• Journal of the Korean Data and Information Science Society
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• v.12 no.2
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• pp.57-64
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• 2001

In the Taguchi parameter design, the product-array approach using orthogonal arrays is mainly used. However, it often requires an excessive number of experiments. An alternative approach, which is called the combined-array approach, was suggested by Welch et al (1990) and studied by Vining and Myers (1990) and others. In these studies, only single respouse variable was considered. We propose how to simultaneously optimize multiple responses when there are correlations among responses.

• Journal of Integrative Natural Science
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• v.10 no.1
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• pp.51-57
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• 2017

The Taguchi parameter design in industry is an approach to reducing performance variation of quality characteristic in products and processes. In the Taguchi parameter design, the product array approach using orthogonal arrays is mainly used. It often requires an excessive number of experiments. An alternative approach, which is called the combined array approach, was studied. In these studies, only single response was considered. In this paper we propose how to simultaneously optimize multiresponse for the robust design using the combined array approach.

• BMB Reports
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• v.44 no.4
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• pp.262-266
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• 2011

The aac(6')-Ib gene is the most prevalent gene that encodes aminoglycoside-modifying enzymes and confers resistance to tobramycin, kanamycin, and amikacin. The aac(6')-Ib-cr variant gene can induce resistance against aminoglycoside and fluoroquinolone simultaneously. Two main methods, sequence analysis and the restriction enzyme method, can detect the aac(6')-Ib-cr variant in clinical strains. We collected the 85 strains that were believed to be aac(6')-Ib positive from clinical isolates. Among them, 38 strains were the wild-type; the remaining 47 strains were the aac(6')-Ib-cr variant. Of these 47 strains, 19 simultaneously harbored aac(6')-Ib and aac(6')-Ib-cr. Our study aims to report the characteristics of the 19 strains that simultaneously harbored both genes. This study is the first investigation published in Korea of strains that included both aac(6')-Ib and aac(6')-Ib-cr variant.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.11 no.1
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• pp.9-16
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• 2001

Chromium exposure can be in the forms of environmental pollution and occupational exposure. The harmful effects of chromium on the body greatly differ depending on its valence or solubility. Accordingly, the recommended permissible exposure limit for each chromium compound is different. This study investigated the increase or decrease of distribution and excretion of total chromium exposed simultaneously the soluble Cr+6 and Cr+3 compounds. There were no difference of total chromium concentration in plasma, red bloods cells, urine, organs between simultaneously injected and individually injected soluble Cr+6 and Cr+3 compound. The chromium clearances in urine also showed that there were two phases in the two groups. In the first phase, biological half lives of the total chromium of the two groups have been similar within 24 hr., but in the second phase, biological half life of the group injected simultaneously was 62.7 hr. and was less than that of the other group's 188.3 hr. The average concentration of total chromium in plasma was same with the control, and that of RBCs was $0.218nmol/m{\ell}$ and was slightly increased in comparison with $0.121nmol/m{\ell}$ of the control, which was not statistically significant. As a result, there were no differences of distribution and excretion of chromium between the group exposed simultaneously and the other group exposed separately the soluble Cr+6 and Cr+3 compounds. The biological half life of chromium of the former group in urine was less than that of the other group.

• Parasites, Hosts and Diseases
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• v.54 no.5
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• pp.631-636
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• 2016

This study aimed to develop a multiplex-touchdown PCR method to simultaneously detect 3 species of protozoan parasites, i.e., Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis, the major causes of traveler's diarrhea and are resistant to standard antimicrobial treatments. The target genes included the Cryptosporidium oocyst wall protein for C. parvum, Glutamate dehydrogenase for G. lamblia, and 18S ribosomal RNA (18S rRNA) for C. cayetanensis. The sizes of the amplified fragments were 555, 188, and 400 bps, respectively. The multiplex-touchdown PCR protocol using a primer mixture simultaneously detected protozoa in human stools, and the amplified gene was detected in > $1{\times}10^3$ oocysts for C. parvum, > $1{\times}10^4$ cysts for G. lamblia, and > 1 copy of the 18S rRNA gene for C. cayetanensis. Taken together, our protocol convincingly demonstrated the ability to simultaneously detect C. parvum, G. lamblia, and C. cayetanenesis in stool samples.

• Journal of Environmental Health Sciences
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• v.21 no.3
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• pp.28-37
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• 1995

This study is performed to find out the effects of selenium against cadmium toxicity. The experimental mice were divided into 6 gruops such as control group, cadmium alone treatment group, selenium treatment groups and two simultaneous treatment groups of selenium and cadmium. Mice were given intraperitoneal administration with two dosage of sodium selenite such as 1.0 mg/kg, 2.5 mg/kg body weight and cadmium chloride was administered 3.0 mg/kg body weight. After giving the challenge dose, the concentration of cadmium and metallothionein and histopathological change of liver and kidney were determined. The results were summarized as follows on 1. The simultaneously administration of selenium and cadmium significantly more decreased cadmium concentration in kidney and iiver tissues compared to the administration of cadmium only(P<0.05). 2. The simultaneously administration of selenium and cadmium more increased metallothionein concentration compared to administration of cadmium only. 3. The simultaneously administration of selenium and cadmium more decreased cadmium concentration in urine compared to the administration of cadmium only. 4. When liver and kidney tissues were observed with optical microscope, no obvious changes were visible in those tissues.

• The Korean Journal of Physiology
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• v.27 no.1
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• pp.79-91
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• 1993

The present study was carried out to determine the effects of cocaine (0.25, 1.0, 10.0 mg/kg, i.p.) on the interactions between spontaneously active neurons within ensembles of simultaneously recorded neurons in the primary somatosensory cortex (Sl, n= 20) and the ventroposterolateral (VPL, n= 16) thalamic nucleus of awake rats. Spike triggered cross correlation histograms were constructed between pairs of simultaneously recorded neurons. Among 101 neuronal pairs analyzed, 22.7% showed correlations indicative of various functional connections among the cortical cells, two corticothalamic interactions and one thalamocortical excitatory interaction. There were also 15 cofiring activities among SI cortical cells. These functional connectivities appeared to be modulated (weakened, abolished, or strengthened) during the 5 to 30 min following cocaine injection. The effects of saline were tested as a control, but it did not appear to alter the functional connectivities. In general, cocaine-induced changes of the functional interactions were mainly due to the concomitant alterations of the uncorrelated background discharges. These results suggest that the biphasic effects of cocaine on the spontaneously established neural networks among the SI cortical and the VPL thalamic cells of conscious rat were mainly indirect. However, various changes of the functional interactions by different doses of cocaine appeared to be a possible neural network mechanism for the cocaine induced modulation of afferent somatosensory transmission.

• ETRI Journal
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• v.42 no.1
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• pp.138-149
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• 2020

In this paper, we describe a simultaneously transmitted jamming (ST-jamming) for bi-directional in-band full-duplex (IFD) system to improve information security at the physical layer. By exploiting ST-jamming, each legitimate user transmits data samples and jamming samples together in one orthogonal frequency division multiplexing symbol according to given traffic asymmetry. Regardless of the traffic difference in both directions in IFD communication, eavesdropping of confidential information is prevented in both directions simultaneously without the loss of data rate. We first propose an encoding scheme and the corresponding decoding scheme for ST-jamming to be used by the legitimate users. In addition, we study a transceiver structure of the legitimate users including a baseband modem uniquely designed for the use of ST-jamming. The leakage of confidential information at an eavesdropper is then quantified by studying the mutual information between the confidential transmit signals and the received signals of the eavesdropper. Simulation results show that the proposed ST-jamming significantly reduces the leakage of legitimate information at the eavesdropper.

• Journal of the Korean Society for Precision Engineering
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• v.20 no.7
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• pp.105-113
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• 2003

This paper describes the development of a 6-axis robot's finger force/moment sensor, which measures forces Fx, Fy, Fz, and moments Mx, My, Mz simultaneously, for stably grasping an unknown object. In order to safely grasp an unknown object using the robot's gripper, it should measure the force in the gripping direction and the force in the gravity direction, and perform the force control using the measured forces. Thus, the robot's gripper should be composed of 6-axis robot's finger force/moment sensor that can measure forces Fx, Fy, Fz, and moments Mx, My, Mz simultaneously. In this paper, the 6-axis robot's finger force/moment sensor for measuring forces Fx, Fy, Fz, and moments Mx, My, Mz simultaneously was newly modeled using several parallel-plate beams, designed, and fabricated. The characteristic test of made sensor was performed. and the result shows that interference errors of the developed sensor are less than 3%. Also, Robot's gripper with the 6-axis robot's finger force/moment sensor for the characteristic test of force control was manufactured, and the characteristic test for grasping an unknown object was performed using it. The fabricated gripper could grasp an unknown object stably. Thus, the developed 6-axis robot's finger force/moment sensor may be used for robot's gripper.

• Structural Engineering and Mechanics
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• v.32 no.1
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• pp.95-126
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• 2009

The present contribution addresses the parallelization of advanced simulation methods for structural reliability analysis, which have recently been developed for large-scale structures with a high number of uncertain parameters. In particular, the Line Sampling method and the Subset Simulation method are considered. The proposed parallel algorithms exploit the parallelism associated with the possibility to simultaneously perform independent FE analyses. For the Line Sampling method a parallelization scheme is proposed both for the actual sampling process, and for the statistical gradient estimation method used to identify the so-called important direction of the Line Sampling scheme. Two parallelization strategies are investigated for the Subset Simulation method: the first one consists in the embarrassingly parallel advancement of distinct Markov chains; in this case the speedup is bounded by the number of chains advanced simultaneously. The second parallel Subset Simulation algorithm utilizes the concept of speculative computing. Speedup measurements in context with the FE model of a multistory building (24,000 DOFs) show the reduction of the wall-clock time to a very viable amount (<10 minutes for Line Sampling and ${\approx}$ 1 hour for Subset Simulation). The measurements, conducted on clusters of multi-core nodes, also indicate a strong sensitivity of the parallel performance to the load level of the nodes, in terms of the number of simultaneously used cores. This performance degradation is related to memory bottlenecks during the modal analysis required during each FE analysis.