Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.109-110
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- 2003
A Collaborative Validation Study for the Gpt Delta Mouse Using N-propyl-N-nitrosourea, Diethylnitrosamine, Mitomycin C and Chlorambucil: A Summary Report of the Third Collaborative Study of the Transgenic Mouse Mutation Assay by JEMS/MMS
- Yajima, Nobuhiro (Research Institute of Life Science, Snow Brand Milk Products Co., Ltd.) ;
- Hyogo, Atsushi (Medicinal Safety Research Laboratories, Sankyo Co., Ltd.) ;
- Tamura, Hironobu (Nippon Shinyaku Co., Ltd., Safety Laboratory) ;
- Nakajima, Madoka (Biosafety Research (An-pyo) Center, Foods, Drugs ＆ Pesticides) ;
- Nohmi, Takehiko (Division of Genetics and Mutagenesis, National Institute of Health Sciences)
- Published : 2003.10.01
Abstract
To validate a novel mouse model, gpt delta, for in vivo mutagenesis, the Mammalian Mutagenesis Society (MMS), a subgroup of the Environmental Mutagen Society of Japan (JEMS) (JEMS/MMS), performed a collaborative study as the third trial for transgenic animal assay. In this mouse model, point mutations and deletions re separately identified by gpt (6-thioguanine-resistant) and Spi- (sensitive to P2 interference) selections, respectively.(omitted)
Keywords
- chlorambucil;
- diethylnitrosamine;
- gpt (6-thioguanine-resistant;
- 6-TGr) selection;
- gpt delta transgenic mouse;
- mitomycin C;
- N-propyl-N-nitrosourea;
- packaging efficiency (PE);
- Spi- (sensitive to P2 interference) selection;
- total population