• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제25권4호
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• pp.324-329
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• 1999

The facial esthetics are much affected by nasal changes due to especially its central position in relation to facial outline and so appropriately evaluated should be the functional and esthetic aspects of the nose associated with the facial appearance. Generally, a maxillary surgical movement is known to induce the changes of nasolabial morphology secondary to the skeletal repositioning accompanied by muscular retraction. These changes can be desirable or undesirable to individuals according to the direction and amount of maxillary repositioning. We investigated the surgical changes of bony maxilla and its effects to nasal morphology through the analysis of the lateral cephalogram in the Le Fort I osteotomy. Subjects were 10 patients(male 2, female 8, mean age 22.3 years) and cephalograms were obtained 2 weeks before surgery(T1) and 6 months after surgery(T2). The surgical maxillary movement was identified through the horizontal and vertical repositioning of point A. Soft-tissue analysis of the nasal profile was performed employing two angles: nasal tip projection(NTP), columellar angle(CA). Also, alar base width(ABW) was assessed directly on the patients with a slide gauge. The results were as follows; 1. Both anterior and superior movement above 2mm of maxilla rotated up nasal tip above 1mm. Either anterior or superior movement above 2mm of maxilla made prediction of the amount & direction of NTP changes difficult. Especially, a correlation between horizontal movement of maxilla and NTP rotated-up was P<0.01. 2. Both much highly anterior and superior movement of maxilla is accompanied by more CA increase than either highly. Especially, the correlation between horizontal movement of maxilla and CA change was P<0.05. 3. Anterior and/or superior movement of maxilla was accompanied by the unpredictable ABW widening. 4. The amount of changes of NTP, CA, and ABW is not in direct proportion to amout of anterior and/or superior movement of maxilla. 5. Nasal morphologic changes following Le Fort I osteotomy are affacted by not merely bony repositioning but other multiple factors.

• 한국수산과학회지
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• 제45권5호
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• pp.465-471
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• 2012

To compare the accumulation of paralytic shellfish poison (PSP) in different marine organisms, the occurrence and variation of PSP were surveyed in blue mussel Mytilus edulis, oyster Crassostrea gigas, short neck clam Ruditapes philippinarum, bay scallop Argopecten irradians, and warty sea squirt Styela clava collected from Jinhae Bay, Korea, in 2005 and 2006 year. We also investigated the ability of the blue mussel to detoxify PSP by relaying and depuration (via the water flow or water circulation system). In the marine organisms examined, PSP levels were the highest in blue mussel, followed in order by bay scallop, oyster, short neck clam, and warty sea squirt. Comparing the maximum PSP levels in the bivalve species examined in 2005 and 2006, PSP in blue mussel was 1.6-2.0, 4.0-5.9, and 5.1-6.0 times higher than in bay scallop, oyster, and short neck clam, respectively. Therefore, blue mussel could be useful as a bioindicator for PSP monitoring. With the increasing PSP levels in blue mussel in 2006, the proportion of PSP in its digestive gland increased to 95.1% when the maximum level was detected from the whole tissues of blue mussel on May 29. Subsequently, the PSP proportion in the digestive gland decreased as the PSP level in whole tissue decreased. The detoxification of PSP in blue mussel was greatest with relaying, followed by the water flow, and water circulation systems. Relaying decreased the PSP level below the regulatory limit of $80{\mu}g$/100 g after 2 days in low toxic sample with $124{\mu}g$/100 g, and after 7 days in high toxic sample with $401{\mu}g$/100 g. During depuration in the blue mussel with $401{\mu}g$/100 g via the water flow system, the PSP amounts in the digestive gland decreased by about 50% after 1 day, and about 77% after 7 days. In contrast, the PSP amounts in the soft body, gill, and mantle did not change significantly with depuration.

• Clinics in Shoulder and Elbow
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• 제13권2호
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• pp.202-208
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• 2010

목적: 상완골 근위부 골절에 대하여 최소 침습적 금속판 술식을 시행하고, 임상 결과를 분석하여 유용성을 알아보고자 하였다. 대상 및 방법: 상완골 근위부 골절에 대하여 최소 침습적 금속판 술식을 시행한 27명을 대상으로 하였다. 골절 분류는 2분 골절 16예, 3분 골절 10예였으며, 4분 골절 1예가 포함되었다. 임상적 평가는 UCLA 점수와 KSS 점수 및 운동 범위 회복 정도와 합병증 발생 여부를 조사하였으며, 방사선학적으로는 골유합 기간과 경간각 회복 정도를 평가하였다. 평균 추시 기간은 19개월이었다. 결과: 최종 추시에서 UCLA 점수는 우수가 15예, 양호가 12예였으며 KSS 점수는 평균 91.4점이었다. 또한 최종 견관절 운동 범위는 전방 거상이 평균 $167.2^{\circ}$로 측정되었다. 모든 환자에서 수술 후 평균 14.1주에 골유합을 얻었으며, 경간각 회복 정도는 우수가 24예였으며 보통이 3예였다. 액와 신경 마비나 심부 감염, 금속판의 충돌 증후군 등의 합병증은 발생하지 않았다. 결론: 상완골 근위부 골절에 대한 최소 침습적 금속판 술식은 충분한 해부학적 지식을 숙지하고 시행하면 주변 연부 조직 박리를 최소화하여 합병증 발생을 감소시키고 조기 관절 운동을 가능하게 하므로 상완골 근위부 골절 치료의 효과적인 수술 방법의 하나로 사료된다.

• Journal of Chest Surgery
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• 제39권2호
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• pp.166-170
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• 2006

점액성섬유육종은 성인과 장년의 환자에서 사지의 가장 흔한 연조직 육종의 하나를 나타내고 있다. 하지만 이 종양은 흉벽에서는 희귀하게 발생한다. 58세의 여자환자가 본: 병원 일반외과에서 절제에 이은 수개월 후 재발하여서 우측 아래 흉벽에서 8${\times}$6.5 cm의 거대 종양덩어리를 보였다. 조직은 침윤성 심부에 위치한 피하층 종양이었고 명확한 점액성 변화와 중등도의 세포 충실성을 보이면서 명확한 엽성 성장을 보였다. 종양세포는 다양한 정도의 세포양상과 유사분열을 갖고 있는 방추형세포였고 궁형의 혈관양상을 보였다. 5-100, CD68과 Mac387 그리고 FX IIIa의 면역염색은 음성이었고 Vimentin 염색은 양성을 보였다. 조직양상은 점액성 섬유육종의 증간등급이었다. 광범위절제를 하였고 한달 후 퇴원하였는데 항암제나 방사선치료 없이 결손부위의 피부이식을 준비하고 있다.

• Journal of Periodontal and Implant Science
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• 제31권4호
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• pp.737-747
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• 2001

Regeneration of Periodontium with PRP does not only improve regeneration rate and density of bone but have a possibility to estimate faster healing process for soft tissue. And also, synthetic bone and xenogenic bone graft are effective on regeneration of periodontium. The purpose of this study is to evaluate the effectiveness of synthetic bone ($Biogran^{(R)}$) and xenogenic bone ($BBP^{(R)}$) grafts with the PRP technique on regeneration of periodontium. 52 Generally healthy Pt. who had pocket depth 5mm at any of 6 surfaces of the teeth were in the study at Dept. of Perio. in Dankook Dental Hospital. Open Flap was treated for 18 infra-bony pockets as control group, $Biogran^{(R)}$ with PRP was inserted for 25 infrabony pockets as first test group, and $BBP^{(R)}$ with PRP was inserted for 22 infrabony pockets as 2nd test group. Then evaluation was made after 3 and 6 months 1. 6 months after surgery, each difference of average probing pocket depth was $2.61{\pm}0.23$ for control, $3.40{\pm}0.30$ for 1st test, and $3.45{\pm}0.37$ for 2nd test group. 2. 6 months after surgery, each difference of clinical probing attachment level was $1.39{\pm}0.12$ for control, $2.88{\pm}0,24$ for 1st, and $2.86{\pm}0,27$ for 2nd test group. 3. 6 months after surgery, each difference of Maximal probing attachment level was $1.11{\pm}0.16$ for control, $3.28{\pm}0.30$ for 1st, and $3.27{\pm}0.35$ for 2nd test group. 4. There were significant differences for clinical change of each three group which were between average probing pocket depth and clinical attachment level of 3,6 months and minimal and maximal attachment level after 6 months 5. There were significant differences for average probing pocket depth which were only at control group and 2nd test group between 1 and 6months. For clinical attachment level and minimal and maximal proving attachment level, there was a significant difference after 6month of surgery. 6. There was no significant difference between two test groups for average probing depth, clinical attachment level, and minima1 and maximal probing attachment level. As the result, PRP with bone graft is very effective for regeneration of periodontium and there is no difference between xenogenic bone and synthetic bone.

• 대한소아치과학회지
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• 제32권4호
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• pp.620-627
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• 2005

조기 교정치료의 목적은 현재 존재하는 문제점들을 바로잡고 발생 가능한 문제점들을 차단하며 상황이 점점 악화되는 것을 미리 방지하는 것이다. 근기능적인 영향이 치열과 안모성장에 미치는 영향은 정상 치열구조에 형태적 변이를 일으키고 이미 존재하는 부정교합을 가속화시키게 된다. 따라서 이런 근기능적인 영향이 부정교합에 미치는 영향을 조기에 차단하여 부정교합이 악화되는 것을 예방하고 부가적으로 일어날 수 있는 문제점들을 막고자 하였다. 근기능치료는 1960년대 구강 습관을 치료하는 것으로부터 촉진되어 현재까지 많은 장치를 이용한 치료가 시행되고 있다. 최근 기존의 기능적 교정 장치가 가지고 있는 단점을 없애며 치아와 악골 배열과 관련된 근기능적인 습관을 조절할 수 있도록 혼합치열기의 부정교합을 가지고 있는 아동에게 적절한 장치로 Pre-orthodontic $TRAINER^{(R)}$가 소개되었다. Pre-orthodontic $TRAINER^{(R)}$는 $6{\sim}10$세 영구 전치가 맹출한 혼합 치열기 어린이에서 특히 하악 전치부 밀집이나, 전치부 반대교합, 2급 부정교합, 과개 교합을 가졌을 경우 사용될 수 있다. 또 만성적인 구호흡이나 손가락 빨기 버릇, 잘못된 연하습관을 가진 어린이에게도 유용하게 사용될 수 있다. 본 증례는 단국대학교 소아치과에 교정치료를 하기 위해 내원한 환자들 중에서 본격적인 교정치료 시작 전 습관조절을 위해 Pre-orthodontic $TRAINER^{(R)}$를 이용하여 만족할 만한 결과를 얻었기에 보고하는 바이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제19권3호
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• pp.265-286
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• 1997

Bone morphogenetic proteins(BMPs) are a group of transforming growth factor beta(TGF-${\beta}$)-related factors and multifunctional proteins, especially the only known biologic factors capable of inducing endochondral bone formation at an extraskeletal site. This study was performed to investigate the effect of the partially purified porcine BMP(pBMP) at an ectopic site. PBMP was partially purified from porcine bone matrix and its activity was monitored by an in vivo bioassay. The purification method utilized extraction of the bone-inducing activity with 4M guanidine, followed by chromatography on heparin-Sepharose. Active fractions were assayed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. And the fractions were reconstituted with inactive insoluble collagenous bone matrix from rats, acid soluble type I collagen from rat tail and chondroitin-6-sulfate sodium salt and implanted into the pectroralis muscle pouches of Sprague-Dawley rats. And the carrier complex was implanted on the opposite side as control. The rats were sacrificed at the day of 1st, 3rd, 5th, 7th, 11th, 14th and 21st after implantation and examined histologically, radiologically and biochemically. And alkaline phosphatase activity and calcium content were used as indices of bone formation. The results were as follows ; 1. Active fractions were localized in a zone between 31 and 40 KDa on SDS-PAGE. 2. The implanted 3.0mg of the partially purified pBMP induced cartilage and bone in the muscle tissue of rats through an endochondral ossification process. 3. Inactive insoluble bone matrix, type I collagen and chondroitin-6-sulfate have functioned as carriers for pBMP, but revealed some foreign body reactions. 4. Soft X-ray didn't reveal significant change between the experimental and the control group. 5. The alkaline phosphatase activities in the experimental group of 5th, 7th, 11th, 14th and 21st were increased significantly compared with control (p<0.01) with the peak in the group of 11th day. 6. With time, the calcium content of the experimental group increased. And the calcium contents in the experimental group of 11th, 14th and 21st were increased significantly compared with control (p<0.01).

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권2호
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• pp.100-105
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• 2012

Purpose: In general, the surgical treatment for mandibular retrognathism is represented by two methods, distraction osteogenesis (DO) and mandibular osteotomy surgery. The DO is mostly preferred when the degree of advancement of mandible is large. However, the postoperative stability of mandibular advancement using DO have not been actively investigated. Therefore, in the present study we have compared the postoperative stability between DO and bilateral sagittal split ramus osteotomy (BSSRO) in mandibular retrognathism. Methods: Seven patients who had been treated by DO and thirteen patients with BSSRO were included in this study. Serial lateral cephalograms were analyzed by manual tracing and the amount of the mandibular elongation was measured. To evaluate the postoperative stability, positional changes of the condylar position and B point were analyzed. Results: Mean amount of mandibular advancement was $6.51{\pm}3.57mm$ for BSSRO group and $12.43{\pm}4.35mm$ for DO group, respectively. There was no significant difference in age between the two groups (P>0.05). Mean follow up periods were 10.77 months for BSSRO group and 11.28 months for DO group, respectively. After mandibular advancement, mean positional changes in the condyle were $0.56{\pm}1.43mm$ horizontally and $0.72{\pm}1.61mm$ vertically for BSSRO group and $0.53{\pm}1.56mm$ horizontally and $0.56{\pm}1.75mm$ vertically for DO group, respectively. Mean change of distance from B point to Y-axis was $-1.76{\pm}0.83mm$ for BSSRO group and $-2.14{\pm}1.82mm$ for DO group, respectively. According to the condylar position and B point, there were no significant differences in postoperative stability between the two groups (P>0.05). Conclusion: There was no significant difference in postoperative stability between DO and BSSRO group according to condylar position and B point. Based on the results of the present study, it is hypothesized that DO would be a good treatment choice for severe mandibular retrognathism because DO could achieve more mandibular advancement and concurrent soft tissue elongation.

• 대한치과교정학회지
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• 제34권2호
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• pp.109-119
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• 2004

이 연구는 제 2 대구치를 발거하고 하악 제 1 대구치의 후방이동을 위해 CPHG(cervical pull head gear)와 경우에 따라 III급 고무줄을 사용하여 고정성 교정장치로 치료한 III급 부정교합자의 치료전후 안면골 및 치아치조부, 연조직의 평균변화를 알아보기 위해 시행되었다. 평균 ANB가 $-1.4^{\circ}$ 이고 IMPA가 $85^{\circ}$인 중등도이하의 III급 부정교합자 15명을 대상으로 치료전후 측모두부 X-선 규격사진의 평균 두개안면부 측면 중첩모식도를 작성하고 계측 분석한 바 다음과 같은 결과를 얻었다. 1. 전안면고경에 대한 전하안면고경의 비율은 $0.6\%$증가(P<0.01)하였고, 하악 평면각이 $1.5^{\circ}$증가(P<0.05)하였다. 2. 전방 두개저에 대한 하악골 위치는 미약하게 후하방회전하였다. 3. 하악 제 1 대구치가 4.06mm(P<0.001)후방경사이동하였고 하악 전치는 설측으로 $3.2^{\circ}$경사이동(P<0.05)하였다. 4. 하순의 후퇴로 인한 안모의 개선이 이루어졌다. 이상의 결과를 종합할 때 골격성 부조화가 중등도 이하인 III급 부정교합자에서 하악 제 1대구치의 후방이동을 용이하게 하고 하악 전치의 지나친 설측경사를 피하기 위해 제 2 대구치를 발거하는 것은 조심스러운 증례의 선택시 치료에 유용하리라 사료된다. 그러나 본 연구에서는 제 2 대구치 발거 후 제 3대구치의 맹출 및 치료후 예후에 대한 장기적인 관찰은 이루어지지 못하여 향후 이에 대한 계속적인 연구가 필요하리라 생각된다.

• 대한소아치과학회지
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• 제50권2호
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• pp.229-238
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• 2023

이 연구의 목적은 2011년부터 2020년까지 대한민국 소아 청소년 환자들의 혀유착증 진단과 그 수술적 치료의 동향을 조사하는 것이다. 건강보험심사평가원의 보건의료 빅데이터 개방시스템에서 제공하는 자료를 이용하여 혀유착증의 진단과 설소대 수술 시행의 연간 경향을 분석하였다. 설소대 수술 시행과 관련된 세부 요인을 조사하기 위해, 소아청소년 환자표본자료를 이용하였다. 혀유착증 진단의 경우 2011년 10만 명당 204.4명에서 2020년 356.6명으로 증가하는 경향을 보였으며, 설소대 수술은 26.8명에서 34.3명까지 증가하였다. 설소대 수술에 대한 로지스틱 회귀분석 결과, 남자가 여자보다 수술을 진행할 확률이 높았고, 0 - 4세의 연령군에서 가장 높은 진료 확률을 보였으며 병원급 요양기관에서 수술이 시행될 확률이 가장 높았다. 0 - 4세 연령군에서는 소아청소년과에서, 5 - 9세의 연령군에서는 소아치과에서 가장 많이 수술이 진행되었다. 그 이상의 연령에서는 보존과와 구강악안면외과에서 가장 높은 비율로 수술을 시행하였다. 혀의 기능은 악안면의 성장에 영향을 미칠 수 있는 만큼, 소아치과의사는 성장하는 어린이의 구강 연조직의 기능적 관리있어서도 면밀한 주의 및 관심을 기울여야 할 것으로 사료된다.