• Title/Summary/Keyword: State Dependence

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Decreased Voltage Dependent $K^+$ Currents in Cerebral Arterial Smooth Muscle Cells of One-Kidney, One-Clip Goldblatt Hypertensive Rat

  • Oh, Young-Sun;Kim, Se-Hoon;Kim, Hoe-Suk;Jeon, Byeong-Hwa;Chang, Seok-Jong;Kim, Kwang-Jin
    • The Korean Journal of Physiology and Pharmacology
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    • v.3 no.5
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    • pp.471-479
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    • 1999
  • The Kv channel activity in vascular smooth muscle cell plays an important role in the regulation of membrane potential and blood vessel tone. It was postulated that increased blood vessel tone in hypertension was associated with alteration of Kv channel and membrane potential. Therefore, using whole cell mode of patch-clamp technique, the membrane potential and the 4-AP-sensitive Kv current in cerebral arterial smooth muscle cells were compared between normotensive rat and one-kidney, one-clip Goldblatt hypertensive rat (lK,lC-GBH rat). Cell capacitance of hypertensive rat was similar to that of normotensive rat. Cell capacitance of normotensive rat and 1K,lC-GBH rat were $20.8{\pm}2.3$ and $19.5{\pm}1.4$ pF, respectively. The resting membrane potentials measured in current clamp mode from normotensive rat and 1K,lC-GBH rat were $-45.9{\pm}1.7$ and $-38.5{\pm}1.6$ mV, respectively. 4-AP (5 mM) caused the resting membrane potential hypopolarize but charybdotoxin $(0.1\;{\mu}M)$ did not cause any change of membrane potential. Component of 4-AP-sensitive Kv current was smaller in 1K,lC-GBH rat than in normotensive rat. The voltage dependence of steady-state activation and inactivation of Kv channel determined by using double-pulse protocol showed no significant difference. These results suggest that 4-AP-sensitive Kv channels playa major role in the regulation of membrane potential in cerebral arterial smooth muscle cells and alterations of 4-AP-sensitive Kv channels would contribute to hypopolarization of membrane potential in 1K,lC-GBH rat.

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Novel Erbium(III)-Encapsulated Complexes Based on ${\pi}$-Extended Anthracene Ligands Bearing G3-Aryl-Ether Dendron: Synthesis and Photophysical Studies

  • Baek, Nam-Seob;Kim, Yong-Hee;Roh, Soo-Gyun;Lee, Dong-Hyun;Seo, Kang-Deuk;Kim, Hwan-Kyu
    • Macromolecular Research
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    • v.17 no.9
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    • pp.672-681
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    • 2009
  • A series of inert and photo-stable Er(III)-encapsulated complexes based on ${\pi}$-extended dendritic anthracene ligands bearing G3-aryl-ether dendron ([G3-AnX]-$CO_2H$), which retain different ${\pi}$-bridging systems, such as single (X= S), double (X= D) and triple (X= T) bonds was designed and synthesized to establish the structure-property relationship. The near infrared emission intensities of Er(III)-encapsulated complexes were enhanced dramatically by increasing the ${\pi}$-conjugated extension of anthracene ligands. The time-resolved luminescence spectra show monoexponential decays with a lifetime of $2.0{\sim}2.4ms$ for $Er^{3+}$ ions in thin films, and calculated intrinsic quantum yields of $Er^{3+}$ ions are in the range of $0.025{\sim}0.03%$. As a result, all Er(III)-encapsulated dendrimer complexes exhibit the near IR emission with the following order: $Er^{3+}-[G3-AnD]_3$(terpy) > $Er^{3+}-[G3-AnS]_3$(terpy) ${\approx}$ $Er^{3+}-[G3-AnT]_3$(terpy), because $Er^{3+}-[G3-AnD]_3$(terpy) has a higher relatively spectral overlap J value and energy transfer efficiency. In addition, the lack of detectable phosphorescence and no significant spectral dependence of the ${\pi}$-extended anthracene moieties on the solvent polarity support energy transfer from their singlet state to the central $Er^{3+}$ ion taking place in $Er^{3+}-[G3-AnX]_3$(terpy).

The Mechanism of the Decomposition of a Bronchodilator, S-Nitroso-N-acetyl-D,L-penicillamine (SNAP), by a Bronchoconstrictor, Aqueous Sulfite: Detection of the N-Nitrosohydroxylamine-N-sulfonate ion

  • Holder, Alvin A.;Marshall, Sophia C.;Wang, Peng George;Kwak, Chee-Hun
    • Bulletin of the Korean Chemical Society
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    • v.24 no.3
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    • pp.350-356
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    • 2003
  • The mechanism of the decomposition of a bronchodilator, S-nitroso-N-acetyl-D,L-penicillamine (SNAP) by a bronchoconstrictor, aqueous sulfite, has been investigated in detail. The decomposition was studied using a conventional spectrophotometer at 336 nm over the ranges: 0.010 ≤ $[S^{IV}]_T$ ≤ 0.045 mol $dm^{-3}$, 3.96 ≤ pH ≤ 6.80 and 15.0 ≤ θ≤ 30.0 ℃, 0.60 ≤ I ≤ 1.00 mol $dm^{-3}$, and at ionic strength 1.00 mol $dm^{-3}$ (NaCl). The rate of reaction is dependent on the total sulfite concentration and pH in a complex manner, i.e., $k_{obs}\;=\;k_1K_2[S^{IV}]_T/ ([H^+]\;+\;K_2)$. At 25.0 ℃, the second order rate constant, $k_1$, was determined as $12.5\;{\pm}\;0.15\;mol^{-1}\;dm^3\;s^{-1}$. ${\Delta}H^{neq}\;=\;+32\;{\pm}\;3 kJ\;mol^{-1}\;and\;{\Delta}S^{\neq}\;=\;-138\;{\pm}\;13\;J\;mol^{-1}K^{-1}$. The N-nitrosohydroxylamine-N-sulfonate ion was detected as an intermediate before the formation of any of the by-products, namely, N-acetyl-D,L-penicillamine. The effect of concentration of aqueous copper(Ⅱ) ions on this reaction was also examined at pH 4.75, but there was no dependence on $[Cu^{2+}]$. In addition, the $pK_a$ of SNAP was determined as 3.51 ± 0.06 at 25.4 ℃ [I = 1.0 mol $dm^{-3}$ (NaCl)].

Enhanced Piezoelectric Properties of Lead-Free La and Nb Co-Modified Bi0.5(Na0.84K0.16)0.5TiO3-SrTiO3 Ceramics

  • Malik, Rizwan Ahmed;Hussain, Ali;Maqbool, Adnan;Zaman, Arif;Song, Tae Kwon;Kim, Won Jeong;Kim, Myong Ho
    • Korean Journal of Materials Research
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    • v.25 no.6
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    • pp.288-292
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    • 2015
  • New lead-free piezoelectric ceramics $0.96[\{Bi_{0.5}(Na_{0.84}K_{0.16})_{0.5}\}_{1-x}La_x(Ti_{1-y}Nb_y)O_3]-0.04SrTiO_3$ (BNKT-ST-LN, where $x=y=0.00{\leq}(x=y){\leq}0.015)$ were synthesized using the conventional solid-state reaction method. Their crystal structure, microstructure, and electrical properties were investigated as a function of the La and Nb (LN) content. The X-ray diffraction patterns revealed the formation of a single-phase perovskite structure for all the LN-modified BNKT-ST ceramics in this study. The temperature dependence of the dielectric curves showed that the maximum dielectric constant temperature ($T_m$) shifted towards lower temperatures and the curves became more diffuse with an increasing LN content. At the optimum composition (LN 0.005), a maximum value of remnant polarization ($33C/cm^2$) with a relatively low coercive field (22 kV/cm) and high piezoelectric constant (215 pC/N) was observed. These results indicate that the LN co-modified BNKT-ST ceramic system is a promising candidate for lead-free piezoelectric materials.

Mössbauer Study of AIFeO3 (AIFeO3 물질의 Mössbauer 분광학적 연구)

  • We, Jee-Hoon;Kim, Sam-Jin;Kim, Chul-Sung
    • Journal of the Korean Magnetics Society
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    • v.16 no.1
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    • pp.14-17
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    • 2006
  • [ $AIFeO_3$ ]has been studied by x-ray diffraction (XRD), vibrating sample magnetometer, Mossbauer spectroscopy. The crystal structure is found to orthorhombic with the lattice parameters being $a_0=4.983\;{\AA},\;b_0=8.554\;{\AA},\;c_0=9.239\;{\AA}$, Magnetic hysteresis curve for $AIFeO_3$ showed weakly ferromagnetic phase at room temperature and a asymmetric shape dependent on the direction of applied field at low temperature. The Curie temperature determined by the temperature dependence of magnetization is 250 K. Mossbauer spectra of $AIFeO_3$ have been taken from 4.2 K to 295 K. Isomer shift at room temperature are found to be $0.11\~0.32\;mm/s$, which is consistent with ferric state. The absorption lines widths become broader with increasing temperature, which is attributed to the Fe ions distribution of each cation site and anisotropy energy difference of each sublattice.

Optimal design of binary current leads cooled by cryogenic refrigerator (극저온 냉동기로 냉각되는 이중전류도입선의 최적설계)

  • Song, S.J.;Chang, H.M.
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.9 no.4
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    • pp.552-560
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    • 1997
  • Analysis is performed to determine the optimal lengths or cross-sectional areas of refrigerator-cooled current leads that can be applied to the conduction-cooled superconducting systems. The binary current lead is composed of the series combination of a normal metal at the upper(warm) part and a high $T_c$ superconductor(HTS) at the lower(cold) part. The heat conduction toward the cold end of HTS part constitutes a major refrigeration load. In addition, the joint between the parts should be cooled by a refrigerator in order to reduce the load at the low end and maintain the HTS part in a superconducting state. The sum of the work inputs required for the two refrigeration loads needs to be minimized for an optimal operation. In this design, three simple models that depict the refrigeration performance as functions of cooling temperature are developed based on some of the existing refrigerators. By solving one-dimensional conduction equation that take into account the temperature-dependent properties of the materials, the refrigeration works are numerically calculated for various values of the joint temperature and the sizes of two parts. The results show that for given size of HTS, there exist the optimal values for the joint temperature and the size of the normal metal. It is also found that the refrigeration work decreases as the length of HTS increases and that the optimal size of normal metal is quite independent of the size of HTS. For a given length of HTS, there is an optimal cross-sectional area and it increases as the length increases. The dependence of the optimal sizes on the refrigerator models employed are presented for 1kA leads.

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The Effect of Product Involvement on Consumer Purchase Process (제품관여(製品關輿)가 소비자(消費者) 과정(過程)에 미치는 영향(影響))

  • Young, Jung-Moon
    • Korean Business Review
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    • v.11
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    • pp.101-122
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    • 1998
  • This study is to analyze the effect of product involvement on consumer purchase process. From review on previous involvement literatures, enduring product involvement can be defined as "a person's arousal and motivational state activated by product on the basis of his basic value, objective and ego-relevance." To evaluate the effect of involvement on product purchase process, 11 hyphotheses concerning behavioral aspects which is expected to comprise consumer purchase process and to be influenced by degree of involvement were constructed: prepurchase information search, alternative brand comparision, utilization of product attribute, brand differentiation, brand commitment, product knowledge, influence of reference group, dependence on price, price awareness, cognitive dissonance and purchase optimization. Hyphotheses are tested with data from 388 housewives through 20 item involvement scale developed with multi-dimensional perspective on involvement. The scale successfully provides rank order of 8 selected products expected to cover the spectrum of product involvement: formal clothes, coffee, washing machine, shampoo, perfume, detergent, soft drink, pain-reliever as the order of product involvement. Major findings of this study are as follow. First of all, incresed differences were found in hihg involvement product like formal clothes with respect to the degree of prepurchase information search, alternative brand comparision, utilization of product attribute, influence of reference group in any method of analysis. Secondly, invlovement should be interpreted as a consumer characteristic rather than a product one. This means that consumers involve themselves with products, instead products themselves do not have any involvement.

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A Thermal Model for Silicon-on-Insulator Multilayer Structure in Silicon Recrystallization Using Tungsten Lamp (텅스텐 램프를 이용한 실리콘 재결정시의 SOI 다층구조에 대한 열적모델)

  • 경종민
    • Journal of the Korean Institute of Telematics and Electronics
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    • v.21 no.5
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    • pp.90-99
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    • 1984
  • A onetimensional distribution of the temperature and the heat source in the SOI (silicon-on-insulator) multi-layer structure illuminated by tungsten lamps from both sides was obtained by solving the heat equation in steady state on a finite difference grid using successive over-relaxation method. The heat source distribution was obtained by considering such features as spectral components of the light source, multiple reflection at the internal interfaces, temperature and frequency dependence of the light absorption coefficient, etc. The front and back surface temperatures, which are boundary conditions for the heat equation, were derived from a requirement that they satisfy the radiation conditions. The radiation flux as well as the conduction flux was considered in modelling the thermal behaviour at the internal interfaces. Since the temperature and the heat source profiles are strongly dependent upon each other, the calculation of each profile was iterated using the updated profile of the other until they are consistent with each other. The experimental temperature at the front surface of the wafer as measured by Pyrometer was about 1200$^{\circ}$K, while the simulated temperature was 1120$^{\circ}$K.

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Microstructure and Giant Magnetoresistance of AgCo Nano-granular Alloy Films (Ag-Co합금박막의 두께에 따르는 미세구조 변화 및 자기저항 거동)

  • 이성래;김세휘
    • Journal of the Korean Magnetics Society
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    • v.8 no.3
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    • pp.131-137
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    • 1998
  • The thickness dependence of the microstructure and the giant magnetoresistance behavior of co-evaporated Co-Ag granular alloy films were investigated. The maximum magnetoresistance ratio of 24% was observed in the the as-deposited state of the 40 at. % Co alloy having 200 nm thickness. The surface scattering contributed about 20% to the total resistivity in the 20 nm thick films. The MR ratio dropped sharply when the film thickness was below 50 nm. The reduction in the Co particle size and the increase in solid solubility of Ag in fcc Co when the film thickness decreased were observed using a high resolution TEM. The aspect ratio of the Co particles was also affected by the film thickness. Those microstructural changes as well as the surface induced spin flipping play a significant role in the $\Delta$p change.

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Investigation of High Frequency Properties of Y-type Hexaferrite Dependence on Synthesis Condition (소결 조건에 따른 Y-type Hexaferrite의 고주파 특성)

  • Lim, Jung Tae;Kim, Chul Sung
    • Journal of the Korean Magnetics Society
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    • v.24 no.2
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    • pp.56-59
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    • 2014
  • The samples of $Ba_2CoZnFe_{12}O_{22}$ was synthesized by the solid-state reaction method. The toroids of $Ba_2CoZnFe_{12}O_{22}$ were sintered with various sintering temperature at 1050, 1100, 1150, and $1200^{\circ}C$, and studied by x-ray diffractometer, vibrating sample magnetometer, network analyzer, and Mssbauer spectrometer. From the XRD patterns, the density of samples increased with increasing sintering temperature. From the magnetic hysteresis curves up to 10 kOe at 295 K, the saturation magnetization ($M_s$) of $Ba_2CoZnFe_{12}O_{22}$ samples in various sintered at 1050, 1100, 1150 ,and $1200^{\circ}C$ were showed around $M_s$= 33.0 emu/g. However, With increasing sintering temperature, the coercivity ($H_c$) of samples decrease. Complex permeability and permittivity of samples in various sintering temperatures were measured between 100MHz to 4 GHz. With increasing sintering temperature, the permeability of samples increase.