• The Journal of Korean Physical Therapy
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• 제22권1호
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• pp.61-66
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• 2010

Purpose: The purpose of this study was to investigate the change in sympathetic nervous system responses of healthy adult women with changes in stimulus intensity of high frequency transcutaneous electrical nerve stimulation. Methods: Twenty-four healthy subjects (women) received high frequency electrical stimulation of the forearm. The subjects were randomly assigned to one of two groups; a low intensity stimulation group (n=12) and a high intensity stimulation group (n=12). The electrode attachment was arranged on the forearm of the dominant arm and the electricity stimulus time was 20 minutes. Measured items included skin conductance, pulse rate, skin temperature, and respiration rate. Each was measured at 4 times. Results: Skin conductance and skin temperature showed significant group by time interactions, though there were no significant group and time effects. There were no significant differences according to time, group effect, and a group by time interaction in pulse and respiration rates. Conclusion: High frequency and high intensity electrical stimulation may be helpful for the improvement of sudomotor function through the activation of the sympathetic nervous system. Also, high frequency and low intensity electrical stimulation may be helpful for the reduction of sudomotor function via inhibition of the sympathetic nervous system.

• 정신신체의학
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• 제31권1호
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• pp.19-24
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• 2023

Objectives : Biofeedback is a useful non-pharmacological treatment for panic disorder (PD), but no studies have identified physiological markers related to the treatment response. This study investigated predictors of the treatment response for biofeedback in patients with PD. Methods : A retrospective study based on the electronic medical records of 372 adult patients with PD was performed. Patients received biofeedback treatment at least once, and physiological markers including heart rate, heart rate variability, respiratory rate, skin conductance, skin temperature, and electromyography were collected before the treatment began. The patients were classified as responders or non-responders based on the change in Clinical Global Impression-Severity (CGI-S) score. Results : The response rate to biofeedback treatment was 30.4%. Multivariable logistic regression analysis revealed that a higher CGI-S score at baseline and fewer benzodiazepine prescriptions were associated with a better response to biofeedback treatment. According to subgroup analyses, the baseline CGI-S score, dose of benzodiazepines, and skin conductance are candidate predictors of the response to biofeedback treatment in men, while only baseline disease severity was associated with the treatment response in women. Conclusions : The present results suggest that skin conductance may be target marker and predictor for biofeedback in male patients with PD.

• 대한임상전기생리학회지
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• 제8권2호
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• pp.19-24
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• 2010

Purpose : This study aims to examine the influences of galvanic vestibular stimulation on autonomic reaction of normal adults. Methods : Participants in this research totaled 28 (14 men and 14 women). Galvanic vestibular stimulation was conducted with a binaural electrode configuration for 60 sec. Galvanic vestibular stimulation measurements were conducted with the subjects in a prone position. Measured items included skin conductance, blood flow, pulse rate, and respiratory rate. Measurements were repeated for a total of five times, before application, during application, after application, 5 minutes after application and 10 minutes after application. Results : Skin conductance reaction showed statistically significant differences in changes depending on time after galvanic vestibular stimulation and there were statistically differences in changes of blood flow, pulse rate and respiratory rate after galvanic vestibular stimulation. Conclusion : Blood flow, pulse rate and respiratory rate of autonomic reactions were not influenced by galvanic vestibular stimulation, but skin conductance reaction was influenced by it and it was found that it was reduced during and after stimulation rather than before stimulation. Consequently, it was considered that galvanic vestibular stimulation affected the autonomic reaction.

• Korean Journal of Acupuncture
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• 제26권4호
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• pp.39-52
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• 2009

Objectives : Cue reactivity is a key factor that modulates motivational goal-directed behavior associated with compulsive drug-taking and relapse. We investigated whether acupuncture attenuated the skin conductance response and the heart rate response to smoking-related visual cues in smokers. Methods : Twenty-nine smokers were treated with real acupuncture (RA) or sham acupuncture (SA). The stress response inventory was measured on the 5th day after quitting smoking. The skin conductance response and the heart rate were measured to evaluate the autonomic changes to the smoking related visual cues on the same day. Results : The sympathetic alterations in skin conductance and the heart rate induced by the smoking-related visual cues were significantly lower in the RA group, as compared to the SA group. The stress response inventory, such as somatization and frustration, in the RA group was significantly lower than that of the SA group. Conclusions : Acupuncture ameliorated the stress symptoms as well as the sympathetic activation to smoking cues during withdrawal. These findings indicate that acupuncture might be a useful tool in smoking cessation by inhibiting smoking cues-induced autonomic responses.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 2002년도 춘계학술대회 논문집
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• pp.107-113
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• 2002

We examined the psychophysiological effects of navigation in a virtual reality (VR). Subjects were exposed to the VR, and required to detect specific objects. Ten electrophysiological signals were recorded before, during, and after navigation in the VR. Six questionnaires on the VR experience were acquired from 45 healthy subjects. There were significant changes between the VR period and the pre-VR control period in several psychophysiological measurements. During the VR period, eye blink, skin conductance level, and alpha frequency of EEG were decreased but gamma wave were increased. Physiological changes associated with cybersickness included increased heart rate, eye blink, skin conductance response, and gamma wave and decreased photoplethysmogram and skin temperature. These results suggest an attentional change during VR navigation and activation of the autonomic nervous system for cybersickness. These findings would enhance our understanding for the psychophysiological changes during VR navigation and cybersickness.

• The Korean Journal of Physiology and Pharmacology
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• 제9권2호
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• pp.131-135
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• 2005

Potassium channels in human skin fibroblast have been studied as a possible site of Alzheimer disease pathogenesis. Fibroblasts in Alzheimer disease show alterations in signal transduction pathway such as changes in $Ca^{2+}$ homeostasis and/or $Ca^{2+}-activated$ kinases, phosphatidylinositol cascade, protein kinase C activity, cAMP levels and absence of specific $K^+$ channel. However, little is known so far about electrophysiological and pharmacological characteristics of large-conductance $Ca^{2+}$-activated $K^+$ ($BK_{Ca}$) channel in human fibroblast (CRL-1474). In the present study, we found Iberiotoxin- and TEA-sensitive outward rectifying oscillatory current with whole-cell recordings. Single channel analysis showed large conductance $K^{+}$ channels (106 pS of chord conductance at +40 mV in physiological $K^+$ gradient). The 106 pS channels were activated by membrane potential and $[Ca^{2+}]_i$, consistent with the known properties of $BK_{Ca}$ channels. $BK_{Ca}$ channels in CRL-1474 were positively regulated by adenylate cyclase activator ($10{\mu}M$ forskolin), 8-Br-cyclic AMP ($300{\mu}M$) or 8-Br-cyclic GMP ($300{\mu}M$). These results suggest that human skin fibroblasts (CR-1474) have typical $BK_{Ca}$ channel and this channel could be modulated by c-AMP and c-GMP. The electrophysiological characteristics of fibroblasts might be used as the diagnostic clues for Alzheimer disease.

• 대한의용생체공학회:의공학회지
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• 제44권1호
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• pp.33-40
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• 2023

Transcutaneous auricular vagus nerve stimulation (taVNS) is known to be effective in improving symptoms of numerous diseases such as depression and epilepsy by increasing vagus nerve activity through electrical stimulation. The purpose of this study is to investigate the effect of vagus nerve stimulation on the activity of autonomic nervous system and the changes in postprandial blood glucose levels. Seven healthy adults participated in a non-invasive transcutaneous auricular vagus nerve stimulation experiment. taVNS (25 Hz, 200 ㎲, biphasic pulse) was applied to the cymba concha (taVNS group) or the earlobe (Sham-taVNS group) of the left ear. As autonomic nervous system signals, skin conductance level, skin temperature, and heart rate were recorded during the application of taVNS. Postprandial blood glucose changes due to food intake were recorded at 5 min intervals for 25 minutes after taVNS or sham-taVNS. The taVNS showed a significantly lower skin conductance level than the shamtaVNS (p < 0.05). The increase rate of postprandial blood glucose was significantly lower in the taVNS than in the sham-taVNS (p < 0.05). These results showed that taVNS reduced the activity of the sympathetic nerve system and alleviated early rise in postprandial blood glucose. Although further studies in diabetic patients are needed, this study suggest that taVNS has a potential for clinical use to improve postprandial blood glucose.

• 감성과학
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• 제7권3호
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• pp.27-35
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• 2004

본 연구는 피부전도도(skin conductance response), 말초혈관 반응(peripheral plethysmograph), 피부온도 (skin temperature)와 심박수(heart rate)와 같은 다양한 생리신호를 측정하여 운전자의 심리반응을 통하여 적정 운전상태를 분석하고자 하였다. 운전자의 심리반응을 측정 및 분석하기 위하여 하드웨어와 알고리듬을 개발하였으며, 운전상황은 자동차 시뮬레이터를 이용하여 다양한 가상 운전상황을 설정하고 생리신호를 측정하였다. 측정 결과 운전자 생리신호가 운전환경의 변화에 따른 심리적 긴장 또는 이완 수준을 잘 반영하고 있고, 감정적 변화에는 다소 둔감한 것으로 나타났다. 이를 심리적 순위척도를 이용하여 정량화하여 심리적 적정 운전범위를 제안하였다. 본 연구의 결과는 추후 운전자의 안전운전이나 건강상태를 모니터링 하기 위한 시스템 개발의 자료로 활용할 수 있을 것이다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.271-274
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• 1997

Skin temperatures, heart rates and skin conductance levels were tested in order to extract the biological characteristics of the physical constitutional types in according to the Lee's 4 type physical constitutional theory. The subjects of this experiment were 14 ; 5 Macro-Negative subjects, 5 Micro-Negative subjects, 3 Micro-Positive subjects and 1 Macro-Positive subject. All subjects were stimulated with 2.5Hz 30V peak-peak pulses for 2 minutes. As the results, in normal prestimulation state the skin temperatures of the trunk in Micro-Positive and Macro-Positive subjects were higher than those of Macro-Negative and Micro-Negative subjects. In Macro-Negative subjects the reflected skin temperature of lever was the highest in the anterior trunk. In Micro-Negative subjects the reflected skin temperature of kidney was the highest in the trunk. In Micro-Positive subjects the reflected skin temperature of stomach was the highest in the trunk. In Macro-Positive subject the reflected skin temperature of lung was the highest in the trunk. In transient poststimulation state, heart rate was decreased in 7 cases among of 10 Macro-Negative and Micro-Negative subjects, but it was iscreased in 3 cases among of 4 Micro-Positive and Macro-Positive subjects. And the hand temperature was increased in 8 cases among of 10 Macro-Negative and Micro-Negative subjects, but it was decreased in 3 cases among of 4 Micro-Positive and Macro-Positive subjects.

• 한국음향학회:학술대회논문집
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• 한국음향학회 1998년도 학술발표대회 논문집 제17권 1호
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• pp.291-296
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• 1998

In the experiment carried out on 20 college students, recorded were frontal, temporal and occipital EEG, skin conductance response, skin conductance level, heart rate and respiration rate during listening to two music fragments with different affective valences and white noise administered immediately after negative visual stimulation. Analysis of physiological patterns observed during the experiment suggests that affective auditory stimulation with music is able to selectively modulate autonomic and cortical activity evoked by preceding aversive visual stimulation and to restore initial baseline levels. On other hand, physiological responses to white noise, which does not possess emotion-eliciting capabilities, evokes response typical for orienting reaction after the onset of a stimulus and is rapidly followed by habituation. Observed responses to white noise were similar to those specific to attention only and had no evidence for any emotion-related processes. Interpretation of the obtained data is considered in terms of the role of emotional and orienting significance of stimuli, dependence of effects on the background physiological activation level and time courses of attention and emotion processes. Physiological parameters are summarized with regard to their potential utility in differentiation of psychological processes induced by auditory stimuli.