• 산업경영시스템학회지
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• 제26권4호
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• pp.31-41
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• 2003

This paper deals with a cell formation problem for a set of m-machines and n-processing parts. Generally, a cell formation problem is known as NP-completeness. Hence the cell formation problem with multiple objectives is more difficult than single objective problem. The paper considers multiple objectives; minimize number of intercell movements, minimize intracell workload variation and minimize intercell workload variation. We propose a multiple objective genetic algorithms(MOGA) resolving the mentioned three objectives. The MOGA procedure adopted Pareto optimal solution for selection method for next generation and the concept of Euclidean distance from the ideal and negative ideal solution for fitness test of a individual. As we consider several weights, decision maker will be reflected his consideration by adjusting high weights for important objective. A numerical example is given for a comparative analysis with the results of other research.

• Journal of information and communication convergence engineering
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• 제4권1호
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• pp.36-40
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• 2006

A new method of digital image analysis technique for medical images of cancer cell is presented. This paper deals with the cancer cell discrimination. The object images were the Thyroid Gland cell images that were diagnosed as normal and abnormal. This paper proposes a new discrimination method based on fuzzy logic algorithm. The focus of this paper is an automatic discrimination of cells into normal and abnormal of medical images by dominant feature parameters method with fuzzy algorithm. As a consequence of using fuzzy logic algorithm, the nucleus were successfully diagnosed as normal and abnormal. As for the experimental result, average recognition rate of 64.66% was obtained by applying single parameter of 16 feature parameters at a time. The discrimination rate of 93.08% was obtained by proposed method.

• 대한임상검사과학회지
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• 제47권1호
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• pp.39-45
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• 2015

We investigated whether multiple infections can be used as predictors of progression to carcinogenesis in accordance with the cytological diagnosis in women receiving abnormal cytologic diagnosis as analysis genotype and compared to single infection. HPV prevalence is highest in the age of under 30 years old woman, HPV prevalence is started to lower after 30 years old and started to increase over 60 years old as like a U-shape. The specific HPV genotypes is an important factor because increased single infection and reduced multiple infections and appeared single infection with AC in progressing carcinogenesis. HPV 16 revealed the statistical significance at the single infection in squamous cell lesions, and HPV 18 revealed the statistical significance at the single infection in adenocarcinoma with showed HPV 16, 58, 18, 52-type distribution.

• 전기화학회지
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• 제12권1호
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• pp.61-67
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• 2009

Flow-field design has much influence over the performance of proton exchange membrane fuel cell (PEMFC) because it affects the pressure magnitude and distribution of the reactant gases. To obtain the pressure magnitude and distribution of reactant gases in five kinds of flow-field designs, computational fluid dynamics (CFD) analysis was performed. After the CFD analysis, a single cell test was carried out to obtain the performance values. As expected, the pressure differences due to different flow-field configurations were related to the PEMFC performance because the actual performance results showed the same tendency as the results of the CFD analysis. A large pressure drop resulted in high PEMFC performance. The single serpentine configuration gave the highest performance because of the high pressure difference magnitudes of the inlet/outlet. On the other hand, the parallel flow-field configuration gave the lowest performance because the pressure difference between inlet and outlet was the lowest.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권2호
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• pp.117-127
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• 2001

The high-level expression of a human single chain urokinase-type plasminogen activator (scu-PA) was achieved by employing a methotrexate (MTX)-dependent gene amplification system in Chinese hamster ovary (CHO) cells. By cotransfecting and coamplifying a scu-PA expression plasmid and dihydrofolate reductase (DHFR) minigene, several scu-PA expressing CHO cell lines were selected and gene-amplified. These recombinant cell lines, NGpUKs, secreted a completely processed scu-PA of 54 kD and up to 60mg/L was accumulated in the culture medium when they were adapted to an optimal MTX concentration. Over 95% of the scu-PA expressed was secreted in the culture medium and identified having the proper function of a plasminogen activator when activated by plasmin. Based on a genomic Southern analysis, a representative subclone, MGpUK-5, exhibited MTX-dependent scu-PA gene amplification, plus the initial single-copy gene of scu-PA eventually turned into about 150 copies of the amplified gene of scu-PA after gradual adaptation to 2.0$\mu$M of MTX. Meanwhile, the transcripts kof the scu-PA gene increased, although -early saturation of transcription was identified at 0.1$\mu$M of MTX. The scu-PA production by the MGpUK-5 subclone also increased relative to the gene amplification and increased transcripts, however, the relationship was not linearly proportional. Accordingly, since the MGpUK cell lines expressed elevated levels of enzymatically active scu-PA, these cell lines could be applied to the largescale production of scu-PA.

• 한국통신학회논문지
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• 제22권8호
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• pp.1755-1764
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• 1997

본 논문에서는 ATM 스위치의 단일버퍼를 논리적으로 분할하는 버퍼관리 메카니즘을 제안하고, 컴퓨터 시뮬레이션을 수행하여 할당된 가중치와 제안된 셀 처리 스케줄링 알고리즘(scheduling algorithm)에 대한 트래픽(CBR/VBR/ABR)의 셀 손실확률 및 셀 지연시간을 분석하였다. 제안한 스위치의 버퍼링 시스템은 입력되는 트래픽을 특성별로 분류하여 논리적으로 분할된 버퍼에 저장하고, 스위치의 출력포트로 셀을 전송하기 위하여 동적인 라운드 로빈(round-robin) 서비스를 수행한다. 또한, 버퍼에 가중치를 설정하여 트래픽의 QoS를 보장할 수 있는 4가지의 라운드 로빈 셀 서비스 스케줄링을 분석하였다. SIMSCRIPT II.5를 이용한 시뮬레이션에서 스위치로 입력되는 트래픽은 트래픽 기술자 파라메터를 이용하여 CBR/VBR/ ABR 트래픽이 혼합된 3가지 클래스 트래픽으로 모델링하였으며 VBR과 ABR트래픽은 ON/OFF 소스로, CBR트래픽은 Poisson 소스로 모델링하였다. 본 논문에서 제안하는 버퍼관리 메카니즘과 셀 서비스 알고리즘을 분석한 결과 버퍼에 할당된 가중치의 크기와 가중치를 변화시키는 VC내퍼의 종류, 그리고 적용하는 셀 처리 알고리즘 등에 따라 각 VC가 요구하는 QoS를 보상할 수 있음을 알았다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.3057-3060
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• 2015

Background: Cytological examination of pleural effusions is very important in the diagnosis of malignant lesions. Thoracentesis is the first investigation to be performed in a patient with pleural effusion. In this study, we aimed to compare traditional with cell block methods for diagnosis of lung disease accompanied by pleural effusion. Materials and Methods: A total of 194 patients with exudative pleural effusions were included. Ten mililiters of fresh pleural fluid were obtained by thoracentesis from all patients in the initial evaluation. The samples gathered were divided to two equal parts, one for conventional cytological analysis and the other for analysis with the cell block technique. In cytology, using conventional diagnostic criteria cases were divided into 3 categories, benign, malignant and undetermined. The cell block sections were evaluated for the presence of single tumor cells, papillary or acinar patterns and staining with mucicarmine. In the cell block examination, in cases with sufficient cell counts histopathological diagnosis was performed. Results: Of the total undergoing conventional cytological analyses, 154 (79.4%)were reported as benign, 33 (17%) as malignant and 7 (3.6%) as suspicious of malignancy. With the cell block method the results were 147 (75.8%) benign, 12 (6.2%) metastatic, 4 (2.1%) squamous cell carcinoma, 18 (9.3%) adenocarcinoma, 5 (2.6%) large cell carcinoma, 2 (1%) mesothelioma, 3 (1.5%) small cell carcinoma, and 3 (1.5%) lymphoma. Conclusions: Our study confirmed that the cell block method increases the diagnostic yield with exudative pleural effusions accompanying lung cancer.

• 순환기질환의공학회:학술대회논문집
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• 순환기질환의공학회 2005년도 제5회 학술대회 초록집
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• pp.11-12
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• 2005

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2001년도 Korean Environmental Mutagen Society
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• pp.176-176
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• 2001

• Journal of Electrical Engineering and Technology
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• 제11권2호
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• pp.367-376
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• 2016

This paper presents a cell balancing method for a single switch flyback converter with a multi-winding transformer. The conventional method using a flyback converter with a multi-winding transformer is simple and easy to control, but the voltage of each secondary winding coil might be non-uniform because of the unequal effective turn-ratio. In particular, it is difficult to control the non-uniform effect using turn-ratios because secondary coil has a limited number of turns. The non-uniform secondary voltages disturb the cell balancing procedure and induce an unbalance in cell voltages. Individual cell control by adding a switch for each cell can reduce the undesirable effect. However, the circuit becomes bulky, resulting in additional loss. The proposed method here uses the conventional flyback converter with an adjustment made to the output filters of the cells, instead of the additional switch. The magnitude of voltage applied to a particular cell can be reduced or increased according to the adjusted filter and the selected switching frequency. An analysis of the conventional converter configuration and the filter design method reveals the possibility of adequate cell balancing control without any additional switch on the secondary side.