• Journal of Pharmaceutical Investigation
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• v.23 no.3
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• pp.179-186
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• 1993

In vitro dissolution test and pharmacokinetic study in human volunteers were conducted to evaluate the pharmacokinetic characteristics of 150 mg furbiprofen sustained-release capsule (FPSR-150). As a reference product, 50 mg flurbiprofen conventional-release capsule (FPCR-50) was used. Dissolution tests of two products were run using the paddle method in 450 : 540 (v/v %) mixture of simulated gastric and intestinal fluids (K.P. VI) by adjusting medium pH according to time. FPCR-50 was dissolved very rapidly, and it took about 1.5 hr for FPCR-50 to be dissolved over 90%, whereas 15 hr for FPSR-150. Also, in pharmacokinetic study, ten healthy male volunteers were administered one capsule of FPSR-150 or two capsules of FPCR-50 (FPCR-l00) with randomized two period cross-over study. Significant differences between FPCR-l00 and FPSR-150 were found in mean times to reach peak concentration, mean resident times and mean terminal phase halflives, while not in AUC/Dose (Student's t-test). In ANOVA for AUC/Dose to compare the bioavailabilities of two FP products, there was no significant difference. From the comparison of the simulated steady-state plasma concentration-time curves following multiple medications of FPCR-50 (3 capsules a day, dosing interval=8 hrs) and FPSR-150 (1 capsule a day) based on the above results obtained from single doses of two FP products, it was noted that the medication of FPSR-150 is more useful in clinical application rather than FPCR-50.

• Journal of the Korean Society of Propulsion Engineers
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• v.4 no.2
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• pp.61-70
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• 2000

The performance simulation program on the turboprop engine(PT6A-62), which is a main engine of the first trainer KT-1 in republic of Korea, was developed. Characteristics of engine components were required for the steady-state performance analysis including on and off design point analysis. In most cases, these were substituted for what scaled from well known engine components characteristics with the scaling law. The developed program was compared with CASTURB program which is well known for the simulation performance analysis, such as analysis results of mass flow rate, compressor pressure ratio, fuel flow rate, power, specific fuel consumption ratio and turbine inlet temperature in the following four cases, to evaluate whether the developed program is acceptable or not. The first case was the sea level static standard condition and other cases were considered with various flight Mach numbers, altitudes. After verifying the developed program, the partload performance analysis was carried out. Transient performance analysis for various fuel schedules were performed. When the fuel step increase of 0.1sec was performed, the overshoot of the compressor turbine inlet temperature occurred. However, the fuel ramp increase for longer than 0.1sec time was performed, the overshoot could be eliminated.

• Korean Journal of Veterinary Research
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• v.14 no.1
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• pp.1-7
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• 1974

Little work has been done on the changes in the blood picture occurring at different ages in cattle. In our country Kim (1963) and Jeong (1965) recorded the blood picture of mature Korean native cattle and, recently, Mun et al. (1974) has recorded the blood picture of Holstein cows. And a comprehensive survey of the blood picture of Korean native cattle has not been made. The object of the present investigation was to make good this deficiency, and to suggest standards for the blood picture of Korean native cattle at frequent intervals from birth to maturity. The cattle were kept under average farming conditions in this country. Observations were made at the following ages: at birth; 1, 2 and 4 days; 1, 2 and 4 weeks; 2,4,6 and 9 months; 1, 2 and 3 years of age. Blood samples were drawn from the jugular vein. Erythrocyte enumerations, concentration of hemoglobin in blood and hematocrit values were made in usual manner. Erythrocyte counts increased from $8{\times}10^6/mm^3$ during the first week to a level of $10{\times}10^6/mm^3$ at 2 months of age, showing steady state untill 6 months of age; it then fell to adult level ($8{\times}10^6/mm^3$) at 9 months of age. Concentration of hemoglobin in blood and hematocrit values were closely related to the changes of erythrocyte counts. The values increased from 10 g/100 ml and 31~35 ml/100 ml during the early life to 11 g/100 ml and 38 ml/100 ml at 2 months of age, showing steady state untill 6 months of age; these then fell to adult level (10 g/100 ml and 31~34 ml/100 ml) at 9 months of age for concentration of hemoglobin in blood and hematocrit values, respectively. Mean corpuscular volume and mean corpuscular hemoglobin showed a common pattern. The values were $42{\sim}43{\mu}m^3$ and 12.4 pg during the early life and fell a little to 6~9 months of age; these then increased to reach adult levels of $43{\mu}m^3$ and 12.6 pg for mean corpuscular volume and mean corpuscular hemoglobin, respectively. Mean corpuscular hemoglobin concentration was little affected with age.

• The Korean Journal of Physiology and Pharmacology
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• v.2 no.2
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• pp.233-239
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• 1998

Stimulated alveolar macrophages and neutrophils produce nitric oxide, a free radical by an inducible nitric oxide synthase(iNOS), which reacts with superoxide anion to form peroxynitrite, a more highly reactive toxic species. The objectives of the present study were to evaluate acute inflammatory lung injury and to determine iNOS mRNA induction and nitric oxide production by rat broncho-alveolar lavage cells following intratracheal treatment of silica. After 4 h exposure to silica, differential counts of broncho-alveolar lavage cells and lactate dehydrogenase(LDH) activity as well as total protein in the broncho-alveolar lavage fluid were determined. Broncho-alveolar lavage cells were also assayed for iNOS mRNA and the productions of nitrite and nitrate measured in the cells cultured. Differential analysis of broncho-alveolar lavage cells showed that the number of alveolar macrophages slightly decreased following silica treatment; however, red blood cells, lymphocytes, and neutrophils significantly were increased by 9-, 14-, and 119-fold following silica treatment, respectively, compared with the saline control. It was also found significant increases in the LDH activity and total protein in the lavage fluid obtained from silica-treated rats, indicating silica-induced acute lung injury. Northern blot analysis demonstrated that the steady state levels of iNOS mRNA in broncho-alveolar lavage cells were increased following silica treatment. The productions of nitrite and nitrate in the cultured cells were significantly increased by 2-fold following silica treatment, respectively, which were attenuated by the NOS inhibitor $N{\omega}-nitro-L-arginine-methyl$ ester(L-NAME) and partially reversed by L-arginine. These findings suggest that nitric oxide production in alveolar macrophages and recruited neutrophils is increased in response to silica. Nitric oxide may contribute in part to acute inflammatory lung injury.

• BMB Reports
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• v.30 no.1
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• pp.21-25
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• 1997

The growth. freezing resistance and electrophoretic protein patterns of carrot callus cultures were investigated following treatment with NaCl for various' intervals at 20$^{\circ}C$. Following 7 day exposure to 250 mM NaCl. freezing tolerance increased, which was measured by 2.3.5-triphenyl tetrazolium chloride (TTC) assay and fresh weight was reduced compared to control cells. Changes of electrophoretic patterns of total and boiling stable proteins were investigated using one or two dimensional gel system. Several proteins with molecular weight of 43 and 21 kDa increased by NaCl treatment. The most prominent change was detected in 21 kDa protein. The steady state level of this protein increased in NaCl treated cells, but decreased in control cells. Twenty one kDa protein was detected only in the NaCl treated cell when boiling stable protein was analyzed. The isoelectric point of 21 kDa protein was identified as 5.7. The timing of increase of 21 kDa protein was correlated to freezing resistance which implied the role of this protein in the induction of freezing resistance of the cell.

• 제어로봇시스템학회:학술대회논문집
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• 2003.10a
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• pp.101-106
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• 2003

In the area of tracking control, it is important to design not only the controllers but also the trajectories to which a system has to follow. $5^{th}$ order polynomial is often used with constraints of initial and final states. Smooth ending with possible minimum time is important for many systems because of vibration or jerky motions. Examples are increased with development of technology in smaller, more accurate systems. On the base of a polynomial like trajectory generation method from a paper in ACC2002 and RIC(Robust Internal-loop Compensator) control scheme of Robotics and Bio-mechanics lab. of POSTECH, generalized and expanded polynomial like trajectory generation method is showed.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.139-145
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• 2001

The purpose of present study is to find design parameters and operating conditions of the HVAC system in a subway platform. The simulation was carried out for the flow, heat and mass transfer for heating, ventilating and air-conditioning(HVAC) environments in the subway platform. The steady-state. incompressible flow assumption and standard $k-{\varepsilon}$ turbulence model are adopted. The location of HVAC air inlet above platform and the volume flow rate of curtain air released from inlet B are chosen as main parameters in this study. The results of present study are following: In the case of existence of train, the heat and contaminant released under the train have no effect on the average temperature and mass fraction of contaminant in the platform, but heat released on the train has influence on the average temperature in the platform. Train acts as an obstacle to exhaust the contaminant in the platform, but has good effect on the average temperature in the platform.

• Proceedings of the KSME Conference
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• 2001.06d
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• pp.771-776
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• 2001

By matching a well established fast throughflow code, with standard loss correlations, and an efficient optimization algorithm, a new design system has been developed, which optimizes inlet and exit flow-field parameters for each blade row of a multistage axial flow turbine. The compressible steady state inviscid throughflow code based on streamline curvature method is suitable for fast and accurate flow calculation and performance prediction of a multistage axial flow turbine. A general purpose hybrid constrained optimization package, iSIGHT has been used, which includes the following modules: genetic algorithm, simulated annealing, modified method of feasible directions. The design system has been demonstrated using an example of a 5-stage low pressure steam turbine for 800MW thermal power plant previously designed by HANJUNG. The comparison of computed performance of initial and optimized design shows significant improvement in the turbine efficiency.

• Proceedings of KOSOMES biannual meeting
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• 2003.11a
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• pp.123-126
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• 2003

In the present paper, the analysis is on the safe navigation between ships moving each other in restricted waterways under the external force, such as wind or current The numerical simulation of manoeuvring motion was carried out to propose an appropriate safe speed and distance between ships, which is required to avoid marine disasters from the viewpoint of marine safety. From the inspection q this investigation, it indicates the following result In case of proximal navigation between ships under the wind and current, the low-speed vessel is potentially hazardous because the rudder force if low-speed vessel needed for steady-state course-keeping is not sufficient, compared to the high-speed vessel The manoeuvring characteristic based on this investigation will be very useful for keeping the safety of navigation from the practical point of ships design and traffic control in restricted waterways.

• 제어로봇시스템학회:학술대회논문집
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• 1993.10a
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• pp.206-211
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• 1993

This paper presents a new identification method which utilizes fuzzy inference in parameter identification. The proposed system has an additional control loop where a real plant is replaced by a plant model. The control system to be designed is to satisfy the following specifications: 1) It has zero steady-state error. 2) It has adequate damping characteristics. 3) 1),2) satisfied, it has a shortest rise-time. Fuzzy rules describe the relationship between comparison results of the features and magnitude of modification in the model parameter values. This method is effective in auto-tuning because the response of the closed loop is verified. The proposed method is tested in simulation for several plants with high-order lags and dead-times.