• Safety and Health at Work
• /
• v.5 no.4
• /
• pp.186-190
• /
• 2014

Background: Physical exercise during leisure time is known to increase physical capacity; however, the long-term effects on work ability and work strain are inconclusive. The aim of this study was to investigate the effects of a 6-month physical exercise program on work ability and work strain after 6 months and 30 months, among women with menopausal symptoms at baseline. Methods: A questionnaire including questions on work ability and work strain was mailed in the beginning, at 6 months and after 30 months after the intervention to occupationally active women participating in a randomized controlled study on physical exercise and quality of life. The intervention included aerobic exercise training 4 times per week, 50 minutes per session. Work ability was measured with the Work Ability Index (WAI) and with questions about physical and mental work strain. Results: Women aged 47-62 years (N=89) who were occupationally active at baseline were included in the analyses. The increase in WAI from baseline to the end of the exercise intervention (6 months) was statistically significantly greater among the intervention group than among the control group (regression coefficient 2.08; 95% confidence interval 0.71-3.46). The difference between the groups persisted for 30 months. No significant short- or long-term effects on physical and mental work strain were found. Conclusion: A 6-month physical exercise intervention among symptomatic menopausal women had positive short-term as well as long-term effects on work ability.

• Nuclear Engineering and Technology
• /
• v.55 no.5
• /
• pp.1630-1643
• /
• 2023

The correct situation awareness (SA) of operators is important for managing nuclear power plants (NPPs), particularly in accident-related situations. Among the three levels of SA suggested by Ensley, Level 3 SA (i.e., projection of the future status of the situation) is challenging because of the complexity of NPPs as well as the uncertainty of accidents. Hence, several prediction methods using artificial intelligence techniques have been proposed to assist operators in accident prediction. However, these methods only predict short-term plant status (e.g., the status after a few minutes) and do not provide information regarding the uncertainty associated with the prediction. This paper proposes an algorithm that can predict the multivariate and long-term behavior of plant parameters for 2 h with 120 steps and provide the uncertainty of the prediction. The algorithm applies bidirectional long short-term memory and an attention mechanism, which enable the algorithm to predict the precise long-term trends of the parameters with high prediction accuracy. A conditional variational autoencoder was used to provide uncertainty information about the network prediction. The algorithm was trained, optimized, and validated using a compact nuclear simulator for a Westinghouse 900 MWe NPP.

• Toxicological Research
• /
• v.8 no.2
• /
• pp.171-177
• /
• 1992

To investigate a short term screening method for carcinogenic quinone compounds, 8-hydroxydeoxyguanosine (8-OHdG), an oxidative DNA damage, was determined in the kidney and liver DNA isolated from Sprague-Dawley rats after i.p.injection of 7 mg/kg adriamycin (AM), 7mg/kg tetrahydropyranyladriamycin (THP), and 10mg/kg daunomycin (DM) by HPLC-electrochemical detector system. 8-OHdG was also determined from rat hepatocvtes and calf thymus DNA exposed to AM, DM and THP. When rats were treated with DM and THP, 8-OHdG was significantly increased in the kidney compared to control group, and remained at high level (7.9~9.0, 8-OHdG/dG${\times}10^4$)at the end of experiments (48hr after treatment). 8-OHdG level in cultured hepatocyte exposed to AM, DM and THP was 1.5~2 fold higher than control at all time points. (1,2,3,4hr after treatment). From calf thymus DNA exposed to AM, DM and THP, 8-OHdG was 2.5 fold higher than of control. These results suggest that quantitation of 8-OHdG may provide a useful marker for identifying target organ in oxidative chemical carcinogenesis and for short term screening of free radical generating carcinogens.

• Journal of Digital Convergence
• /
• v.11 no.10
• /
• pp.287-294
• /
• 2013

This study were proposed for the promotion policy on public confidence in nuclear power recovery schemes. To this end, the existing survey and secondary data review and public distrust of nuclear power plant safety issues were raised. In addition, the meta-analysis data were analyzed by using. Promote public confidence in nuclear power plants recovered three major policy presented. First, the nuclear power plant for the economical / safety communication strategy, short term / long term in terms proposed. Second, strengthen the nuclear power plant reliability and short-term communication strategy / long term in terms proposed. Finally, Korea Hydro & Nuclear Power's long-term image building measures proposed. The results of this study Korea's nuclear power plants to increase confidence in the effect is expected to be presented.

• Proceedings of the Korean Society of Applied Pharmacology
• /
• 1994.04a
• /
• pp.336-336
• /
• 1994

In order to develope the in vitro short term screen-ing method for carcinogen, we studied a purification method for thymine glycol in oxidaized DNA. Thymine glycol (5,6-dihydroxy-5, 6-dihydrothymine) is the major stable radiolysis poduct in thymine by chemical oxidants and ionzing radiation and it is a useful biomarker among oxidized DNA adducts, related with carcinogenests. Standard thymine glycol was prepared by oxidation of 〔$^3$H〕 thymine with KMnO$_4$ followed by purification with HPLC-LSC system and it was assayed by TLC and gas chromatography-MSD. 〔$^3$H〕 DMA adducts was isolated from E. coli (wild type ) treated with oxidative agents such as benzo(a)pyrene, adriamycin, aflatoxin B$_1$ and KBrO$_3$. These oxidative agents generated free radicals in cells by oxidative metabolism. As a result, thymine glycol was produced in cultured E. coli by four chemicals. This result shows that this methodology should be useful tool in screening oxidative carcinogen.

• Proceedings of the Safety Management and Science Conference
• /
• 2002.11a
• /
• pp.305-319
• /
• 2002

International capital movement has made progress at global liberalization of finance and foreign exchange, international monetary norm changing into floating exchange rate system, easiness of collection of information and trade at improvement of information communication technology from early of 1970's. Results of empirical test for relation between foreign exchange rate or various determination factors of foreign exchange rate and interest rate are followed by next sentences. First, according to relation between foreign exchange rate and interest rate, correlation for each of variables after OECD entrance is increased. But, long-term ＆short-term interest rate is affected by Hanbo ＆ Kia's bankruptcy, continuous large scale coporates bankruptcy and crisis of foreign exchange. Therefore, financial instability is occured. If portfolio investment fund has been inflow as it is mollified by continuous shortage of foreign exchange and fall of country's credit rating, it is expected to have positive effect for long-term & short-term interest rate from appreciation of won against dollar. Second, results from relation between determination factor of foreign exchange rate and interest rate are followed by next sentences. If surplus of current account and goods account is continued, yield of corporate bond is to be stable. But, margin of surplus is expected to diminish after second quarter 98, and difference between external and domestic interest (after adjusting foreign exchange rate) is to be diminished. And if net inflows of foreign investor's fund (stock and bond) is diminished, it is to have negative effect for yield of corporate bond. According to foreign investor's investment movement of previous years, hedge md were stayed at least during two years in Mexico. It means that sudden capital outflow is not to be happened at Korea. But if external factors from depreciation of yen and China's renminbi are instable, interest rate is expected to increase from capital's outflows. Third, if it is to decrease instability of foreign exchange rate from increase in surplus of future current account, credit rating's upwardness, stability of yen and renminbi, foreign exchange rate is expected to be stable. It is expected to have continuous stability from short-term interest rate to long-term interest rate in this empirical test.

• Nuclear Engineering and Technology
• /
• v.38 no.6
• /
• pp.459-482
• /
• 2006

A geochemical approach to the long-term safety of waste disposal is discussed in connection with the significance of actinides, which shall deliver the major radioactivity inventory subsequent to the relatively short-term decay of fission products. Every power reactor generates transuranic (TRU) elements: plutonium and minor actinides (Np, Am, Cm), which consist chiefly of long-lived nuclides emitting alpha radiation. The amount of TRU actinides generated in a fuel life period is found to be relatively small (about 1 wt% or less in spent fuel) but their radioactivity persists many hundred thousands years. Geological confinement of waste containing TRU actinides demands, as a result, fundamental knowledge on the geochemical behavior of actinides in the repository environment for a long period of time. Appraisal of the scientific progress in this subject area is the main objective of the present paper. Following the introductory discussion on natural radioactivities, the nuclear fuel cycle is briefly brought up with reference to actinide generation and waste disposal. As the long-term disposal safety concerns inevitably with actinides, the significance of the aquatic actinide chemistry is summarized in two parts: the fundamental properties relevant to their aquatic behavior and the geochemical reactions in nanoscopic scale. The constrained space of writing allows discussion on some examples only, for which topics of the primary concern are selected, e.g. apparent solubility and colloid generation, colloid-facilitated migration, notable speciation of such processes, etc. Discussion is summed up to end with how to make a geochemical approach available for the long-term disposal safety of nuclear waste or for the performance assessment (PA) as known generally.

• Proceedings of the Safety Management and Science Conference
• /
• 2011.11a
• /
• pp.551-556
• /
• 2011

This research presents an implementation strategy of Process Capability Index (PCI) according to the types of process characteristics. The types of process feature are classified as four perspectives of variation range, time period, error position, and process stage. The paper examines short-term or long-term PCI, within or between variation, position of precision or accuracy, and inclusion of measurement or calibration stage. Moreover, the study proposes normality test of unilateral PCI.

• Annals of Hepato-Biliary-Pancreatic Surgery
• /
• v.28 no.2
• /
• pp.220-228
• /
• 2024

Backgrounds/Aims: Postoperative pancreatic fistula is the key worry in the ongoing debate about the safety and effectiveness of total laparoscopic pancreaticoduodenectomy (TLPD). Laparoscopic-assisted pancreaticoduodenectomy (LAPD), a hybrid approach combining laparoscopic resection and anastomosis with a small incision, is an alternative to TLPD. This study compares the short-term outcomes and oncological efficacy of LAPD vs. open pancreaticoduodenectomy (OPD). Methods: A retrospective analysis of data of all patients who underwent LAPD or OPD for periampullary carcinoma at a tertiary care center in Northeast India from July 2019 to August 2023 was done. A total of 30 LAPDs and 30 OPDs were compared after 1:1 propensity score matching. Demographic data, intraoperative and postoperative data (30 days), and pathological data were compared. Results: The study included a total of 93 patients, 30 underwent LAPD and 62 underwent OPD. After propensity score matching, the matched cohort included 30 patients in both groups. The LAPD presented several advantages over the OPD group, including a shorter incision length, reduced postoperative pain, earlier initiation of oral feeding, and shorter hospital stays. LAPD was not found to be inferior to OPD in terms of pancreatic fistula incidence (Grade B, 30.0% vs. 33.3%), achieving R0 resection (100% vs. 93.3%), and the number of lymph nodes harvested (12 vs. 14, p = 0.620). No significant differences in blood loss, short-term complications, pathological outcomes, readmissions, and early (30-day) mortality were observed between the two groups. Conclusions: LAPD has comparable safety, technical feasibility, and short-term oncological efficacy.

• Journal of the Korea Safety Management & Science
• /
• v.16 no.3
• /
• pp.1-7
• /
• 2014

In this study, based on the international standard the quantitative assessment model for the level of safety, health and environment was developed. As a result of applying this model, the company(workplace) which has established improvement plan based on quantitative assessment of short-term and long-term requirements, and implemented it was acquired more higher level of safety, health and environment by more than the existing ones.