• Journal of Korean Medicine Rehabilitation
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• v.30 no.2
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• pp.153-164
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• 2020

Objectives This study is designed to evaluate the safety of Soshihotang soft extract in healthy male volunteers. Methods 12 healthy male volunteers were recruited and this study was carried out by a single center. Laboratory test results, vital signs of the volunteers were collected to evaluate safety. According to registration order, the 12 subjects were allocated by serial number. To evaluate safety, blood samples were taken and vital signs were checked 4 times-screening, pre administration, post administration and follow up-during the whole trial. The incidence of all adverse effects are shown in percentage. The mean and standard deviation were used to to describe and summarize continuous data. To evalate the effectiveness of the intervention, data of blood tests was analyzed by Wilcoxon signed rank test or paired T-test (p<0.05). Results In the case of red blood cell, hemoglobin, hematocrit, neutrophils, protein, albumin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transpeptidase values, the normality test result of the variable for the difference value before and after the dosing has a significance level <0.05. But most of values did not deviate from the normal range, and the deviation from the normal range could not be regarded as the significance associated with this clinical trial. And adverse event wasn't observed associated with the clinical trial drug. Conclusions Soshihotang soft extract were considered to be safe for healthy male volunteers.

• Korean Journal of Pharmacognosy
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• v.42 no.3
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• pp.271-275
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• 2011

Sosihotang is a herbal medicine traditionally used to treat chronic liver disease. This study was performed to investigate the effect of steaming Sosihotang at a $121^{\circ}C$ on its major compounds and neuroprotective activity. We evaluated quantitative changes of 6 major compounds in Soshihotang, saikosaponin A, homogentisic acid, baicalin, ginsenoside $Rg_3$, glycyrrhizin and 6-gingerol using HPLC-DAD. After steaming produce, saikosaponin A, homogentisic acid, baicalin, glycyrrhizin and 6-gingerol in Sosihotang were decreased and ginsenoside $Rg_3$ was increased. The neuroprotective activity of steamed Sosihotang was determined by MTT assay, comparing to Sosihotang. The steamed sosihotang showed a higher neuroprotective activity than Sosihotang. In conclusion, steam produce could improve neuroprotective activity of Soshihotang.

• Journal of Korean Traditional Oncology
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• v.28 no.1
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• pp.1-9
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• 2023

Objectives: To demonstrate an improvement of neuropathic pain after surgical site infection in a patient with anorectal cancer by administration of Soshihotang (SSHT). Methods: A 65-year-old female patient diagnosed with anorectal cancer was administered SSHT to relieve her neuropathic pain induced by surgical site infection. SSHT was administered from 4/22 to 5/2. Clinical outcomes were assessed using a numeric rating scale (NRS), and opioids administered to relieve her pain was calculated. Results: During 10 days of treatment, the NRS scale of neuropathic pain was improved and the dosage of opioids administered reduced to less than half. Conclusions: This case suggests that SSHT could be effective for the management of neuropathic pain induced by surgical site infection.

• The Journal of Internal Korean Medicine
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• v.12 no.1
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• pp.183-188
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• 1991

The following results were obtained according to these fact which is considered peviodically and bibliographically ; 1. The cause of bleeding of cough was Oegampunghan(外感風寒), Pyosaoesok(表邪外束), Chohwasangpye(燥火傷肺) in external cause, Eumhuhwadong(陰虛火動), Sinhu(腎虛), Hyulhu(血虛), Damhwajukyul(痰火積熱), Pyesuyul(肺受熱) ect. in internal cause. 2. The symptoms of bleeding of cough because of external cause was similar to generally cold symptom, because of internal cause were similar to Yeumhuhwadong(陰虛火動) and generanl Huyul(虛熱) symptom. 3. The treatment of external were Mahwangtang, Soshihotang, Sabaeksan ect. internal were Samultang, Yookmijihwangtang, Jaeumganghwatang, Gesosan ect.

• Journal of Haehwa Medicine
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• v.18 no.2
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• pp.21-29
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• 2009

The 'Half outside and half inside(半表半裏)' is the part which is located between outside and inside, and it is regarded as the nickname of ShaoYang(少陽) in Sanhanlun(傷寒論). About the meaning of 'Half outside and half inside', many medical scientists agreed that the 'outside' is 'TaiYang(太陽)', but they didn't agreed the meaning of 'inside'. One group insisted the 'inside' is 'YangMing (陽明)', the other group instisted that 'TaiYin(太陰)'. To know which opinion is correct, I analyed the Kwigyung(歸經) of herbs in Soshihotang(小柴胡湯) which has a close relationship with ShaoYang, and it is proved that the Kwigyung of herbs is the Foot ShaoYang-GALL BLADDER Meridian(足少陽膽經), Hand TaiYin-LUNG Meridian(手太陰肺經), and Foot TaiYin-SPLEEN Meridian(足太陰脾經). So I concluded that the 'inside' is not 'YangMing' but 'TaiYin'.

• Journal of the Daesoon Academy of Sciences
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• v.39
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• pp.249-274
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• 2021

The aim of this article is to investigate the religious medical treatments performed by Kang Jeungsan as recorded in The Canonical Scripture, the main scripture of the Korean new religion, Daesoon Jinrihoe. The unity of mind and body is the core principle underlying Kang Jeungsan's religious medical treatments. He believed treating the mind of his patients was more important and necessary than treating their diseases. As such, he believed the only way to treat critical illness was to keep preserve the mind-body unity of his patients. Massage was a physical therapy often used by Kang Jeungsan. The medicinal materials that he commonly used were the Four-substance Decoction (四物湯 samultang), Minor Bupleurum Decoction (小柴胡湯 soshihotang), quince (木瓜 mokgwa *Pseudocydonia sinensis; not papaya), and rehmannia (生地黃 saengjihwang). Kang Jeungsan's religious medical treatments were characteristic of Daoist healing methods. His Daoist style healing methods included multiple techniques such as treating diseases through correcting Qi, exorcising malevolent entities, transferring diseases to a different host, removing a disease through the changing of clothes, pouring medicine into the ground, combining the usage of talisman and incantations, and treating the common people. Among these techniques, Jeungsan's pouring medicine into the ground was especially innovative.

• The Journal of Korean Medicine
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• v.16 no.1 s.29
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• pp.71-95
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• 1995

To be helpful to the treatment of pulmonary cancer with oriental medicine, we got clinical reports together and analyzed the data. The results were obtained as follows: 1. The treating methods could be summarized as three methods that were reinforcing vital energy, eliminating harmful Qi, and reinforcing vital energy with eliminating harmful Qi. The methods of reinforcing vital energy were supplementing Qi & Yin, increasing pahological heat & reinforcing kidney, augmenting Qi & blood, supplementing vital energy and strengthening fundermental energy, reinforcing spleen and increasing Qi, lubricate Yin and lung, and the other methods of eliminating harmful Qi were transforming pathological fluid and softening, clarifying heat and eliminating poison, dipersing lung and softening, toxicding and softening, guiding Qi and activating blood, clarifying heat and dispersing lung, guiding Qi and counteracting stress etc., and the methods of supplementing vital energy with eliminating poison were reinforcing spleen and transforming pathological fluid, increasing Qi and activating blood, supplementing Yin and clarifying heat, reinforcing spleen and dry the dampness, lubricating lung and transforming patholigical fluid and supplementing Qi and activating blood. 2. The oriental prescriptions used for pulmonary cancer were Chunkeum-Weekyungtang & Sohamhwingtang, Jinhayookgunjatang, Hyulboochukeotang, Bokbangkyogonamtang was reported to be effective in the treatment of metastasis. 3. Bokbangshinjingtang and haewool were applied for the complications of pulmonary cancer, Soshihotang for fever, hangamryung for tumor pain. Prunus ansu Komarov, Eriobotrya japonica Lirdley, Pyrrosiae lingua Farwel, Steomon japonica Miguel, Maximowiczia chinensis Ruprecht var, Morus bombycis Koidzumi for cough, Panax Pseudo-ginseng Wall. var, Bletilla striata Reichenbach f., Acacia catechu(兒茶) for hemoptysis, Lonicerae flos, Aspongopus chinensis(九香蟲) for chest pain, Cypsum Fibrosum, Gazella gutturosa, Scutellaria baicalensis Georgi, Gypsophila oldhamiana Miquel for fever, Lepidii semen descurainiae semen, Belamcanda chinensis D.C, Gnaphalium affine(佛耳草) for asthma. 4. For the reduction of side effect by chemotherapy and radiotherapy it was known that supplementing Qi was used chiefly for side effect of chemotherapy and augmenting Yin applied to side effect of radiotherapy. 5. The oriental presciptions were suggested for the side effect by chemotherapy and radiotherapy ; Sammaekaek(參麥液), Whaebokwontang(化瘀復元湯), Hwangjungomitang(黃精五味湯), Yukmijihwangtang(六味地黃湯), Hyangsayukgunjatang(香砂六君子湯), Samlyeekulsan for side effect by chemotherapy while Geumgweisingiwhan, Hwanglyentang(黃連湯), Hwanglyenhaedoktang(黃連解毒湯), Yangyeunchungpeitang(養陰淸肺湯), Idongtang(二冬湯), Jayeunkanghwatang(滋陰降火湯) for side effect by radiotherapy.

• Journal of Korean Medical classics
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• v.28 no.1
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• pp.173-194
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• 2015

Objectives : It is told that Hyungbangsabaeksan is important to treat the Soyangin(少陽人) disease in Dongyisusebowon. Though Hyungbangsabaeksan is widely applied in Soyangin(少陽人) disease, it is difficult to understand the meaning of Hyungbangsabaeksan and also hard to use clinically. In this study, We tried to reveal the fundamental meaning of the Hyungbangsabaeksan and the indication of Hyungbangsabaeksan. Methods : We mainly studied diseases in Dongyisusebowon. The use of drug in Soyang disease(少陽病) is relatively difficult. So we firstly reviewed Mang-um disease(亡陰證) that is almost close to the Interior syndrome(裏病) and an Analogous Hak(似瘧) that is one of the interior syndrome. Based on the understanding of interior syndrome, We tried to understand Hyungbangsabaeksan in the usage of the drug in Soyang disease(少陽病). Results : We found the key point of indication of Hyungbangsabaeksan in Mang-um disease(亡陰證) of Exterior cold syndrome(表寒病) and an Analogous Hak of Interior syndrome. Also based on that, We identified characteristics of Soyang disease(少陽病). Therefore, we inferred that there are significant symptoms in Soyang disease(少陽病) that Hyungbangsabeaksan could be applied. Conclusions : Reviewing the usage of Hyungbangsabeaksan in Mang-um disease(亡陰證) and an Analogous Hak, we found that Interior syndrome is important in indication of Hyungbangsabeaksan. Also we found that Hyungbangsabeaksan is especially applied when irreversible transition of the disease can be predicted. Based on this, We concluded Hyungbangsabeaksan is preventively used in specific Soyang disease(少陽病), of which the machanism of the disease is similar.

• Journal of Society of Preventive Korean Medicine
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• v.27 no.1
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• pp.69-87
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• 2023

Objectives : This study collected and analyzed information related to preventive formulas from continuously published and revised COVID-19 treatment guidelines in various regions of China. Methods : We collected treatment guidelines published in different regions of China and categorized formulas for prevention and medical observation period listed in them according to the editions. The categorized preventive formulas were compared by type and target group. Results : Herbal medicines used for prevention included formulas derived from Korean medical classics, such as Okbyeongpungsan(玉屏風散) and Eunkyosan(銀翹散). The newly composed formulas, totaling over 100, were created by adding, subtracting, and combining formulas such as Sang-gukeum(桑菊飮), Eunkyosan(銀翹散), Sasammaekmundongtang(沙參麥門冬湯), Okbyeongpungsan(玉屏風散), Gwakhyangjeong-gisan(藿香正氣散), and Soshihotang(小柴胡湯). Patent medicines including Huoxiangzhengqi capsule(藿香正氣膠囊), Lianhuaqingwen capsule(連花淸瘟膠囊), Shufengjiedu capsule(疏風解毒膠囊), and Jinhuaqinggan granule(金花淸感顆粒) were frequently used, mainly targeting close contacts. These medicines were used differently depending on the specific population group, such as the general population, the elderly, children, pregnant women, and patients with underlying diseases, and were also applied differently according to the individual's constitution. Conclusion : We were able to identify various background factors contained in the guidelines for the use of preventive formulas presented by TCM group, and understand the social conditions that enabled the group to provide such guidelines. Through this, thorough preparation should be made so that the Korean Medicine can actively respond to another future pandemic.