• International Journal of Concrete Structures and Materials
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• 제10권2호
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• pp.163-175
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• 2016

This paper presents a revised procedure for computation of double-K fracture parameters of concrete split-tension cube specimen using weight function of the centrally cracked plate of finite strip with a finite width. This is an improvement over the previous work of the authors in which the determination of double-K fracture parameters of concrete for split-tension cube test using weight function of the centrally cracked plate of infinite strip with a finite width was presented. In a recent research, it was pointed out that there are great differences between a finite strip and an infinite strip regarding their weight function and the solution of infinite strip can be utilized in the split-tension specimens when the notch size is very small. In the present work, improved version of LEFM formulas for stress intensity factor, crack mouth opening displacement and crack opening displacement profile presented in the recent research work are incorporated. The results of the double-K fracture parameters obtained using revised procedure and the previous work of the authors is compared. The double-K fracture parameters of split-tension cube specimen are also compared with those obtained for standard three point bend test specimen. The input data required for determining double-K fracture parameters for both the specimen geometries for laboratory size specimens are obtained using well known version of the Fictitious Crack Model.

• 한국멀티미디어학회논문지
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• 제12권5호
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• pp.677-687
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• 2009

모바일 환경은 데이터 콘텐츠 이용에 유리한 조건을 갖고 있음에도 불구하고, MPEG-4 BIFS 기반 환경에서는 진보된 데이터 콘텐츠 구현이 쉽지 않다. BIFS는 VRML을 모태로 하여 방송 콘텐츠와는 타켓 콘텐츠 및 콘텐츠 개발 어프로치가 다르며, 모바일 방송환경에서 이용하기에는 표준이 너무 복잡하여 구현이 쉽지 않기 때문이다. 따라서 본 논문에서는 시청자가 방송 콘텐츠와 상호작용할 수 대화형 3D 객체 및 GUI를 제공하는 진보된 모바일 TV 콘텐츠 모델을 제시하고자 하며, 이를 실제 DMB 환경에 적용함으로써 향후 모바일 방송 콘텐츠의 발전 방향을 제시하고자 한다. 모바일 방송 콘텐츠에서의 3D 객체 표현을 위해 MPEG-4 BIFS 3D 노드를 분석하여 VRML 프로파일의 서브셋을 구성하였으며, GUI 표현을 위한 노드틀을 새로 정의하여 콘벤츠 개발 단계에서 활용할 수 있도록 하였다. 이와 같은 연구를 통해 모바일 데이터 콘텐츠 구성 시 3D 그래픽스와 인터랙션 표현이 쉬워진다면, 콘텐츠 개발의 효율성을 증대되어 모바일 방송 환경에 적합한 다양한 콘텐츠 개발이 활성화 될 수 있을 것이라 기대된다.

• 한국항행학회논문지
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• 제19권6호
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• pp.607-613
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• 2015

최근의 이동통신 트래픽의 증가 수요에 대처하기 위한 10 GHz 이상의 M/W(microwave) 이동통신용 단거리 백홀을 설계하기 위해서는 구축지점에서의 강우 페이드에 의한 감쇠와 어스 벌지 및 프레넬 존 등 지형적 대기조건을 종합적으로 고려해야 한다. 이에 본 논문에서는 국내 강우강도 표준 값을 이용하여 여러 주파수 대역에서 경로길이를 이론적으로 계산하고, SMIS (spectrum management intelligence system)를 활용한 대도심의 전파경로 프로파일을 분석한다. 이 결과를 토대로 해외의 최소 경로길이 기준과 비교분석을 행해 현재 모든 주파수에 대해 10 km로 정하고 있는 국내 기준 값을 주파수 대역별로 세분화하여 최소 경로길이를 제시한다. 본 논문의 결과는 국내 도시에서의 이동통신용 M/W 백홀 설계의 기본 데이터를 제공하여 고주파수 대역의 단거리 광대역 이동통신 백홀용으로 주파수의 유효이용을 촉진시키는데 유용하게 활용될 것이다.

• Journal of Nutrition and Health
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• 제29권10호
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• pp.1087-1095
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• 1996

The study was carried out to investigate a new type of functional foods with hypotensive effect which is critical in the prevention and treatment of hypertension and related circulatory diseases. The experimental diets(A, B, C) were prepared from plant based ingredients such as buckwheat, potato, perilla seed with different ratios formulated as an edible form appropriate for human consumption according to AIN-77 standard. Control group(D) was fed commercial rat chow. Twety-four 15-week-old SDR(Sprague Dawley rats) and twenty-four 20-week-old SHR(spontaneously hypertensive rats), weighing 200g respectively, were assigned to 4 treatments of 6 rats each in a completely randomized design. Blood pressure was measured at 7 day interval by tail-cuff sphygmomanometer using an IITC cuff pump and amplifier. The growth rates of both SHR and SDR were not statistically different in comparions with the control except those of diet B and C in SDR and SHR, respectively(p<0.05). When exprimental diets were fed, systolic blood pressure of SDR and SHR at day 28 had been lowered by 17-20 mmHg(ave. of 19.6mmHg for both strains) compared with the reference pressure at day 0. The levels of HDL-cholesterol were increased, while the levels of LDL-cholesterol consistently decreased in both strains when experimental diets were fed(p<.05). Plasma total cholesterol levels were not different among treatments. Plasma triglyceride levels were higher in control diet(commercial rat chow) due to two times higher fat content of control diet itself(p<.05). Atherogenic indices were lower compared to those of control when the experimental diets were fed in both strains (p,.05). The results suggest that the antihypertensive diets mainly consisting of plant-based ingredients may possibly effective in relieving hypertension as well as circulatory diseases.

• Journal of Nutrition and Health
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• 제45권4호
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• pp.303-314
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• 2012

The purpose of this study was to investigate the relationship between dietary fat intake, anthropometric data, blood lipids, C-reactive protein, and adiponectin in Korean male college students. Forty-eight subjects were divided into 2 groups based on dietary fat intake: UERF (under 30% of energy ratio for fat source), AERF (above 30% of energy ratio for fat souce). We collected dietary intake data using 24-hour dietary recall for 3 days. Anthropometric and biochemical parameters were measured by using standard methods. Segmental body composition analysis was carried out using an 8-electrode multifrequency bioelectrical impedance method of body fat estimation. There was no significant difference in anthropometric data and serum lipid profile between UERF and AERF group. Serum C-reactive protein level was significantly higher in the AERF group compared to the UERF group. Although there was no significant difference in serum adiponectin level between UERF and AERF groups, subjects had lower adiponectin levels. Correlation data show that serum adiponectin level was positively correlated with vegetable intake (p < 0.05). In addition, dietary fat intake had a positive correlation with meat (p < 0.01), whereas a negative correlation with grain (p < 0.01), vegetables (p < 0.05), and fish (p < 0.05). These results suggest that the increased fat intake of non-obese Korean male college students is associated with their increased serum C-reactive protein concentration. Therefore, proper guidelines on fat intake and nutrition education are necessary for the prevention and management of metabolic syndromes.

• 대기
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• 제17권4호
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• pp.339-348
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• 2007

Global Environment Laboratory at Yonsei University in Seoul ($37.57^{\circ}N$, $126.95^{\circ}E$) has carried out the ozone layer monitoring program in the framework of the Global Ozone Observing System of the World Meteorlogical Organization (WMO/GAW/GO3OS Station No. 252) since May of 1984. The daily measurements of total ozone and the vertical distribution of ozone amount have been made with the Dobson Spectrophotometer (No.124) on the roof of the Science Building on Yonsei campus. From 2004 through 2006, major parts of the manual operations are automated in measuring total ozone amount and vertical ozone profile through Umkehr method, and calibrating instrument by standard lamp tests with new hardware and software including step motor, rotary encoder, controller, and visual display. This system takes full advantage of Windows interface and information technology to realize adaptability to the latest Windows PC and flexible data processing system. This automatic system also utilizes card slot of desktop personal computer to control various types of boards in the driving unit for operating Dobson spectrophotometer and testing devices. Thus, by automating most of the manual work both in instrument operation and in data processing, subjective human errors and individual differences are eliminated. It is therefore found that the ozone data quality has been distinctly upgraded after automation of the Dobson instrument.

• Toxicological Research
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• 제26권3호
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• pp.185-192
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• 2010

Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about 8 g/kg) of the feed for a period of 3 months and 6 months. The fatty acid composition profile as indicated GC-MS, showed significantly slight dose-dependent increases in the levels of unsaturated fatty acids, particularly, arachidonic acid (C20: 4n6), oleic acid, linoleic acid, eicosadienoic acid, eicosapentaenoic acid (EPA) (C20: 5) concentration in the the ad libitum IS-fed groups compared to the control group in SD abdominal fat over 6 month period. Over viewing of the SD and Ob mice treated Isaria sinclairii powder; there were increases in the single (mono) unsaturated fatty acids ratio but decreases in polyunsaturated fatty acid. In IS-fed groups in proportion to the treatment period, this Dongchunghacho also induced an increase in the level of same result of unsaturated fatty acid in C57BL/6 obese (ob/ob) mice over a 6-month period treatment compared to those given 10% dry mulberry leaf powder (ML) or silkworm powder mixed with the standard diet.

• 대한약침학회지
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• 제19권2호
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• pp.114-121
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• 2016

Objectives: Lung cancer remains a deadly disease with unsatisfactory overall survival. Cisplatin, a standard platinum (Pt)-based chemotherapeutic agent, has the potential to inhibit the growth of lung cancer. Its use, however, is occasionally limited by severe organ toxicity. However, until now, no systematic study has been conducted to verify its efficacy with proper experimental support in vivo. Therefore, we examined whether biosynthesized Pt nanoparticles (NPs) inhibited human lung cancer in vitro and in vivo to validate their use in alternative and complementary medicine. Methods: We evaluated the in vitro and the in vivo anticancer efficiencies of biosynthesized Pt NPs in a subcutaneous xenograft model with A549 cells. Severe combined immune deficient mice (SCID) were divided into four groups: group 1 being the vehicle control group and groups 2, 3 and 4 being the experimental groups. Once the tumor volume had reached $70-75mm^3$, the progression profile of the tumor growth kinetics and the body weights of the mice were measured every week for 6 weeks after oral administration of Pt NPs. Doses of Pt NPs of 500, 1,000 and 2,000 mg/kg of body weight were administered to the experimental groups and a dose of honey was administered to the vehicle control group. The efficacy was quantified by using the delay in tumor growth following the administration of Pt NPs of A549 human-lung-cancer xenografts growing in SCID mice. Results: The in vitro cytotoxicity evaluation indicated that Pt NPs, in a dose-dependent manner, inhibited the growth of A549 cells, and the in vivo evaluation showed that Pt NPs at the mid and high doses effectively inhibited and delayed the growth of lung cancer in SCID mice. Conclusion: These findings confirm the antitumor properties of biosynthesized Pt NPs and suggest that they may be a cost-effective alternative for the treatment of patients with lung cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권2호
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• pp.463-466
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• 2016

Glioblastoma (GBM) is the most common and aggressive type of primary brain neoplasm. The current standard therapy for GBM consists of maximal surgical resection within safe limits, followed by radiation therapy (RT) and chemotherapy with temozolomide. Despite advances in treatment, the prognosis of GBM remains poor. Epileptic seizure is one of the most common symptoms in patients with GBM. Valproic acid (VPA), a histone deacetylase inhibitor, is often used as an anti-epileptic drug in patients with brain neoplasms due to its effectiveness and low toxicity profile. Several in vivo and in vitro studies have indicated that VPA has radiosensitizing effects for gliomas and radioprotective influence on normal brain tissue or hippocampal neurons. The results of several retrospective studies have also indicated potential benefit to improve survival of patients with GBM. Moreover, the promising treatment results of a phase 2 trial of concurrent radiation therapy, temozolomide, and VPA for patients with GBM have been recently reported. The use of VPA in patients with GBM has thus recently receiving more attention. In this article, we review the role of VPA in radiation therapy for GBM, focusing on the clinical evidence.

• 한국도서관정보학회지
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• 제39권4호
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• pp.353-376
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• 2008

본 연구의 주된 목적은 메타데이터 응용프로파일 설계에 필요한 분석 과정 방법론을 개발하고, 개발된 방법론에 따라 한국문화예술교육진흥원을 위한 총괄적인 메타데이터 응용프로파일을 설계하는 것이다. 분석과정은 기존 표준 메타데이터의 분석, 이용자 요구 분석, 콘텐트 분석으로 나뉘어 진행되었다. 각 과정을 수행하기 위한 방법론을 상세하게 기술하였으며 이와 함께 응용프로파일을 설계할 때 메타데이터 설계의 기본지침을 활용하였다. 이런 방법론을 문화예술교육진흥원 사례에 적용하고, 각 방법론이 메타데이터 요소 추출에 있어 어떤 역할을 하는지 논의하였다. 본 연구에서 개발된 체계적인 메타데이터 응용프로파일 설계 방법론이 향후 다른 도메인 응용프로파일 설계의 지침서로 활용될 수 있기를 기대한다.