• Microbiology and Biotechnology Letters
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• v.28 no.1
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• pp.26-32
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• 2000

Electrostatic forces contribute to the high degree of enzyme transition state complementarity in enzyme catalyzed reaction and such forces are modified by the solvent through its dielectric constant and polar properties. The contributions of electrostatic interaction to the formation of ES complex and the stabilization of transition state of the trypsin catalyzed reaction were probed by kinetic studied with high pressure and solvent dielectric constant. A good correlation has been observed between the increase of catalytic efficiency of trypsin and the decrease of solvent dielectric constant. Activation volume linearly decreased as the dielectric constant of solvent decreased, which means the increase in the reaction rae. Moreover, the decrease of activation volume by lowering the solvent dielectric constant implies a solvent penetration of the active with and a reduction of electrostatic energy for the formation of dipole of the active site oxyanion hole. When the 야electric constant of the solvents was lowered to 4.7 unit, the loss of activation energy and that of free energy of activation were 2.262 KJ/mol and 3.169 KJ/mol, respectively. The results of this study indicate that the high pressure kinetics combined with solvent effects can provide unique information on enzyme reaction mechanisms, and the controlling the solvent dielectric constant can stabilize the transition state of the trypsin-catalyzed reaction.

• Korean Journal of Computational Design and Engineering
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• v.12 no.2
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• pp.87-94
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• 2007

The functional behavior of a consumer electronic product is nearly all expressed with human-machine interaction (HMI) tasks. Although physical prototyping and computer aided design (CAD) software can show the appearance of the product, they cannot properly reflect its functional behavior. In this paper, we propose an approach to virtual prototyping (VP) that incorporates HMI functional simulation into virtual reality techniques in order to enables users to capture not only the realistic look of a consumer electronic product but also its functional behavior. We adopt state transition methodology to capture the HMI functional behavior of the product into a state transition chart, which is later used to construct a finite state machine (FSM) for the functional simulation of the product. The FSM plays an important role to control the transition between states of the product. We have developed a VP system based on the proposed approach. The system receives input events such as mouse clicks on buttons and switches of the virtual prototype model, and it reacts to the events based on the FSM by activating associated activities. The system provides the realistic visualization of the product and the vivid simulation of its functional behavior using head-mounted displays (HMD) and stereo speakers. It can easily allow users to perform functional evaluation and usability testing. A case study about the virtual prototyping of an MP3 player is given to show the usefulness of the proposed approach.

• Journal of Magnetics
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• v.16 no.2
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• pp.192-195
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• 2011

The phase transition of vortex matter from solid to liquid was studied in iron-based superconductors. Based on the traditional vortex glass theory, we have examined the magnetoresistivity data of iron-based superconductors using our extended thermal activation model: $\rho(B,T)=\rho((T-T_g(B))/(T_c(0)-T_g(B)))^{v(z-1)}$. We predict that the magnetic field-dependent area S + $S_0$ which integrates $\rho$ with T is proportional to $B^{\beta}$, where ${\beta}$ is the vortex glass transition exponent. From our calculation, the vortex glass transition exponent is 0.33, close to the exponent of area $S_0$ + S is 0.31 in $SmO_{0.9}F_{0.1}FeAs$; the exponent of area S is 0.63, which is close to the irreversibility line exponent 2/3. Both of the results show the validity of our model. In addition, our model is shown to be effective in describing irreversibility behavior in layered superconductors.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.335-338
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• 2005

Though GF(2) CA can only handle data with bit units, GF(2$^{p}$) CA can handle data with byte units. In this paper we analyze the state-transition of nongroup cellular automata(CA) with a single attractor over GF(2$^{p}$). And we propose the constructing method of the state-transition diagram of a linear SACA over GF(2$^{p}$) by using the concept of basic path. Also we propose the state-transition diagram of the nonlinear complemented SACA by using the state-transition diagram of a linear SACA.

• Archives of Pharmacal Research
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• v.11 no.3
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• pp.181-184
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• 1988

The effect of clover saponin on the phase transition of liposomal lipid bilayers of dimyristoyl phosphatidylcholine was investigated with differential scanning calorimetry. The thermograms of the liposomal bilayers incorporated with the clover saponin were obtained, and the enthalpy changes and the sizes of cooperative unit of the transition were calculated. The results showed that incorporation of the clover saponin into the liposomal bilayers effectively reduced the transition temperature at which the transition from solid state to liquid-crystalline state occurs, and broadened the thermogram peaks. It also reduced the size of cooperative unit of the transition. These results indicate that the clover saponin might have significant effect on the fluidity of biological membranes.

• Journal of Microbiology and Biotechnology
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• v.15 no.3
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• pp.587-594
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• 2005

The contribution of electrostriction of water molecules to the stabilization of the negatively charged tetrahedral transition state of a lipase-catalyzed reaction was examined by means of kinetic studies involving high-pressure and solvent dielectric constant. A good correlation was observed between the increased catalytic efficiency of lipase and the decreased solvent dielectric constant. When the dielectric constant of solvents was lowered by 5.00 units, the losses of activation energy and free energy of activation were 7.92 kJ/mol and 11.24 kJ/mol, respectively. The activation volume for $k_{cat}$ decreased significantly as the dielectric constant of solvent decreased, indicating that the degree of electrostriction of water molecules around the charged tetrahedral transition state has been enhanced. These observations demonstrate that the increase in the catalytic efficiency of the lipase reaction with decreasing dielectric constant resulted from the stabilization of electrostatic energy for the formation of an oxyanion hole, and that this stabilization was caused by the increase of electrostricted water around the charged tetrahedral transition state. Therefore, we conclude that the control of solvent dielectric constant can stabilize the tetrahedral transition state, thus lowering the activation energy.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.10
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• pp.195-204
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• 1996

We suggest a transform method form asynchronous finite state machines (AFSMs) into signal transition graphs (STGs) for speed-independent circuit synthesis. Existing works synthesize nodes in the state graph increases exponentially as the number of input and output signals increases. To overcome the problem of the exponential data complexity, we transform AFSMs into STGs so that the previous synthesis algorihtm form STGs can be applied.Accoridng to the experimental results, it turns out that our synthesis method produces more efficient circuit than the previous synthesis methods.

• Bulletin of the Korean Chemical Society
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• v.11 no.6
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• pp.557-560
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• 1990

The transition from one stable steady state branch to another stable steady state branch in a simple metabolic system with positive feedback is discussed with the aid of the bimodal Gaussian probability distribution method. Fluctuations lead to transitions from one stable steady state branch to the other, so that the bimodal Gaussian evolves to a new distribution. We also obtain the fractional occupancies in the two stable steady states in terms of a parameter characterizing conditions of the system.

• International Journal of Naval Architecture and Ocean Engineering
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• v.10 no.4
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• pp.477-490
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• 2018

Effects of inflow Reynolds number (Re), turbulence intensity (I) and pressure gradient on the transition flow over a blade section were studied using the ${\gamma}-Re{\theta}$ transition model (STAR-CCM+). Results show that the $Re_T$ (transition Re) at the transition location ($P_T$) varies strongly with Re, I and the magnitude of pressure gradient. The $Re_T$ increases significantly with the increase of the magnitude of favorable pressure gradient. It demonstrates that the $Re_T$ on different blade sections of a rotating propeller are different. More importantly, when there is strong adverse pressure gradient, the $P_T$ is always close to the minimum pressure point. Based on these conclusions, the $P_T$ on model propeller blade surface can be estimated. Numerical investigations of pressure distribution and transition flow on a propeller blade section prove these findings. Last, a simple method was proposed to estimate the $P_T$ only based on the propeller geometry and the advance coefficient.

• Journal of the Korean Chemical Society
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• v.53 no.2
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• pp.99-110
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• 2009

Characteristics of supercooled liquid and glass, which are the states involved in glass transition, are reviewed. These states are non-equilibrium states, therefore, the glass transition is different from the usual phase transitions. Theories of glass transition and related experimental methods are briefly summarized.