• Title/Summary/Keyword: Single Subject Experimental Study

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Do spontaneously decreasing estradiol levels prior to triggering of ovulation adversely impact in vitro fertilization outcomes?

  • Grin, Leonti;Berkovitz-Shperling, Roza;Zohav, Eyal;Namazov, Ahmet;Leyetes, Sophia;Friedler, Shevach
    • Clinical and Experimental Reproductive Medicine
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    • v.47 no.3
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    • pp.213-220
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    • 2020
  • Objective: The aim of this study was to explore the potential adverse effect of spontaneously decreasing serum estradiol (SE) levels on in vitro fertilization (IVF) outcomes. Methods: This retrospective single-subject study analyzed IVF cycles conducted at a hospital IVF unit between 2010 and 2017. Overall, 2,417 cycles were analyzed. Only cycles with spontaneously decreasing SE before human chorionic gonadotropin (hCG) triggering were included. Each patient served as her own control, and subsequent cycles were analyzed for recurrent SE decreases. The main outcome was the number of oocytes retrieved. Results: Cycle characteristics were similar between the study (SE decrease) and control groups, with the exception of the median SE on the day of hCG triggering (899.7 pg/mL; interquartile range [IQR], 193-2,116 pg/mL vs. 1,566.8 pg/mL; IQR, 249-2,970 pg/mL; p< 0.001). The study group, relative to the control group, had significantly fewer total oocytes (5 [IQR, 2-9] vs. 7 [IQR, 3-11]; p= 0.002) and significantly fewer metaphase II (MII) oocytes (3 [IQR, 1-6] vs. 4 [IQR, 2-8]; p= 0.001) retrieved. The study group had fewer cleavage-stage embryos than the control cycles (3 [IQR, 1-6] vs. 4 [IQR, 2-7]; p= 0.012). Compared to cycles with a ≤ 20% SE decrease, cycles with a > 20% decrease had significantly fewer total and MII oocytes retrieved. SE decrease recurred in 12% of patients. Conclusion: A spontaneous decrease in SE levels adversely affected IVF outcomes, with a linear correlation between the percentage decrease and the number of oocytes retrieved. SE decrease can repeat in later cycles.

A Systematic Review of Cognitive Orientation to Daily Occupational Performance for Children with Developmental Coordination Disorder (발달성협응장애 아동의 인지기반 작업수행(Cognitive Orientation to daily Occupational Performance; CO-OP) 중재에 대한 체계적 고찰 )

  • Choi, Yeon-Woo;Kim, Kyeong-Mi
    • The Journal of Korean Academy of Sensory Integration
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    • v.20 no.3
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    • pp.72-85
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    • 2022
  • Objective : This study was conducted to examine self-selected goals and the outcome measures used in the Cognitive Orientation to daily Occupational Performance (CO-OP) approach for Developmental Coordination Disorder. Methods : Studies published from January 2012 to October 2022 in the PubMed, Embase, ScienceDirect, Cochrance Library databases were searched. Keywords used for search were ('developmental coordination disorder' OR 'DCD') AND ('Cognitive Orientation to daily Occupational Performance' OR 'Cognitive Orientation to Occupational Performance' OR 'CO-OP'). Among 211 searched studies, 7 selected studies that match the thesis of this study were analyzed. Results : The selected studies showed a relatively high level of evidence overall, including two randomized experimental studies, one non-random two-group study, three non-random one-group studies, one single-subject study. The self-selected goals preference of the children was high in the order of play, education, and daily life activities. Most of applicable sessions were conducted 10 times during a 1-h period, and intervention effects showed positive outcomes on the occupation performance motor domain. To measure the effectiveness of CO-OP, the improvement of occupational performance was evaluated using Canadian Occupational Performance Measure (COPM) and Performance Quality Rating Scale (PQRS), and the improvement of motor skills was evaluated using Movement Assessment Battery for Children (M-ABC). Conclusion : This study is expected to be used as basic clinical data when applying the CO-OP approach to Developmental Coordination Disorder.

A Statistical Analysis on Nursing-Related These in Korea (우리나라 간호학 및 간호학 관련 학위논문 분석)

  • Kim, Hui-Geol;Lee, Yeong-Suk
    • The Korean Nurse
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    • v.34 no.5
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    • pp.68-81
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    • 1996
  • In order to see the development of nursing related research activities in Korea over the last three decades, abstracts of almost all of the Masters and Ph. D. theses that had appeared from 1961 up to August 1991 were collected. Number of theses amounted to 1779(76%) out of a total of 2354 theses. We analysed the papers research patterns, which are research problem, research design, population, place. Here is what we have found. 1). The types of research problems were as follows. 58.0% papers did factor-analysis, 29.1% studied factor~relations, 11.4% situation relations and 1.5% did situation~creations. With respect to the years, we found that the factor-analysis papers decreased with time but the factor~relating, the situation -relating, and the situation~creating papers were increased. Especially the situation-creating paper increased notably since the 80s'. Relating to the kind of degrees, we found that for M.S.theses 60.2% of the papers did factor-analysis, 29.0% the factor-relating studies, 10.4% the situation-relating studies, and 0.4% the situation -creating studies. For the Ph.D. theses 30.5% did the factor~relating, 30.5% the situation-relating. and 20.0% the situation-creating papers. Considering the graduate schools, we found that the regular graduate schools and the graduate school of education produced about the same number of papers of each kind, but 81.2% and 64.6% papers produced by the graduate school of public health and the graduate school of public administration, respectively, did the factor-analysis thus taking majority of the papers. 2). Research designs were as follows : 10.8% experimental studies, 89.0% non experimental studies, and 0.2% quality studies were found. So the majority of the research designs were nonexperimental. We see a meaningful difference between the M.S.theses showing 9.8% experimental studies and 90. 1% nonexperimental studies. and Ph.D. theses showing 28.4% experimental studies and 68. 4% nonexperimental studies. Relating to the graduate schools, we find that the regular graduate schools and the graduate school of education with 15.8% and 10.6% experimental studies respectively, did a little more experimental studies than other schools. but still the regular graduate schools, the graduate school of public health, and the graduate school of education each show 83.8%, 97.4%, and 89.4% nonexperimental studies, so most schools are concentrating on nonexperimental studies. 3). On the relation between research problem and research design, experimental studies show 88.0% of situation-relations and 6.8% of factor-relations. Nonexperimental studies had factor-analysis taking the majority by 64.4% and 31.9% were factor-relations. 4). On the research subjects, we have 90.8% of the papers dealing with a single subject and 9.2% of the papers dealing with two or more subjects. Most of the research subjects are patients or nurses for the regular graduate schools and the graduate school of education, but for the graduate school of administration as much as. 60% of the studies took nurses as subjects. Subjects taken were patients, nurses. and students in decreasing order for the M.S. theses and for patients, women, and nurses again in decreasing order for the Ph.D.theses. 5). On the places of study, we've had 47, 8% of the studies done in hospital rooms, 15, 1% in schools, and 9, 6% in the local community, With respect to the years, we found 36.7% in the hospital rooms, 22.4% in the schools, and 14, 8% in the local communities in the 1970's and 50.1%in the hospital rooms, 13.4% in the schools. and 9, 2% in the local communities in the 80's.

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The Effects of Restaurant Video Taping and Job Communication Drawing Board Production Activities on Cooking Job Skills of High School Students with Intellectual Disabilities (식당 비디오 테이핑 및 직무 의사소통 그림판 제작활동이 지적장애 고등학생의 조리직무기술에 미치는 효과)

  • Kim, Young-Jun;Kim, Wha-Soo
    • The Journal of the Convergence on Culture Technology
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    • v.8 no.1
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    • pp.19-29
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    • 2022
  • This study was conducted with the aim of verifying the effects of restaurant video taping and job communication drawing board production activities on cooking job skills of high school students with intellectual disabilities. The study participants consisted of three students with intellectual disabilities enrolled in the high school course of a special school, and the experimental environment consisted of a kitchen in the restaurant and a classroom in the special school. For the research design, the technique of multiple probe design across subjects according to a single subject research was used. The intervention program consisting of independent variables was applied as a linkage procedure in which study participants videotaped the kitchen's environmental facilities, tools, materials, and staff perform cooking job skills and then taped data from the classroom scene on a job communication drawing board. Cooking job skills consisting of dependent variables are defined as the performance of research participants cooking gimbap directly in the kitchen of the restaurant. As a result of the study, it was found that participants effectively acquired, maintained, and generalized cooking job skills through intervention programs.

The Effects of Functional Task Training on Activities of Daily Living in the Fall Experienced Elderly (기능적 과제훈련이 낙상경험노인의 일상생활수행능력에 미치는 영향: 단일대상연구)

  • Woo, Ji Hee;Park, Hae Yean;Kim, Jong Bae
    • Therapeutic Science for Rehabilitation
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    • v.5 no.1
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    • pp.43-54
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    • 2016
  • Objective : The purpose of this study was to investigate the effects of occupational therapeutic intervention including functional task training on activities daily living of falls experienced elderly. Methods : This study used a single subject experimental design with alternating treatment and reversal design. One participant who have had falls experience among the community-dwelling elderly completed. This study a total of 18 sessions were conducted. Fall Efficiency Scale(FES), Berg Balance Scale(BBS) and task modification scale were used to assess the activities of daily living during each session, and Canadian Occupational Performance Measure(COPM) and Assessment of Home-based Activities(AHA) were used to evaluate the activities of daily living at pre-and post-test. Results : The participant showed significant improvements in the FES, BBS scores. However, the improvement was greater when progressive resistance exercise was practised along with functional task training. COPM and AHA scores improved at post-test. Conclusions : These findings provide evidence for occupational therapeutic intervention for falls-experienced elderly.

Effects of the Food Expression Activity Program on Subjective memory, Depression, and Self-expression in the Elderly living in the Elders Attending Senior Citizen Clubs (푸드표현활동 프로그램이 경로당 이용 노인의 주관적 기억력, 우울, 자기표현에 미치는 효과)

  • Kim, So-Yeong;Kim, Da-Hyeon;Park, Eun-Jin;Byun, Ji-Yeon;Jin, Min-Gyeong;Hong, Min-Cho;Han, Eun-Kyoung
    • Journal of the Korean Applied Science and Technology
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    • v.37 no.5
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    • pp.1171-1179
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    • 2020
  • This study is an experimental study on the single group pre-post test design for the effects of the food expression activity program on subjective memory, depression, and self-expression of the elderly. 36 elderly people attending Senior Citizen Club from two locations in S City participated. A total of six session programs were applied from January 8 to February 17, 2020. The questionnaire survey conducted subjective momory, depression, and self-expression before and after the program. The contents of the intervention consisted of physical relaxation, cognitive activities, and various food activities. In the result of this study, the food expression activity program were statistically significant differences in subjective memory(t=2.67, p=.011), depression(t=3.88, p<.001), and self-expression(t=2.09, p=.044). Therefore, it is expected that the food expression activity program can be applied as a nursing intervention to reduce depression and improve subjective memory and self-expression in the elders attending senior citizen clubs.

Sensory Integration Interventions for Children with Autism Spectrum Disorder in Korea: A Systematic Review (국내 자폐스펙트럼장애 아동을 대상으로 제공되는 감각통합 중재방법: 체계적 고찰)

  • Park, Young-Ju
    • The Journal of Korean Academy of Sensory Integration
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    • v.20 no.3
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    • pp.48-59
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    • 2022
  • Objective : This study was intended to systematically consider the sensory integration intervention methods offered in Korea for children with autism spectrum disorder and to provide an evidence base for the application of sensory integration interventions. Methods : The subjects of this study were published studies in a national journal for the last 10 years from January 2011 to December 2020. The databases used for the search were RISS and DBpia. The search terms were 'autism', 'autism spectrum', 'sensory integration', and 'intervention'. A total of 10 studies were used in the analysis, which were analyzed at the qualitative and methodological quality of the research evidence and the results were presented according to the PICO (Patient, Intervention, Comparison, Outcome). Results : In the research analysis, the quality level of the evidence was highest at level IV, followed by level II. The methodological quality of the evidence was the most common for 'Good' research, followed 'Fair'. The study subjects were children with autism spectrum disorder and their parents, and the experimental design had the highest frequency of single-subject studies. Interventions have the highest number of studies confirming adaptive behavior and sensory modulation, and the evaluation tools used to measure interventions have the highest frequency of sensory profiles and Canadian occupational performance measures (COPM). All 10 studies used in the analysis showed positive improvements and statistically significant effects on various outcome values from sensory integration interventions. Conclusion : In the recent clinical environment, sensory integration interventions have been continuously conducted in children with autism spectrum disorder. In future research, it is necessary to conduct research on various sensory integration intervention methods and the high quality of the evidence for the application of sensory integration interventions.

The thermodynamic efficiency characteristics of combined cogeneration system of 120MW (120MW급 열병합 복합발전시스템의 열역학적 효율 특성)

  • Choi, Myoungjin;Kim, Hongjoo;Kim, Byeongheon
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.6
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    • pp.29-36
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    • 2017
  • In this study, acombined cogeneration power plant produced two types of thermal energy and electric or mechanical power in a single process. The performance of each component of the gas turbine-combined cogeneration system was expressed as a function of the fuel consumption of the entire system, and the heat and electricity performance of each component. The entire system consisted of two gas turbines in the upper system, and two heat recovery steam generators (HRSG), a steam turbine, and two district heat exchangers in the lower system. In the gas turbine combined cogeneration system, the performance test after 10,000 hours of operation time, which is subject to an ASME PTC 46 performance test, was carried out by the installation of various experimental facilities. The performance of the overall output and power plant efficiency was also analyzed. Based on the performance test data, the test results were compared to confirm the change in performance. This study performed thermodynamic system analysis of gas turbines, heat recovery steam generators, and steam turbines to obtain the theoretical results. A comparison was made between the theoretical and actual values of the total heat generation value of the entire system and the heat released to the atmosphere, as well as the theoretical and actual efficiencies of the electrical output and thermal output. The test results for the performance characteristics of the gas turbine combined cogeneration power plant were compared with the thermodynamic efficiency characteristics and an error of 0.3% was found.

An Analysis of Tendencies of Studies on Herbal Acupuncture - Focusing on domestic theses since 2001 about anti-inflammation, pain relief and anti-obesity effects, including safety- (약침(藥鍼)의 연구 동향에 대한 분석 - 항염(抗炎) ${\cdot}$ 진통(鎭痛) ${\cdot}$ 비만(肥滿) 및 안전성(安全性)에 관한 연구를 중심으로 -)

  • Kang, Jun-Hyuk;Heo, Dong-Seok;Yoon, Il-Ji;Oh, Min-Seok
    • The Journal of Korean Medicine
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    • v.28 no.2 s.70
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    • pp.93-113
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    • 2007
  • Objective : To research Trends of studies about anti-inflammation and pain relief, obesity, and safety of herbal acupuncture therapy by analyzing domestic theses, published since 2001, about herbal acupuncture therapy. Methods : Domestic theses, published since 2001, mentioning anti-inflammation or pain relief, obesity, or safety of herbal acupuncture therapy were reviewed and analyzed. These theses were then classified by university, year, and subject. Results : The following results were obtained in this study. 1. Among published theses related to anti-inflammation effects of herbal-acupuncture, studies about arthritis comprised the most part, 52. In theses relating to causes of arthritis, 16 were about adjuvant, which was the most, followed by Type II collagen, LPS and carrageenan. Blood test, reactions of inflammation and revelation of cytokine and immune cellswere methods for evaluating anti-inflammation effect. The tendency of experimental methods was to focus on molecular biologic method. 2. In theses related to pain relief, many clinical attempts with herbal injection were carried out, and Carthami Flos and Scolopendrawere used most. Observing reduction of pain inducing factor and checking behavioral change were methods for evaluating pain relief. 3. In theses related to obesity, research focused on effects in association with spots on the body suitable for acupuncture. There were also attempts comparing effectiveness between single injections and complex injections. Astraball Radix, Angelica Gigantis Radix, Coicis Semen and Taeumjowetang were used. Evaluation of anti-obesity effects were by weight loss, food efficiency, blood lipid profile and evaluation of liver function. 4. In theses related to safety of herbal-acupuncture, Herba Chelidonii Chaenonelis Fructus, Clematis Florida Thunb, Corydalidis Tuber, Paeoniae Radix, and Carthami Flos which marked 2 theses each were most studied. Methods of evaluating safety were mostly by observing liver and kidney functions based on blood test, and by applying herbal injections to clinical treatment. Conclusion : Herbal acupuncture is being used in various ways associating with its anti-inflammation, pain relief and anti-obesity effect. Studies on efficacy and mechanism of herbal acupuncture are being conducted even at the molecular biology level.

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A Study of Conservative Treatment for Patients with Osteoarthritis of the TMJ (측두하악골관절염 환자의 보존적 치료에 관한 연구)

  • Son, Dae-Eun;Ok, Seung-Joon;Ko, Myung-Yun;Ahn, Yong-Woo
    • Journal of Oral Medicine and Pain
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    • v.32 no.2
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    • pp.227-239
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    • 2007
  • To evaluate the treatment outcome after conservative treatment in patients with osteoarthritis of the TMJ(OA), the subjects were chosen among the patients who presented to the Department of Oral Medicine of Pusan National University Hospital, diagnosed as osteoarthritis of the TMJ, and treated with conservative methods from 1994 to 2006. 101 patients with diagnosis of osteoarthritis of the TMJ were selected as the experimental group and 74 patients with diagnosis of masticatory muscle disorders(MMD) were selected as the control group. Subjective symptoms and clinical findings were investigated to evaluate and compare the subject's status at the first and the last visit. The results were as follows : 1. In the OA group, satisfactory treatment outcome was obtained with conservative methods. But, at the last visit, the symptoms of the OA group were not improved enough compared with those of the MMD group. 2. In the OA group, radiographic findings of panorama view and transcranial projection were positive by about 60 percent. But, computed tomography and single photon emission computed tomography were positive by more than 90 percent. 3. At the last visit of the OA group, the joint noise was reduced significantly. 4. In the majority of the OA group, satisfactory treatment outcome was obtained with conservative methods such as medication, physical therapy, and occlusal stabilization appliance. In the majority of the MMD group, satisfactory outcome was obtained with medication and physical therapy. 5. It took the OA group from 6 months to 2 years to be cured well while the MMD group within 6 months.6. The OA group needed more than 10 times' treatment for satisfactory outcome while the MMD group needed less than 10 times' treatment.