• Pediatric Infection and Vaccine
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• 제26권3호
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• pp.194-198
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• 2019

Streptococcus dysgalactiae subsp. dysgalactiae (SDSD)에 의한 사람 감염병을 보고한 사례가 많지 않으며, S. dysgalactiae subsp. equisimilis (SDSE)에 의한 감염병이 대부분이다. 저자들은 생후 22일 된 신생아에서 SDSD와 단순포진 바이러스의 동시감염에 의한 수막염을 경험하였으며, 뇌경색 및 경막하삼출 등이 합병되어 총 4주간의 항균제를 투여하고 치료를 완료하였다. 본 증례의 원인 균주가 소아의 침습감염의 원인으로 알려진 바가 없으나, 오염된 동물을 통한 감염 뿐 아니라, 돌발 감염의 원인균이 될 수 있을 것으로 생각되어 1예를 보고하는 바이다.

• Journal of Veterinary Science
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• 제21권4호
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• pp.57.1-57.11
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• 2020

Background: Streptococcus dysgalactiae subspecies equisimilis (SDSE) acts as an etiological agent for lameness, neurological signs, and high mortality in pigs. Despite its importance in pig industries and zoonotic potential, little is known about the effects of this pathogen. Objectives: This study aimed to determine the molecular characteristics and antimicrobial resistance of SDSE strains isolated from diseased pigs. Methods: A total 11 SDSE isolates were obtained from diseased pigs. Bacterial identification, PCR for virulence genes, emm typing, and antimicrobial resistance genes, multilocus sequence typing, and antimicrobial susceptibility test were performed. Results: Nine isolates were from piglets, and 8 showed lameness, sudden death, or neurological signs. The isolates were PCR-positive for sla (100%), sagA (100%), and scpA (45.5%), and only 1 isolate amplified the emm gene (stL2764). Eight different sequence types were detected, categorized into 2 clonal complexes and 4 singletons. All the isolates in this study were included in a small cluster, which also contained other strains derived from humans and horses. The minimum inhibitory concentrations for the tested beta-lactams were low, while those for macrolides, tetracyclines, and fluoroquinolones were relatively high. PCR analysis of the macrolide and tetracycline resistance genes demonstrated that the isolates carried erm(B) (18.2%, n = 2), mef(A/E) (9.1%, n = 1), tet(M) (18.2%, n = 2), and tet(O) (90.2%, n = 10). Two isolates presented a mutation in parC, which is associated with fluoroquinolone resistance. Conclusion: This study provided insight into swine-derived SDSE, as it is related to veterinary medicine, and elucidated its zoonotic potential, in the context of molecular epidemiology and antimicrobial resistance in public health.