• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.75-82
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• 2017

The effects of acepromazine on human ether-$\grave{a}$-go-go-related gene (hERG) potassium channels were investigated using whole-cell voltage-clamp technique in human embryonic kidney (HEK293) cells transfected with hERG. The hERG currents were recorded with or without acepromazine, and the steady-state and peak tail currents were analyzed for the evaluating the drug effects. Acepromazine inhibited the hERG currents in a concentration-dependent manner with an $IC_{50}$ value of $1.5{\mu}M$ and Hill coefficient of 1.1. Acepromazine blocked hERG currents in a voltage-dependent manner between -40 and +10 mV. Before and after application of acepromazine, the half activation potentials of hERG currents changed to hyperpolarizing direction. Acepromazine blocked both the steady-state hERG currents by depolarizing pulse and the peak tail currents by repolarizing pulse; however, the extent of blocking by acepromazine in the repolarizing pulse was more profound than that in the depolarizing pulse, indicating that acepromazine has a high affinity for the open state of the channels, with a relatively lower affinity for the closed state of hERG channels. A fast application of acepromazine during the tail currents inhibited the open state of hERG channels in a concentration-dependent. The steady-state inactivation of hERG currents shifted to the hyperpolarized direction by acepromazine. These results suggest that acepromazine inhibits the hERG channels probably by an open- and inactivated-channel blocking mechanism. Regarding to the fact that the hERG channels are the potential target of drug-induced long QT syndrome, our results suggest that acepromazine can possibly induce a cardiac arrhythmia through the inhibition of hERG channels.

• Journal of Advanced Marine Engineering and Technology
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• 제35권7호
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• pp.966-973
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• 2011

Power distribution onboard vessel is typically configured as ungrounded system due to the ability to continuously supply electric power even when an earth fault occurs. The impedance connections between 3 phase power lines and hull cause the line-to-hull voltages to become unstable and increased in case the impedances are unbalanced, bringing the situation susceptible to electric shock and deterioration of insulation material. Also the line-to-hull voltage can reach to a certain maximum value in the steady state depending on the distributed capacitances and grounding resistances between lines and hull. This study suggests how to find and calculate the maximum line-to-hull voltage in view of magnitude and phase angle based on the vector diagram.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2016년도 전력전자학술대회 논문집
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• pp.231-232
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• 2016

This paper investigates the design of multi-winding coupled inductor for minimum inductor current ripple. Based on the general circuit model of coupled inductor together with the operating principles of dc-dc converter, the relationship between the ripple size of inductor current and the coupling factor is derived under the different duty ratio. The optimal coupling factor of n-phase multi-winding coupled inductor which corresponds to a minimum inductor ripple current becomes -(1/n-1), i.e. a complete inverse coupling without leakage inductance, as the duty ratio of steady-state operating point approaches 1/n, 2/n, ${\cdots}$ or (n-1)/n. In an opposite manner, the optimal coupling factor value of zero, i.e. zero mutual inductance, is required when the duty ratio of steady-state operating point approaches either zero or one. Therefore, coupled inductors having optimal coupling factor can minimize the ripple current of inductor and inductor size.

• 한국유체기계학회 논문집
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• 제14권2호
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• pp.29-34
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• 2011

Aerodynamic torque of wind turbine is highly nonlinear due to the nonlinear interactions between wind and blade. The aerodynamic nonlinearity is represented by nonlinear power and torque coefficients which are functions of wind speed, rotational speed of rotor, and pitch angle of blade. It is essential from the viewpoint of understanding and analysis of dynamic characteristics for wind turbine to linearize the aerodynamic torque and define aerodynamic nonlinear parameters as derivatives of aerodynamic torque with respect to the three parameters. In this paper, a linearization method of the aerodynamic torque from power coefficient is presented through differentiating it by the three parameters. And steady-state values of three aerodynamic nonlinear parameters according to wind speed are obtained and their nonlinear characteristics are investigated.

• Journal of Advanced Marine Engineering and Technology
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• 제40권5호
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• pp.412-417
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• 2016

A fin of finite width with infinitely small thickness is assumed to be placed horizontally between two horizontal parallel plates of infinite extension in the exactly central position. The lower plate and the half of the upper plate are kept at a constant lower temperature, and the remaining upper plate is kept at a constant higher temperature. The fin is also kept at a constant temperature (variable). Steady-state two-dimensional laminar natural convection is analyzed as a problem of boundary value under a boundary-fitted conformal mapping system, using a spectral finite difference scheme, with a condition of doubly-connectedness. The steady-state solution is obtained as a limit of the transient solution.

• 대한기계학회논문집A
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• 제21권2호
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• pp.337-345
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• 1997

An analysis is presented for the response of a beam constrained by a nonlinear spring to a harmonic excitation. The system is governed by a linear partial differential equation with a nonlinear boundary condition. The method of multiple scales is used to reduce the nonlinear boundary value problem to a system of autonomous ordinary differential equations of the amplitudes and phases. The case of the third-order subharmonic resonance is considered in this study. The autonomous system is used to determine the steady-state responses and their stability.

• 전기의세계
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• 제26권6호
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• pp.86-92
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• 1977

The phenomenon of non-steady-state current flow through the interface traps during the dielectric relaxation of MOS device is presented. Experimental method is also described for determining the energy distribution of interface traps, which is based on isothermal dielectric relaxation current technique. Actually, the energy distribution of interface traps was obtained by measuring the transient current through the traps at Si-SiO$_{2}$ interface only in lower-half of the bandgap. It is shown that the trap energy distributio has peak value 1.72*10$^{13}$ cm$^{-2}$ eV$^{-1}$ near 0.73eV approximately.

• 제어로봇시스템학회논문지
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• 제7권4호
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• pp.295-303
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• 2001

The demand for steam generators is increasing in industrial systems in which the design strategy should be implemented for safe and efficient operation of steam generators. It is, however, difficult to design a controller by the conventional method because of the nonlinear dynamics of the steam generator and influences by the set value of disturbance. This paper presents an automatic parameter optimization technique for a multivariable fuzzy controller using evolutionary strategy, At first, we use the steady state information such as a steady state gain matrix(SSGM) and a relative gain matrix(RGM). We can obtain much information on the control inputs and the outputs of the boiler-turbine system from the matrices. In order to determine the structure of the controller by using RGM and SSGM, the fuzzy rules are trained by evolutionary strategy. The good performance of the proposed multivariable fuzzy controller is verified through simulations.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 1998년도 The Korea Society for Simulation 98 춘계학술대회 논문집
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• pp.50-55
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• 1998

In this paper we use discrete simulation method to get the criteria of system evaluation required in the case of designing the complicated probabilistic event system having discrete probabilistic variables and to search the effective and reliable alternatives to satisfy the objective value of the given system through on-line, single run within the short time period. If we find the alternative we construct the algorithm which change values of decision variables and determining alternative by using the stopping algorithm which end the simulation in the steady state of system. In order to prevent the loss of data when we analyze the acquired design alternative in the steady state we provide the background of the estimation of the autoregressive model and mean and confidence interval for evaluating correctly the objective function obtained by the small amount of output data through the short time period simulation.

• 대한전기학회논문지:전기기기및에너지변환시스템부문B
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• 제48권11호
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• pp.663-669
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• 1999

This paper presents new self excited DC-DC converters such as Buck-boost type, Buck type and also non-inverting Buck-boost type. The proposed converters has the following advantages: simple topology, small number of circuit components, easy control method. Therefore, these converters are suitable for the portable appliances with battery source. It is especially suited for low power DC-DC conversion applications where non isolation output power is usually required. The steady state characteristics of proposed self exciting Buck-boost DC-DC converter are analysis and the result shows good agreement with experimental value. Furthermore the experimental results for 50W class self oscillating Buck-boost DC-DC converter have been obtained, which demonstrate the high efficiency and good performance.