• Journal of Biomedical Engineering Research
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• v.38 no.1
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• pp.43-48
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• 2017

Chemotherapy, radiation therapy, and surgery are major methods to treat cancer. However, current cancer treatments report severe side effects and high recurrences. Recent studies about engineering nanoparticles as a drug carrier suggest possibilities in terms of specific targeting and spatiotemporal release of drugs. While many nanoparticles demonstrate lower toxicity and better targeting results than free drugs, they still need to improve their performance dramatically in terms of targeting accuracy, immune responses, and non-specific accumulation at organs. One possible way to overcome the challenges is to make precisely controlled nanoparticles with respect to size, shape, surface properties, and mechanical stiffness. Here, we demonstrate $500{\times}200nm$ discoidal polymeric nanoconstructs (DPNs) as a drug delivery carrier. DPNs were prepared by using a top-down fabrication method that we previously reported to control shape as well as size. Moreover, DPNs have multiple payloads, poly lactic-co-glycolic acid (PLGA), polyethylene glycol (PEG), lipid-Rhodamine B dye (RhB) and Salinomycin. In this study, we demonstrated a potential of DPNs as a drug carrier to treat cancer.

• Journal of the Korean Society for Railway
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• v.16 no.1
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• pp.40-46
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• 2013

Based on Korean railway design standards, the thicknesses of the reinforced roadbeds of conventional and high speed railways are different, and so too, for the size distribution of the ballast particles. Accordingly, considerable cost would be required to increase operating speeds of conventional lines, in particular related to changing from a ballasted track system to a ballastless one. In this study, applicability of a roadbed which supports conventional ballasted track, for use as a ballastless track for a high speed rail line was examined. A reinforced roadbed for a conventional railway is 20cm thick, and the type of material used for a conventional reinforced roadbed is M-40 (crushed gravel for road embankments). A dynamics test was conducted to evaluate the occurrence of the permanent settlement of the track substructure. These results suggest that, without changes to the track substructure, an operational speed of 400km/h is feasible with a ballastless track. This result; however, is from laboratory experiments. Further studies, such as numerical analyses or field validation, are required.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.5
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• pp.345-352
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• 2014

In this paper, the CAD data for the optimal shape design obtained by isogeometric shape optimization is directly used to fabricate the specimen by using 3D printer for the experimental validation. In a conventional finite element method, the geometric approximation inherent in the mesh leads to the accuracy issue in response analysis and design sensitivity analysis. Furthermore, in the finite element based shape optimization, subsequent communication with CAD description is required in the design optimization process, which results in the loss of optimal design information during the communication. Isogeometric analysis method employs the same NURBS basis functions and control points used in CAD systems, which enables to use exact geometrical properties like normal vector and curvature information in the response analysis and design sensitivity analysis procedure. Also, it vastly simplify the design modification of complex geometries without communicating with the CAD description of geometry during design optimization process. Therefore, the information of optimal design and material volume is exactly reflected to fabricate the specimen for experimental validation. Through the design optimization examples of elasticity problem, it is experimentally shown that the optimal design has higher stiffness than the initial design. Also, the experimental results match very well with the numerical results. Using a non-contact optical 3D deformation measuring system for strain distribution, it is shown that the stress concentration is significantly alleviated in the optimal design compared with the initial design.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.9-12
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• 2008

The semi-rigid joint is the shape of middle that can supplement the defect of pin joints and accept the good point of rigid joints. Recently, a study on the pin joints is activated in the country, but because the study on semi-rigid joints is not many, this study tried to prove with producing test model of three shape. The test models are rigid joint HI-R, semi-rigid joint HI-S, pin joint HI-P. As a result of the test, respectively HI-R, HI-S, HI-P appeared shear failure of joint, flexure failure of the top fixing, flexure failure of the lower part slipping stair slab, and the maximum strength is measured to 51.74, 51.4, 24.63kN, the stiffness is appeared 1.58, 1.19, 0.37 respectively, The yield strength is respectively kept 44.5, 47.3, 24kN, and ductility ratio is appeared to 3.31, 2.32, 1.54, when is based on KBC code, sag of the acting service load is appeared that HI-P model is over the standard. When is based on distribution of bars strain ratio, HI-S seems similar behavior incipiently, but after the yield, the semi-rigid joint was able to be judged better than pin joint because of the stress allotment of joint internal elements.

• 한국지구물리탐사학회:학술대회논문집
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• 2004.08a
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• pp.25-48
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• 2004

Structures show the phehomena of deformation and lowering of function with time-lapse by artificial environments and changes of geotechnical conditions or accumulation of initial deformation elements. This study aims the structural assessment of cultural property, Chum-Sung-Dae, located in Kyeongju city, Korea. It was built about 1,300 years ago, and has undergone deformation and ground-subsidence with time-lapse. Non-destructive evaluation techniques were applied to the Chum-Sung-Dae, to protect it from survey Because of this reason, 3D precise laser scanning surveying system was applied to measure the exact size of Chum-Sung-Dae, displacement and declining angles. Geophysical exploration also was applied to study the subsurface distribution of geotechnical parameters or physical properties. Natural frequencies were measured from real and model of Chum-Sung-Dae to study the dynamic characteristics of vibration and/or earthquake load and stiffness of structures.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1995.04a
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• pp.258-263
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• 1995

미래 정보와 시대에서 중추적인 역할을 할 광관련 멀티미디어 장비들은 최근 관련 산업계에서 주목을 받기 시작하고 있고 특히 기존 VTR(Video Tape Recorder) 시장을 대체할 차세대 DVDR(Digital Video Disk Recorder)는 기술전쟁이라고 할 정도로 선진 기업의 연구가 치열해지고 있다. DVDR 시스템에서는 필요한 정보들을 레이저빔을 이용한 광학신호로 바꾸어 광디스크에 기록, 재생하는 광픽업이 절대적으로 필요하게 된다. 그런데 광픽업의 위치추종기구인 Actuator는 정확한 위치추종(.+-.1.$\mu$m 오차이내)을 할 수 있는 성능이 요구되며 서보의 특성상 20KHz 이하에서 불필요한 모우드가 가진되지 않는 정밀부품이어야 하므로 Actuator 각 부품의 동적인 특성을 명확히 규명할 필요가 있다. 따라서 본 연구에서는 우선 Actuator 각 부품과 가동부 전체의 중량 및 진동해석을 통해 동특성을 조사하였다. 그리고 Actuator의 중요한 기본성능중 하나인 구동감도 확보여부를 검토할 필요가 있기 때문에 유한요소법 프로그램인 ANSYS를 이용하여 자기회로 부분에 대한 해석을 구하였다. 또한 가동부와 자기회로 등 하위부품을 조립하는 과정에서 발생하는 조립오차로 인해 불필요한 공진과 회전형상이 야기될 수 있으므로 동특성 및 문제점 파악을 위한 민감도 분석이 필요하다. 따라서 본 연구에서는 가동부의 관성 모멘트 값과 강체에 대한 일반식을 이용한 자체 프로그램을 작성하여 조립공차를 구하였다. 이와같은 과정을 통해 구해진 설계값을 바탕으로 실제 제작된 Actuator에 대해서는 비접촉식 측정방법을 통해 동특성값을 측정하였고 이를 해석값과 상호 비교하였다.동강성행렬법(dynamic stiffness matrix method)을 이용하여 해석하고자 한다. 수준임이 입증되었다. 본 연구의 결과를 토대로우리나라 젊고 건강한 남성에게 적합한 무게상수는 작업자군에 대하여 25.05kg, 학생군에 대하여 20.24kg 으로 나타나 이는 미국 NIOSH 안전기준과 대체로 일치함을 발견하였다.ive structures utilized in Client/server architecture for distribution and cooperative processing of application between server and client this study presents two different data management methods under the Client/server environment; one is "Remote Data Management Method" which uses file server or database server and. the other is "Distributed Data Management Method" using distributed database management system. The result of this study leads to the conclusion that in the client/server environment although distributed application is assumed, the data could become centralized (in the case of file server or database server) or decentralized (in the case of distributed

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1995.04a
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• pp.153-158
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• 1995

보 및 평판의 진동에 대해서 에너지의 손실은 재료감쇠를 이용한 표면감쇠처리나 지지부에서의 감쇠처리에 의하여 증가될 수 있다. 감쇠재료를 이용한 표면감쇠처리의 예로서 보/평판 표면에 접착되는 감쇠 테이프나 코팅등은 아주 효과적임이 입증되었다. 마찬가지로 지지부 감쇠처리는 점탄성재료의 삽입에 의해서 설명될수 있다[1]. 보/평판의 감쇠에 대한 최근의 많은 연구들은 진동하고 있는 보/평판의 표면에 적용하는 감쇠 테이프 혹은 적층형태의 감쇠 처리방법에 대해서 주로 수행되었다. 일반적으로 표면감쇠처리방법은 진동감소에 아주 효과적이지만 실제 적용상에서 항상 가능한 것은 아니며, 이와 같은 경웨는 지지부 감쇠 처리방법에 의존하게 된다[2]. 감쇠특성을 갖는 점탄성재료를 실제로 적용할 때 보/평판의 유한한 길이가 점탄성재료로 지지되며 점탄성재료의 물성치와 치수에 따라서 계의 모우드 매개변수(고유진동수, 계의 손실계수 그리고 모우드형상)가 크게 달라진다. 그리고 이와 같은 계에 대해서는 지지부의 거동보다는 전체 시스템의 고유진동수와 손실계수 그리고 보 영역에서의 모우드 형상에 더 관심이 있으므로 지지부 영역을 집중매개변수(lumped parameter)로 나타내어 계를 해석할 수 있다. 일반적으로 보와 평판의 경계에서는 병진 및 회전방향의 강성 뿐만 아니라 두 강성사이에 연성효과도 동시에 발생하게 되므로 이 항을 고려하여 계를 모델링해야 한다. 본 연구에서는 우선 점탄성 재료에 의한 지지부영역의 등가 강성계수들을 구하고 경계에 강성행렬을 갖는 보의 등가시스템을 얻는다. 그리고 등가시스템의 주파수방정식으로부터 모우드 매개변수에 대한 지지부의 영향을 살펴본다. 또한 시스템이 비교적 복잡한 사각 평판의 진동에 대해서도 동강성행렬법(dynamic stiffness matrix method)을 이용하여 해석하고자 한다. 수준임이 입증되었다. 본 연구의 결과를 토대로우리나라 젊고 건강한 남성에게 적합한 무게상수는 작업자군에 대하여 25.05kg, 학생군에 대하여 20.24kg 으로 나타나 이는 미국 NIOSH 안전기준과 대체로 일치함을 발견하였다.ive structures utilized in Client/server architecture for distribution and cooperative processing of application between server and client this study presents two different data management methods under the Client/server environment; one is "Remote Data Management Method" which uses file server or database server and. the other is "Distributed Data Management Method" using distributed database management system. The result of this study leads to the conclusion that in the client/server environment although distributed application is assumed, the data could become centralized (in the case of file server or database server) or decentralized (in the case of distributed database system) and the data management method through a distributed database system where complete responsi

• Journal of the Korean Society of Radiology
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• v.5 no.6
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• pp.391-400
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• 2011

Pneumonia is an infection of the lungs and respiratory system and can be classified by a variety of factors such as infectious agents, etiology, infection area, and other criteria. From a 46-year-old male, who was suspected of being infected with atypical pathogen pneumonia and underwent such tests as serological testing, examination of sputum, urine examination, parasite examination, bronchoscopy, needle biopsy and so on, no significant abnormality was found. This patient also showed no specific symptoms like auscultatory abnormalities, high fever, nonproductive cough, muscle stiffness, sputum production, dyspnea. Prescription of broad-spectrum oral antibiotics and ant-parasitic didn't seem to be effective against bacterial and atypical pathogen. The patient's condition alternately repeated between natural cure and recurrence. The average healing process during which scarring, nodule recurrence and disappearance on the lungs happened was about 20 days. Chest radiography and chest high resolution computerized tomographic scans(HRCT scan) was performed to depict parenchymal aberrations and demarcate the extent and distribution of atypical pathogen pneumonia. As a result, chest radiography did not show the specific symptoms, whereas areas of opacity (seen as white) which represent consolidation were revealed in chest HRCT scan. This indicates that only chest radiography is not that useful for early diagnosis of atypical pathogen pneumonia in patients, since it can't show exactly what the symptom is because of the barriers such as diaphragm, liver, and spine. Therefore, it is desirable that chest HRCT should be used in the diagnosis to compare with the results of chest radiography. Here, report with literature investigations the case of recurrent atypical pathogen pneumonia.

• Composites Research
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• v.29 no.3
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• pp.111-116
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• 2016

The tilting pad journal bearing for the turbo compressor application has a role to support high speed and heavy loading rotor. White metal has been widely used for the bearing material but the conventional bearing is immediately suspended and induces serious serious damage to the rotor under the unexpected oil cut situation or the insufficient oil film formation. The carbon fiber reinforced composite having high specific stiffness, specific strength and excellent tribological characteristics can solve these seizure problems. In this work, the study on the durability of high thermal resistance carbon fiber/epoxy composite tilting pad journal bearing under oil cut situation was conducted. The material properties of the composite materials including tensile, compressive and interlaminar properties were measured at room and high temperature of oil cut situation. To investigate the possibility of failure of composite tilting pad journal bearing under oil cut situation, the stress distribution of the composite bearing was analyzed via finite element analysis and the Tsai-Wu Failure index was calculated. To verify the failure analysis results, the oil cut tests for the composite tilting pad journal bearing were conducted using industrial test bench.

• Journal of the Korean Wood Science and Technology
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• v.43 no.4
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• pp.456-462
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• 2015

365 pieces of domestic $38{\times}140{\times}3600mm$ Red pine structural lumber were machine graded conforming to a softwood structural lumber standard (KS F 3020). The allowable bending stresses calculated for each grade were compared with the values currently tabulated in the standard. Four calculation methods for lower $5^{th}$ percentile bending stress were non-parametric estimation with 75% confidence level, 2-parameter and 3-parameter Weibull distribution fit, and bending modulus of rupture (MOR)-modulus of elasticity (MOE) regression based method. Only the data set of Grades E8, E9, and E10 were statistically eligible for the $5^{th}$ percentile calculation. The MOR-MOE regression based method only was able to estimate the lower $5^{th}$ percentile values theoretically for the full range of grades. The results showed that all allowable bending stresses calculated were lower than the design values tabulated in the standard. This implies that the current machine grading system has the pitfall of structural safety. Improvement in current machine grading system could be achieved by introducing the bending strength and stiffness combination grade system.