• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제32권1호
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• pp.10-16
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• 2021

Objectives: The aim of this study was to compare the compliance, efficacy, and satisfaction associated with methylphenidate and atomoxetine for treating attention-deficit/hyperactivity disorder (ADHD). Methods: The subjects were 44 patients who met the Diagnostic and Statistical Manual of Mental Disorder-5 diagnostic criteria for ADHD and were treated with methylphenidate or atomoxetine. The methylphenidate formulations included immediate release (IR), extended release (ER), and osmotic-controlled release oral delivery system (OROS). Patients and parents reported the average number of days per week the medication was taken. Efficacy was assessed using the ADHD Rating Scale. Satisfaction with medication scale (SAMS)-parent report form and SAMS-self-report form were used to evaluate parents' and patients' satisfaction, respectively. Results: Patients and parents were more satisfied with methylphenidate than with atomoxetine. There were no significant differences in the compliance with and efficacy of methylphenidate and atomoxetine. Compliance with methylphenidate IR and ER was markedly lower than that with OROS methylphenidate or atomoxetine. Conclusion: Methylphenidate OROS formulation can be considered a suitable option given its high rates of compliance, satisfaction, and efficacy.

• Fisheries and Aquatic Sciences
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• 제24권9호
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• pp.311-317
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• 2021

Inclusion effect of various levels of jack mackerel meal (JMM) acting as feed attractants and/or stimulants in diets on the growth, feed consumption, feed utilization and whole body composition of rockfish was investigated. Three hundred juvenile rockfish were randomly allocated into 15 flow-through tanks. Five experimental diets supplemented with JMM at 0%, 1%, 3%, 5%, and 10% at the expense of anchovy meal were prepared and referred to as the JMM0, JMM1, JMM3, JMM5, and JMM10 diets, respectively. Weight gain, specific growth rate (SGR) and feed consumption of fish tended to improve with dietary levels of JMM. The greatest weight gain, SGR and feed consumption were observed in fish fed the JMM10 diet, followed by the JMM5, JMM3, JMM1, and JMM0 diets, in that order. Condition factor (CF) of fish tended to improve with dietary inclusion levels of JMM. Growth performance, feed consumption and CF of fish tended to improve with dietary inclusion levels of JMM ranging from 0% to 10%.

• 한국양식학회:학술대회논문집
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• 한국양식학회 2003년도 추계학술발표대회 논문요약집
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• pp.68-69
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• 2003

The present study was conducted to investigate the effects of dietary supplementation of $\beta$-1,3 glucan and feed stimulants(BAISM) as a feed additive for juvenile olive flounder (Paralichthys olivaceus). Eight experimental diets supplemented with $\beta$-1,3 glucan and feed stimulants at 0%, $\beta$-1,3 glucan 0.05% ＋ Baism 0.45%, $\beta$-1,3 glucan 0.05% ＋ Baism 0.95%, $\beta$-1,3 glucan 0.10% ＋ Baism 0.90%, $\beta$-1,3 glucan 0.10% ＋ Baism 1.90%, $\beta$-1,3 glucan 0.15% ＋ Baism 1.35%, $\beta$-1,3 glucan 0.15% ＋ Baism 2.85% and $\beta$-1,3 glucan 0.30% ＋ Baism 2.70% of diets as a dry-matter(DM) basis were prepared. Three replicate groups of fish averaging 9.2 $\pm$ 0.1g (Mean $\pm$ SD) were randomly distributed in each aquarium as a group of 15 fish and fed one of eight experimental diets for seven weeks. After the feeding trial, $\beta$-1,3 glucan 0.10% ＋ Baism 0.90%, $\beta$-1,3 glucan 0.10% ＋ Baism 1.90% diets had a higher weight gain (WG), feed efficiency(FE), specific growth rate(SGR) and protein efficiency ratio(PER) than did fish fed 0%, $\beta$-1,3 glucan 0.05% ＋ Baism 0.45%, $\beta$-1,3 glucan 0.05% ＋ Baism 0.95%, $\beta$-1,3 glucan 0.15% ＋ Baism 2.85% and $\beta$-1,3 glucan 0.30% ＋ Baism 2.70% (P<0.05). however, there was no significant difference among fish fed $\beta$-1,3 glucan 0.05% ＋ Baism 0.45%, $\beta$-1,3 glucan 0.05% ＋ Baism 0.95%, $\beta$-1,3 glucan 0.15% ＋ Baism 2.85% and $\beta$-1,3 glucan 0.30% ＋ Baism 2.70%(P>0.05). and $\beta$-1,3 glucan 0.10% ＋ Baism 0.90% diets had a higher peak value of CL(Chemiluminescence) and lysozyme activity, than did fish fed the other diets (P<0.05). These results indicated that dietary sipplementation of $\beta$-1, 3 glucan and Baism affected growth, feed efficiency, specific growth rate, protein efficiency ratio, Peak value of CL and Lysozyme activity, and the optimum dietary supplementation level of $\beta$-1, 3 glucan and Baism as a feed additive could be approximately $\beta$-1, 3 glucan 0.10% ＋ Baism 0.90% of diet in juvenile olive flounder (Paralichthys olivaceus).

• 한국수산과학회지
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• 제35권2호
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• pp.196-200
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• 2002

우리나라 해산어 양식의 주요 대상 어종인 넙치의 섭식 촉진 물질을 확인하기 위하여 몇 가지 아미노산, 핵산관련물질, 염기성 물질 및 산가수분해물의 섭식촉진 효과를 수조 실험을 통해 검토하였다. Glycine, IMP, GMP 및 betaine은 다소의 섭식 촉진 효과가 인정되었으며 천연 단백질 자원의 산 가수분해물인 KH가 가장 우수한 섭식촉진 효과를 보였다. KH는 사료 중량에 대하여 $1.05\%$ (w/w)까지 섭식촉진 효과가 증가하였으나 그 이상의 농도에서는 효과가 거의 일정하였다. 산 가수분해물의 pH는 섭식촉진에 영향을 미치지 않았고, 물질의 흔합에 따른 상승효과는 KH와 glycine의 조합이 가장 우수하였다. 대조군 사료는 총 급이량의 $58.2\%$를 섭취한 반면 섭식촉진 사료는 $83.3\%$를 섭취하여 섭식촉진물질의 첨가는 섭식량의 증가 뿐 아니라 사료 효율의 개선에 현저히 기여하였다. 그리고 섭식촉진 물질의 조합에 따른 단가 상승은 기본사료 가격의 $0.05\%$ 이내에 불과하여 경제성이 충분하며 실용화가 가능한 것으로 예상하였다. 한편 본 연구 결과의 적용을 확대하기 위해서는 장차 넙치 성어에 대한 연구도 필요할 것으로 보인다.

• 약학회지
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• 제48권1호
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• pp.99-103
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• 2004

Acanthopanax species (Araliaceae) has been traditionally used as analgesics, stimulants of immune system, and replenishment of body functions. Acanthopanax divaricatus var. albeofructus is a indigenous plant in Korea. The anti-lipid peroxidation activities of the loaves and root bark extracts of A divaricatus var. albeofructus were determined. Activities of MeOH extracts were examined in vitro and in vivo with control group intoxicated by carbon tetrachloride. Both extracts showed significant inhibitory effects on the lipid peroxidation.

• The Journal of Korean Physical Therapy
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• 제20권3호
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• pp.61-68
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• 2008

Purpose: Protein kinase C (PKC) is a member of a family of serine/threonine kinases that are activated by diacylglycerol (DG) and PKC stimulants. PKC play a key role in signal transduction, including muscle contraction, cell migration, apoptosis, cell proliferation and differentiation. However, the mechanism relating mitogen-activated protein kinases (MAPKs) and PKC, especially in the volume-dependent hypertensive state, remains unclear. Methods: In the present study, I investigated the relationship between PKC and MAPKs for isometric contraction, PKC translocation, and enzymatic activity from normotensive sham-operated rats (NSR) and aldosterone-analogue deoxycorticosterone acetate (DOCA) hypertensive rats (ADHR). Results: Systolic blood pressure was significantly increased in ADHR than in NSR. Physiological salt solution (PSS)-induced resting tension and the intracellular $Ca^{2+}$ concentration ([$Ca^{2+}{_i}$]) were different in the ADHR and NSR. The expression of PKC$\alpha$, PKC$\beta$II, PKC$\delta$, PKC$\varepsilon$ and PKC$\xi$ were different between the cytoplasmic and membranous fractions. However, expression of the PKC isoforms did not differ for the ADHR and NSR. The use of 12-deoxyphorbol 13-isobutyrate (DPB, a PKC stimulant) induced isometric contraction in $Ca^{2+}$-free medium, which was diminished in muscle strips from ADHR as compared to NSR. Increased vasoconstriction and phosphorylation induced by the use of 1 ${\mu}$M DPB were inhibited by treatment with 10 ${\mu}$M PD098059 and 10 ${\mu}$M SB203580, inhibitors of extracellular-regulated protein kinase 1/2 (ERK1/2) and p38 MAPK from ADHR, respectively. Conclusion: These results suggest that the development of aldosterone analogue-induced hypertension is associated with an altered blood pressure, resting tension, [$Ca^{2+}{_i}$], and that the $Ca^{2+}$-independent contraction evoked by PKC stimulants is due to the activation of ERK1/2 and p38 MAPK in volume-dependent hypertension. Therefore, it is suggested that PKC activity affects volume-dependent hypertension and the need to develop cardiovascular disease-specialized physical therapy.

• 대한간호학회지
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• 제27권4호
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• pp.777-786
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• 1997

The purpose of this study was to examine the conditions of drug use and to find the main factors that lead students to start and select drugs in their circumstances. The "other drugs" in this study means analgesics, hypnotics, stimulants, tranqualizers, and drinks including caffeine. The sample was 1,900 students and 1,412 responses were analyzed. Variables in the study included prescription provision by parents, drug use by friends, attitudes to drugs, drinking and smoking activities, and poly drug use Analysis of the data was done using descritive statistics, chi square, and, to find the determinants on other drug use, multiple logistic regression was performed. Data were analysed by SAS/PC programs. Of the subjects 86.6% of the students have had experienced with alcohol and 49.8% of them continue to use it, and 37.9% of the students have had experienced with smoking and 22.1% of them continue to smoke. The rates of using other drugs were as followed : analgesic 33.3%, hypnotics 4.3%, sedatives 4.4%, stimulants 8.7%, and 242 students have had experienced with more than two different kinds of drugs of the same time including alcohol and smoking. With the exception of alcohol and smoking, 126 students were continuing to use more than two different kinds of drugs. And 2.3 kinds of drugs were the average that were being used at the same time by poly drug users, alcohol and smoking excepting. In conclusion, the determinants of other drug use can be summarized as poly drug use, drug use by friends, obedience to drug prescription of parents, and time of first using drugs.

• 대한화학회지
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• 제35권6호
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• pp.659-666
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• 1991

질소를 함유한 흥분제와 마약성 진통제 18종류의 약물들을 gas chromatography-nitrogen phosphorus detector(GC-NPD)를 사용하여 human urine으로부터 동시에 신속하게 분석할 수 있는 최적조건을 찾기 위하여 pH 변화와 추출용매 변화에 따른 회수율을 조사하였다. pH 8.5에서 에테르를 추출용매로 사용하였을 때 가장 적은 방해영향과 가장 좋은 회수율을 나타냈다. NPD에 대한 각 약물들의 상대 감응인자를 구하였고, 이 상대감응인자는 약물이 가지고 있는 질소원자의 갯수가 증가할수록 작은 값을 나타냈다. 생체시료 중의 약물들을 신속하게 검정하기 위하여 내부표준물질인 diphenylamine에 대한 relative retention time(RRT)을 작성하였다. 상대머무름 시간은 0.1% 이하의 정밀도를 나타냈다.

• 생물정신의학
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• 제21권2호
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• pp.37-48
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• 2014

Besides from medical data, the patients who were previously called as attention disorder, mental instability, moral imbeciles, or moral defectives, can also be identified by exploring literatures and historical figures. In the past, as we can notice from the titles, they were recognized as a 'moral defect group'. And rather than treating them, separation from the society was the main solution. After the endemic encephalitis from 1917 to late 1920s, however, many survivors suffered from behavioral problems similar to those of the previous 'moral defect group' and studies on the relationship between brain damage and behavior problems were started henceforth. After being known as the 'minimal brain dysfunction', it was developed into the current attention-deficit/hyperactivity disorder. While the disease concept changed and developed over time, after numerous trials and errors, treatment medication starting from central nervous system stimulants such as amphetamine and methylphenidate is used for treatment in children and adult patients with ADHD, and most recently non-stimulants such as atomoxetine has become the one of the first line treatment options. Although we went through a thorough verification process of the safety and efficacy of the medication by contemplating the historical development process, we believe that adjustment is needed for remaining concerns on medication abuse and slight differences in disease paradigm and therapeutic philosophy depending on cultures.

• Mass Spectrometry Letters
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• 제5권4호
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• pp.104-109
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• 2014

Nonmedical use of prescription stimulants such as methylphenidate (MPH) and amphetamine (AP) by normal persons has been increased to improve cognitive functions. Due to high potential for their abuse, reliable analytical methods were required to detect these prescription stimulants in biological samples. A direct injection liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and implemented for simultaneous determination of MPH, AP and their metabolites ritalinic acid (RA) and 4-hydroxyamphetamine (HAP) in human urine. Urine sample was centrifuged and the upper layer ($100{\mu}L$) was mixed with $800{\mu}L$ of distilled water and $100{\mu}L$ of internal standards ($0.2{\mu}g/mL$ in methanol). The mixture was then directly injected into the LC-MS/MS system. The mobile phase was composed of 0.2% formic acid in distilled water (A) and acetonitrile (B). Chromatographic separation was performed by using a Capcell Pak MG-II C18 ($150mm{\times}2.0mm$ i.d., $5{\mu}m$, Shiseido) column and all analytes were eluted within 5 min. Linear least-squares regression with a 1/x weighting factor was used to generate a calibration curve and the assay was linear from 20 to 1500 ng/mL (HAP), 40-3000 ng/mL (AP and RA) and 2-150 ng/mL (MPH). The intra- and inter-day precisions were within 16.4%. The intra- and inter-day accuracies ranged from -15.6% to 10.8%. The limits of detection for all the analytes were less than 4.7 ng/mL. The suitability of the method was examined by analyzing urine samples from drug abusers.