• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2004년도 Annual Meeting of the Korean Society ofApplied Pharmacology
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• pp.18-34
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• 2004

This paper will review data obtained primarily from our preclinical investigations that show that exposure to stress has a significant impact on drug taking. Stress increases reward associated with psychomotor stimulants, possibly through a process similar to sensitization, and a growing clinical literature indicates that there is also a link between substance abuse and stress in human addicts. One explanation for the high concordance between stress-related disorders and drug addiction is the self-medication hypothesis, which suggests that a dually-diagnosed person often uses the abused substance to cope with tension associated with life stressors or to relieve symptoms of anxiety and depression resulting from a traumatic event. However, another characteristic of drug self-administration is that drug delivery and its subsequent effects on the HPA axis are under the direct control of the individual. This controlled activation of the HPA axis may result in the production of an internal state of arousal or stimulation that is actually sought by the individual (i.e., the sensation-seeking hypothesis). During abstinence, however, exposure to stressors or drug-associated cues can stimulate the HP A axis to remind the individual about the effects of the abused substance, thus producing craving and promoting relapse. Stress reduction, either alone or in combination with pharmacotherapies targeting the HPA axis may prove beneficial in reducing cravings and promoting abstinence in individuals seeking treatment for addiction. Of primary importance is to reduce the impact of cocaine-associated environmental stimuli on the HPA axis so that they no longer function as triggers for relapse.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2009년도 제33회 추계학술대회논문집
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• pp.82-85
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• 2009

우주발사체용 액체추진기관 개발에 있어서, 분사기는 연소성능과 안정성을 결정짓는 매우 중요한 요소로써 이에 대한 분무특성 이해는 필수적으로 이루어져야 한다. 본 연구에서 알아보고자 하는 분사기는 중앙에서 기체산화제를 제트로 분사하고 외부에서 액체연료를 와류(스월)형으로 분사하는 형태이다. 분무형상은 리세스별로 CCD 카메라를 이용한 직접사진기법을 통해 측정하였다. 실제 연소조건과의 모사를 위해 기체질소와 물을 사용하였고, 운동량비를 주요 상사인자로 두어 대기압 수류 시험조건을 도출하여 분무특성을 알아보았다. 또한 기체-액체 운동량비의 영향을 알아보기 위한 연구가 추가적으로 이루어졌다.

• 한국의상디자인학회지
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• 제17권3호
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• pp.61-71
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• 2015

In this study, visual evaluation was performed with changes in peplums design to provide data which can enhance wearing image effects at the production of peplums one-piece. According to changes in volume and position of peplums, a total of 9 stimulants were chosen. Then, they were evaluated using a seven-point rating scale against 50 fashion students. The data has been analyzed by Factor Analysis, ANOVA, $Scheff{\acute{e}}$'s Test and the MCA method. The results of the study are as follows : 1. According to factor analysis, the components of visual evaluation depending on the changes in volume and position variations of peplums were divided into four factors: elegance, individuality, upper body correction and upper body emphasis. 2. According to visual evaluation depending on changes in the position variations of peplum, 'high waist' and 'natural waist' revealed a significant difference in elegance, individuality and upper body correction. 'Low waist' was observed in all four positions. 3. According to visual evaluation depending on the changes in volume of peplums, a significant difference at $45^{\circ}$ was observed in except for elegance. Significant differences at $90^{\circ}$ and $180^{\circ}$ were observed in all four positions. 4. In terms of interactions over in volume and position variations of peplums, interaction effects were found in two factors.

• 한국한의학연구원논문집
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• 제3권1호
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• pp.289-319
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• 1997

Non-medical use of drugs to enhance performance at Olympic Games by athletes has been prohibited by the International Olympic Committee(IOC) since 1968 on medical and ethical grounds. IOC wants to protect athlete from harmful side effect of drugs due to misuse of it. It also, ethically, wants to have Games run on fair base, not fortified by performance enhancing drugs, The banned substances include stimulants, narcotic analgesics, anabolic sterolds, ${\beta}-blockers$ and diuretics. In order to prevent the positive reaction in the doping test induced by herb medicine, this study was done on about Bojungchisheup-tang. The laboratory set up doping analyses methods to cover as many drugs as possible without sacrificing sensitivity and specificity within one procedure. Its screening method consisted of four different procedures. The results were negative. According to the above results, Bojungchisheup-tang taken by athletes would show the negative reaction in the doping test. So its prescription for athletes can be given without worries of the doping test.

• 보건교육건강증진학회지
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• 제7권1호
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• pp.72-82
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• 1990

The actual condition of drug abuse by some Juveniles in our country and effects of some elements on their drug abusing were observed providing basic materials for health education to juveniles to contribute to the health improvement of them and the reduction of the harmfulness of drug abuse. 1035 third school year students of some senior high schools in Seoul were subjected to the questionnaire survey. The results could be summarized as follows : 1. Among the twelve kinds of drug involved in the study, alcohol (72.0%), cigarette (44.2%), stimulants (23.9%), analgesics (7.9%) appeard abused in the order named. 2. As for the motives of using antitussives, 30.1% of students answered because of curiosity, then 28.8%, in order to get a calm condition, and then 16.4%, to get along with friends. 3. As the result from seeing how much each drug abuser is contact with his family, frends, school, social surroundings and himself, every abuser appeared having higher degree of discontentment with family, school, society and himself excepting friends. 4. And when analyzed the relationship between their misconducting and drug-abusing, a close relationship was shown : mere abusers among misconduct-experienced students, and more misconduct-experienced students among abusers.

• 약학회지
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• 제35권4호
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• pp.341-347
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• 1991

It was reported that protein carboxymethylation is involved in amylase secretion of parotid gland by isoproterenot. It was also suggested that a small part of the total cellular protein carboxymethylation is directly involved in pancreatic enzyme secretion. On the contrary, other authors reported that there is no relationship between protein carboxymethylation and secretion in pancreas and parotid gland. In recent study, it was proposed that a methyl acceptor protein plays a limited modulatory role in the coupling of cytosolic $Ca^{++}$ accumulation and exocytosis. In this study, the effects of cholinergic and adrenergic agents on the activities of protein methylase II in pancreatic tissues were examined to test the relationship between protein methylation and pancreatic secretion. The results are as follows. The activity of amylase was slightly increased at the concentration of $10^{-5}$ M of isoproterenol and norepinephrine. The activities of protein methylase I and II were decreased by isoproterenol and norepinephrine, but the activities of protein methylase III were hardly changed. The cholinergic stimulants acetylcholine and carbachol at a concentration of $10^{-5}$ M increased the activities of protein methylase I and decreased the activitiy of protein methylase III compared with control.

• 한국의류학회지
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• 제29권9_10호
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• pp.1230-1240
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• 2005

The purpose of this study was to apply a scientific and systematic method for assessing fashion goods' TV ads effects by EEG and questionnaires as determined by the type of ads appeal. Ads stimulants used in the survey were limited to underwear and sportswear that were advertised during $2000{\sim}2002$ on TV: 4 information-transferring and 4 emotion-evoking ads were used. Subjects were thirty healthy male and female college students. EEG was extracted from six lobes and the recorded EEG was analyzed by the range of frequency of ${\theta},\;{\alpha}\;and\;{\beta}$ waves. Data were analyzed by SPSS 11.0 with reliability test, $x^2$-analysis, t-test and frequency analysis. The emotion-evoking ads showed higher scores in memory, recall and attitude towards the ads. The responses of ${\theta}\;and\;{\alpha}$ wave were active throughout the ads but the response of ${\beta}$ wave was not. The results by the survey and the EEG test showed high similarities, indicating the EEG tests could be used as the supplementary tool for measuring ads effects.

• 대한한의학회지
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• 제17권2호
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• pp.394-404
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• 1996

Epilepsy is a chronic cerebral. disease resulting from a variety of factors, which is a syndrome with chief complaint of recurrent seizure caused by abnormal electrical discharge of cerebral nerve cell, while the clinical result showed that epilepsia occurs more frequently in pediatrics. A Child having the chief complaint of recerrent vomiting for 2 months undergone the brain and abdominal C.T, MRI, and gastric endoscopy, when the child was normal. While vomiting gas too serious to administer a medicine, a cyclic vomiting repeated with its discontinuation for 2-3 days after continuation for 10 days. As a result, the child visited the ambulatorium of our hospital and then was hospitalized and treated over two times, when there was a remarkably improvement. There was no any particular complaint for 1 year and 2 months, then, the child complained moderate headache. For thjs reason, we performed again electroencephalography, when there appeared in epilepsia opinion. Since then, we have experienced a case of autonomic nervous seizure which was significantly improved by anticonvulsant, and a therapy by using the phlegm resolvents and central stimulants for treating epilepsy(豁痰醒腦治癎法) as an oriental medicine. Therefore, it is to report both treatment view of oriental medicine and analysis on Oriental and Western medical literatures.

• 식물병연구
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• 제24권2호
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• pp.99-112
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• 2018

Certain agrochemicals may be tuned for increased effectiveness when downsized to nanoparticles (NPs), where one dimension is less than 100 nm. The NPs may function as fertilizers, pesticides and products to improve plant health through seed priming, growth promotion, and induction of systemic tolerance to stress. Formulations will allow targeted applications with timed release, reducing waste and pollution when compared to treatments with bulk-size products. The NPs may be a single component, such as nano-ZnO as a fertilizer, or be composites of compatible materials, for example where N, P, and K plus micronutrients are available. The active materials could be loaded into porous carriers or tethered to base nanostructures. Coatings could include such natural products alginate, chitosan, zein, or silica. Certain NPs are taken up and transported in the plant's phloem and xylem so systemic effects are feasible. Timed and targeted release of the active product could be achieved in response to changes in pH or availability of ligands within the plant or the rhizosphere. Global research has revealed the many potentials offered by NP formulations to aid sustainability in agriculture. Current work will provide information needed by regulatory agencies to assess their safety in the agricultural setting.

• Journal of Plant Biotechnology
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• 제6권3호
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• pp.157-163
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• 2004

An efficient system for the regeneration of adventitious shoots from in vitro cultured leaf sections of Lycium chinense Miller was developed and silent somaclones from the regenerants detected with RAPD method. Among the eight media tested (B5, SH, N&N, 1/2MS, MS, 3/2MS, GD and WPM), and four cytokinins (BA, kinetin, 2ip and zeatin) with different concentrations (1, 5, 10, 20, 30 and 40 $\mu{M}$), 1/2 MS medium supplemented with 20 and 30 $\mu{M}$ zeatin showed the best regeneration frequency (100% and 93.7%) and higher average number of shoots (9.0 and 9.4). All regenerants easily elongated after subculturing on 1/4MS without growth stimulants and produced spontaneous adventitious roots from their basal parts. With phenotypically normal 40 regenerants, RAPD analysis with 15 different random primers was performed to examine the cryptic somaclonal variants. No substantial differences in banding patterns were found in the amplified polymorphic DNAs implying no DNA changes during dedifferentiation into adventitious shoots. However, one (OPF-4) of the 15 primers detected silent somaclonal variation in one regenerant in which two different polymorphic bands did not appear when compared with the rest regenerants. The results indicate that regenerantion via intervening callus phase can be used to establish true-to-type planting stocks for homogeneous population.