• Journal of Korean Neurosurgical Society
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• 제48권5호
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• pp.399-405
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• 2010

Objective : Patients with spontaneous intracerebral hemorrhage (ICH) presenting within 24 hours of symptom onset are known to be increased risk of hematoma expansion which is closely correlated with morbidity and mortality. We investigated whether tiny enhancing foci ('Spot sign') on axial view of 3-dimensional computed tomography angiography (3D-CTA) source images can predict subsequent hematoma expansion in spontaneous ICH. Methods : During a 2-year period (March 2007-March 2009), we prospectively evaluated 3D-CTA of 110 patients with spontaneous ICH. Based on source images of 3D-CTA, patients were classified according to presence or absence of 'Spot sign'; 'Spot sign' (+) group, 'Spot sign' (-) group. Radiological factors and clinical outcomes were compared between two groups. Results : Hematoma expansion occurred in 16 patients (15%). Mean Glasgow Coma Scale (GCS) score of patients with hematoma expansion was significantly different compared to score of patients without hematoma expansion (5 vs. 9, P < 0.001). Nineteen patients (16%) of 110 ICH patients demonstrated 'spot sign' on 3D-CTA. Among the 'spot sign' (+) group, 53% of patients developed hematoma expansion. Conversely 7% of patients without 'spot sign' demonstrated the hematoma expansion (p < 0.001). Initial volume and location of hematoma were significantly not associated with hematoma expansion except shape of hematoma. Conclusion : Our study showed that patients with hematoma expansion of spontaneous ICH had significant clinical deterioration. And the fact that 'spot sign' (+) group have higher risk of hematoma expansion suggests the presence of 'spot sign' on source images of 3D-CTA can give a clue to predict hematoma expansion in spontaneous ICH.

• Journal of Radiation Protection and Research
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• 제29권2호
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• pp.129-139
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• 2004

의료 및 산업체에서 중형방사선 선원의 사용증가는 정규 및 사고시 작업자와 일반인에 대해 방사선 노출의 위험을 초래한다. 본 연구에서는 중형 의료용 선원을 사용하는 $^{99m}Tc$ 발생기에 대한 위험도 평가를 수행하였다. 사건수목기법을 활용하여 국내 현실에 적합한 시나리오를 도출하였으며, 정규 및 사고시로 나누어 작업자와 일반인에 대해서 몬테칼로 기법에 의거한 불확실성 분석을 수행하였다. 아울러 위험도결과에 가장 영향을 미치는 인자를 알아보기 위해 5가지 독립변수에 대한 민감도 분석을 수행하였다. 빈도수의 기여로 인해 정규작업에 대한 위험도가 사고시 위험도보다 높게 평가되었다. $^{99m}Tc$ 발생기의 경우 정규작업 시 작업자 $0.6mSvy^{-1}$, 일반인 $0.014mSvy^{-1}$ 이며 사고시 작업자 $3.96mSvy^{-1}$, 일반인 $0.0016mSvy^{-1}$로 평가되었다. 정규작업 보다 사고시의 불확실성 범위가 10배 정도 더 높게 나타났다. 또한 민감도 분석 결과 선원의 강도, 작업거리, 작업시간이 위험도에 가장 영향을 미치는 인자로 나타났다. 이리한 위험도 평간 방법론과 결과는 중대형 선원에 대한 위험도 정보 활용 규제 (Risk-Informed Regulation)에 유용할 것으로 기대한다.

• 디지털콘텐츠학회 논문지
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• 제19권4호
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• pp.771-777
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• 2018

본 연구는 재난 재해 시 해당 지역의 취약성 및 재해 위험성분석을 보다 세밀하고 광범위한 분석을 진행하기 위하여 빅데이터 기반 재난 재해 위험도 분석 프레임워크를 제안하였다. 오픈소스 기반 재해 위험도 평가 분석 소프트웨어를 활용하여 대용량의 데이터가 단 시간 내에 처리될 수 있도록 분산 및 병렬처리가 가능한 프레임 워크를 소개한다. 제안하는 시스템의 재난재해 분석 성능평가 시 기존 시스템에 비해 빠른 분석 처리 성능 결과를 도출하였으며 재난 재해 상황 분석 및 재난 유형별 최적화된 의사결정을 지원하는데 주요 프레임워크로 활용될 수 있을 것이다. 본 연구를 통해 재난 재해 상황 시 정확한 판단과 분석과 효과적인 대응을 통한 사전대비가 가능할 것이며, 정확한 피해 산정 예측에 따른 신속한 대응이 가능하여 피해 규모를 최소화시키는데 기여할 수 있을 것이다.

• Journal of Preventive Medicine and Public Health
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• 제32권4호
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• pp.513-525
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• 1999

Objectives : High-normal blood pressure' is a factor influencing decision to initiate targeted intensive intervention strategy in westernized populations. JNC-VI offered the vigorous lifestyle modification for persons with 'high-normal blood pressure', who could be early detected. As a hypertension seems to be the result of multiple genetic factors operating in concert with associated environmental factors, it will be necessary to identify the high-normal blood pressure as a risk factor of hypertension for applying primary prevention strategy in Korean people. Methods : Although cohort study design might be adequate to recruit incidence cases, to keep time sequence of events, and to prevent information bias, nested case-control study was chosen for avoiding measurement errors because hypertension is a benign disease. Source population was the 'Seoul Cohort' participants and follow-up was done by using Korea Medical Insurance Corporation's database on the utilization of health services from 1 Jan93 to 30Jun97. Incidence cases were ascertained through the chart review, telephone contacts, and direct blood pressure measurements. Controls included the pairing of 4 individuals to each case on the basis of age. Results : As 75% of 247 incident cases had high-normal blood pressure, the crude odds ratio for hypertension was 2.04 (95% CI 1.47-2.83). Another statistically significant risk factors of hypertension were body mass index, dietary fiber, alcohol consumption, weekly activity and history of quitting smoking. The multivariate odds ratio of high-normal blood pressure adjusted for all risk factors was 1.84 (95% CI 1.31-2.56). Among high-normal blood pressure group, body mass index, weekly ethanol amounts, weekly physical activity, and dietary fiber except history of quitting smoking were still risk factors of hypertension. Conclusion : 'High-normal blood pressure' is a risk factor for hypertension in Korean middle-aged men, which represents that the vigorous lifestyle modification for persons with 'high-normal blood pressure' is need.

• Asian Pacific Journal of Cancer Prevention
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• 제15권7호
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• pp.3247-3252
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• 2014

Background: Genetic factors have been shown to play an important role in the development of cancers. However, individual studies may fail to completely demonstrate complicated genetic relationships because of small sample size. Therefore, we performed a meta-analysis to evaluate the association of E-selectin Ser128Arg (S128R) with cancer risk. Materials and Methods: A literature search in PubMed, Embase, Web of Science, Science Direct, SpringerLink, EBSCO, Wanfang, and Chinese National Knowledge Infrastructure databases was carried out to identify studies of the association between E-selectin S128R polymorphism and cancer risk. The odds ratio (OR) with 95% confidence intervals (95%CIs) were used to assess the strength of association. Results: A total of eight studies involving 1,675 cancer cases and 2,285 controls were included in the meta-analysis. In overall populations, S128R polymorphism seemed to be associated with cancer risk (Arg allele vs Ser allele: OR=1.65, 95%CI =1.33-2.04, p<0.01; Arg/Arg+Arg/Ser vs Ser/Ser: OR=1.87, 95%CI =1.48-2.36, p<0.01; Arg/Ser vs Ser/Ser: OR=1.80, 95%CI =1.51-2.14, p<0.01). Similarly, subgroup analysis by ethnicity and source of control also revealed that this polymorphism was related to cancer risk. Conclusions: Our meta-analysis revealed that there was association between the E-selectin S128R polymorphism and the risk of cancer. Further large and well-designed studies are needed to confirm this association.

• Geomechanics and Engineering
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• 제35권6호
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• pp.581-591
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• 2023

North Anatolian Fault Zone is tectonically active with recent earthquakes (Mw7.6 1999-Kocaeli and Mw7.2 1999-Düzce earthquakes) and it passes through Marmara region, which is highly industrialized, densely populated and economically important part of Turkey. Many power plants, located in Marmara region, are exposed to high seismic hazard. In this study, open source OpenQuake software has been used for the probabilistic earthquake hazard analysis of Marmara region and risk assessment for the specified energy facility. The SHARE project seismic zonation model has been used in the analysis with the regional sources, NGA GMPEs and site model logic trees. The earthquake hazard results have been compared with the former and existing earthquake resistant design regulations in Turkey, TSC 2007 and TBSCD 2018. In the scope of the study, the seismic hazard assessment for a typical natural gas combined cycle power plant located in Marmara region has been achieved. The seismic risk assessment has been accomplished for a typical control building located in the power plant using obtained seismic hazard results. The structural and non-structural fragility functions and a consequence model have been used in the seismic risk assessment. Based on the seismic hazard level with a 2% probability of exceedance in 50 years, considered for especially these type of critical structures, the ratios of structural and non-structural loss to the total building cost were obtained as 8.8% and 45.7%, respectively. The results of the study enable the practical seismic risk assessment of the critical facility located on different regions.

• 한국대기환경학회지
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• 제24권1호
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• pp.72-82
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• 2008

Benzene is a very harmful and toxic compound known as human carcinogen by all routes of exposure. Owing to the risky feature of benzene, several countries such as Japan, UK and EU have established the ambient air quality standard and protect from that risk of it. Korea also has designated it as one of the criteria air pollutants and established the concentration limit ($5\;{\mu}g/m^3$) in the air and is going to apply the standard from 2010. Benzene is emitted from various sources such as combustion plants, production processes, waste treatment facilities and also automobiles. Mobile source is known as one of the major emission sources of benzene. In this study, we estimated the domestic emissions of benzene from mobile source and compared the results with those of advanced countries. Mobile source was divided into 2 categories, Le., on-road source and non-road source. The total emissions of benzene from mobile source were estimated as 3,106 tons/yr and 1,612 tons/yr was emitted from on-road source and 1,494 tons/yr was from non-road source. Emission ratio of benzene from on-road source showed that 80.0% was from passenger cars, 10.1% was from taxis, 7.2% was from light-duty vehicles, 2.5% was from heavy-duty vehicles and 0.2% was from buses. In the case of non-road source, the distribution showed that 66.3% was from construction machineries, 14.5% was from locomotives, 11.7% was from ships, 7.1% was from agriculture equipments and 0.5% was from aircrafts. The cold-start emissions were estimated as 942 tons/yr and this value was almost 1.5 times greater than that for hot engine emissions (608 tons/yr). In addition, the fuel-based distribution was 65.9%, 31.1% and 2.8% from gasoline, LPG and diesel vehicles, respectively. The emission ratio from mobile source occupied 65% and 30% of total benzene emissions in USA and UK, respectively. In case of Korea, the emission ratio of benzene from mobile source occupied 29% (15% from on-road source, 14% from non-road source) which showed similar value with UK.

• 한국조리학회지
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• 제22권4호
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• pp.114-127
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• 2016

본 연구에서는 소셜커머스를 이용하는 외식소비자들을 대상으로 재이용의도에 영향을 미치는 요인으로 지각된 위험과 상품구매 시 가격을 고려하는 정도인 가격의식성을 제시하여 영향관계를 검증해 보고자 한다. 이러한 검증결과를 통해 외식소비자들의 소셜커머스에 대한 행동의도를 파악하여 외식소셜커머스 관련 업체들의 마케팅전략 수립 시 활용할 수 있는 유용한 실무적 시사점을 제공하는데 본 연구의 목적을 두고자 한다. 연구의 공간적 범위와 조사대상은 소셜커머스에서 외식상품을 구매한 경험이 있는 전국의 20세 이상 남녀 내국인 거주자로 하였으며, 표본추출을 위한 소셜커머스 업체는 연간 방문자 수 기준으로 2014년 쇼핑 앱 순위에서 1위를 차지한 쿠팡으로 선정하였다. 조사대상자 중에서 쿠팡을 이용해 외식상품을 구매한 경험이 있는 지를 사전질문을 통해 파악한 후 경험이 있다고 응답한 사람을 대상으로 설문조사를 실시하였다. 연구결과, 정보위험과 개인보안위험, 심리적 위험, 시간손실위험은 재이용의도에 부정적인 영향이 있는 것으로 나타났으나 사회적 위험과 재무적 위험은 아무런 영향을 미치지 않는 것으로 나타났다. 가격의식성은 재이용의도에 긍정적인 영향을 미치는 것으로 나타났다. 외식소비자들의 지속적인 소셜커머스 이용에 영향을 미치는 요인으로 지각된 위험과 가격의식성의 중요성을 규명하였다.

• 시큐리티연구
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• 제50호
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• pp.11-32
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• 2017

영국은 2004년 국가재난관리법(Civil Contingencies Act 2004)을 통하여 "Emergency"라는 결과중심의 단일 재난개념을 확립하고 있으며, 이를 통하여 유형과 관계없이 다양한 위험에 대비/대응할 수 있는 시스템을 구축하고 있다. 역사적으로 볼 때는, 평시 재난관리체계와 민방위 체계가 서로 합쳐져 오늘날의 통합형 재난관리체계(Integrated Emergency Management)로 이어진 것이다. 영국의 재난관리체계는 지역단위에서의 대비 및 대응을 원칙으로 하고 있으며, 이를 위하여 각 대응기관 간의 상호협력과 정보공유를 강조하고 있다. 또한 지역사회 및 영국 전체에서 재난위험성을 진단하고 평가하는 제도, 즉 지역사회 위험목록(Community Risk Register) 및 국가위험목록(National Risk Register) 제도가 잘 구축되어 있으며, 그 평가결과 역시 국민들에게 공개되어 있다. 본 연구에서는 이러한 재난위험성 평가 제도를 비롯하여 영국 재난관리체계의 전체 특징 및 특히 최근 변화를 종합적으로 살펴보고, 이를 바탕으로 우리나라의 재난관리체계가 나갈 방향에 대한 정책적 함의를 도출하고자 하였다. 본 연구에서는 (1) (영국에서 기이 이루어진) 완전 통합형 재난관리체계의 도입 그리고 이에 따른 민방위 조직의 발전적 해체 및 단일 재난개념의 사용, (2) 경찰을 비롯한 각 긴급대응기관 간 상호운용성(Inter-operability) 확보를 위한 법제도 개선, (3) (영국의 지역사회 위험목록 및 국가위험목록과 같은) 지역 및 국가단위의 재난위험성을 평가할 수 있는 제도의 도입이라는 세 가지 정책적 함의를 제시해보았다.

• Preventive Nutrition and Food Science
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• 제7권3호
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• pp.327-331
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• 2002

Tea is a pleasant, popular and safe beverage in the world. During the past decade, epidemiological studies have shown that tea catechins intake is associated with lower risk of cardiovascular disease. Tea provides a dietary source of health-promoting components to help humans reduce a wide variety of cancer risks and chronic diseases. The antioxidative activity of tea-derived catchins has been extensively studied. The antioxidant effect is a synergistic action between catechins e.g. EGCG, EGC, ECG, EC, pheophytins a and b, and other components in tea leaves, which aye more bioavailable for human body. Green tea has a Higher content of catechins than other kinds of tea. Green tea extract with hot water has high potential and more efficiency to reduce cancer risk than any other tea products or pure EGCG. Protein, iyon, and other food components may interfere with the bioavailability of ten catechins. Interaction of catechins with drug affects the cancer-preventive activity of some cancer-fighting medication. Further studies are required to determine the bioavailability of tea catechins and cancer-preventive functionality.