• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
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• pp.77-85
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• 2004

A significant portion (about 8% in human genome) of mammalian mRNA sequences contains AU(Adenine and Uracil) rich elements or AREs at their 3' untranslated regions (UTR). These mRNA sequences are usually stable. ARE motifs are assorted into three classes. The importance of AREs in biology is that they make certain mRNA unstable. We analyzed the occurrences of AREs and Alu, and propose a possible mechanism on how human mRNA could acquire and keep A REs at its 3' UTR originated from Alu repeats. Interspersed in the human genome, Alu repeats occupy 5% of the 3' UTR of mRNA sequences. Alu has poly-adenine (poly-A) regions at the end that lead to poly -thymine (poly-T) regions at the end of its complementary Alu. It has been discovered that AREs are present at the poly -T regions. In the all ARE's classes, 27-40% of ARE repeats were found in the poly -T region of Alu with mismatch allowed within 10% of ARE's length from the 3' UTRs of the NCBI's reference m RNA sequence database. We report that Alu, which has been reported as a junk DNA element, is a source of AREs. We found that one third of AREs were derived from the poly -T regions of the complementary Alu.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 춘계학술대회
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• pp.2076-2082
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• 2003

A cross-flow fan is widely used on many industrial fields: mining industry, automobile and home appliances, etc. The design point of the cross-flow fan is generally based on the region within low static pressure and high flow rate. It relatively makes high dynamic pressure at low speed because a working fluid passes through an impeller blade twice. However, it has low static pressure efficiency between 30% and 40% because of relative high impact loss. Recently, in the air-conditioning systems, the operating behaviors at the off-design points are highly regarded to broaden the application area for various air-cooling loads. Especially, at the lower flow rate, there exists a rapid pressure head reduction, a noise increase and an irregular flow field against a rearguider as a scroll of centrifugal fan. Numerical analyses are carried out for investigating the flow characteristics in a cross-flow fan including the impeller, the rearguider and the stabilizer. Especially, various types of rearguiders are estimated by numerical and experimental methods to insure the stable operation in the region of lower flow rate. Numerical domains are discretized by hexahedral cells. Three-dimensional, unsteady governing equations are solved using FVM, PISO algorithm, sliding grid system and standard ${\kappa}-{\varepsilon}$ turbulence model. ASHRAE standard fan tester is also used to estimate the performance of the modeled crossflow fan.

• 공업화학
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• 제8권4호
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• pp.617-623
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• 1997

폴리솔베이트-핵산올-물의 3성분계의 상거동에 관한 메카니즘을 조사한 것으로, 등방성인 미셀영역에서 비등방성인 모자이크 액정상을 편광현미경에 의해 관찰하였다. 액정상 및 다른 상들은 약 20~70 wt% 범위에서 관측되었으며, 이 영역에서는 보다 안정한 유화계나 분산계의 포뮬레이션에 대한 기본적인 데이터를 제공할 수 있다. 알킬기의 탄소수 증가에 따라 3상 영역이 감소한 반면에, 2상 영역이 증가되었으며 비등방성 액정상은 관찰되지 않았다.

• 생명과학회지
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• 제13권5호
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• pp.751-755
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• 2003

Cyclic AMP receptor proteins(CRP) activate many genes in Escherichia coli by binding of cAMP with not fully known mechanism. CRP existed as apo-CRP in the absence of cAMP, $CRP;(cAMP)_2$$_2$ at low(micromolar) cAMP concentration, or $CRP;(cAMP)_4$ at high(millimolar) concentration of cAMP. This study is designed to measure the thermal stability of S83G CRP, which substituted glycine for serine at amino acid 83 position, with CD spectrapolarimeter at 222nm by the constant elevation of temperature from $20^{\circ]C\; to\; 90^{\circ}C\; at\; 1^{\circ}C/min$. The non-linear regression analysis showed that melting temperatures were 68.4, 72.0, and $82.3^{\circ}C$ for no cAMP, 0.1mM cAMP, and 5mM cAMP, respectively. Result showed the strong thermal stability of CRP by binding of additional cAMP molecules to region between the hinge region and helix-turn-helix(HTH) motif at 5mM cAMP concentration.

• International Journal of Quality Innovation
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• 제1권1호
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• pp.89-96
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• 2000

Evolutionary operation (EVOP) is a continuous improvement system which explores a region of process operating conditions by deliberately creating some systematic changes to the process variable levels without jeopardizing the product. It is aimed at securing a satisfactory operating condition in full-scale manufacturing processes, which is generally different from that obtained in laboratory or pilot plant experiments. Information on how to improve the process is generated from a simple experimental design. Traditional EVOP procedures are established on the assumption that the variance of the response variable should be small and stable in the region of the process operation. However, it is often the case that process noises have an influence on the stability of the process. This process instability is due to many factors such as raw materials, ambient temperature, and equipment wear. Therefore, process variables should be optimized continuously not only to meet the target value but also to keep the variance of the response variables as low as possible. We propose a scheme to achieve robust process improvement. As a process performance measure, we adopted the mean square error (MSE) of the replicate response values on a specific operating condition, and used the Kruskal-Wallis test to identify significant differences between the process operating conditions.

• 천문학회보
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• 제35권2호
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• pp.48.2-48.2
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• 2010

Quiescent filaments are bigger, more stable, and longer lived than active region filaments. So, the shape of a quiescent filament changes little during its lifetime and a fast motion of plasma rarely occurs. But when it is dynamically influenced by external phenomena, a rapid motion of plasma may temporarily occur. By analyzing the motion of plasma we can infer some of the magnetic structure permeating such an excited quiescent filament. We analyzed the H$\alpha$ images of a quiescent filament in the northern hemisphere that was observed at Big Bear Solar Observatory on 2004 August 2, and found that: 1) the filament was excited by a flare that occurred in a remote active region located in the southern hemisphere, 2) By this excitation, a part of the filament moved vertically upward and horizontally out of main body, and then it stayed there without much motion. Then after it moved vertically downward and horizontally to the main body, 3) the final position of plasma, however, was not the same as the initial position, being about 14Mm above it. We suggest that the filament was initially in a more or less static equilibrium. The excitation of the filament broke the initial equilibrium, and then brought about a new one that is different from the original one. Since the filament should have magnetic field, it is likely that both the equilibria may have been maintained by diplike magnetic structures. Furthermore, the transition from one equilibrium to another as we inferred should have accompanied a permanent change of magnetic configuration as well.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2003년도 추계학술대회
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• pp.881-886
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• 2003

In spite of its simple design, structure and operating mechanism, swing check valves are one of the critical components which adversely affect the safety of the nuclear power plants if they fail to function properly. Therefore, it is important to evaluate the performance condition of the swing check valves in safety-related systems. The performance characteristics of swing check valves include opening characteristics, the minimum required flow velocity, the pressure drop at design flow, the disc stability, and the effect of the upstream disturbances. Among factors to identify the performance of a swing check valve, a method to evaluate the opening characteristics and the minimum required flow velocity, which guarantees to fully open the disc and hold the disc without motion, are presented to determine the operating region of the swing check valve, such as stable, tapping, or oscillation. Based on the determined operating region and opening characteristics, the simple methods of wear and fatigue analyses of the specific parts of the valve are also described.

• 대기
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• 제19권4호
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• pp.331-344
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• 2009

A sensitivity study has been performed using ARPS (Advanced Regional Prediction System) version 5.2.10 in a downslope windstorm case of 12-13 February 2006. The purpose of this study was to find out the role of the inversion layer of temperature mainly in relation to the strength of the downslope winds over the Yeongdong region located downstream of the Taebaek mountains. Under the conditions of N (Brunt-$V{\ddot{a}}is{\ddot{a}}la$ frequency)=0.008 and N=0.016, the effects of the presence of the inversion layer, its variation of height of the layer, and the depth of the layer were identified. The sensitivity experiments suggested that the inversion layer effected the downstream wind speed of the mountains under both conditions of N=0.008 and N=0.016, and notably when the inversion layer was located near the mountain crest the downstream wind speed of the mountains was strong (~ $27ms^{-1}$) only under the condition of N=0.016. In addition, when the atmosphere was rather stable (N=0.016) and the depth of the layer was relatively thin (765 m) the downstream wind speed of the mountains was the strongest (~ $30ms^{-1}$) among the sensitivity experiments.

• 한국연소학회지
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• 제3권2호
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• pp.13-27
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• 1998

The optimization of frontal device including fuel nozzle and swirler is required to secure the mixing of fuel and air and the combustion stability leading the reduction of pollutant emissions and the increase of combustion efficiency in gas turbine combustor. The effects of injection nozzle and swirler on the flow field, spray characteristics and consequently the combustion stability, were experimentally investigated by measuring the velocity field, droplet sizes of fuel spray, lean combustion limit and the temperature field in the main combustion region. Flow fields and spray characteristics were measured with APV(Adaptive Phase Doppler Velocimetry) under atmospheric condition using kerosine fuel. Temperatures were measured by Pt-Pt13%Rh, R-type thermocouple which was 0.2mm thick. Spray and flame was visualized by ICCD(Intensified Charge Coupled Device) camera. It was found that the dual swirler resulted in the biggest recirculation zone with the highest reverse flow velocity at the central region, which lead the most stable combustion. The various combustion characteristics were observed as a function of the geometries of injector and swirler, that gave a tip for the better design of gas turbine combustor.

• 한국환경복원기술학회지
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• 제7권1호
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• pp.10-18
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• 2004

The urban ecosystem, unlike the natural ecosystem, has been affected by the urban environment, so the existences of normal creatures have been threatened and eventually the stability has declined to consist of those that have adapted to such. Therefore, by creating a list of such organisms, their number of variety can be found out and their ecological distinction can be understood. Because flora is known to be an ecological index reflecting region's effects of human and societal environments, weather, and climates, it is a useful method of finding out the ecological position and distinctiveness of that region. The study site is part of watershed at Yangjae Stream, Kahngnam-ku, Seoul. In this study, the difference of flora in each land use type are investigated by plant identification. The purpose of this study is to evaluate the city's plant surviving environment, and eventually to contribute to the restoration of urban green spaces by finding out the plants which are appropriate for the corresponding environment. After doing the study, it was found that the urban forest is the most stable urban ecosystem while the urban park is seriously disturbed, and ecologically unstable. The urban stream is also disturbed continuously.