• Title/Summary/Keyword: Sim-Hak

Search Result 605, Processing Time 0.029 seconds

Effects of Yeonsan Ogye on monosodium iodoacetate-induced osteoarthritis in rats (연산오계(連山烏鷄)가 monosodium iodoacetate로 골관절염(骨關節炎)을 유도(誘導)한 랫드에 미치는 영향(影響))

  • Sim, Boo-Yong;Choi, Hak-Joo;Ji, Joong-Gu;Kim, Dong-Hee
    • The Korea Journal of Herbology
    • /
    • v.32 no.2
    • /
    • pp.41-47
    • /
    • 2017
  • Objective : The aim of this study is to investigate anti-arthritis activity using a korea's natural monument No. 265 designate 'Yeonsan-Ogye'. In this study, research by using extracts from different concentration of the Yeonsan-Ogye through an MIA-induced arthritis animal model was being conducted in vivo and scientifically verifying the efficacy of medicinal food. Methods : Yeonsan-Ogye was administered 500 mg/kg/day, 1000 mg/kg/day, 2000 mg/kg/day to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at $60mg/m{\ell}$. MMP-9, COMP, CTXII, calcitonin and glycosaminoglycan level in serum were measured by ELISA. The changes of relative hind paw weight bearing ratio by Incapacitance Test Meter and The cartilage of meniscus volume was examined and 3-D high-resolution reconstructions of the cartilage of meniscus were obtained using a Micro-CT system. Also, the histopathological analysis of knee was observed by H&E and safranin-O staining. Results : Production of MMP-9, COMP (all groups) and CTXII (500, 1000 mg/kg/day) level in serum was decreased, respectively, in comparison with control. The other way, production of calcitonin (500, 1000 mg/kg/day) and glycosaminoglycan (all groups) level in serum, Hind paw weight bearing ratio (all groups) was increased, espectively, in comparison with control. The cartilage of patella volume in micro-CT increased significantly. In addition, all groups showed a increase in the cartilage volume and proteoglycan. Conclusion : The results for Yeonsan-Ogye showed significant antiarthritis activity in serum and the cartilage. Therefore, it is thought to be that Yeonsan Ogye can be utilized as a variety of new korea medicie and health foods against arthritis diseases.

How to Identify Critical Nodes of National Infrastructure Systems in Megacities (메가시티 국가기반체계의 핵심노드 식별 방법)

  • Sim, Jun Hak;Jang, chan Kyu;Park, Sung Jun;Kim, Ki Won;Cho, Sang Keun;Park, Sang Hyuk
    • The Journal of the Convergence on Culture Technology
    • /
    • v.8 no.6
    • /
    • pp.531-536
    • /
    • 2022
  • Megacities are emerging all over the world and gradually becoming the center of an country. Therefore, Megacities are inevitably exposed to various threats such as existing, potential, supra-national, and non-military. In particular, as seen in the recent Ukraine-Russia war, national infrastructure systems has become a major target of enemies. However, considering the size of Megacities, various types of threats, and limited resources, it is impossible to completely protect all national infrastructure systems. Therefore, wisdom is necessary to identify and protect critical nodes. The critical node is the vital point to which the national infrastructure is connected. To this end, in this study, as a method for logically and systematically identifying critical nodes, Node centrality analysis method, which is a network theory, and the Center of Gravity analysis method, which is a military theory, were presented.

Determination of vitamin P1 by chemiluminescence method (화학발광법에 의한 비타민 P1의 정량)

  • Jin, Seung Oh;Lee, Sang Hak
    • Analytical Science and Technology
    • /
    • v.21 no.1
    • /
    • pp.20-24
    • /
    • 2008
  • A chemiluminescence method has been developed to determine vitamin $P_1$ in aqueous solution which is based on the enhancement of the intensity of lucigenin using lucigenin-$H_2O_2$ as chemiluminogenic system. The effects of experimental parameters such as concentrations of lucigenin, pH and concentrations of $H_2O_2$ were studied. The present method allows the determination of vitamin $P_1$ over the range $7.5{\times}10^{-6}{\sim}5.0{\times}10^{-4}mol/L$. The detection limit was $5.7{\times}10^{-7}mol/L$. The relative standard deviation was 0.75 % for 10 determinations of $7.5{\times}10^{-5}mol/L$ vitamin $P_1$. The correlation coefficient of the working curve was 0.9984 (S/N=3).

A Study on Improvement of Soldier Mental Health Care Using Wearable Devices (웨어러블 기기를 이용한 군 장병 정신건강 관리 향상 방안)

  • In-Chan Kim;Sang-Keun Cho;Jun-Hak Sim;Jong-Hoon Kim;Sang-Hyuk Park
    • The Journal of the Convergence on Culture Technology
    • /
    • v.9 no.6
    • /
    • pp.801-805
    • /
    • 2023
  • In Korea, the population is continuously decreasing due to the decrease in fertility rates. Military troops are continuously decreasing, but soldiers' suicide, mental health care and medicine prescriptions, and inadequate decisions are increasing. In other words, the mental health of the intestines is getting worse. The mental health of the soldiers is a personal problem, but it can also have a big impact on the troops. This is because accidents such as suicide, divorce, and military leave lead to the restriction of the combat power and the deterioration of fraud. Currently, domestic and foreign academics are studying mental health care plans using wearable devices. The Korean military can also use this to objectively measure the mental health of soldiers and use the accumulated big data to predict and measure various situations. In this study, this study suggests mental health care measures for military soldiers using wearable devices, and further research will be conducted smoothly to improve the mental health of our soldiers.

A Very Low-Bit-Rate Analysis-by-Synthesis Speech Coder Using Zinc Function Excitation (Zinc 함수 여기신호를 이용한 분석-합성 구조의 초 저속 음성 부호화기)

  • Seo Sang-Won;Kim Jong-Hak;Lee Chang-Hwan;Jeong Gyu-Hyeok;Lee In-Sung
    • The Journal of the Acoustical Society of Korea
    • /
    • v.25 no.6
    • /
    • pp.282-290
    • /
    • 2006
  • This paper proposes a new Digital Reverberator that models Analog Helical Coil Spring Reverberator for guitar amplifiers. While the conventional digital reverberators are proposed to provide better sound field mainly based on room acoustics, no algorithm or analysis of digital reverberators those model Helical Coil Spring Reverberator was proposed. Considering the fact that approximately $70{\sim}80$ percent of guitar amplifiers are still with Helical Coil Spring Reverberator, research was performed based not on Room Acoustics but on Helical Coil Spring Reverberator itself as an effector. After performing simulations with proposed algorithm, it was confirmed that the Digital Reverberator by proposed algorithm provides perceptually equivalent response to the conventional Analog Helical Coil Spring Reverberators.

Recurrent Uterine Cervical Carcinoma: Spectrum of Imaging Findings

  • Joon-Il Choi;Seung Hyup Kim;Chang Kyu Seong;Jung Suk Sim;Hak Jong Lee;Kyung-Hyun Do
    • Korean Journal of Radiology
    • /
    • v.1 no.4
    • /
    • pp.198-207
    • /
    • 2000
  • Uterine cervical carcinoma is one of the most common malignant tumors occurring in females. After primary treatment, patients are usually followed up with CT or MRI and the findings of these modalities may be the first sign of recurrent disease. Because earlier additional treatment by chemotherapy or radiation therapy may improve the prognosis, the early detection of recurrent cervical carcinoma is clinically important. In this article, we review the CT and MR imaging findings of recurrent uterine cervical carcinoma, and assign them to one of four groups: a) recurrence at the primary site, involving the intrapelvic organs, b) extension to the pelvic side-wall, c) metastases to pelvic and extrapelvic lymph nodes, or d) metastases to distant organs. A further contribution of CT and MR imaging is the detection of hydronephrosis due to ureteral obstruction. The cases in each group are illustrated and discussed, and since an awareness of the spectrum of imaging findings of recurrent cervical carcinoma is likely to lead to its early detection, radiologists should be familiar with the information presented.

  • PDF

Intercomparison of Shortwave Radiative Transfer Models for Aerosol-laden Atmospheres (에어러솔 대기에서 단파 영역에서의 복사전달모델들의 상호비교)

  • Yoo, Jung-Moon;Jeong, Myeong-Jae;Lee, Kyu-Tae;Kim, Jhoon;Rhee, Ju-Eun;Hur, Young-Min;Kim, Bo-Mi;Lee, Yun-Gon;Lee, Jae-Hwa;Yoon, Jong-Min;Lee, Won-Hak
    • Journal of the Korean earth science society
    • /
    • v.29 no.2
    • /
    • pp.128-139
    • /
    • 2008
  • Intercomparison among the three radiative transfer models (RTMs) which have been used in the studies for COMS, was carried out on the condition of aerosol-laden atmospheres. Also the role of aerosols in the atmospheric radiation budget was analyzed. The results (hereafter referred to as H15) from Halthore et al.'s study (2005) were used as a benchmark to examine the models. Aerosol Radiative Forcing (ARF) values from the three RTMs, calculated under two conditions of Aerosol Optical Thickness (AOT=0.08, 0.24), were systematically underestimated in comparison to H15 in the following shortwave components; 1) direct and diffuse irradiance at the surface, 2) diffuse upward fluxes at the surface and the top of the atmosphere, and 3) atmospheric absorbance. The ARF values for the direct and diffuse fluxes at the surface was $-10{\sim}-40Wm^{-2}$. The diffuse upward values became larger with increasing both AOT and Solar Zenith Angle (SZA). Diffuse upward/downward fluxes at the surface were more sensitive to the SZA than to the atmospheric type. The diffuse downward values increased with increasing AOT and decreasing SZA. The larger AOT led to surface cooling by exceeding the reduction of direct irradiance over the enhancement of diffuse one at the surface. The extinction of direct solar irradiance was due mainly to water vapor in tropical atmospheres, and to both ozone and water vapor in subarctic atmospheres. The effect of water vapor in the tropics was $3{\sim}4$ times larger than that of the ozone. The absorbance values from the three RTMs agree with those from H15 within ${\pm}10%$.

How Skin Care Ingredient Concentrations Can Modulate the Effect of polyols and Oils on Skin Moisturization and Skin Surface Roughness (화장품 원료 중 폴리올, 오일 농도에 따른 피부 보습과 피부 표면 거칠기의 변화)

  • Nam, Gae-Won;Kim, Seung-Hun;Kim, Eun-Joo;Kim, Jin-Han;Chae, Byung-Guen;Lee, Hae-Kwang;Moon, Seong-Joon;Kang, Hak-Hee;Chang, Ih-Seop
    • Journal of the Society of Cosmetic Scientists of Korea
    • /
    • v.31 no.4 s.54
    • /
    • pp.337-342
    • /
    • 2005
  • The aim of this study was to evaluate the influence of different skin care ingredient concentrations on the effect of polyols and oils on the human skin moisturization and skin surface roughness. Polyols and oils were essential ingredients to make a skin care formulation. But these were still not understood how much concentration(s) were tested on human skin in the aspect of efficacy and sensory. We studied to examine various concentrations of ingredient by cosmetic companies using noninvasive methods. Polyols were composed of glycerol and butylene glycol (BG) as 1:1 ratio, and oils were hydrogenated polydecene, cetyl ethylhexanoate and pentaerythrityl tetraethylhexanoate (PTO(R), Stearinerie Dubois Fils Co., France) as 1:1:1 ratio. All compounds were tested $0{\sim}27%dml$ Polyols and $0{\sim}35%dml$ oils in O/W emulsions. We investigated the effect of water contents and the effect of stratum corneum roughness in forearm skin after application of compounds. Water contents of the skin measured by skin capacitance and skin surface roughness measured visual scoring of skin surface biopsy through the scanning electron microscopy. Water contents of the skin were highly related to amount of polyols (to 20%) and oils (to 12%). Correlation coefficients were 0.971 and 0.985 respectively (p<0.01), 2 h after application. Skin surface roughness was positively correlated with polyol contents in concentration dependent manner, and depend on oils up to 6%. The ratio of coefficient was 2.5 to 1 (polyol to oils) by regression analysis. Further studies will be conducted with other ingredients such as surfactants, lipids and aqueous materials, and with ether methods for noninvasive measurement.

Evaluation of Basic Oxygen Furnace Slag as Soil Conditioner in the Rice Paddy Field (논토양 벼재배에서 제강슬래그의 토양개량제로서의 시용 효과)

  • Lim, June-Taeg;Lee, Yeen;Park, In-Jin;Lee, Choong-Il;Hyun, Kyu-Hawn;Kwon, Byung-Sun;Kim, Hak-Jin
    • Korean Journal of Soil Science and Fertilizer
    • /
    • v.32 no.3
    • /
    • pp.295-303
    • /
    • 1999
  • An experiment was conducted to evaluate the possibility of using basic oxygen furnace (BOF) slag as a soil conditioner in rice paddy field. In 1997, rice (Oryza sativa B. cv. Dongjinbyeo) crop was cultivated under different application rates of BOF slag at three different places, Inandong Sunchon city, Youjunglee Bosung province, and Nampyung Najoo city. In each paddy field, five treatments, four application rate of BOF slag (0, 4, 8, $12Mg\;ha^{-1}$) and one application rate of lime ($2Mg\;ha^{-1}$) were tried with three replications. Plant height, number of tillers per hill, leaf area per hill, leaf dry weight, calm dry weight or shoot dry weight per hill were measured five times at the interval of seven days. Chemical contents of rice plants and soil were also measured at the same sampling date Yield were estimated by harvesting $6.6m^2$ per experimental unit and yield components were measured by sampling 10 plants per experimental unit at the harvest date. Application of BOF slag hardly affected contents of soil organic matter, available phosphate and potassium in soil. Soil pH and contents of Ca, Mg, Fe and $SiO_2$ enhanced as BOF slag rate increased. Enhancement of soil pH by ROF slag treatment appeared to be closely related with increase in soil Ca content. Application tate of $2Mg\;ha^{-1}$ of lime showed almost the same effect, in increase of soil Ca content as application rate of $4{\sim}8Mg\;ha^{-1}$ of BOF slag, Fe content in soil decreased sharply as time passed after slag treatment and stabilized more or less at the later sampling date. Contents of inorganic matter in plant such as total nitrogen, phosphate, potassium and Mg were not affected by BOF slag treatment. However, contents of Ca, Fe, and $SiO_2$ in plants increased as slag rate became higher. The growth of rice plants with BOF slag treatment was more or less slower but continued persistently up to the later growth stage, so that growth of plants with BOF slag treatment was almost the same nr even greater than that of control or lime treatment. However, BOF slag rate of $12Mg\;ha^{-1}$ seemed to be too high because all the measurements of plant, growth at this rate showed lower values than those of other treatments at all the sampling dates. Treatments of BOF slag $4Mg\;ha^{-1}$ or $8Mg\;ha^{-1}$ showed higher rough rice yield than other treatments, so that the optimum BOF slag ratein rice paddy field seemed to be in the rage of $4{\sim}8Mg\;ha^{-1}$.

  • PDF

Quantitative Analysis of The Fruit Flesh of Prunus mume Siebold & Zuccarni. (매실 과육성분의 분석)

  • Lee, Oh-Kyu;Lee, Hak-Ju;Shin, Yu-Su;Ahn, Yun-Gyong;Jo, Hyun-Jin;Shin, Hyeon-Cheol;Kang, Ha-Young
    • Korean Journal of Medicinal Crop Science
    • /
    • v.15 no.3
    • /
    • pp.143-147
    • /
    • 2007
  • The fruit flesh of four Prunus mume cultivated varieties, P. mume 'Nanko', P. mume 'Viridicalyx', P. mume 'Baigo', P. mume var, microcarpa 'Koshusaisho' Siebold & Zuccarni, were ground and extracted with ethyl acetate and their chemical components were analyzed by GC/MS-SIM. In the ten compounds which was used fer the calibration, maleic anhydride, citraconic anhydride, 5-hydroxymethylfurfural, vanillin, linoleic acid, ethyl linoleate, and squalene were determined in all the four cultivated varieties. However, palmitic acid was detected only in P. mume var. microcarpa 'Koshusaisho'. Isopropyl palmitate was found only in P. mume 'Baigo' and var, microcarpa 'Koshusaisho', while stearic acid was determined in P. mume 'Nanko', 'Viridicalyx', and var, microcarpa 'Koshusaisho'. In the variation of quantities, maleic anhydride was contained 245.4, 153.6, 20.1, and 2.7 ppm in P. mume 'Baigo', 'Nanko', var. microcarpa 'Koshusaisho', and 'Viridicalyx', respectively. Citraconic anhydride was also contained 637.4, 543.1, 150.7, and 38.7 ppm in P. mume 'Baigo', 'Nanko', var. microcarpa 'Koshusaisho', and 'Viridicalyx', respectively. The amounts of stearic acid were 105.5, 64.4, and 32.3 ppm in P. mume var. microcarpa 'Koshusaisho', 'Viridicalyx', and 'Nanko', respectively. Squalene was found in amounts of 7.6, 1.7, 1.0, and 0.5 ppm in P. mume var. microcarpa 'Koshusaisho', 'Baigo', 'Nanko', and 'Viridicalyx', respectively. The amounts of other minor compounds also were varied in the P. mume cultivated varieties.