• Structural Engineering and Mechanics
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• v.37 no.2
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• pp.253-256
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• 2011

• KSBB Journal
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• v.31 no.4
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• pp.219-227
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• 2016

Valsartan, a drug for the treatment of cardiovascular disease, exhibited low bioavailability which was caused by, at least in part, limited solubility at low pH. Present investigation deals with the preparation and characterization of gastro-retentive drug delivery system (GRDDS) using valsartan solid dispersion. We prepared solid dispersion using surfactants (Poloxamer 407) and alkalizer ($Na_2CO_3$) which may to be useful for improving solubility of valsartan at low pH and evaluated by saturated solubility of valsartan in distilled water. Valsartan gastro-retentive (GR) tablets containing solid dispersion prepared and evaluated by weight variation, floating time and dissolution rate. Compression at lower pressures resulted in the tablets floating over simulated gastric fluid (pH 1.2) for more than 17 h. In vitro release of valsartan from GR tablet was dependent on the amount of poloxamer 407 and hydroxypropyl methylcellulose. On the basis of evaluation parameter, formulation E-3 was selected as a final formulation. Therefore, it can be concluded that the GR tablets containing solid dispersion may be exploited successfully for the delivery of poorly drug such as valsartan.

• 한국전산유체공학회:학술대회논문집
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• 2009.04a
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• pp.277-282
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• 2009

A temperature equation which is derived from an enthalpy transport equation by using an assumption of a constant specific heat is very attractive for analyses of heat and fluid flows. It can be used for an analysis of a solid-fluid conjugate heat transfer, and it does not need a numerical method to find temperature from a temperature-enthalpy relation. But its application is limited because of the assumption. A new method is derived in this study, which is a temperature-explicit formulation of the energy equation. The enthalpy form of the energy equation is used in the method. But the final discrete form of the equation is expressed with temperature. It can be used for a solid-fluid conjugate heat transfer and multiphase flows. It is found by numerical tests that it is very efficient and as accurate as the standard enthalpy formulation.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.27 no.9
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• pp.1579-1588
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• 2003

In this paper, the finite element equations for the transient linear viscoelastic stress analysis are presented in time domain, whose variational formulation is derived by using the Galerkin's method based on the equations of motion in time integral. Since the inertia terms are not included in the variational formulation, the time integration schemes such as the Newmark's method widely used in the classical dynamic analysis based on the equations of motion in time differential are not required in the development of that formulation, resulting in a computationally simple and stable numerical algorithm. The viscoelastic material is assumed to behave as a standard linear solid in shear and an elastic solid in dilatation. To show the validity of the presented method, two numerical examples are solved nuder plane strain and plane stress conditions and good results are obtained.

• Structural Engineering and Mechanics
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• v.77 no.6
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• pp.765-777
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• 2021

Recently, the plate bending analysis has been interpreted in terms of the tensor's components of curvatures and bending moments by presenting the conceptual perspectives of the Hydrostatic Method of Analysis (HM) and theoretical formulations that combine the continuum mechanics with the graphical statics analysis, the theory of thin orthotropic and isotropic plates, and the elasticity theory. In pursuance of uncovering a genuine formulation of the plate's flexural differential equations, that possess the general-covariance and coordinates-independency. This study had then, tackled various natural and structural problems in both solid and fluid branches of the continuum mechanics in a description of such theoretical and conceptual attainment in uncovering the dimensional independent diffeomorphism covariant partial differential laws.

• Biotechnology and Bioprocess Engineering:BBE
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• v.6 no.6
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• pp.419-425
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• 2001

A dense pellicular solid matrix has been fabricated by coating 4% agarose gel on to dense zironia-silica(ZS) spheres by watr-in-oil emulsification . The agarose evenly laminated the ZS bead to a depth of 30㎛, and the resultin gpellicular assembly was characterised by densities up to 2.39g/mL and a mean particle dimeter of 136 ㎛. In comparative fluidisation tests, the pellicular solid phase exhibited a two-fold greater flow velocity than commercial benchmark ad-sorbents necessary to achieve common values of bed expansion. Furthermore, the perlicular parti-cles were characterised by improved qualities of chromatographic behaviour, particularly with re-spect to a three-fold increase in the apparent effective diffusivity of lysozyme within a pellicular assembly modified with Cibacron Blue 3GA. The properties of rapid protein adsorption/desorp-tion were attributed to the physical design and pellicular deployment of the reactive surface in the solid phase. When combined with enhanced feedstock throughput, such practical advantages recommend the pellicular assembly as a base matrix for the selective recovery of protein products from complex, particulate feedstocks(whole fermentation broths, cell disruptates and biological extracts).

• Structural Engineering and Mechanics
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• v.21 no.5
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• pp.571-590
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• 2005

An 8 node assumed stress hexahedral element with rotational degrees of freedom is proposed for static and free vibration analyses. The element formulation is based directly on an 8-node element. This direct formulation requires fewer computations than a similar element that is derived from an internal 20-node element in which the midside degrees of freedom are eliminated by expressing them in terms of displacements and rotations at corner nodes. The formulation is based on Hellinger-Reissner variational principle. Numerical examples are presented to show the validity and efficiency of the present element for static and free vibration analysis.

• Coupled systems mechanics
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• v.7 no.5
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• pp.583-610
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• 2018

This paper discusses the issues associated with modeling frictional contact between solid bodies undergoing large deformations. The most common model for friction on contact interfaces in solid mechanics is the Coulomb friction model, in which two distinct responses are possible: stick and slip. Handling the transition between these two phases computationally has been a source of algorithmic instability, lack of convergence and non-unique solutions, particularly in the presence of large deformations. Most computational models for frictional contact have used penalty or updated Lagrangian approaches to enforce frictional contact conditions. These two approaches, however, present some computational challenges due to conditioning issues in penalty-type implementations and the iterative nature of the updated Lagrangian formulation, which, particularly in large simulations, may lead to relatively slow convergence. Alternatively, a plasticity-inspired implementation of frictional contact has been shown to handle the stick-slip conditions in a local, algorithmically efficient manner that substantially reduces computational cost and successfully avoids the issues of instability and lack of convergence often reported with other methods (Laursen and Simo 1993). The formulation of this approach, however, has been limited to the small deformations realm, a fact that severely limited its application to contact problems where large deformations are expected. In this paper, we present an algorithmically consistent formulation of this method that preserves its key advantages, while extending its application to the realm of large-deformation contact problems. We show that the method produces results similar to the augmented Lagrangian formulation at a reduced computational cost.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.412.2-413
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• 2002

Purpose. To prepare polymer based physical mixtures or solid dispersions containing solubilizing compositions using a spray-dryer. Methods. Lovastatin.simvastatin.aceclofenac and cisapride were selected as poorly water-soluble drugs. Dextrin. poly(vinylalcohol). poly(vinylpyrrolidone)and polyethylene glycol were chosen as solubilizing carriers for solid dispersions. The solid dispersions containing solubilizing compositions without drug were prepared without using organic solvents or tedious changes of formulation compositions. (omitted)

• Journal of the Society of Cosmetic Scientists of Korea
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• v.33 no.4
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• pp.219-225
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• 2007

Bis-ethylhexyloxyphenolmethoxyphenyltrizine (BEMT) is one of the most widely used chemical UVA+UVB double absorbers in sunscreen products. But topical application of BEMT is restricted due to its defects in product. The purpose of this study is to adopt the sunscreen product of solid lipid nano-particles containing BEMT (BEMT-SLN). The particle diameters, the encapsulation efficiencies and the crystallization index (C.I.) are about 330nm, 93.3 % and the 4.3 %. As a result, in vitro penetration and release of BEMT were generally higher in O/W emulsion than the SLN formulation. However in vivo study, it was shown that the rate of release could be decreased by 80 % in the SLN formulation. The sun protection factor (SPF) of the SLN formulation increased by 100 % in the in vitro UV protection test. Therefore, SLN formulation potentiated the UV-blocking power of BEMT. This study suggest that SLN can be used for the encapsulation of BEMT.