• Proceedings of the Korean Society of Toxicology Conference
• /
• 2003.10b
• /
• pp.109-110
• /
• 2003

To validate a novel mouse model, gpt delta, for in vivo mutagenesis, the Mammalian Mutagenesis Society (MMS), a subgroup of the Environmental Mutagen Society of Japan (JEMS) (JEMS/MMS), performed a collaborative study as the third trial for transgenic animal assay. In this mouse model, point mutations and deletions re separately identified by gpt (6-thioguanine-resistant) and Spi- (sensitive to P2 interference) selections, respectively.(omitted)

• Journal of Korea Water Resources Association
• /
• v.56 no.8
• /
• pp.509-520
• /
• 2023

Various drought indices are widely used for assessing drought conditions which are affected by many factors such as precipitation, soil moisture, and runoff. The values of drought indices varies depending on hydro-meteorological data and calculation formulas, and the judgment of the drought condition may also vary. This study selected four calculation components such as precipitation data length, accumulation period, probability distribution function, and parameter estimation method as the sources of uncertainty in the calculation of standardized precipitation index (SPI), and evaluated their contributions to the uncertainty using root mean square error (RMSE) and linear mixed model (LMM). The RMSE estimated the overall errors in the SPI calculation, and the LMM was used to quantify the uncertainty contribution of each factor. The results showed that as the accumulation period increased and the data period extended, the RMSEs decreased. The comparison of relative uncertainty using LMM indicated that the sample size had the greatest impact on the SPI calculation. In addition, as sample size increased, the relative uncertainty related to the sample size used for SPI calculation decreased and the relative uncertainty associated with accumulation period and parameter estimation increased. In conclusion, to reduce the uncertainty in the SPI calculation, it is essential to collect long-term data first, followed by the appropriate selection of probability distribution models and parameter estimation methods that represent well the data characteristics.

• Proceedings of the Korea Environmental Mutagen Society Conference
• /
• 2003.10a
• /
• pp.109-110
• /
• 2003

• International Journal of Highway Engineering
• /
• v.19 no.3
• /
• pp.65-70
• /
• 2017

PURPOSES : Pavement Management System contains the data that describe the condition of the road. Under limited budget, the data can be utilized for efficient plans. The objective of this research is to develop a mixed integer program model that maximizes remaining durable years (or Lane-Kilometer-Years) in road maintenance planning. METHODS : An optimization model based on a mixed integer program is developed. The model selects a cluster of sectors that are adjacent to each other according to the road condition. The model also considers constraints required by the Seoul Metropolitan Facilities Management Corporation. They select two lanes at most not to block the traffic and limit the number of sectors for one-time construction to finish the work in given time. We incorporate variable cost constraints. As the model selects more sectors, the unit cost of the construction becomes smaller. The optimal choice of the number of sectors is implemented using piecewise linear constraints. RESULTS : Data (SPI) collected from Pavement Management System managed by Seoul Metropolitan City are fed into the model. Based on the data and the model, the optimal maintenance plans are established. Some of the optimal plans cannot be generated directly in existing heuristic approach or by human intuition. CONCLUSIONS:The mathematical model using actual data generates the optimal maintenance plans.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.29 no.5
• /
• pp.383-388
• /
• 2018

This paper presents a 1.8 GHz six-port-based impedance modulator using CMOS technology, which can select an arbitrary load impedance with switch control. The proposed 1.8-GHz impedance modulator comprises a Wilkinson power divider, three quadrature hybrid couplers, and four SP3T switches for each load impedance selection. The measured insertion loss of -13 dB and the input/output return losses of >10 dB are achieved in the range of 1.4~2.2 GHz. The low drop output regulator for a stable 3.3 V DC power and the serial peripheral interface(SPI) for an easy digital control are integrated. The chip size, including the pads, is $1.7{\times}1.8mm^2$.

• Journal of Microbiology and Biotechnology
• /
• v.10 no.2
• /
• pp.272-274
• /
• 2000

Temperate bacteriophage P2 has a nonessential gene called old(overcoming lysoginization defection). In the presence of old, the growth of the host (Escherichia coli) with recBC- genotype is ingibited, and another bacteriophage, lambda, cannot superinfect. The Old protein has been shown to possess an exonuclease actibity. Three mutant P2s(old 1, old 17, old 49) which did gene was coned into expression vectors to produce hexahistidine-tagged proteins. The proteins were affinity-purified and shown to lose its exonuclease activity on both double-stranded and single-stranded DNA substrates. Thus, it was concluded that the lambda exclusion was related to Old's exonuclease activity.

• The Journal of the Acoustical Society of Korea
• /
• v.28 no.3
• /
• pp.229-238
• /
• 2009

This paper describes a sound engine of Korean traditional instruments, which are the Gayageum and Taepyeongso, by using a TMS320F2812. The Gayageum and Taepyeongso models based on commuted waveguide synthesis (CWS) are required to synthesize each sound. There is an instrument selection button to choose one of instruments in the proposed sound engine, and thus a corresponding sound is produced by the relative model at every certain time. Every synthesized sound sample is transmitted to a DAC (TLV5638) using SPI communication, and it is played through a speaker via an audio interface. The length of the delay line determines a fundamental frequency of a desired sound. In order to determine the length of the delay line, it is needed that the time for synthesizing a sound sample should be checked by using a GPIO. It takes $28.6{\mu}s$ for the Gayageum and $21{\mu}s$ for the Taepyeongso, respectively. It happens that each sound sample is synthesized and transferred to the DAC in an interrupt service routine (ISR) of the proposed sound engine. A timer of the TMS320F2812 has four events for generating interrupts. In this paper, the interrupt is happened by using the period matching event of it, and the ISR is called whenever the interrupt happens, $60{\mu}s$. Compared to original sounds with their spectra, the results are good enough to represent timbres of instruments except 'Mu, Hwang, Tae, Joong' of the Taepyeongso. Moreover, only one sound is produced when playing the Taepyeongso and it takes $21{\mu}s$ for the real-time playing. In the case of the Gayageum, players usually use their two fingers (thumb and middle finger or thumb and index finger), so it takes $57.2{\mu}s$ for the real-time playing.