• 대한치과교정학회지
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• 제33권1호
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• pp.31-39
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• 2003

본 연구는 성장에 의한 변화를 예측하는 현재의 방법이 실제로 골격성 III급 부정교합자의 진단과 치료계획에 적절히 사용될 수 있는지를 판단해 보기 위해 초진 시 골격성 III급 부정교합으로 진단받고 성장 종료 후 악교정 수술을 받기 위해 재내원한 골격성 III급 부정교합자 25명(남자 13명, 여자 12명)을 대상으로 시행되었다. 초진시 채득된 측모 두부방사선 사진에서 Ricketts의 성장예측법을 통해 성장 종료 후의 상태를 예측한 후, 악교정 수술을 위해 재내원 했을 때 채득된 측모 두부방사선 사진에서 계측된 실제 성장량과 비교분석 함으로써 다음과 같은 결론을 얻었다. 1. 예측치와 관측치의 일치정도를 평가해본 결과 Porion Location, Ramus Position, Facial Depth, Facial Axis, Mandibular Plane angle, Maxillary Convexity에서의 예측치가 관측치와 차이를 보이고 있어 이 항목에 대한 Ricketts 성장예측법의 예측치가 실제 성장량을 잘 설명해주지 못함이 관찰되었다. 2. 하악골체의 성장량은 정상 성 장량과 유사하였으나 Porion Location, Ramus Position이 정상적인 성장과정을 벗어나면서 하악골의 전방위치를 유도하였다. 3. 골격성 III급 부정교합자에서는 성장의 양과 방향이 비정상적인 성장변화를 나타내어 정상 성장에서라면 변화를 보이지 않을 하악지의 전방 위치, 하악이부의 전상방 회전등이 일어나 하악 전돌의 경향이 악화될 수 있다.

• Asian-Australasian Journal of Animal Sciences
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• 제20권10호
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• pp.1612-1617
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• 2007

In this study, we have compared the skeletal muscle proteome at various stages of porcine postnatal development. Korean native pigs were divided into five postnatal stages of 30, 70, 130, 170 and 300 d and their loin muscles were analyzed for muscle proteome by using two-dimensional electrophoresis and mass spectrometry. We found 5 proteins showing a consistent pattern during skeletal muscle growth. Four proteins were identified as myosin light chain 1 slow-twitch (MLC1sa) isoform, troponin T, triosephosphate isomerase (TIP) and DJ-1 protein. The remaining protein was not identified. Two muscle fiber proteins of MLC1sa isoform and troponin T showed a high expression level at an early postnatal stage and then their levels were decreased markedly during growth stages. On the other hand, the expression of TIP and DJ-1 protein, which are well known as catalysis enzyme and antioxidant-related protein, respectively, were linearly increased during growth stages. Thus, the stage-related muscle proteins may be useful as parameters for understanding the developmental characteristics of biochemical and physiological properties in Korean native pig skeletal muscle.

• Animal cells and systems
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• 제16권6호
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• pp.431-437
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• 2012

Calpains are a class of proteins that belong to the calcium-dependent, non-lysosomal cysteine proteases. There are three major types of calpains expressed in the skeletal muscle, namely, ${\mu}$-calpain, m-calpain, and calpain 3, which show proteolytic activities. Skeletal muscle fibers possess all three calpains, and they are $Ca^{2+}$-dependent proteases. The functional role of calpains was found to be associated with apoptosis and myogenesis. However, calpain 3 is likely to be involved in sarcomeric remodeling. A defect in the expression of calpain 3 leads to limb-girdle muscular dystrophy type 2A. Calpain 3 is found in skeletal muscle fibers at the N2A line of the large elastic protein, titin. A substantial proportion of calpain 3 is activated 24 h following a single bout of eccentric exercise. In vitro studies indicated that calpain 3 can be activated 2-4 fold higher than normal resting cytoplasmic [$Ca^{2+}$]. Characterization of the calpain system in the developing muscle is essential to explain which calpain isoforms are present and whether both ${\mu}$-calpain and m-calpain exist in differentiating myoblasts. Information from such studies is needed to clarify the role of the calpain system in skeletal muscle growth. It has been demonstrated that the activation of ubiquitous calpains and calpain 3 in skeletal muscle is very well regulated in the presence of huge and rapid changes in intracellular [$Ca^{2+}$].

• Molecules and Cells
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• 제28권6호
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• pp.589-593
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• 2009

In this study, the roles of the p38 MAPK, ERK1/2 and JNK signaling pathway in IGF-I-induced AR induction and activation were examined. C2C12 cells were treated with IGF-I in the absence or presence of various inhibitors of p38 MAPK (SB203580), ERK1/2 (PD98059), and JNK (SP600125). Inhibition of the MAPK pathway with SB203580, PD98059, or SP600125 significantly decreased IGF-I-induced AR phosphorylation and total AR protein expression. IGF-I-induced nuclear fraction of total AR and phosphorylated AR were significantly inhibited by SB203580, PD98059, or SP600125. Furthermore, IGF-I-induced AR mRNA and skeletal ${\alpha}-actin$ mRNA were blocked by those inhibitors in dose-dependent manner. Confocal images showed that IGF-I-induced AR nuclear translocation from cytosol was significantly blocked by SB203580, PD98059, or SP600125, suggesting that the MAPK pathway regulates IGF-I-induced AR nuclear localization in skeletal muscle cells. The present results suggest that the MAPK pathways are required for the ligand-independent activation of AR by IGF-I in C2C12 skeletal muscle cells.

• 대한치과교정학회지
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• 제37권1호통권120호
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• pp.29-43
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• 2007

본 연구는 성장기 II급 부정교합자를 골격 형태에 따라 분류하여 액티베이터 사용 효과를 비교, 분석하고 그 결과를 진단, 치료 계획 수립 등 임상 과정에 연계시키기 위해 시행되었다. 실험은 수완부 방사선 사진상 Fishman 분류의 2, 3, 4 단계로 최대성장기 이전의 II급 부정교합자를 대상으로 하였다. 대조군은 ANB 3도 이상이며 악정형 장치 치료를 받지 않고 치열교정 치료만 받은 환자로 총 25명(남자 15명, 여자 10명)이고 실험군은 액티베이터 치료를 받은 환자로 총 116명(남자 53명, 여자 63명)이었다. Articular angle과 gonial angle을 이용하여 골격 형태를 hyperdivergent type과 hypodivergent type으로 분류하여 액티베이터 치료효과를 비교한 결과 hypodivergent한 골격 형태를 가진 환자에서 더 큰 효과를 보였다. 따라서 성장기 II급 부정교합자의 진단과 치료계획 수립 시 안모의 골격 형태 분류를 통해 액티베이터의 효과를 예측할 수 있다고 생각한다.

• 대한치과교정학회지
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• 제17권1호
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• pp.135-148
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• 1987

To investigate the relationship between craniofacial growth and bone maturity of the hand wrist in normal occlusion, the author took cephalogram and handwrist radiogram of 391 students (male 192, female 199) and assessed the measurements of cephalogram according to skeletal maturity stages of the hand and wrist. In this study, four skeketal stages and 36 linear, angular measurements of the cephalometrics were selected. In hand-wrist X-ray the bones used to determine skeletal maturity were the middle phalanges of the third finger, and distal epiphysis of the radius. In cephalogram, the landmark used to measure the angle and length were N, S, Po., Ar., Go., Me., Gn., Pog., Point B, Point A, ANS, PNS, Or., U1, L1, U6, L6 etc.. The results were as follows, 1. The table of mean, standard deviation, p-value from measurements were made in each group and both sex. 2. The increased measurements according to skeletal maturity were anterior cranial bese length, posterior cranial base length, ramus height, anterior facial height, posterior facial height, L1 to mandibular plane (mm), facial plane angle. In contrast to, decreased measurements were genial angle, facial cnvexity and facial plane angle. 3. Denture pattern measurements (IMPA, FMIA, occlusal plane to Go-Gn, interincisal angle, U1 to SN plane, U1 to SN plane, U1 to facial plane, L1 to facial plane etc.) .had nothing to do with skeletal maturity. 4. Skeletal maturity had close relationship with craniofacial growth, but had little to do with tooth development.

• 대한치과교정학회지
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• 제53권1호
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• pp.35-44
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• 2023

Objective: Surgically assisted maxillary protraction is an alternative protocol in severe Class III cases or after the adolescent growth spurt involving increased maxillary advancement. Correction of the maxillary deficiency has been suggested to improve pharyngeal airway dimensions. Therefore, this retrospective study aimed to analyze the airway changes cephalometrically following surgically assisted maxillary protraction with skeletal anchorage and Class III elastics. Methods: The study population consisted of 15 Class III patients treated with surgically assisted maxillary protraction combined with skeletal anchorage and Class III elastics (mean age: 12.9 ± 1.2 years). Growth changes were initially assessed for a mean of 5.5 ± 1.6 months prior to treatment. Airway and skeletal changes in the control (T0), pre-protraction (T1), post-protraction (T2), and follow-up (T3) periods were monitored and compared using lateral cephalometric radiographs. Statistical significance was set at p < 0.05. Results: The skeletal or airway parameters showed no statistically significant changes during the control period. Sella to nasion angle, N perpendicular to A, Point A to Point B angle, and Frankfort plane to mandibular plane angle increased significantly during the maxillary protraction period (p < 0.05), but no significant changes were observed in airway parameters (p > 0.05). No statistically significant changes were observed in the airway parameters in the follow-up period either. However, Sella to Gonion distance increased significantly (p < 0.05) during the follow-up period. Conclusions: No significant changes in pharyngeal airway parameters were found during the control, maxillary protraction, and follow-up periods. Moreover, the significant increases in the skeletal parameters during maxillary protraction were maintained in the long-term.

• Journal of Nutrition and Health
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• 제24권1호
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• pp.20-29
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• 1991

This study was carried out to compare the protein quality of lamb and beef meat. by feeding to growing rats. Sixty weanling rats, 30 males and 30 females, were blocked into 12 groups(6 gruops of males and 6 groups of females). They were fed casein. beef, or lamb as a protein source at two levels, 6 and 15%, for 5 weeks. The amount of food intake. food efficiency ratio, protein efficiency ratio. body weight gain. and the weights of skeletal muscles and liver were measured. Nitrogen retention, protein content in the liver and skeletal muscles, and the levels of protein and cholesterol in the serum were also assayed. Summarzing the results, there were no significant differences between lamb and beef on the growth and nitrogen utilization in the rats fed same percentage of protein diet. However. rats fed 15% protein diet showed significantly higher growth rate than those fed 6%. Therefore, it can be concluded that lamb is as good a protein food as beef in terms of protein quality.

• Journal of mucopolysaccharidosis and rare diseases
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• 제2권1호
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• pp.5-7
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• 2016

Mucolipidoses II and III alpha/beta (ML II and ML III) are lysosomal disorders in which the essential mannose-6-phosphate recognition marker is not synthesized onto lysosomal hydrolases and other glycoproteins. The disorders are caused by mutations in GNPTAB, which encodes two of three subunits of the heterohexameric enzyme, N-acetylglucosamine-1-phosphotransferase ML II, recognizable at birth, often causes intrauterine growth impairment and sometimes the prenatal "Pacman" dysplasia. The main postnatal manifestations of ML II include gradual coarsening of neonatally evident craniofacial features, early cessation of statural growth and neuromotor development, dysostosis multiplex and major morbidity by hardening of soft connective tissue about the joints and in the cardiac valves. Fatal outcome occurs often before or in early childhood. ML III with clinical onset rarely detectable before three years of age, progresses slowly with gradual coarsening of the facial features, growth deficiency, dysostosis multiplex, restriction of movement in all joints before or from adolescence, painful gait impairment by prominent hip disease. Cognitive handicap remains minor or absent even in the adult, often wheelchair-bound patient with variable though significantly reduced life expectancy. As yet, there is no cure for individuals affected by these diseases. So, clinical manifestations and conservative treatment is important. This review aimed to highlight the extra-skeletal clinical problems in ML II and III.

• 대한치과교정학회지
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• 제28권2호
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• pp.285-295
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• 1998

임상 교정에서 성장하는 환자의 성장 단계를 이해하는 것은 매우 중요한 의미를 지닌다. 환자의 골성숙도를 평가하기 위해서 수완부골 방사선 사진이 비교적 흔히 사용되고 있으며, 측모 두부계측 방사선 사진에서 경추골의 발육을 조사하여 성장 정도를 평가할 수 있다. 본 연구에서는 교정 환자에서 일상적 기록으로 얻을 수 있는 측모 두부계측 방사선 사진을 통해 경추골의 성숙도(Cervical Vertebrae Maturation Indicators : CVMI)를 평가하고, 그와 동일 환자가 동일한 날에 촬영한 수완부골 방사선 사진에서 골성숙도(Skeletal Maturity Indicators SMI)를 평가하여 그 분포율과 상관성을 조사, 검토한 결과 다음과 같은 결론을 얻었다. 1. 수완부골 방사선 사진에서 평가한 골성숙도와 측모 두부계측 방사선 사진에서 평가한 경추골 성숙도는 매우 높은 상관 관계를 나타내었다. 2. SMI와 CVMI를 이용한 골성숙도 평가에서 CVMI 1은 SMI 1, 2와, CVMI 2는 SMI 3, 4와, CVMI 3은 SMI 6, 7과, CVMI 4는 SMI 7, 8과, CVMI 5는 SMI 9, 10과, CVMI 6은 SMI 11과 각각 높은 상호 연관성을 보였다. 3. 제 2경추골과 제 3경추골의 형태변화를 분리하여 경추골 성숙도를 평가하였을 때 제 2경추골 하연에서만 곡선화가 나타나고 제 3 경추골에서는 곡선화가 나타나지 않는 경우가 CVMI 2에서는 10.38%로, CVMI 3에서는 6.56%로 매우 낮았다. 4. 수완부골과 경추골에서 평가된 각 골성숙 단계에서 환자의 남녀별 평균 연령과 표준 편차를 조사한 결과 성장 시기의 개인별 차이가 크게 나타났으며, 여자가 남자 보다 다소 조기에 골성숙이 일어나고 성장 종료 시점도 24개월정도 빠르게 일어났다.