• Korean Journal of Soil Science and Fertilizer
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• v.45 no.1
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• pp.51-58
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• 2012

Salinity is one of the most relevant abiotic factor limiting crop yield and its net primary productivity. In addition, salinity induces an increased stress ethylene synthesis in plants which, in turn, exacerbate the responses to the stressor. Bacterial single or co-inoculation effect was tested using previously characterized plant growth promoting (PGP) bacteria Brevibacterium iodinum RS16 and Methylobacterium oryzae CBMB20 on maize and sorghum-sudan grass hybrid under different concentrations of NaCl. Non-inoculated maize and sorghum-sudangrass hybrid showed 33.4% and 20.0% reduction in seed germination under highest NaCl (150 mM) level tested. However, under the same NaCl concentration, co-inoculation with B. iodinum RS16 and M. oryzae CBMB20 PGP strains increased the seed germination in maize (16.7%) and sorghum-sudangrass hybrid (4.4%). In Gnotobiotic growth pouch experiments conducted for maize and sorghum-sudangrass hybrid, co-inoculation of PGP B. iodinum RS16 and M. oryzae CBMB20 mitigated the salinity stress and promoted root length by 22.9% and 29.7%, respectively. Thus the results of this study could help in development of potential bioinoculants that may be suitable for crop production under saline conditions.

• Clinical and Experimental Pediatrics
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• v.57 no.7
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• pp.310-316
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• 2014

Purpose: Prader-Willi syndrome (PWS) is a complex genetic disorder that results from the lack of paternally expressed genes in the chromosome 15q11-q13 region. This study was performed to delineate the clinical features of PWS infants and toddlers and the effects of two-year growth hormone (GH) treatment according to gender and age at the start of treatment. Methods: The clinical characteristics and the results of the GH treatment were reviewed retrospectively for 30 PWS patients diagnosed by molecular genetic testing and clinical manifestations. Results: The mean age at diagnosis with PWS was 13.7 months (2-47 months of age). All patients showed the characteristics of facial dysmorphism, including brown hair and almond-shaped eyes. Most patients showed developmental delays/mental retardation (93.3%), cryptorchidism (75%), feeding problems in infancy (73.3%), and neonatal or infantile hypotonia (66.7%). Among 30 patients, 14 PWS infants and toddlers had been treated with GH for more than two years. Two years of GH treatment resulted in an improvement in head circumference-standard deviation score (HC-SDS), body weight-SDS, insulin-like growth factor-1 (IGF-1) SDS, IGF binding protein-3 (IGFBP-3) SDS, lean body mass, and bone mineral content, especially in IGFBP-3 SDS and motor development in PWS patients younger than two years of age. There was significant increase in IGF-1 SDS and IGFBP-3 SDS among male PWS patients after GH treatment. Conclusion: Our study showed increases in IGFBP-3 SDS and an improvement in motor development among individuals under two years of age after GH treatment, and significant difference in IGF-1 SDS and IGFBP-3 SDS by gender.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6869-6874
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• 2013

Background: Vascular endothelial growth factor and matrix metalloproteinases are two important factors for angiogenesis associated with breast cancer growth and progression. The present study was aimed to examine the effects of tamoxifen and tranilast drugs singly or in combination on proliferation of breast cancer cells and also to evaluate VEGF and MMP-9 expression and VEGF secretion levels. Materials and Methods: Human breast cancer cell lines, MCF-7 and MDA-MB-231, were treated with tamoxifen and/or tranilast alone or in combination and percentage cell survival and proliferative activity were evaluated using LDH leakage and MTT assays. mRNA expression and protein levels were examined by real-time RT-PCR and ELISA assay, respectively. Results: LDH and MTT assays showed that the combined treatment of tamoxifen and tranilast resulted in a significant decrease in cell viability and cell proliferation compared with tamoxifen or tranilast treatment alone, with significant decrease in VEGF mRNA and protein levels. We also found that tamoxifen as a single agent rarely increased MMP-9 expression. A decrease in MMP-9 expression was seen after treatment with tranilast alone and in the combined treatment MMP-9 mRNA level was decreased. Conclusions: This combination treatment can able to inhibit growth, proliferation and angiogenesis of breast cancer cells.

• Weed & Turfgrass Science
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• v.3 no.2
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• pp.137-142
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• 2014

This study was conducted to investigate the effect of silicate mixed with nitrogen fertilizer on improving the growth and reducing nitrogen input of zoysiagrass. Plant height, fresh and dry weight of shoots, roots, and stolons, the number of shoots and total of stolons length were increased with highest in silicate mixed with nitrogen 24 kg/10a than nitrogen 24 kg/10a, and it showed no significance in silicate mixed with nitrogen 18 kg/10a. Nitrogen use efficiency in mixed silicate fertilizer was increased by 25-30% than single nitrogen fertilization. Moreover, the contents of available $SiO_2$, and organic matters of silicate fertilization on soil was higher than not silicate fertilization on soil. The silicate enhanced the growth and density of zoysiagrass, while it was a crucial factor to affect the chemical property of the soil.

• Journal of Information Technology Services
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• v.20 no.5
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• pp.89-104
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• 2021

Food delivery service combined with IT technology and HMR (Home Meal Replacement) are rapidly growing due to the COVID-19. Recently, the demand for salads along with HMR has increased among office workers in their 20s and 30s who are interested in health and beauty. Freshcode is a food startup with 6 years of experience that started selling salad products through O2O service. Freshcode applied for a patent for a service that collects orders from nearby areas and delivers them on the same day to a designated delivery address 'FCOSPOT' to save shipping costs. In March 2021, in recognition of the growth potential of the regular delivery service, Freshcode received an investment of 6 billion won in Series A. This study may have practical implications to early-stage startups and scale-up stage startups through a longitudinal case study on the growth of a single company. As for the research method, the lean startup methodology and lean canvas were used in the early stage of startup. In particular, the process of the build-measure and learn feedback-loop, which is the core of lean startup methodology, was applied to each major decision-making step. In the scale-up stage after 5 years, the business model canvas was used to schematize the growth as a food online O2O platform to verify continuous innovation. This case study has three main findings. First, the idea of 'FCOSPOT' was successfully implemented through the Lean Startup methodology. Second, Freshcode demonstrated the scalability of the differentiated business model of shared base delivery O2O. Third, a key factor of success was the digital integrated communication operation strategy that maximizes the experience for the created customers.

• The Korea Journal of Herbology
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• v.24 no.4
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• pp.31-37
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• 2009

Objectives : The rapid progress seen in the Chinese medical and pharmaceutical industries since the mid.Ming Dynasty, and the resulting surge in demand for medicinal herbs led to the emergence of dedicated medicinal herb markets. A representative example was the medicinal herb market of Qizhou (today's Anguo) in Hebei Province. This paper examines various factors that contributed to the transformation and growth of Qizhou into and as a major medicinal herb market of China. Methods : Along with the examination of geographical factors, this study attempts to link the development of Qizhou as a center for medicinal herbs trade with legends related to the Medicine Lord Temple (Yao Wang Miao), a local shrine dedicated to the mythical Medicine Kings. Results : The main argument of this study is that although the emergence of Qizhou as China's largest marketplace for medicinal herbs was significantly helped by its proximity to Beijing, a huge source of demand, as well as its convenient location easily accessible from all parts of the country, and the large herbal production from surrounding areas, the single.most important contributing factor was the body of legends attributing to this city a magical healing energy. Conclusions : The example of Qizhou may also suggest that in pre.modern eras, legends related to supernatural healing power, associated to a city or town, were as important contributing factors to its emergence and growth as a dedicated medicinal herb market as its location or ease of access.

• Proceedings of the Korea Association of Crystal Growth Conference
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• 1996.06a
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• pp.258-292
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• 1996

In the last year great interest appears to YBCO thin films preparation on different substrate materials. Preparation of epitaxial film is a very difficult problem. There are many requirements to substrate materials that must be fullfilled. Main problems are lattice mismatch (misfit) and similarity of structure. From paper [1] or follows that difference in interatomic distances and angles of substrate and film is mire important problem than similarity of structure. In this work we present interatomic distances and angle relations between substrate materials belonging to ABCO4 group (where A-Sr or Ca, B-rare earth element, C-Al or Ga) of different orientations and YBCO thin films. There are many materials used as substrates for HTsC thin films. ABCO4 group of compounds is characterized by small dielectric constants (it is necessary for microwave applications of HTsC films), absence of twins and small misfit [2]. There most interesting compounds CaNdAlO4, SrLaAlO4 and SrLaGaO4 were investigated. All these compounds are of pseudo-perovskite structure with space group 14/mmm. This structure is very similar to structure of YBCO. SLG substrate has the lowest misfit (0.3%) and dielectric constant. For preparation of then films of substrates of this group of compound plane of <100> orientation are mainly used. Good quality films of <001> orientations are obtained [3]. In this case not only a-a misfit play role, but c-3b misfit is very important too. Sometimes, for preparation of thin films substrates of <001> and <110> orientations were manufactured [3]. Different misfits for different YBCO faces have been analyzed. It has been found that the mismatching factor for (100) face is very similar to that for (001) face so there is possibility of preparation of thin films on both orientations. SrLaAlO4(SLA) and SrLaGaO4(SLG) crystals of general formula ABCO4 have been grown by the Czochralski method. The quality of SLA and SLG crystals strongly depends on axial gradient of temperature and growth and rotation rates. High quality crystals were obtained at axial gradient of temperature near crystal-melt interface lower than 50℃/cm, growth rate 1-3 mm/h and the rotation rate changing from 10-20pm[4]. Strong anisotropy in morphology of SLA and SLG single crystals grown by the Czochralski method is clearly visible. On the basics of our considerations for ABCO4 type of the tetragonal crystals there can appear {001}, {101}, and {110} faces for ionic type model [5]. Morphology of these crystals depend on ionic-covalent character of bonding and crystal growth parameters. Point defects are observed in crystals and they are reflected in color changes (colorless, yellow, green). Point defects are detected in directions perpendicular to oxide planes and are connected with instability of oxygen position in lattice. To investigate facets formations crystals were doped with Cr3+, Er3+, Pr3+, Ba2+. Chromium greater size ion which is substituted for Al3+ clearly induces faceting. There appear easy {110} faces and SLA crystals crack even then the amount of Cr is below 0.3at.% SLG single crystals are not so sensitive to the content of chromium ions. It was also found that if {110} face appears at the beginning of growth process the crystal changes its color on the plane {110} but it happens only on the shoulder part. The projection of {110} face has a great amount of oxygen positions which can be easy defected. Pure and doped SLA and SLG crystals measured by EPR in the<110> direction show more intensive lines than in other directions which allows to suggest that the amount of oxygen defects on the {110} plane is higher. In order to find the origin of colors and their relation with the crystal stability, a set of SLA and SLG crystals were investigated using optical spectroscopy. The colored samples exhibit an absorption band stretching from the UV absorption edge of the crystal, from about 240 nm to about 550 m. In the case of colorless sample, the absorption spectrum consists of a relatively weak band in the UV region. The spectral position and intensities of absorption bands of SLA are typical for imperfection similar to color centers which may be created in most of oxide crystals by UV and X-radiation. It is pointed out that crystal growth process of polycomponent oxide crystals by Czochralski method depends on the preparation of melt and its stoichiometry, orientation of seed, gradient of temperature at crystal-melt interface, parameters of growth (rotation and pulling rate) and control of red-ox atmosphere during seeding and growth (rotation and pulling rate) and control of red-ox atmosphere during seeding and growth. Growth parameters have an influence on the morphology of crystal-melt interface, type and concentration of defects.

• Journal of Bio-Environment Control
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• v.27 no.2
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• pp.132-139
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• 2018

The photosynthetic rate is an indicator of the growth state and growth rate of crops and is an important factor in constructing efficient production systems. The objective of this study was to develop a canopy photosynthetic rate model of romaine lettuce using the three variables of $CO_2$ concentration, light intensity, and growth stage. The canopy photosynthetic rates of the lettuce were measured at five different $CO_2$ concentrations ($600-2,200{\mu}mol{\cdot}mol^{-1}$), five light intensities ($60-340{\mu}mol{\cdot}m^{-2}{\cdot}s^{-1}$), and four growth stages (5-20 days after transplanting) in three closed acrylic chambers ($1.0{\times}0.8{\times}0.5m$). A simple multiplication model expressed by multiplying three single-variable models and the modified rectangular hyperbola model including photochemical efficiency, carboxylation conductance, and dark respiration, which vary with growth stage, were also considered. In validation, the $R^2$ value was 0.923 in the simple multiplication model, while it was 0.941 in the modified rectangular hyperbola model. The modified rectangular hyperbola model appeared to be more appropriate than the simple multiplication model in expressing canopy photosynthetic rates. The model developed in this study will contribute to the determination of an optimal $CO_2$ concentration and light intensity with the growth stage of lettuce in plant factories.

• Journal of Life Science
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• v.17 no.12
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• pp.1622-1626
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• 2007

This study was conducted to identify useful single nucleotide polymorphisms (SNPs) and determine their association with economically important traits in pig population. Four candidate gene analyses have identified important chromosomal regions and major genes associcated whit economic traits of the pig. For application of the chromosomal information to the pig industry using DNA technology, SNP markers were developed by comparative re-sequencing of polymerase chain reaction (PCR) products of 4 candidate genes (CSF2, IL4, MYOD, RIP140). PCR restriction fragment length polymorphism (PCR-RFLP) assays were developed for these 4 SNPs and used to genotype Berkshire pig populations in Korea.

• Korean Journal of Environment and Ecology
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• v.32 no.2
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• pp.215-224
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• 2018

The climate change is expected to weaken the habitat of Pinus densiflora and P. thunbergii, but they are still in high demand for planting. This study aims to suggest the rational community planting design based on natural forests' community structure in the southeastern region of Korea (warm temperate zone). For this study, we surveyed 22 plots of Pinus densiflora community and 60 plots of P. thunbergii community in Busan Metropolitan City which is located in the southeastern part of the Korean peninsula. We investigated the diameter of breath hight (DBH) and population of each tree layer in a $100m^2$ quadrat and used a regression analysis to derive a regression equation for estimating the mean number of planting individuals in each DBH. The coefficient between canopy layer's DBH and growth individuals per unit area ($100m^2$) was 0.700 for P. thunbergii communities and 0.533 for P. densiflora communities, indicating very high explanatory power by single factor. The predicted regression equation of between DBH and growth density was $Y=31.176e^{-0.055x}$ (X=DBH, Υ=growth individuals per $100m^2$) for P. thunbergii communities and $Y=38.351e^{-0.059x}$ for P. densiflora communities. Planting densities of P. densiflora communities and P. thunbergii communities in southeast region were higher than the central region.