• 대한한방내과학회지
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• 제11권2호
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• pp.137-147
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• 1990

I studied some important medical liter atures in order to examine the cause of Aphasia and found out some facts as follows : 1. Hwang Je Nae Kgong(黃帝內經) is more referred exogenous causes of disease of Aphasia than endogenous causes of disease. 2. Among many causes of Aphasia, exogenous causes of disease was cinsidered to be most common in Soh Shi Je Byong Won Hu chong Rhon(巢氏諸病源喉總論), which has had a wide influence down the ages. 3. Chon Keum Yo Bang(千金要方), Chi Tae Bhi Yo(外臺秘要), Tae Pyong Song Hye Bang(太平聖惠方), Song Je Chong Rok(聖濟總綠). Bu In Yang Bang(婦人良方) and so forth had been quoted from Hwang Je Nae Kyong and Soh Shi Je Byong Won Hu Chong Ron(巢氏諸病源喉總論). 4. In the ming dynasty had been quoted non-exo-endogenous causes of disease and the Kinds of Aphasia and prescription. 5. In the Choeun dynasty and the Ching dynasty, exogenous causes of disease was confined to the quotation of the books referred to above as well, but endogenous causes of disease was developed. 6. Today is refered kidney and Aphasia. The cause of Aphasia obtained was as follows. The exogenous cause of disease is wind, wind and cold, wind and heat. The endogenous cause of disease is pregnancy, heart block of postpartum, weakness of heart and kidney, impairment of seven modes of emotions, stagnation of phlegm and phlegm-fire, hemorrhage. The non exo-endogenous causes of disease is sing ballads and call out.

• 동의생리병리학회지
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• 제25권3호
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• pp.431-437
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• 2011

Recently, there are so many studies that herbal composition has the effect on enhancing the memorial ability. But there are few studies whether it has effect on enhancing attentional ability. The purpose of present study is to prove the effects of a herbal composition(ChongA 100) on enhancing not only memorial but also attentional ability. The memorial ability interfered by amyloid-${\beta}$ was evaluated with passive avoidance test Y-maze task. The attentional ability was studied with attentional set-shifting task(ASST). The 200mg/kg of ChongA100 could significantly recover the shortened latency of passive avoidance test and the interfered alternation of Y-maze task. The number of trials in ASST was significantly reduced as well. Our study suggests that it has effects on enhancing both memorial and attentional ability.

• 혜화의학회지
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• 제8권2호
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• pp.123-132
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• 2000

The following results were obtained through studies related to bao(胞). 1 Bao(胞) is also called as uterus, zizang(子臟), baogong(胞宮), xieshi(血室), dantian(丹田), mingmen(命門), baomen(胞門), and guanyuan(關元). It is one of the extraordinary organs. Both of man and woman have it. 2 Man controls qi(氣), so dantian(丹田) which is considered xieshi(血室) for man doesn't have it's own shape and woman controls blood so xieshi(血室) has it's own shape. 3 Bao(胞) is in front of rectum, back of bladder, between guanyuan(關元) and 氣海. shape of 女子胞 is up side down triangle, the lower one branch is neck of uterus and the upper two branches are oviduct. Inside of Bao(胞) is vacant. 4 Bao(胞) is the origin of making essence and blood, and the place of completing essence, energy, and spirit(精氣神). Bao(胞) controls menstruation and also conceives and brings up embryo in woman. 5 Bao(胞) is related with channels of Du, Ren, Chong, and Dai directly and also related with twelve main meridians. Especially channels of Ren, and Chong control Bao(胞) the most importantly. 6 Bao(胞) is related with kidney, liver, and spleen very intimately.

• Molecules and Cells
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• 제39권3호
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• pp.217-228
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• 2016

To generate a biobetter that has improved therapeutic activity, we constructed scFv libraries via random mutagenesis of several residues of CDR-H3 and -L3 of hu4D5. The scFv clones were isolated from the phage display libraries by stringent panning, and their antiproliferative activity against HER2-positive cancer cells was evaluated as a primary selection criterion. Consequently, we selected AH06 as a biobetter antibody that had a 7.2-fold increase in anti-proliferative activity ($IC_{50}$: 0.81 nM) against the gastric cancer cell line NCI-N87 and a 7.4-fold increase in binding affinity ($K_D$: 60 pM) to HER2 compared to hu4D5. The binding energy calculation and molecular modeling suggest that the substitution of residues of CDR-H3 to W98, F100c, A101 and L102 could stabilize binding of the antibody to HER2 and there could be direct hydrophobic interactions between the aromatic ring of W98 and the aliphatic group of I613 within HER2 domain IV as well as the heavy and light chain hydrophobic interactions by residues F100c, A101 and L102 of CDR-H3. Therefore, we speculate that two such interactions were exerted by the residues W98 and F100c. A101 and L102 may have a synergistic effect on the increase in the binding affinity to HER2. AH06 specifically binds to domain IV of HER2, and it decreased the phosphorylation level of HER2 and AKT. Above all, it highly increased the overall level of p27 compared to hu4D5 in the gastric cancer cell line NCIN82, suggesting that AH06 could potentially be a more efficient therapeutic agent than hu4D5.

• Journal of the Korean Statistical Society
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• 제25권1호
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• pp.81-94
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• 1996

This paper suggests a new criterion for testing the general linear hypothesis about coefficients in multivariate growth curve model. It is developed from a Bayesian point of view using the highest posterior density region methodology. Likelihood ratio test criterion(LRTC) by Khatri(1966) results as an approximate special case. It is shown that under the simple case of vague prior distribution for the multivariate normal parameters a LRTC-like criterion results; but the degrees of freedom are lower, so the suggested test criterion yields more conservative test than is warranted by the classical LRTC, a result analogous to that of Berger and Sellke(1987). Moreover, more general(non-vague) prior distributions will generate a richer class of tests than were previously available.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 춘계학술대회 논문집
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• pp.592-595
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• 2009

In recent years, geothermal heat pump (GHP) systems have become increasingly popular for heating and cooling in buildings. The Standing Column Well (SCW) method is one of the most efficient GHP system. Because it use groundwater for heat transfer material. In SCW systems, water is re-circulated between the well and the building (heat pump). It is only a short time since this method has been applied in domestic. So we have to refer to the developed countries' guides and manuals of SCW. In this paper, several design and construction points of SCW method are filed. We used real operation data of SCW system at Chong-Ju Univ. site for economical efficiency analysis. As a result, the payback period of Chong-Ju Univ. site is calculated at 7.23 years.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.138-139
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• 2002

The diverse, widespread, and exceedingly numerous family of natural products constructed from five carbon building-units and so comprising compounds with $C_{5}$, $C_{10}$, $C_{15}$, $C_{20}$, ${\cdots}$, $C_{40}$ skeletons (together with a few higher members) are synoymously termed terpenes or terpenoids. Among the terpene classes, the triterpenes ($C_{30}$ skeletones) form the largest group and are widely distributed in the plant kingdom, either in the free state or as esters or glycosides, although a few important members found in the animal kingdom such as squalene and a number of tetracyclic component including lanosterol. (omitted)

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 B
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• pp.503-505
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• 1998

The position control of an induction motor using Feedforward Neural Networks(FNNs) was studied in this paper. A teaching signal was obtained from sliding surface without a particular signal. And the FNNs team through the back propagation algorithm so as to reduce the error between the real position of the motor and the reference value. The structure of a controller was designed simply, for the fast calculating response which is certainly necessary for induction motor position control. And to show the superiority of this controller, 3-phase vector control induction motor whose power capacity is 2.2kw was modeled, and it was simulated.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 하계학술대회 논문집 D
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• pp.2089-2091
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• 2001

In this paper, a hybrid controller that consists of a conventional PD controller and a neural network controller which adapts to various control conditions by online learning is used and a new learning algorithm of the neural networks is used to prevent weights of neural network from diverging. A conventional PI controller and the hybrid controller is applied to speed control of 3 phase induction motor. So in comparison with a PD controller, we prove superiority of hybrid controller by experiments.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2004년도 하계종합학술대회 논문집(2)
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• pp.553-556
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• 2004

In this paper, we present a new efficient multi-level hardware/software partitioning algorithm for system-on-a-chip design. Originally the multi-level partitioning algorithm are proposed to enhance the performance of previous iterative improvement partitioning algorithm for large scale circuits. But when designing very complex and heterogeneous SoCs, the HW/SW partitioning decision needs to be made prior to refining the system description. In this paper, we present a new method, based on multi-level algorithm, which can cover SoC design. The different variants of algorithm are evaluated by a randomly generated test graph. The experimental results on test graphs show improvement average $9.85\%$ and $8.51\%$ in total communication costs over FM and CLIP respectively.