The Journal of Korean Physical Therapy
- Volume 20 Issue 3
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- Pages.61-68
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- 2008
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- 1229-0475(pISSN)
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- 2287-156X(eISSN)
The Activity of Hypertension-related Protein Kinase C and the Relationship of Physical Therapy
고혈압-연관 단백질 부활효소 C의 활성과 물리치료의 상관성
- Kim, Jung-Hwan (Dept. of Physical Therapy, College of Health & Welfare, Yongin University)
- 김중환 (용인대학교 보건복지대학 물리치료학과)
- Published : 2008.09.25
Abstract
Purpose: Protein kinase C (PKC) is a member of a family of serine/threonine kinases that are activated by diacylglycerol (DG) and PKC stimulants. PKC play a key role in signal transduction, including muscle contraction, cell migration, apoptosis, cell proliferation and differentiation. However, the mechanism relating mitogen-activated protein kinases (MAPKs) and PKC, especially in the volume-dependent hypertensive state, remains unclear. Methods: In the present study, I investigated the relationship between PKC and MAPKs for isometric contraction, PKC translocation, and enzymatic activity from normotensive sham-operated rats (NSR) and aldosterone-analogue deoxycorticosterone acetate (DOCA) hypertensive rats (ADHR). Results: Systolic blood pressure was significantly increased in ADHR than in NSR. Physiological salt solution (PSS)-induced resting tension and the intracellular
Keywords
- Deoxycorticosterone acetate (DOCA)-salt hypertension;
- Protein kinase C (PKC);
- Mitogen-activated protein kinase;
- Physical therapy