-in behavior are explained and categorized using seven parameters - Uniaxial Compressive Strength (UCS), Rock Quality Designation (RQD), joint surface condition, in-situ stress condition, ground water condition, earthquake & ground vibration, tunnel span. This study eventually introduces a new index called Cave-in Behavior Index (CBI) which explains the behavior of cave-in under given in-situ conditions expressed by the seven parameters. In order to assess the mutual interactions of the seven parameters and to evaluate the weighting factors for all the interactions, survey data of the experts' opinions and Rock Engineering Systems (RES) were used due to lack of field observations. CBI was applied to the tunnel site of Seoul Metro Line No. 9. UDEC analyses on 288 cases were done and occurrences of cave-in in every simulation were examined. Analyses on the results of 288 cases of simulations revealed that the average CBI for the cases when cave-in for different patterns of tunnel support was estimated by a logistic regression analysis.

• Journal of Korean Society of Steel Construction
• /
• v.19 no.6
• /
• pp.737-749
• /
• 2007

Flexural design of double composite box girder over the interior pier for three-span continuous bridge was performed by the LRFD method. The maximum span length of the continuous bridge ranged from 80m to 120m and the relative ratio of the span length was assumed to be 1:1.25:1. The girder section was designed for the strength limit state and service limit state with additional design check for constructibility. Before the bottom concrete and compression flange showed a complete composite action, the buckling of lower compression flange was checked. The flexural stiffness and flexural resistance characteristics for the section and for the constituent members such as tension flange, compression flange, and web were analyzed for different thicknesses of the bottom concrete on top of the compression flange. The effect of the distribution ratio of steel between the top and bottom flanges was investigated by analyzing ductility behavior and stress distribution through the girder's depth for several different relative area ratios of steel between the top and bottom flanges. It was found that a total amount of 15% of steel can be saved by applying the double composite system compared with that of the conventional composite system.

• Journal of Korean Society of Steel Construction
• /
• v.28 no.5
• /
• pp.345-354
• /
• 2016

In the present study, hybrid moment connections of welding and bar reinforcement for composite beam-column connections were proposed. Concrete-filled octagonal tube and U-section were used for the column and beam, respectively. In the beam-column connection, the top flange and web of the beam U-section were connected to the column plate by welding. However, to reduce stress concentration at the weld joints, the bottom flange of the beam was not welded to the column plate. Instead, to transfer the tension force of the beam flange, reinforcing bars passing through the column plate were used. Four exterior connections with conventional welded and hybrid moment connections were tested under cyclic loading and their cyclic behaviors were investigated. The test results showed that the hybrid moment connections successfully transferred the beam moment to the column. The strength and ductility of the hybrid moment connections were comparable to the conventional welded moment connection with exterior diaphragm; however, the connection performance was significantly affected by the details of the hybrid moment connection.

• Tunnel and Underground Space
• /
• v.26 no.5
• /
• pp.363-374
• /
• 2016

All five independent elastic constants of a transversely isotropic rock sometimes need to be determined from a single specimen. Saint-Venant approximation has been widely used for a long time in the analysis of single specimen test. This paper has proven how this empirical equation can be mathematically transformed into a form of the apparent Young's modulus based on theory of elasticity. The transformed equation is a monotonous function on anisotropic angle and can be useful in the analysis of the in-situ stress measurement in an anisotropic rock mass. The estimations of data in literatures have shown that the measured values of $G^2$ are uniform on anisotropic angles and smaller than that of Saint-Venant's case. This decrement may be caused by sliding of the interface of strata and the decrement rate is inferred to relate well with the combination of bonding condition of strata and strength of rock material. Accumulation of these kinds of studies in the future enables to define the decrement and to determine elastic constants of a transversely isotropic rock from a single specimen from modifying Saint-Venant approximation.

• Composites Research
• /
• v.12 no.3
• /
• pp.8-16
• /
• 1999

Carbon woven fabric/C/SiC composites were fabricated by multiple impregnations of carbon woven fabric/carbon preform with the polymer precursor of SiC, i.e., polycarbosilane. In addition, two kinds of low density carbon/carbon preforms which had different fiber volume fraction and fiber orientation, i.e., a carbon woven fabric(${\thickapprox}$55 vol%)/carbon and a chopped carbon fiber${\thickapprox}$40 vol%)/carbon composites, were reaction-bonded with a silicon melt at 1$700^{\circ}C$ in a vacuum to fabricate dense carbon fiber/Si/SiC composites. The reaction-bonding process increased the density to ~2.1 g/$cm^3$ from 1.6 g/$cm^3$ and 1.15 g/$cm^3$ of a carbon woven and a chopped carbon preforms, respectively. All of the composites fractured with extensive fiber pull-out. The higher the density the higher the stiffness and proportional limit stress. The mechanical properties obtained from a three-point bend and tension tests were compared. The ratios of the peak tensile stresses to the bending strengths of a carbon woven and a chopped carbon composites were about one-third, respectively. The carbon woven fabric/Si/SiC composites with density of 2.06 g/$cm^3$ showed ~120 MPa of ultimate strength and ~80 MPa of proportional limit in bend testing.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.31 no.1C
• /
• pp.53-63
• /
• 2011

This paper investigates the effects of tunnelling-induced ground movements on nearby structures, considering soil-structure interactions of different ground (loose sand, dense sand, soft clay, stiff clay) and construction conditions (ground loss). The response of four-story block structures, which are subjected to tunnelling-induced ground movements, has been investigated in different ground and construction conditions (ground loss) using numerical analysis. The structures for numerical analysis has been modelled using Discrete Element Method (DEM) to have real cracks when the shear and tensile stress exceed the maximum shear and tensile strength. The response of four-story block structures has been investigated with a ground movement magnitude and compared in terms of ground and construction conditions (ground loss) considering the magnitude of deformations and cracks in structures. In addition, the damage levels, which are possibly induced in structures, has been provided in terms of ground and construction conditions (ground loss) using the state of strain damage estimation criterion (Son and Cording, 2005). The results of this study will provide a background for better understandings for controlling and minimizing building damage on nearby structures due to tunnelling-induced ground movements.

• Journal of Korean Society of Steel Construction
• /
• v.29 no.2
• /
• pp.181-192
• /
• 2017

A beam splice method using inclined end-plates and high-strength tension bolts was developed. The end-plates welded to a bracket and a spliced beam are connected each other by using the tension bolts. In the present study, six exterior beam-to-column moment connections were tested under cyclic loading. Test parameters were the end-plate details and bolt arrangements. All specimens were designed so that moment resistances of the end-plates and bolts were greater than the required moment at the beam splice, in accordance with the design methods of AISC Design Guide 4. Test results showed that in the beam splices with the extended end-plates, the beam moment successfully transferred to the bracket, without any defeats such as excessive prying action of the end plates and brittle failure at the end plate-to-beam flange weld joints. However, the deformation capacities of the overall beam-to-column connections were limited due to the brittle failure of the beam-to-column flange weld joints. From the test results, recommendations for seismic design and detailing of the beam-to-column moment connection with inclined end-plate beam splice were given.

• Women's Health Nursing
• /
• v.8 no.3
• /
• pp.412-423
• /
• 2002

This study was designed to evaluate the effect of pelvic floor muscle exercise using biofeedback and electrical stimulation after normal vaginal delivery. The data were collected from November 1999 to April 2000 at a university hospital located in Seoul, Korea. Out of 49 women with normal vaginal delivery, 25 of experimental group(with exercise) and 24 of control group(without exercise) were questioned about lower urinary symptoms, discomfort during sexual intercourse and daily life. The maximum pressure of pelvic floor muscle contraction(MPPFMC) and duration of pelvic floor muscle contraction(DPFMC) were measured at pre-treatment, the end of treatment and 8 weeks after a treatment program. The pelvic floor muscle exercise program(using biofeedback and electrical stimulation) was applied to the experimental group twice a week for 4 weeks at the incontinence clinic and the pelvic floor muscle exercise at home for that time and more 8 weeks. Data were analyzed by t-test, $x^2$-test, Fisher's exact test and the repeated measures ANOVA. The results were as follows; 1) MPPFMC(p=0.000) and DPFMC(p=0.021) were significantly increased in the experimental group. 2) In the lower urinary symptoms, daily frequency(p=0.001), nocturia(p=0.002), incontinence episode(p=0.016), stress incontinence(p=0.012), quantity of incontinence(p=0.026), straining(p=0.041), and strength of stream(p=0.009) were significantly decreased in the experimental group. 3) Discomfort during sexual intercourse had not a significant difference between the two groups, which was not significantly decreased as time passed. 4) In the discomfort during daily life, activity restriction(p=0.042), exercise restriction (p=0.008), interpersonal relationship restriction(p=0.046), and discomfort of general life(p=0.027) showed a significant difference between the two groups, which were not significantly decreased as time passed. In conclusion, it is suggested that the pelvic floor muscle exercise using biofeedback and electrical stimulation might be a safer and more effective program for the improvement of postpartum pelvic muscle contraction.