• The Korean Journal of Blood Transfusion
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• v.29 no.3
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• pp.229-239
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• 2018

The circulatory system is closely related to the inter-relationship between the anatomy of the heart and blood vessels, and the fluid dynamic properties of blood. The physical properties of blood, which affect blood flow, are called hemorheologic factors. Hemorheologic factors, such as blood viscosity and erythrocyte aggregation, are influenced mainly by hematocrit. A higher hematocrit level results in an increase in blood viscosity, erythrocyte aggregation, which impedes the circulation itself, and tissue oxygenation. An excess of serum ferritin causes injury to vascular endothelial cells and erythrocytes via oxygen free radicals. In addition, an excess of blood can aggravatee the adverse effects of the hemorheologic parameters and induce atherogenesis, microcirculatory disturbances, and major cardiovascular events. A preventive and therapeutic approach with a phlebotomy or blood donation has been stimulated by the knowledge that blood loss, such as regular donations, is associated with significant decreases in key hemorheologic variables, including blood viscosity, erythrocyte aggregation, hematocrit, and fibrinogen. Major cardiovascular events have been improved in regular blood donors by improving blood flow and microcirculation by decreasing the level of oxidative stress, improving the hemorheologic parameters, and reducing the serum ferritin level. Confirmation of the positive preventive and therapeutic effects of blood donations on cardiovascular disease by a well-designed and well-controlled Cohort study may be good news to patients with cardiovascular disease or at risk of these diseases, as well as patients who require a transfusion.

• Journal of the Korean Geotechnical Society
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• v.35 no.4
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• pp.15-26
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• 2019

The stability of the gravity quay wall against earthquakes is evaluated on the basis of the allowable displacement of the wall. To estimate the displacement caused by external forces, empirical equations based on the Newmark sliding block method or numerical analysis are widely used. In numerical analysis, it is possible to analyze precisely a complicated site and structure, but difficult to set the appropriate parameters and environments; there are limitations in obtaining reliable results, depending on one's level of expertise. The Newmark method, with only seismic motions, is widely used because it is simpler than numerical simulations when estimating permanent displacement. However, the empirical equations do not have any parameters for the response characteristics and sliding block of the structure, and sliding blocks being assumed as rigid bodies does not consider the nonlinear behavior of the soil and interaction with the structure. Therefore, in order to evaluate the seismic stability of the gravity quay wall, a newly-developed empirical equation is needed to overcome the above-mentioned limitations. In this study, numerical simulations are performed to analyze the response characteristics of the backfill of the structure, and to propose an optimal method of calculating the active area. For this purpose, finite element analyses were performed to analyze the response characteristics, and stress-strain relationships for various seismic motions. As a result, the response characteristics, sliding block, and failure surface of the backfill vary depending on the input seismic motions.

• Journal of Korea Water Resources Association
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• v.54 no.9
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• pp.681-692
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• 2021

Vegetation processes have a significant impact on rainfall runoff processes through evapotranspiration control, but are rarely considered in the conceptual lumped hydrological model. This study evaluated the model performance of the Hapcheon Dam watershed by integrating the ecological module expressing the leaf area index data sensed remotely from the satellite into the hydrological partition module. The proposed eco-hydrological model has three main features to better represent the eco-hydrological process in humid regions. 1) The growth rate of vegetation is constrained by water shortage stress in the watershed. 2) The maximum growth of vegetation is limited by the energy of the watershed climate. 3) The interaction of vegetation and aquifers is reflected. The proposed model simultaneously simulates hydrologic components and vegetation dynamics of watershed scale. The following findings were found from the validation results using the model parameters estimated by the SCEM algorithm. 1) Estimating the parameters of the eco-hydrological model using the leaf area index and streamflow data can predict the streamflow with similar accuracy and robustness to the hydrological model without the ecological module. 2) Using the remotely sensed leaf area index without filtering as input data is not helpful in estimating streamflow. 3) The integrated eco-hydrological model can provide an excellent estimate of the seasonal variability of the leaf area index.

• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.575-584
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• 2021

Objective : Cervical expansive laminoplasty is an effective surgical method to address multilevel cervical spinal stenosis. During surgery, the spinous processes of C2 and C7 are usually preserved to keep the insertion points of the cervical musculature and nuchal ligament intact. In this regard, dome-like laminectomy (undercutting of C7 lamina) instead of laminoplasty is performed on C7 in selected cases. However, resection of the lamina can weaken the C7 lamina, and stress fractures may occur, but this complication has not been characterized in the literature. The objective of the present study was to investigate the incidence and risk factors for C7 laminar fracture after C7 dome-like laminectomy and its impact on clinical and radiological outcomes. Methods : Patients who underwent cervical open-door laminoplasty combined with C7 dome-like laminectomy (n=123) were classified according to the presence of C7 laminar fracture. Clinical parameters (neck/arm pain score and neck disability index) and radiologic parameters (C2-7 angle, C2-7 sagittal vertical axis, and C7-T1 angle) were compared between the groups preoperatively and at postoperatively at 3, 6, 12, and 24 months. Risk factors for complications were evaluated, and a formula estimating C7 fracture risk was suggested. Results : C7 lamina fracture occurred in 32/123 (26%) patients and occurred at the bilateral isthmus in 29 patients and at the spinolaminar junction in three patients. All fractures appeared on X-ray within 3 months postoperatively, but patients did not present any neurological deterioration. The fracture spontaneously healed in 27/32 (84%) patients at 1 year and in 29/32 (91%) at 2 years. During follow-up, clinical outcomes were not significantly different between the groups. However, patients with C7 fractures showed a more lordotic C2-7 angle and kyphotic C7-T1 angle than patients without C7 fractures. C7 fracture was significantly associated with the extent of bone removal. By incorporating significant factors, the probability of C7 laminar fracture could be assessed with the formula 'Risk score = 1.08 × depth (%) + 1.03 × length (%, of the posterior height of C7 vertebral body)', and a cut-off value of 167.9% demonstrated a sensitivity of 90.3% and a specificity of 65.1% (area under the curve, 0.81). Conclusion : C7 laminar fracture can occur after C7 dome-like laminectomy when a substantial amount of lamina is resected. Although C7 fractures may not cause deleterious clinical outcomes, they can lead to an unharmonized cervical curvature. The chance of C7 fracture should be discussed in the shared decision-making process.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.3
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• pp.94-100
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• 2021

To improve the productivity of cargo containment construction for a membrane LNG carrier, it is important to shorten the installation period and process of the scaffolding system, which is a construction workbench of a cargo containment for a membrane LNG carrier. As an effective method, opinions are being gathered to enlarge the lifting unit from the existing two stages to eight stages. On the other hand, the stresses around the pin and hole will increase significantly because of the increase in lifting load according to the large size of the module. The purpose of this study was to establish a new large module-lifting plan by introducing TRIZ to solve these problems. This study adopted a method to utilize 40 inventive principles, which is one of the various problem-solving tools of TRIZ. First, technical contradictions were derived, the engineering parameters were selected. Second, efficient inventive principles were selected to overcome the technical contradictions using a contradiction matrix. Finally, the general and specific solutions were derived through the selected inventive principle, and structural analysis confirmed that the stress generated in the structure was low. The utility of TRIZ was confirmed by the successful lifting of large modules using the established lifting method.

• Journal of the Korean Wood Science and Technology
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• v.31 no.5
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• pp.72-79
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• 2003

In reliability based design(RBD) method, the distribution characteristics of mechanical properties of material are basic input variable. Therefore, distribution type and parameters of mechanical properties should be determined accurately. Until now, the properties were derived from tests with small, clear specimens. However, the test conditions should emulate as nearly as possible the way in which the timber would be used in practice and the test results should, as closely as possible, reflect the structural end use conditions to which the timber products would be subjected. In this study, structural timbers (38mm by 140mm, 3.0m long) were graded by visual assessment of growth characteristics and defects. And then bending tests were conducted on 498 structural size timbers. For each grade, the distribution type and the parameters of mechanical properties were determined for each grade. For the determination of best-fit distribution type, comparing of square error between distribution types and KS test were conducted. Best-fit distribution type of bending strength(MOR) is weibull distribution for all grade. In case of MOE, normal distribution is best-fit.

• Journal of the Korean Geotechnical Society
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• v.23 no.3
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• pp.123-131
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• 2007

A series of CIDC triaxial tests and cone penetration tests in calibration chamber were performed to investigate the relationship between state parameter and normalized cone resistance far dredged Busan sand. From the results of the triaxial tests, the critical state line of Busan sand was established, and the critical state parameters found to be $M=1.39(\phi_{cs}=34^{\circ}),\;\Gamma=1.07$ and $\lambda=0.068$. By analyzing the state parameters and corresponding cone resistances for calibration chamber specimens, the relationship between normalized cone resistance and state parameter for Busan sand was defined as $(q_c-p)/p'=27.6\exp(-10.9\Psi)$. This relationship was also shown to be independent of the stress history. From the comparison of the slope of the normalized cone resistance, m, and the normalized cone resistance at $\Psi=0$, $\kappa$, with those of various sandy soils from over the world, the relationship of m and $\kappa$ with $\lambda_{ss}$ of Busan sand was concluded to show a good agreement with the result published previously, while Busan sand had the largest $\kappa$ among the soils with similar $\lambda_{ss}$ values.

• Journal of Marine Life Science
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• v.8 no.2
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• pp.150-159
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• 2023

To determine the toxic effects of the mirror carp, Cyprinus carpio nudus on waterborne nitric acid exposure, they were exposed to waterborne nitric acid at 0, 4, 20, 100, 500, and 2,500 mg NO₃^-/L for 96 h. The semi-lethal concentration (LC₅₀) of the scented fish by 96 hours of acute exposure to nitric acid was 1,433.54 mg NO₃^-/L. The physiological changes of waterborne nitric acid exposure on mirror carp were evaluated through hematologic properties, and RBC count showed a significantly decreased (p < 0.05). The change in the ion control ability of the mirror carp according to exposure to waterborne nitric acid was evaluated through the plasma inorganic component, and calcium and magnesium were significantly decreased (p < 0.05) in the plasma inorganic component. The health and stress status of the mirror carp due to exposure to waterborne nitric acid were evaluated through plasma organic ingredients, and the plasma organic component glucose showed a significantly increase (p < 0.05). Changes in liver damage and enzyme activity due to waterborne nitric acid exposure were evaluated through plasma enzyme components, the enzymatic activities of plasma AST, ALT, and ALP were significantly decreased (p < 0.05) in high levels of waterborne nitric acid exposure. The results of the present study suggest that waterborne nitric acid exposure to C. carpio nudus can toxicly affect survival, hematologic properties, and plasma components.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.4
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• pp.505-513
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• 2017

Objective: This study was performed to evaluate whether ambient temperature and dietary glycerol addition affect growth performance, and blood metabolic and immunological parameters, in beef cattle. Methods: Twenty Korean cattle steers ($405.1{\pm}7.11kg$ of body weight [BW], $14.2{\pm}0.15$ months of age) were divided into a conventional control diet group (n = 10) and a 2% glycerol- added group (n = 10). Steers were fed 1.6% BW of a concentrate diet and 0.75% BW of a timothy hay diet for 8 weeks (4 weeks from July 28th to August 26th and 4 weeks from August 27th to September 26th). Blood was collected four times on July 28th, August 11th, August 27th, and September 26th. Results: The maximum indoor ambient temperature-humidity index in August (75.8) was higher (p<0.001) than that in September (70.0), and in August was within the mild heat stress (HS) category range previously reported for dairy cattle. The average daily gain (ADG; p = 0.03) and feed efficiency (p<0.001) were higher in hotter August than in September. Glycerol addition did not affect ADG and feed efficiency. Neither month nor glycerol addition affected blood concentrations of cortisol, triglyceride, or non-esterified fatty acid. Blood concentrations of cholesterol, low-density lipoprotein, high-density lipoprotein, glucose, and albumin were lower (p<0.05) on August 27th than on September 26 th, and blood phosphorus, calcium and magnesium concentrations were also lower on August 27th than on September 27th. Glycerol addition did not affect these blood parameters. Percentages of $CD4^+$ T cells and $CD8^+$ T cells were higher (p<0.05) on July 28th than on August 27th and September 26th. The blood $CD8^+$ T cell population was lower in the glycerol supplemented-group compared to the control group on July 28th and August 27th. Conclusion: Korean cattle may not be significantly affected by mild HS, considering that growth performance of cattle was better in hotter conditions, although some changes in blood metabolic and mineral parameters were observed.

• Clinical and Experimental Reproductive Medicine
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• v.34 no.3
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• pp.159-166
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• 2007

Objective: To investigate whether semen parameters in infertile couples who undergone intrauterine insemination (IUI) change in the subsequent IUI cycle and the subsequent in vitro fertilization (IVF) cycle. Methods: Fifty-three infertile couples who had failed to become pregnant after the first IUI cycle with computer-assisted semen analysis (CASA) were included. After the first IUI, thirty-eight couples underwent the second IUI (Group 1), and fifteen underwent IVF-ET procedure (Group 2). All semen parameters including semen volume, concentration, motility and total motile sperm count were analyzed in the second IUI or IVF-ET procedure for comparison with the result of first IUI. Results: There were no significant differences in husband age, interval between the first and second procedure and cause of infertility. In Group 1, only sperm motility at the time of the latter IUI was significantly decreased when compared to the former IUI irrespective of the first semen parameters. In Group 2, sperm concentration, motility and total motile sperm count at the time of subsequent IVF were lower than the former IUI. By sub-analyses of Group 2, in the group of optimal semen parameter at IUI cycle, sperm concentration and total motile sperm count at the time of subsequent IVF were lower than the former IUI, while in the group of suboptimal semen parameter at IUI cycle, only sperm motility at the time of subsequent IVF were lower than the former IUI. Conclusion: The semen parameters in couples converted to IVF cycle were more adversely affected than those remained in IUI cycle. Further study on psychological stress should be necessary to explain the reason.