• Journal of Pharmaceutical Investigation
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• v.40 no.6
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• pp.353-356
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• 2010

Although liposomes have been applied as drug delivery systems in various fields, the usage was limited due to the low encapsulation efficiency compared to other carrier systems. Here, cationic liposomes were prepared by mixing 1,2-dioleoyl-3-trimethylammoniopropane (DOTAP) as a cationic lipid, 1,2-dioleoyl-sn-glycerol-phosphoethanolamine (DOPE) and cholesterol (CH), and the liposomes were hydrated by varying the aqueous phases such as phosphate-buffered saline (PBS), 5% dextrose, and 10% sucrose in order to improve the encapsulation efficiency of bovine serum albumin (BSA). The particle size and zeta potential were determined by dynamic light scattering method and in vitro release patterns were investigated by spectrophotometry. Particle size and zeta potential of liposomes were varied depending on the ratio of DOTAP/DOPE/CH in range of 270-350 nm and 0.8-9.7 mV, respectively. Moreover, the addition of polyethylene glycol (PEG) improved the encapsulation efficiency from 37% to 43% as well as reduced particle sizes of liposomes while the liposomes were hydrated in PBS. When the liposomes were hydrated with 10% sucrose, the encapsulation efficiency of BSA was higher than any other groups. Whereas PBS was used as hydration solution, lower encapsulation efficiency was obtained compared with other groups. More than 60% of BSA was released from the liposomes hydrated with 10% sucrose; thereafter another 20% of BSA was released. Therefore, release pattern of BSA from cationic liposomes was extended release in this study. From the results, cationic liposomes dispersed in 10% sucrose would be potential carrier with high encapsulation efficiency.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.5
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• pp.207-214
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• 2020

Nowadays, the use of smart phones and various electronic devices is increasing, the Internet and SNS are activated, and we live in the flood of information. The amount of information has grown exponentially, making it difficult to look at a lot of information, and more and more people want to see only key keywords in a document, and the importance of research to extract topics that are the core of information is increasing. In addition, it is also an important issue to extract the topic and compare it with the past to infer the current trend. Topic modeling techniques can be used to extract topics from a large volume of documents, and these extracted topics can be used in various fields such as trend prediction and data analysis. In this paper, we inquire the topic of the three-year papers of 2016, 2017, and 2018 in the field of computing using the LDA algorithm, one of Probabilistic Topic Model Techniques, in order to analyze the rapidly changing trends and keep pace with the times. Then we analyze trends and flows of research.

• Bulletin of the Korean Chemical Society
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• v.32 no.1
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• pp.59-64
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• 2011

Degree of unsaturation in fatty acid molecules plays an important role in the formation of vesicles. Vesicle formation from C18 fatty acids with different amount of double bonds such as oleic acid, linoleic acid and linolenic acid with the incorporation of 1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DPPE-PEG2000) have been examined by TEM. Critical vesicular concentrations (CVC) of the vesicle suspension are determined by turbidity and surface tension methods. The CVC of fatty acids increases when the amount of unsaturation in the alkyl chain increases. On the other hand, stability of vesicle suspension has been examined by using particle size and zeta potential at $30^{\circ}C$. There was a dramatic decrease in particle size measurement from mono-unsaturation to tri-unsaturation which could be due to the effect of fluidity in the membrane bilayer caused by different degree of unsaturation. The values of zeta potential for vesicles that were formed without the incorporation of DPPE-PEG2000 were in the range of -70 mV to -100 mV. It has been observed that the incorporation of DPPEPEG2000 to the vesicle reduces the magnitude of zeta potential. However, this phenomenon does not obviously seen in fatty acid vesicles formed by linoleate-linoleic acid and linolenate-linolenic acid. We therefore conclude that the addition of DPPE-PEG2000 does not effectively improve the stability of the linoleate-linoleic acid and linolenatelinolenic acid vesicle at pH 9.0 after the evaluation of their particle size and zeta potential over a period of 30 days. Although the vesicles formed were not stable for more than 10 days, they have displayed the potential in encapsulating the active ingredients such as vitamin E and calcein. The results show that the loading efficiencies of vitamin E are of encouraging value.

• Journal of Periodontal and Implant Science
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• v.43 no.4
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• pp.191-197
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• 2013

Purpose: Nitric oxide (NO) is a short-lived bioactive molecule that is known to play an important role in the pathogenesis of periodontal disease. In the current study, we investigated the effect of the flavonoid quercetin on the production of NO in murine macrophages activated with lipopolysaccharide (LPS) from Prevotella intermedia, a pathogen related to inflammatory periodontal disease, and tried to elucidate the underlying mechanisms of action. Methods: LPS was isolated from P. intermedia ATCC 25611 cells by the standard hot phenol-water method. The concentration of NO in cell culture supernatants was determined by measuring the accumulation of nitrite. Inducible NO synthase (iNOS) and heme oxygenase-1 (HO-1) protein expression, phosphorylation of c-Jun N-terminal kinase (JNK) and p38, inhibitory ${\kappa}B$ $(I{\kappa}B)-{\alpha}$ degradation, and signal transducer and activator of transcription 1 (STAT1) phosphorylation were analyzed via immunoblotting. Results: Quercetin significantly attenuated iNOS-derived NO production in RAW246.7 cells activated by P. intermedia LPS. In addition, quercetin induced HO-1 protein expression in cells activated with P. intermedia LPS. Tin protoporphyrin IX (SnPP), a competitive inhibitor of HO-1, abolished the inhibitory effect of quercetin on LPS-induced NO production. Quercetin did not affect the phosphorylation of JNK and p38 induced by P. intermedia LPS. The degradation of $I{\kappa}B-{\alpha}$ induced by P. intermedia LPS was inhibited when the cells were treated with quercetin. Quercetin also inhibited LPS-induced STAT1 signaling. Conclusions: Quercetin significantly inhibits iNOS-derived NO production in murine macrophages activated by P. intermedia LPS via anti-inflammatory HO-1 induction and inhibition of the nuclear factor-${\kappa}B$ and STAT1 signaling pathways. Our study suggests that quercetin may contribute to the modulation of host-destructive responses mediated by NO and appears to have potential as a novel therapeutic agent for treating inflammatory periodontal disease.

• Journal of Digital Contents Society
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• v.15 no.5
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• pp.587-594
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• 2014

Owing to supply of smart phones and the diffusion of SNS, the number of peoples who are living, linked with us, is incomparably more than in the past. The continuous communication is essential in maintaining good relationship, so peoples have no choice but to seek for most efficient communication method in order to maintain good relationship. This thesis intended to advise how to construct next generation immersive multi-media system, using augmented reality and MPEG-V that have come to the fore recently. In addition, the SNS platform service of new type was suggested in this thesis, in connection with the pairing service. Now, we can create a town in a specific space like the real world, if we utilize the augmented reality that became possible by SNS service and we can talk and exchange informations in that space. This system would provide various services peoples wish to have, interlocking experiences through five senses like sense of vision, sense of hearing, sense of touch and etc..

• Journal of Digital Convergence
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• v.13 no.9
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• pp.201-208
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• 2015

With services such as SNS and facebook, Big Data popularize the use of small size such as micro blogs are increasing. However, the problem of accuracy and computational cost of the search result of big data of a small size is unresolved. In this paper, we propose a subnet selection techniques based probability to improve the browsing speed of the small size of the text information from big data environments, such as micro-blogs. The proposed method is to configure the subnets to give to the attribute information of the data increased the probability data search speed. In addition, the proposed method improves the accessibility of the data by processing a pair of the connection information between the probability of the data constituting the subnet to easily access the distributed data. Experimental results showed the proposed method is 6.8% higher detection rates than CELF algorithm, the average processing time was reduced by 8.2%.

• Journal of Digital Convergence
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• v.12 no.10
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• pp.211-222
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• 2014

This study investigates the antecedents of continuance intention of mobile SNS. In addition, it also explores the mediating role of perceived value in the relationship between the antecedent and continuance intention. This study posits that a social influence, perceived usefulness, privacy concern, and a perceived effort of use are major factors to influence continuance intention of SNS. By using a PLS analysis, this finding suggests that consumers' perception of the value of SNS which is previously overlooked, is a primary determinant of continuance intention, and the other exploratory factors are mediated through perceived value in cognitive aspect. This research aims to examine consumer's SNS continuance intention in terms of consumer's perspective, not just from the technology user perspective. Therefore, this research provides a useful guideline for marketing managers on how to manage Mobile SNS properly.

• Journal of Digital Contents Society
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• v.19 no.2
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• pp.385-392
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• 2018

Iksan is one of medium city in Jellabukdo, South Korea. It has a favorable natural environment for the specialization potential of natural industries and development projects. In addition, it has various historical and cultural resources including Mireuksajji, and KTX Honam line which has been opened for a representative feature as transport city. However, it faces week connection with neighboring cities and large scale of development in neighboring areas, especially in Jeonju and Gunsan. In this paper, we try to classify the urban image assets of Iksan as 'Iksan Station' and 'ktx' on keywords and analyze the possibility of being a center of transportation and logistics through big data analysis extracted from SNS and website. In comparison with Gwangju Songjeong, KTX Honam line station, which has been developed with similar regional characteristics, it is aimed to establish the basis of improvement and establishment of urban image of Iksan city in the future.

• Corrosion Science and Technology
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• v.13 no.1
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• pp.15-19
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• 2014

Recently, anti-fouling paints which does not include the poison components such as tin(Sn), copper(Cu) have been increasingly developed in order to inhibit the environmental contamination of the sea water. Moreover, the wear ratios of these anti-fouling paints are very important problem to prolong their life time in economical point of view. In this study, five types of anti-fouling paints as self polishing type were investigated on the relationship between their polarization characteristics and wear ratios. It was verified that there was apparently a good relationship between the wear ratio and polarization characteristics, for example, the wear ratio increased with increasing the impedance ratio, and increased or decreased with the corrosion potential shifting in the negative or positive direction respectively. In addition, the wear ratio decreased with decreasing the corrosion current density. Consequently, it is suggested that we can qualitatively expect the wear ratio by only measuring the polarization characteristics. Therefore, before the examination of the wear ratio was actually carried out in the field, the evaluation of polarization property in the laboratory may give a available reference data for their developments.

• Membrane Journal
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• v.19 no.4
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• pp.333-340
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• 2009

This paper is designed with the purpose of improving the efficiency of the sulfonic acid ion exchange membranes by radiation induced graft polymerization. It has been shown that the porous hollow fiber membranes could cause permeability blocking between pores and ion exchanged graft chains. Addition of crosslinker such as N-ethylene glycol dimethacrylate will permit to increase the permeation flux. In this research, the ethylene glycol dimethacrylate (EDMA) and diethylene glycol dimethacrylate (DDMA) with different length are used as crosslinkers. The ion exchanged cross-linked membrane (EDMA, DDMA) containing sulfonic acid group by radiation induced grafted polymerization are sn died for adsorb metal ions (Pb). It has been shown that adsorbed metal ions ($Pb^{2+}$) for the EDMA and DDMA membranes with the density of sulfonic acid groups, 1.40 mmol/g and 2.14 mmol/g, respectively are 13.82 mg/g, 17.37 mg/g, accordingly.